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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exercise and Cancer Treatment: The Clinical Application of Exercise Oncology

edited by

Helena Batatinha

and Geovana Leite

submission deadline 10 Sep 2026 | 1 articles | Viewed by 1007 | Submission Open

Keywords: exercise oncology; cancer therapy; immunotherapy; patient outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Interventional Oncologic Therapies

edited by Edward W. Lee and

Dong Il Gwon

submission deadline 15 Sep 2026 | 3 articles | Viewed by 10037 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

First-Line Therapy in Thoracic Oncology

edited by Antonio D'Andrilli and

Giulio Maurizi

submission deadline 15 Sep 2026 | 2 articles | Viewed by 2857 | Submission Open

Keywords: thoracic oncology; lung cancer; thymoma; mediastinal tumors

(This special issue belongs to the Section Cancer Therapy)

The Clinical, Technological, and Scientific Progress of Boron Neutron Capture Therapy

edited by

Shinji Kawabata

submission deadline 15 Sep 2026 | Viewed by 536 | Submission Open

Keywords: boron neutron capture therapy (BNCT); neutron capture therapy (NCT); accelerator-based neutron source; neutron dosimetry; boron drug development; alternative capture agents; radiobiological effects; radiation oncology; interdisciplinary research; clinical translation

(This special issue belongs to the Section Cancer Therapy)

Evidence-Based Care for Managing Oncologic Emergencies in Patients with Cancer

edited by

Aiham Qdaisat

and

Sai-Ching Jim Yeung

submission deadline 15 Sep 2026 | Viewed by 81 | Submission Open

Keywords: oncologic emergencies; cancer; urgent; infections; adverse events; thrombosis; febrile neutropenia; pain; spinal cord compression; goals of care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Breast Cancer: Immune Response, Immune Microenvironment, and Immunotherapy

edited by

Ravindra Deshpande

and

Ann Richmond

submission deadline 15 Sep 2026 | Viewed by 69 | Submission Open

Keywords: breast cancer; immune response; tumor immune microenvironment; immunotherapy resistance; intrinsic and extrinsic mechanisms; immune checkpoint inhibitors; T-cell dysfunction; cytokines; cancer vaccines; tumor immunosuppression

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Advances in Breast Conservation Therapy: A Global Perspective

edited by Tristen S. Park

submission deadline 15 Sep 2026 | Viewed by 34 | Submission Open

Keywords: breast conservation therapy; survival; breast cancer

(This special issue belongs to the Section Cancer Therapy)

T Cells in Hematologic Malignancies: Biology, Microenvironment, and Therapeutic Advances

edited by

Maria Velegraki, MD, PhD

submission deadline 16 Sep 2026 | Viewed by 53 | Submission Open

Keywords: T cells; hematologic malignancies; CAR-T therapy; bispecific T cell engagers; tumor immune microenvironment; T cell dysfunction and exhaustion; leukemia; lymphoma; and myeloma; acute myeloid leukemia and MDS; immunotherapy resistance and relapse; next-generation cellular therapies

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Management of Pancreatic Cancer: 2nd Edition

edited by

Traian Dumitrascu

submission deadline 18 Sep 2026 | Submission Open

Keywords: pancreatic cancer; adenocarcinoma; neuroendocrine carcinomas; molecular and pathological aspects; diagnosis; medical treatment; palliative therapy

Advances in Salivary Gland Carcinoma: 2nd Edition

edited by

Giulio Cantù

submission deadline 20 Sep 2026 | 2 articles | Viewed by 5567 | Submission Open

Keywords: salivary gland tumors; head and neck cancer; facial nerve preservation; facial nerve reconstruction; facial nerve sacrifice; parotid cancer; parotidectomy; prognostic factors

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Molecular Pathology Insights in Thyroid Cancer

edited by Salma Khan

submission deadline 20 Sep 2026 | Viewed by 268 | Submission Open

Keywords: non-coding RNAs; epigenetics; biomarkers; BRAF mutations; RAS mutations; targeted therapy; precision medicine; genomic profiling; tumor heterogeneity; therapeutic resistance

