Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer
edited by Emiko Mizoguchi
submission deadline 31 Mar 2025 | Viewed by 165 | Submission Open
Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer
(This special issue belongs to the Section Cellular Pathology)
Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision
edited by and Janet R. Sparrow
submission deadline 31 Mar 2025 | Viewed by 155 | Submission Open
Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration
Cellular and Molecular Mechanisms of Liver Diseases
edited by Jieyun Jiang
submission deadline 31 Mar 2025 | Viewed by 145 | Submission Open
Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Pathology)
The Epigenetic Landscape of Aging: Mechanisms and Impacts During Cellular and Organismal Longevity
edited by Siyu Shen and
submission deadline 31 Mar 2025 | Viewed by 142 | Submission Open
Keywords: epigenetic regulation; cellular senescence; aging; DNA methylation; histone modification; non-coding RNA; cancer epigenetics; neurodegenerative diseases; musculoskeletal degenerative disorders; cardiovascular diseases
(This special issue belongs to the Section Cellular Aging)
Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management
edited by Luca Antonioli and
submission deadline 31 Mar 2025 | Viewed by 130 | Submission Open
Keywords: purinergic receptors; purinergic signaling; adenosine; ATP; ADP
Host Immunity to Bacterial Infections
edited by Karine Gloux
submission deadline 31 Mar 2025 | Viewed by 121 | Submission Open
Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections
(This special issue belongs to the Section Cellular Immunology)
Glial Cells: Physiological and Pathological Perspective
edited by
submission deadline 31 Mar 2025 | Viewed by 111 | Submission Open
Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies
(This special issue belongs to the Section Cells of the Nervous System)
Cellular Senescence and Senotherapies in the Aging Retina
edited by
submission deadline 31 Mar 2025 | Viewed by 107 | Submission Open
Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy
(This special issue belongs to the Section Cellular Aging)
CRISPR-Based Genome Editing Approaches in Cancer Therapy
edited by Martin Pal
submission deadline 31 Mar 2025 | Viewed by 103 | Submission Open
Keywords: CRISPR; genome editing; cancer therapy; precision medicine
(This special issue belongs to the Section Cell and Gene Therapy)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Mar 2025 | Viewed by 100 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
Impact of Hyponatremia on Cancer Progression and Organ Function: Insights from Murine Models
edited by Giada Marroncini and Mushfiquddin Khan
submission deadline 31 Mar 2025 | Viewed by 32 | Submission Open
Keywords: hyponatremia; cancer progression; neurological disease; heart failure; osteoporosis; liver cirrhosis; kidney injury; vaptans
Development of PET Radiotracers for Imaging Alpha-Synuclein
edited by and Jamie Eberling
submission deadline 1 Apr 2025 | Viewed by 175 | Submission Open
Keywords: alpha-synuclein; Parkinson’ s disease; multiple system atrophy; positron emission tomography
(This special issue belongs to the Section Cellular Aging)
The Role of Secretory RNases and Extracellular RNAs in the Regulation of Inflammation and Organ Injury
edited by and
submission deadline 1 Apr 2025 | Viewed by 120 | Submission Open
Keywords: RNase; extracellular RNAs; inflammation; sepsis; organ injury; innate immunity; neutrophils; monocyte/macrophages; endothelial cells
(This special issue belongs to the Section Tissues and Organs)
Cellular Models in Aging
edited by Michel Satya Naslavsky and Mateus C. Vidigal
submission deadline 1 Apr 2025 | Viewed by 33 | Submission Open
Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly
(This special issue belongs to the Section Cellular Aging)
Recent Advances in Astrocyte Neuron Communication submission deadline 10 Apr 2025 | Viewed by 551 | Submission Open
Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity
(This special issue belongs to the Section Cells of the Nervous System)
Sebaceous Gland in Skin Health and Disease
edited by and Monica Ottaviani
submission deadline 10 Apr 2025 | Viewed by 386 | Submission Open
Keywords: sebaceous gland; sebocytes; sebaceous lipid; sebum; inflammation; sebaceous gland disease; skin diseases; pathophysiology; biomarkers; therapeutics
(This special issue belongs to the Section Cellular Pathology)
Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration submission deadline 10 Apr 2025 | Viewed by 182 | Submission Open
Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases
Cellular and Molecular Mechanisms of Lysosomal Storage Disorders
edited by
submission deadline 15 Apr 2025 | 2 articles | Viewed by 4549 | Submission Open
Keywords: lysosomes; lysosomal storage disorders; enzyme replacement; gene therapy; substrate reduction; pharmacological chaperones; autophagy; endosomal dysfunction
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Autism Spectrum Disorder
edited by Tanya Gandhi and
submission deadline 15 Apr 2025 | 1 articles | Viewed by 1708 | Submission Open
Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies
(This special issue belongs to the Section Cells of the Nervous System)
Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy
edited by Abdullah Saeed
submission deadline 15 Apr 2025 | Viewed by 228 | Submission Open
Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment
(This special issue belongs to the Section Cellular Immunology)
Molecular and Cellular Mechanisms of Treating Fibrosis
edited by Richard Stratton
submission deadline 15 Apr 2025 | Viewed by 203 | Submission Open
Keywords: fibrosis; systemic sclerosis; targeted therapy; extracellular matrix; collagen; organ fibrosis; interstitial lung disease
(This special issue belongs to the Section Cellular Pathology)
Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies
edited by
submission deadline 15 Apr 2025 | Viewed by 176 | Submission Open
Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches
(This special issue belongs to the Section Cellular Immunology)
Recent Progress on Fibrosis and Cardiac Dysfunction submission deadline 15 Apr 2025 | Viewed by 134 | Submission Open
Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 15 Apr 2025 | Viewed by 125 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Stem Cells)
Advances in Bone Biology and Diseases: Pathophysiology, Mechanisms, and Therapeutic Innovations
edited by Baohong Zhao
submission deadline 15 Apr 2025 | Viewed by 99 | Submission Open
Keywords: bone diseases; osteoimmunology; inflammation; osteoporosis; osteoarthritis; Paget’ s disease; bone cancer; bone resorption; bone formation; cytokines; immune cells; pathophysiology; biomarkers; therapeutic strategies; molecular mechanisms; bone metabolism; inflammation-mediated pathways; bone remodeling; diagnostic tools; cellular interactions
(This special issue belongs to the Section Cellular Pathology)
Computational Biophysics in Cellular Biological Systems
edited by and Wenhan Guo
submission deadline 15 Apr 2025 | Viewed by 89 | Submission Open
Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations
Spatial Proteomics and Transcriptomics in Cells
edited by Elizabeth Neumann
submission deadline 15 Apr 2025 | Viewed by 62 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Advances in Biophysics of Cellular Membranes submission deadline 20 Apr 2025 | 3 articles | Viewed by 2865 | Submission Open
Keywords: experimental and theoretical membrane research; membrane proteins; non-bilayer membrane structures; extracellular vesicles; membrane active peptides; cell penetrating peptides; membrane mimetics; lipid– protein interactions; membrane curvature; membrane dynamics
(This special issue belongs to the Section Cellular Biophysics)
Immune Functions and Therapeutic Potential of B Lymphocytes in Autoimmune Disorders
edited by
submission deadline 20 Apr 2025 | 1 articles | Viewed by 1534 | Submission Open
Keywords: engineered immune cells; autoimmune disease; B lymphocyte; animal models; immune tolerance
(This special issue belongs to the Section Cellular Immunology)
Novel Insight into Endothelial Function and Atherosclerosis
edited by Antonio Cutruzzolà, Alessandro Salatino and
submission deadline 20 Apr 2025 | Viewed by 397 | Submission Open
Keywords: atherosclerosis  ; endothelial function  ; nitric oxide  ; flow-mediated dilation  ; biomarkers  ; imaging  ; arterial wall  ; endothelium  ; inflammation
(This special issue belongs to the Section Cells of the Cardiovascular System)
pH Sensing, Signaling, and Regulation in Cellular Processes
edited by Maike Glitsch
submission deadline 20 Apr 2025 | Viewed by 132 | Submission Open
Keywords: extra- and intracellular pH; pH sensing; signaling; and regulation; pH-dependent receptors; proton signaling; ion channels; G-protein-coupled receptors; cell biology and function; physiological and pathological processes; aging; cancer; inflammation; and so on; novel therapeutic strategies and targets
Mechanotransduction: Understanding the Cellular and Tissue Communication Mechanisms of Mechanical Forces
edited by
submission deadline 20 Apr 2025 | Viewed by 64 | Submission Open
Keywords: mechanotransduction; cell/tissue mechanics; physical communication
Macrophage-Epithelial Interplay in Pulmonary Fibrosis
edited by and Farhad Khosravi
submission deadline 20 Apr 2025 | Viewed by 43 | Submission Open
Keywords: macrophages; epithelial cells; idiopathic pulmonary fibrosis (IPF); immune response
Targeting Hallmarks of Cancer submission deadline 25 Apr 2025 | 1 articles | Viewed by 2022 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
Harnessing the Immune System to Fight Pediatric Cancer—Second Edition
edited by
submission deadline 25 Apr 2025 | Viewed by 261 | Submission Open
Keywords: immunotherapy; pediatric cancer; CAR T cells; immune checkpoint inhibitors; tumor microenvironment; therapy resistance; targeted therapy; adoptive cell transfer; stem-like T cells; bispecific antibodies; cancer vaccines
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Mechanisms of Heart Diseases
edited by
submission deadline 25 Apr 2025 | Viewed by 60 | Submission Open
Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies
(This special issue belongs to the Section Cellular Pathology)
Ras Family of Genes and Proteins: Structure, Function and Regulation
edited by , and Rosula Garcia-Navas
submission deadline 28 Apr 2025 | Viewed by 29 | Submission Open
Keywords: HRAS; NRAS; KRAS; RAS-driven tumors; rasopathies; RAS signaling; RAS inhibitors; GAP; GEF; SOS; GRF
Extracellular Vesicles as Diagnostic and Therapeutic Tools in Cancer
edited by Priya Samuel
submission deadline 28 Apr 2025 | Viewed by 26 | Submission Open
Keywords: extracellular vesicles; tumour microenvironment; cancer; biomarkers
(This special issue belongs to the Section Cell Microenvironment)
PI3K/AKT/mTOR Signaling Network in Human Health and Diseases 2.0 submission deadline 30 Apr 2025 | 7 articles | Viewed by 21162 | Submission Open
Keywords: acne; ageing; Akt; Alzheimer’ s disease; autophagy; autoimmunity; PI3K; mTOR; cancer; cardiovascular diseases; diabetes; growth; hamartoma; hypertrophy; inflammation; neurologic; tuberous sclerosis; systemic sclerosis; obesity; Parkinson’ s disease; psoriasis; atopic dermatitis; burns/wound healing; targeted therapy; natural products; biologics
(This special issue belongs to the Section Cell Signaling)
Advances in Diabetes Pathophysiology and Treatment
edited by and
submission deadline 30 Apr 2025 | 3 articles | Viewed by 10842 | Submission Open
Keywords: diabetes mellitus; insulin resistance; islet of Langerhans; insulin; incretin; glucose homeostasis; (ectopic) adipose tissue; adipokines; liver; diabetes cardiovascular complications
(This special issue belongs to the Section Cellular Pathology)
Gene Therapy for Rare Diseases
edited by
submission deadline 30 Apr 2025 | 3 articles | Viewed by 7098 | Submission Open
Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
The Pivotal Role of Tumor Stem Cells in Glioblastoma
edited by and Silvano J. Santini
submission deadline 30 Apr 2025 | 3 articles | Viewed by 5466 | Submission Open
Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment
(This special issue belongs to the Section Stem Cells)
Molecular and Cellular Advances in Gut-Brain Axis
edited by and Radhakrishna Rao
submission deadline 30 Apr 2025 | 1 articles | Viewed by 5094 | Submission Open
Keywords: gut– brain axis; microbiome; omics; diet; biological sex; gender; early-life stress; immunity; mental health; neurodegenerative diseases; metabolic health
(This special issue belongs to the Section Cells of the Nervous System)
Function and Dysfunction of the Caveolar Network in Cell Signaling and Human Disease: An Update after 70 Years of the Discovery of Caveolae
edited by
submission deadline 30 Apr 2025 | 2 articles | Viewed by 4331 | Submission Open
Keywords: cancer; caveolae; caveolin; cavins; cell metabolism; endocytosis; hypertension; lipid homeostasis; lipid rafts; lipodystrophy; mechanobiology; caveolinopathies; muscular dystrophy
(This special issue belongs to the Section Cell Signaling)
State of the Art and Future Prospects in Stem Cell Transplantation
edited by Shin Mineishi
submission deadline 30 Apr 2025 | 2 articles | Viewed by 3374 | Submission Open
Keywords: hematopoietic stem cell transplantation; conditioning; graft-versus-host disease; minimal residual disease; HSCT
(This special issue belongs to the Section Stem Cells)
Physiology of Telocytes
edited by and Mihail E. Hinescu
submission deadline 30 Apr 2025 | 1 articles | Viewed by 2023 | Submission Open
Keywords: telocytes; telopodes; physiology; pathology; tissue homeostasis; regenerative medicine
(This special issue belongs to the Section Cellular Pathology)
Molecular Signalings in Hair Regeneration
edited by Soung-Hoon Lee
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1460 | Submission Open
Keywords: hair regeneration; wound-induced hair follicle neogenesis (WIHN); Wnt/β -catein signaling pathway; sonic hedgehog (SHH) signaling pathway; alopecia treatment
(This special issue belongs to the Section Cell Signaling)
Immunopathogenesis and Therapies of Granulomatous Diseases
edited by Shaikh Muhammad Atif
submission deadline 30 Apr 2025 | 1 articles | Viewed by 990 | Submission Open
Keywords: Granulomatous diseases; tuberculosis; sarcoidosis; chronic beryllium disease (CBD); Crohn's disease; immune cells; genetics; environmental exposures;therapeutic approaches
(This special issue belongs to the Section Cellular Immunology)
The Role of Mitochondria in Cell Development and Regeneration submission deadline 30 Apr 2025 | Viewed by 552 | Submission Open
Keywords: mitochondria; fusion and fission; mtDNA; programmed cell death; cell development; mitochondria-ER contact; organelle
(This special issue belongs to the Section Intracellular and Plasma Membranes)
Role of Mitochondria After Injury
edited by and
submission deadline 30 Apr 2025 | Viewed by 376 | Submission Open
Keywords: electron transport chain; reactive oxygen signaling; mitochondrial permeability transition pore; programmed cell death; mitochondrial repair; mitophagy; energy metabolism
(This special issue belongs to the Section Cell Microenvironment)
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