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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Surgery for Hepato-Pancreato-Biliary (HPB) Cancer

edited by

Gennaro Nappo

and

Michele Pagnanelli

submission deadline 10 Aug 2026 | 10 articles | Viewed by 11004 | Submission Open

Keywords: pancreatic malignancies; HPB malignancies; pancreatic ductal adenocarcinoma; liver cholangiocarcinoma; HPB surgery; liver resection; pancreatic resection

(This special issue belongs to the Section Cancer Therapy)

Bridging Translational and Clinical Oncology in Gastrointestinal Cancers: Molecular Mechanisms to Therapeutic Advances

edited by

Stavros Papadakos

Ioannis Katsaros

and

Stamatios E. Theocharis

submission deadline 10 Aug 2026 | Submission Open

Keywords: gastrointestinal cancers; translational oncology; molecular mechanisms; biomarkers; immunotherapy; radiomics; precision medicine; therapeutic advances

(This special issue belongs to the Section Methods and Technologies Development)

Rare Genitourinary Cancers

edited by

Luis G Medina

and

Philippe E. Spiess

submission deadline 15 Aug 2026 | Viewed by 66 | Submission Open

Keywords: rare genitourinary tumors; penile cancer; testicular cancer; urethral cancer; adrenal cancer; variant histology; upper tract urothelial carcinoma; extramammary Paget’ s disease; urologic oncology; rare cancers

(This special issue belongs to the Section Clinical Research of Cancer)

Immunotherapy for Hematologic Malignancies

edited by Rajesh Ramakrishnan Nair

submission deadline 15 Aug 2026 | Viewed by 62 | Submission Open

Keywords: immune evasion; immunotherapy; CAR-T cell therapy; BiTEs; immunomodulators; checkpoint; inhibitors; bone marrow microenvironment; refractory/relapsed; drug resistance; gene editing

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Clinical Applications of Advanced MRI Technologies for Cancers

edited by

Nicolò Cardobi

submission deadline 15 Aug 2026 | Viewed by 36 | Submission Open

Keywords: advanced MRI techniques; multiparametric imaging; quantitative biomarkers; artificial intelligence; treatment response assessment; precision oncology; radiomics; cancer diagnosis; functional imaging; molecular imaging

(This special issue belongs to the Section Methods and Technologies Development)

Rare Cancers, Diagnostic Challenges and Personalized Therapeutic Approaches in the 21st Century (2nd Edition)

edited by

Jason Roszik

submission deadline 20 Aug 2026 | 1 articles | Viewed by 807 | Submission Open

Keywords: rare cancer; biology; diagnosis; classification; personalized therapeutics; markers

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical, Diagnostic and Neurosurgical Management in Pediatric Neuro-Oncology

edited by

John Ross Crawford

and Michael Levy

submission deadline 20 Aug 2026 | Viewed by 124 | Submission Open

Keywords: neuro-oncology; brain tumors; neuroradiology; proton therapy; pediatric; neurosurgery; treatment; chemotherapy; targeted agents; molecular subtypes; immunotherapy; late effects; radiation therapy

(This special issue belongs to the Section Pediatric Oncology)

Socio-Demographic Factors and Cancer Research: 2nd Edition

edited by

Mitchell S. Fourman

and Amanda N. Goldin

submission deadline 20 Aug 2026 | Viewed by 96 | Submission Open

Keywords: socio-economic disparity; cancer delivery; cancer survival; metastatic cancer; culture-specific cancer outcomes; AI; machine learning

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Contemporary Diagnosis and Management of Prostate Cancer (2nd Edition)

edited by Thomas Jang

submission deadline 22 Aug 2026 | Viewed by 42 | Submission Open

Keywords: prostate cancer; diagnosis; management; radical prostatectomy; biomarkers

(This special issue belongs to the Section Cancer Therapy)

Modern Approach to Oral Cancer

edited by

Maria Maddalena Marrapodi

and

Giuseppe Minervini

submission deadline 30 Aug 2026 | 11 articles | Viewed by 38108 | Submission Open