(This special issue belongs to the Section Cancer Pathophysiology)

Clinical Outcomes in Upper GI Cancers

edited by

Yoshiaki Shoji

submission deadline 20 Sep 2026 | Viewed by 41 | Submission Open

Keywords: esophageal cancer; gastric cancer; esophagogastric junction cancer; surgery; endoscopy; chemotherapy; immuno-therapy; molecural target therapy; biomarker

(This special issue belongs to the Section Clinical Research of Cancer)

Targeting the Vulnerabilities of Oncogene Activation (Second Edition)

edited by

Jack L. Arbiser

submission deadline 25 Sep 2026 | Viewed by 232 | Submission Open

Keywords: tumorigenesis; tumor-suppressor genes; oncogene; target

(This special issue belongs to the Section Methods and Technologies Development)

Role of Iron Metabolism in Tumor Progression

edited by

Xiang Xue

submission deadline 25 Sep 2026 | Submission Open

Keywords: iron metabolism; ferroptosis; tumor microenvironment; oxidative stress; iron chelation therapy; ferritin; transferrin receptor; cancer metabolism; redox homeostasis; therapeutic targeting

(This special issue belongs to the Section Molecular Cancer Biology)

Neurosurgery Research on Brain Tumors: A Focus on Gliomas and Other Intra-Axial Brain Tumors

edited by

Andrea Di Cristofori

, Carlo Giussani, Cesare Zoia and Daniele Bongetta

submission deadline 30 Sep 2026 | 2 articles | Viewed by 4498 | Submission Open

Keywords: neurosurgery; glioma; neuropsychology; neurophysiological monitoring; intraoperative imaging (including iMRI and iOUS); neuroanatomy; outcome; prognosis and quality of life; MRI (including fMRI; MR spectroscopy; perfusion and DTI tractography); radiogenomics; multimodal treatments; druggable targets; artificial intelligence and deep learning

(This special issue belongs to the Section Clinical Research of Cancer)

Decision-Making Biomarkers in the Treatment of Hepatocellular Carcinoma

edited by

Norihiro Imai

and

Dongming Liu

submission deadline 30 Sep 2026 | 3 articles | Viewed by 2732 | Submission Open

Keywords: hepatocellular carcinoma; borderline resectable; conversion therapy; neoadjuvant therapy; immunotherapy; immune-related adverse event; molecular-targeted agent

(This special issue belongs to the Section Cancer Biomarkers)

Tumor Microenvironment Dynamics in Hepatocellular Carcinoma

edited by Joseph Franses and Adam Burgoyne

submission deadline 30 Sep 2026 | 2 articles | Viewed by 2116 | Submission Open

Keywords: liver cancer; immune therapy; biomarkers; treatment resistance; cellular interactions

(This special issue belongs to the Section Tumor Microenvironment)

Novel Advancements in Prostate Cancer Surgery: Indications and Techniques

edited by Valerio Santarelli and

Alessandro Sciarra

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1259 | Submission Open

Keywords: radical prostatectomy; prostate cancer; technology; minimally invasive surgery

(This special issue belongs to the Section Cancer Therapy)

Targeting RNA to Improve Cancer Precision Medicine

edited by

Gabriella Misso

, Anna Grimaldi and Chiara Tammaro

submission deadline 30 Sep 2026 | Viewed by 504 | Submission Open

Keywords: cancer; RNA therapy; RNA delivery; RNA; miRNA; mRNA; siRNA; oligonucleotides; aptamers; precision medicine

(This special issue belongs to the Section Cancer Therapy)

Cancer Immunotherapy-Related Adverse Events and Therapy-Related Accelerated Aging

edited by

Grace Lu-Yao

submission deadline 30 Sep 2026 | Viewed by 141 | Submission Open

Keywords: immune-related adverse events (irAEs); accelerated aging; immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Multimodal Artificial Intelligence/Machine Learning Applications in Malignant Tumors: Diagnosis, Prognosis, and Management

edited by

Sam Payabvash

and Stefan Haider

submission deadline 30 Sep 2026 | Viewed by 131 | Submission Open

Keywords: machine learning; radiomics; cancer imaging; malignancy; survival

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Development of Effective Therapy Targeting the Microenvironment of Cancer (2nd Edition)

edited by

Moriaki Kusakabe

and Kanae Taruno

submission deadline 30 Sep 2026 | Viewed by 106 | Submission Open

Keywords: cancer; tumor microenvironment; cancer therapy; cancer cell; animal level

(This special issue belongs to the Section Tumor Microenvironment)

Tumor-Initiating Cells in Cancer: Their Interactions with Other Cell Types, and Prospective Applications

edited by

Spiros Vlahopoulos

submission deadline 30 Sep 2026 | Viewed by 103 | Submission Open

Keywords: cancer stem cells; cancer stem-like cells; leukemia; chromatin; transcription factors; cellular phenotype; microenvironment; immunity; tumor stroma

(This special issue belongs to the Section Tumor Microenvironment)

Breast Cancer and Pregnancy: Clinical, Translational, and Psychosocial Perspectives

edited by

Alba Di Leone

and

Elena Jane Mason

submission deadline 30 Sep 2026 | Viewed by 92 | Submission Open

Keywords: pregnancy-associated breast cancer; postpartum breast cancer; pregnancy after breast cancer; oncofertility; fertility preservation; breast surgery; maternal outcomes; fetal outcomes; genetic risk; survivorship

(This special issue belongs to the Section Clinical Research of Cancer)

Medical Image-Based Cervical Cancer Prevention, Diagnosis and Treatments

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 30 Sep 2026 | Viewed by 75 | Submission Open

Keywords: medical imaging; 3-dimensional imaging; cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Pediatric Surgery in Oncology: Innovations, Challenges, and Future Directions

edited by Abdelhafeez H. Abdelhafeez and Kokila Lakhoo

submission deadline 30 Sep 2026 | Viewed by 66 | Submission Open

Keywords: pediatric surgical oncology; intraoperative image guidance; minimally invasive surgery; fluorescence guidance; augmented reality; precision cancer surgery

(This special issue belongs to the Section Pediatric Oncology)

Senescence and Cell Plasticity in Cancer Development

edited by

Eva María Verdugo-Sivianes

and Elena Aguado-Domínguez

submission deadline 30 Sep 2026 | Viewed by 62 | Submission Open

Keywords: cellular senescence; cell plasticity; stem cells; SASP; therapy resistance; tumor microenvironment; cancer development

(This special issue belongs to the Section Molecular Cancer Biology)

Psychological Factors and Cancer Survivorship

edited by

Deidre B. Pereira

and Ashley P. Ghiaseddin

submission deadline 30 Sep 2026 | Viewed by 61 | Submission Open

Keywords: psycho-oncology; distress; distress management; biobehavior markers and mechanisms; quality of life outcomes; treatment outcomes; survival outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Cancer Drug Resistance: Mechanisms and Overcoming Strategies

edited by

Jessica M. Konen

submission deadline 30 Sep 2026 | Viewed by 59 | Submission Open

Keywords: intrinsic resistance; acquired resistance; targeted therapy resistance; combination treatment strategies; immunotherapy resistance; tumor heterogeneity

(This special issue belongs to the Section Clinical Research of Cancer)

Redefining Precision Radiotherapy

edited by Srinivasan Vijayakumar

submission deadline 30 Sep 2026 | Viewed by 53 | Submission Open

Keywords: precision radiotherapy; cancer radiotherapy; PRT; RadioTheronostics

(This special issue belongs to the Section Methods and Technologies Development)