Keywords: oral cancer; neoplasm; oral surgery oncogenesis; dentistry oral health

(This special issue belongs to the Section Cancer Therapy)

Pathology of Acute Myeloid Leukemia (AML)

edited by Olga K. Weinberg

submission deadline 30 Aug 2026 | Viewed by 1206 | Submission Open

(This special issue belongs to the Section Cancer Pathophysiology)

Proteometabolomics in Cancer

edited by

Samir M. Hanash

and

Johannes Fahrmann

submission deadline 30 Aug 2026 | Viewed by 69 | Submission Open

Keywords: proteomics; metabolomics; cancer biology; tumor microenvironment; biomarkers; therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Tumor Suppressor and Targeted Therapy in Hepatocellular Carcinoma: From Diagnosis to Treatment (2nd Edition)

edited by

Ching-Sheng Hsu

Po-Heng Chuang

and I-Cheng Lee

submission deadline 30 Aug 2026 | Viewed by 47 | Submission Open

Keywords: tumor suppressor; targeted therapy; hepatocellular carcinoma

(This special issue belongs to the Section Tumor Microenvironment)

Long-Term Health Outcomes and Quality of Life in Survivors of Childhood Cancer

edited by

Esteban Orenes-Piñero

submission deadline 30 Aug 2026 | Viewed by 38 | Submission Open

Keywords: acute lymphoblastic leukemia; brain tumors; childhood cancer survivors; pollutants; environment; quality of life; nutrition; chemotherapy; air and water purification

(This special issue belongs to the Section Pediatric Oncology)

Gastrointestinal Malignancy: Epidemiology and Risk Factors

edited by Patrick Okolo and Chengu Niu

submission deadline 31 Aug 2026 | 7 articles | Viewed by 24909 | Submission Open

Keywords: gastrointestinal cancer; epidemiology; risk factors; molecular markers; genetic factors; therapeutic advancements; prevention strategies; public health; interdisciplinary approaches; clinical impact

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advancing Horizons in Colorectal Surgery: Innovative Approaches and Outcomes

edited by Petros I. Bangeas and Vasileios N. Papadopoulos

submission deadline 31 Aug 2026 | 4 articles | Viewed by 13186 | Submission Open

Keywords: colorectal surgery; postoperative pain; surgical site infections; anastomotic leaks; minimally invasive techniques; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Advancements in “Cancer Biomarkers” for 2025–2026

edited by

Maxim V. Berezovski

submission deadline 31 Aug 2026 | 7 articles | Viewed by 9923 | Submission Open

Keywords: RNA biomarkers; miRNA biomarkers; DNA biomarkers; cell-free DNA (cfDNA); protein biomarkers; metabolomic biomarkers; mutational biomarkers; circulating tumor cells (CTCs); tumor-derived extracellular vesicle (tEV) biomarkers; cellular biomarkers; imaging biomarkers; clinical biomarkers; biomarkers of drug response; biomarkers of genetic predisposition to cancer; epigenetic biomarkers; biomarkers of cancer outcomes; mass spectrometry; next-generation sequencing (NGS); flow cytometry; positron emission tomography (PET); computed tomography (CT); magnetic resonance imaging (MRI); X-rays; ultrasound; electrocardiography (ECG/EKG); endoscopy; biopsy; pulmonary function tests (PFTs); histopathology; cytopathology; immunohistochemistry (IHC); in situ hybridization (ISH); fluorescence in situ hybridization (FISH); liquid biopsy; electron microscopy; digital pathology and image analysis

(This special issue belongs to the Section Cancer Biomarkers)

Feature Review Paper Special Issue in Section Molecular Cancer Biology

edited by

Donat Kögel

submission deadline 31 Aug 2026 | 3 articles | Viewed by 7811 | Submission Open

Keywords: molecular biology; cell biology; cancer; tumor; cancer cell

(This special issue belongs to the Section Molecular Cancer Biology)