Beyond PEGylation: Next-Generation Nanomedicine for Cancer Therapy

edited by

Soumen Saha

submission deadline 30 Sep 2026 | Viewed by 51 | Submission Open

Keywords: nanomedicine; tumor-targeting mechanisms; cancers

(This special issue belongs to the Section Tumor Microenvironment)

CRLM in the Era of Transplant Oncology: New Hope, New Questions

edited by Brian Davidson and

Khurum Khan

submission deadline 30 Sep 2026 | Viewed by 51 | Submission Open

Keywords: colorectal cancer; liver transplant; transplant oncology; chemotherapy; immunotherapy; immunosuppression; genetic profiling; circulating ccDNA; staging; surveillance

(This special issue belongs to the Section Cancer Therapy)

Advances in Brain Tumors

edited by

David S. Baskin

submission deadline 30 Sep 2026 | Viewed by 50 | Submission Open

Keywords: diagnosis; biomarker; treatment; brain tumors

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Combination Therapy for Lymphoma

edited by

Maria Christina Cox

submission deadline 30 Sep 2026 | Viewed by 49 | Submission Open

Keywords: lymphoma; combination therapies; T-cell engagers; immuno-conjugates; targeted drugs

(This special issue belongs to the Section Cancer Therapy)

Pre-Clinical Studies of Personalized Medicine for Cancer Research: 2nd Edition

edited by

Nuno Vale

submission deadline 30 Sep 2026 | Viewed by 48 | Submission Open

Keywords: patient-derived models; genomic profiling; drug screening; biomarker validation; combination therapies; mechanistic studies; tumor heterogeneity; data analysis and interpretation

(This special issue belongs to the Section Molecular Cancer Biology)

Integrated Palliative Care in Advanced Cancer

edited by

Sebastiano Mercadante

submission deadline 30 Sep 2026 | Viewed by 46 | Submission Open

Keywords: integrated palliative care; advanced cancer; cancer pain; symptom management; early integration; supportive care; end-of-life care; patient-centered outcomes; tele-palliative care; refractory symptoms

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Clinical Pharmacology in Lung Cancer—2nd Edition

edited by

Chih-Jen Yang

submission deadline 30 Sep 2026 | Viewed by 42 | Submission Open

Keywords: lung cancer; target therapy; immunotherapy; antiangiogenic agent; chemotherapy; NGS

(This special issue belongs to the Section Cancer Drug Development)

Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—3rd Edition

edited by

Dan Granberg

submission deadline 30 Sep 2026 | Viewed by 40 | Submission Open

Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical Trials and Precision Medicine for Neuro-Oncology

edited by Malaka Ameratunga

submission deadline 30 Sep 2026 | Viewed by 40 | Submission Open

Keywords: clinical trials; neuro-oncology; precision oncology; molecular targets; precision medicine

(This special issue belongs to the Section Clinical Research of Cancer)

New Clinical Insights into Gynecological Malignancies

edited by

Amelia Jernigan

submission deadline 30 Sep 2026 | Viewed by 39 | Submission Open

Keywords: innovative care; data science; precision medicine; uterine cancer; ovarian cancer; vulvar cancer; vaginal cancer

(This special issue belongs to the Section Cancer Therapy)

Extracellular Matrix Proteins in Cancer (2nd Edition)

edited by

Dragana Nikitovic

and Aikaterini Berdiaki

submission deadline 30 Sep 2026 | Viewed by 34 | Submission Open

Keywords: extracellular matrix (ECM); tumor microenvironment (TME); stromal remodeling; cancer-associated fibroblasts (CAFs); fibrous proteins; mechanotransduction; interstitial fluid pressure; proteoglycans and glycoproteins; matrix crosslinking; epithelial-to-mesenchymal transition (EMT); angiogenesis; matrikines; therapy resistance

(This special issue belongs to the Section Tumor Microenvironment)

Translational Advances in Reproductive Cancers: From Targets to Therapies

edited by

Kamila Domińska

submission deadline 30 Sep 2026 | Viewed by 30 | Submission Open

Keywords: reproductive cancers; signal transduction pathways; hormonal regulation; targeted therapy; therapeutic limitations

(This special issue belongs to the Section Molecular Cancer Biology)

The Tumor Microenvironment and Molecular Aberrations Convey Immune Evasion (Third Edition)

edited by

Huey-Jen Lin

submission deadline 30 Sep 2026 | Viewed by 27 | Submission Open

Keywords: CD8+ tumor-infiltrating lymphocytes; cytotoxic T lymphocytes -associated protein 4; dendritic cells; immune evasion; hypoxia-inducible factors; myeloid-derived suppressor cells; natural killer; programmed death receptor and ligand; regulatory T cells; tumor-associated macrophages; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Recent Advances in Myeloma: From Molecular Pathways to Drugs

edited by Natalia Neparidze

submission deadline 30 Sep 2026 | Viewed by 25 | Submission Open

Keywords: myeloma; plasma cell disorders; monoclonal gammopathy; bispecifics; T cell engagers; CART therapy; monoclonal antibodies; MRD

(This special issue belongs to the Section Cancer Drug Development)

PSMA Targeted Strategies and Radioligand Therapies in Prostate Cancer: From Preclinical Models to Clinical Translation

edited by Neha Vapiwala and John Nikitas

submission deadline 30 Sep 2026 | Viewed by 11 | Submission Open

Keywords: prostate cancer; prostate-specific membrane antigen; radioligand therapy; radiopharmaceutical therapy; radiotherapy; theranostics

(This special issue belongs to the Section Cancer Therapy)

Ablation Treatment for Malignant Tumors

edited by

Madelon Dijkstra

Martijn Meijerink

and

Susan Van Der Lei

submission deadline 30 Sep 2026 | Viewed by 11 | Submission Open

Keywords: ablative therapies; thermal ablation; image-guided therapy; minimally invasive; radiofrequency ablation (RFA); microwave ablation (MWA); cryoablation; irreversible electroporation (IRE); malignant tumors; oligometastatic disease; immunotherapy combinations; interventional oncology

(This special issue belongs to the Section Cancer Therapy)

Cytoreductive Surgery, Hyperthermic Intraperitoneal Chemotherapy, and Beyond in Peritoneal Disease: Advances in Clinical Care and Therapeutics

edited by

Benjamin D. Powers

submission deadline 30 Sep 2026 | Viewed by 10 | Submission Open

Keywords: peritoneal surface malignancies; peritoneal carcinomatosis; colorectal cancer; appendiceal cancer; pseudomyxoma peritonei; ovarian cancer; mesothelioma; gastric cancer; small bowel cancer; cytoreductive surgery; HIPEC; PIPAC; photodynamic therapy; chemotherapy; chemoresistance; novel therapies; rare diseases

(This special issue belongs to the Section Cancer Therapy)

Pancreatic Cancer Ultrasound: A Problem-Based Approach

edited by

Carla Serra

and Andrea Boccatonda

submission deadline 30 Sep 2026 | Viewed by 8 | Submission Open

Keywords: cancer; ultrasound; pancreas; CEUS; malignancy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Health-Related Quality of Life in Cancer Survivorship

edited by Deniz Gencer and Elisabeth Coyne

submission deadline 30 Sep 2026 | Viewed by 2 | Submission Open

Keywords: cancer survivorship; health-related quality of life (HRQoL); interventions; psychological support; personalized care; educational resources

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

New Era of Systemic Therapy for Different Types of Skin Cancer

edited by Magdalena Ciazynska

submission deadline 30 Sep 2026 | Viewed by 2 | Submission Open

Keywords: skin cancer systemic therapy; immunotherapy in skin cancer; targeted therapy in skin malignancies; melanoma and nonmelanoma skin cancer; biomarkers and treatment response; resistance mechanisms; combination therapy; real worldreal-world outcomes; novel therapeutic agents; precision oncology

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 1051-1100 on page 22 of 24.

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