Cancer Stem Cells: The Origin of Tumor Relapse and Metastasis

edited by

Ming Tan

and

Evgeniy V. Denisov

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2803 | Submission Open

Keywords: metastasis; cancer stem cell; tumor microenvironment; tumor heterogeneity; plasticity; immune evasion; therapeutic resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Emergencies in Gastrointestinal Surgical Oncology

edited by

Fausto Rosa

Carlo Alberto Schena

and

Nicola De'Angelis

submission deadline 31 Aug 2026 | Viewed by 500 | Submission Open

Keywords: surgical oncology; emergencies; emergency surgery; acute care surgery; palliation; futility in surgery

(This special issue belongs to the Section Clinical Research of Cancer)

CAR T-Cell Therapy and Multiple Myeloma

edited by Jo Caers

submission deadline 31 Aug 2026 | Viewed by 303 | Submission Open

Keywords: multiple myeloma; CAR-T immunotherapy; toxicity; efficacy; tumor models; safety

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Hereditary Cancer: State of the Art

edited by Joanne Ngeow, Jianbang Chiang and

Rashid N. Lui

submission deadline 31 Aug 2026 | Viewed by 140 | Submission Open

Keywords: hereditary cancer syndromes; inherited cancers; cancer genetics and genomics; germline variants; surveillance

(This special issue belongs to the Section Cancer Pathophysiology)

Hypoxia-Targeting Strategies to Improve Cancer Therapy Outcomes

edited by Roben Gieling and Ayse Latif

submission deadline 31 Aug 2026 | Viewed by 75 | Submission Open

Keywords: tumor hypoxia; cancer therapy resistance; hypoxia-targeted therapy; hypoxia-inducible factors (HIFs); hypoxia-activated prodrugs; oxygen-modifying agents; combination therapy; precision drug delivery; tumor microenvironment; translational cancer research

(This special issue belongs to the Section Cancer Therapy)

The Genetic Analysis and Clinical Therapy in Lung Cancer: 2nd Edition

edited by

Francesca Colombo

and Frullanti Elisa

submission deadline 31 Aug 2026 | Viewed by 58 | Submission Open

Keywords: lung cancer; biomarkers; genetic variants; innovative technologies; targeted therapy; immunotherapy; personalized therapy; survival; liquid biopsy pharmacogenomics

(This special issue belongs to the Section Cancer Therapy)

New Advances and Approaches in Thyroid Cancer

edited by

Beatriz Febrero

and José Manuel Rodríguez

submission deadline 31 Aug 2026 | Viewed by 49 | Submission Open

Keywords: thyroid cancer; medullary thyroid cancer; papillary thyroid cancer; follicular thyroid cancer; poorly differentiated thyroid tumours; novel approaches; prognostic biomarkers; risk stratification

(This special issue belongs to the Section Cancer Therapy)

CAR T Cell Therapy in Cancer: Progress and Challenges Across Solid and Hematologic Malignancies

edited by John F. Marshall and Lauren C. Cutmore

submission deadline 31 Aug 2026 | Viewed by 45 | Submission Open

Keywords: CAR-T cell therapy; adoptive cell therapy; immunotherapy; antigen escape; solid tumor; hematologic malignancies

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Human Carcinogens—Chemical Agents, Occupational Exposure and Health Impact

edited by Jun-Pyo Myong

submission deadline 31 Aug 2026 | Viewed by 44 | Submission Open

Keywords: occupational exposure; chemical carcinogens; risk assessment; epidemiology; biomarkers; exposure assessment; preventive strategies; workplace safety; occupational health; regulatory measures

(This special issue belongs to the Section Infectious Agents and Cancer)

Clinical Treatment and Outcomes of Gastrointestinal Cancer

edited by Mary Linton Peters

submission deadline 31 Aug 2026 | Viewed by 44 | Submission Open

Keywords: gastrointestinal cancer; ctDNA; chemotherapy; immunotherapy; financial toxicity; clinical trial participation

(This special issue belongs to the Section Clinical Research of Cancer)

Tumor Microenvironment in Cancer Therapies: Supportive or Hostile?

edited by

Constantin N. Baxevanis

submission deadline 31 Aug 2026 | Viewed by 42 | Submission Open

Keywords: tumor microenvironment; protumor effects; antitumor effects; immune cells; stromal cells; extracellular matrix; cancer therapies

(This special issue belongs to the Section Tumor Microenvironment)

Wnt Signaling Pathway in Cancer Immunotherapy

edited by

Yong-Mi Kim

and

Michael Kahn

submission deadline 31 Aug 2026 | Viewed by 41 | Submission Open

Keywords: Wnt signaling; immunotherapy; immune cells; macrophages; T-cell; CART cells; stromal cells; tumor microenvireonment; cancers; cancer stem cells

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in the Early Diagnosis and Treatment of Gastric Cancer (2nd Edition)

edited by Sharona B. Ross

submission deadline 31 Aug 2026 | Viewed by 37 | Submission Open

Keywords: gastric cancer; tumor resection; liver tumors

(This special issue belongs to the Section Cancer Therapy)

The Unseen Burden: Incidence and Outcomes of Infections in Leukemia

edited by

Elisa Buzzatti

and

Maria Ilaria Del Principe

submission deadline 31 Aug 2026 | Viewed by 35 | Submission Open

Keywords: infection management; infectious risk; antimicrobial therapy; antimicrobial prophylaxis

(This special issue belongs to the Section Infectious Agents and Cancer)

Acute Myeloid Leukemia in Adults (2nd Edition)

edited by

Theodoros Karantanos

submission deadline 31 Aug 2026 | Viewed by 31 | Submission Open

Keywords: acute myeloid leukemia; molecular biology; treatment landscape; resistance mechanisms

(This special issue belongs to the Section Clinical Research of Cancer)

Early Detection and Strategies for Overcoming Therapy Resistance in Lung Cancer and Mesothelioma

edited by

Katalin Dobra

submission deadline 31 Aug 2026 | Viewed by 27 | Submission Open

Keywords: lung cancer; mesothelioma; screening; biomarker; molecular diagnostics; resistance

(This special issue belongs to the Section Cancer Therapy)

Cancer-Therapy-Related Adverse Events (2nd Edition)

edited by

Yinghong Wang

and Pauline Funchain

submission deadline 1 Sep 2026 | 2 articles | Viewed by 2119 | Submission Open

Keywords: cancer; cancer therapy; toxicities; adverse events

(This special issue belongs to the Section Cancer Therapy)

The Role of Minimally Invasive and Minimally Radical Surgery in Cervical and Endometrial Cancer

edited by

Raj Naik

, Marie Plante, Christophe Pomel,

Roberto Tozzi

and Gwénaël Ferron

submission deadline 1 Sep 2026 | Viewed by 80 | Submission Open

Keywords: cervical cancer; endometrial cancer; laparoscopic surgery; minimally invasive surgery; surgical oncology; fertility-sparing surgery; non-radical surgery; conservative surgery

(This special issue belongs to the Section Cancer Therapy)

Prostatectomy Today: Surgical Advances in Prostate Cancer Management

edited by

Ettore Mearini

submission deadline 1 Sep 2026 | Viewed by 45 | Submission Open

Keywords: prostate cancer; robot-assisted radical prostatectomy; robotic system; perioperative outcomes; sexual function; urinary continence; oncological outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Interventional Oncologic Therapies

edited by Edward W. Lee and

Dong Il Gwon

submission deadline 15 Sep 2026 | 3 articles | Viewed by 9077 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer: Immune Response, Immune Microenvironment, and Immunotherapy

edited by

Ravindra Deshpande

and

Ann Richmond

submission deadline 15 Sep 2026 | Viewed by 50 | Submission Open

Keywords: breast cancer; immune response; tumor immune microenvironment; immunotherapy resistance; intrinsic and extrinsic mechanisms; immune checkpoint inhibitors; T-cell dysfunction; cytokines; cancer vaccines; tumor immunosuppression

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Evidence-Based Care for Managing Oncologic Emergencies in Patients with Cancer

edited by

Aiham Qdaisat

and

Sai-Ching Jim Yeung

submission deadline 15 Sep 2026 | Viewed by 44 | Submission Open

Keywords: oncologic emergencies; cancer; urgent; infections; adverse events; thrombosis; febrile neutropenia; pain; spinal cord compression; goals of care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Breast Conservation Therapy: A Global Perspective

edited by Tristen S. Park

submission deadline 15 Sep 2026 | Viewed by 19 | Submission Open

Keywords: breast conservation therapy; survival; breast cancer

(This special issue belongs to the Section Cancer Therapy)

Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-axial Brain Tumors

edited by

Andrea Di Cristofori

, Carlo Giussani, Cesare Zoia and Daniele Bongetta

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3793 | Submission Open

Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning

(This special issue belongs to the Section Clinical Research of Cancer)

Tumor Microenvironment Dynamics in Hepatocellular Carcinoma

edited by Joseph Franses and Adam Burgoyne

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1730 | Submission Open

Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions

(This special issue belongs to the Section Tumor Microenvironment)

Novel Advancements in Prostate Cancer Surgery: Indications and Techniques

edited by Valerio Santarelli and

Alessandro Sciarra

submission deadline 30 Sep 2026 | 1 articles | Viewed by 998 | Submission Open

Keywords: radical prostatectomy; prostate cancer; technology; minimally invasive surgery

(This special issue belongs to the Section Cancer Therapy)

Targeting RNA to Improve Cancer Precision Medicine

edited by

Gabriella Misso

, Anna Grimaldi and Chiara Tammaro

submission deadline 30 Sep 2026 | Viewed by 464 | Submission Open

Keywords: cancer; RNA therapy; RNA delivery; RNA; miRNA; mRNA; siRNA; oligonucleotides; aptamers; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Decision-Making Biomarkers in the Treatment of Hepatocellular Carcinoma

edited by

Norihiro Imai

and

Dongming Liu

submission deadline 30 Sep 2026 | 2 articles | Viewed by 387 | Submission Open

Keywords: hepatocellular carcinoma; borderline resectable; conversion therapy; neoadjuvant therapy; immunotherapy; immune-related adverse event; molecular-targeted agent

(This special issue belongs to the Section Cancer Biomarkers)

Cancer Immunotherapy-Related Adverse Events and Therapy-Related Accelerated Aging

edited by

Grace Lu-Yao

submission deadline 30 Sep 2026 | Viewed by 121 | Submission Open

Keywords: immune-related adverse events (irAEs); accelerated aging; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

The Development of Effective Therapy Targeting the Microenvironment of Cancer (2nd Edition)

edited by

Moriaki Kusakabe

and Kanae Taruno

submission deadline 30 Sep 2026 | Viewed by 92 | Submission Open

Keywords: cancer; tumor microenvironment; cancer therapy; cancer cell; animal level

(This special issue belongs to the Section Tumor Microenvironment)

Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management

edited by

Sam Payabvash

and Stefan Haider

submission deadline 30 Sep 2026 | Viewed by 90 | Submission Open

Keywords: machine learning; radiomics; cancer imaging; malignancy; survival

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Tumor-Initiating Cells in Cancer: Their Interactions with Other Cell Types, and Prospective Applications

edited by

Spiros Vlahopoulos

submission deadline 30 Sep 2026 | Viewed by 78 | Submission Open

Keywords: cancer stem cells; cancer stem-like cells; leukemia; chromatin; transcription factors; cellular phenotype; microenvironment; immunity; tumor stroma

(This special issue belongs to the Section Tumor Microenvironment)

Displaying special issue 1051-1100 on page 22 of 23.

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