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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Advances in Assisted Reproductive Technologies
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 2907 | Submission Open
Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology; morpho kinetics; in vitro gametogenesis; in vitro oocyte maturation; reproductive tissue cryopreservation; artificial intelligence (AI)
(This special issue belongs to the Section Molecular Biology)
MicroRNAs in Physiology and Pathophysiology
edited by Małgorzata Guz
submission deadline 25 Dec 2026 | 3 articles | Viewed by 2873 | Submission Open
Keywords: miRNA; cell physiology; metabolism; cancer; biomarkers; disease; molecular mechanisms; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies, 2nd Edition submission deadline 25 Dec 2026 | 3 articles | Viewed by 2090 | Submission Open
Keywords: Crohn’ s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies in IBD; ulcerative colitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioinspired and Emerging Functionalized Nanostructures for Precision Drug Delivery submission deadline 25 Dec 2026 | 1 articles | Viewed by 1989 | Submission Open
Keywords: nanostructured materials; nanobiomaterials; nanocomposites; drug delivery systems; targeted therapies; controlled release; responsive functionalities; theranostics; biomedical applications; therapeutic innovations; bioinspired nanostructures; personalized medicine
(This special issue belongs to the Section Molecular Nanoscience)
Preimplantation Genetic Testing in Assisted Reproductive Technologies
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 1934 | Submission Open
Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Liver Disease and Primary Liver Cancer: Translational Advances and Therapeutic Perspectives
edited by
submission deadline 25 Dec 2026 | 3 articles | Viewed by 1731 | Submission Open
Keywords: liver disease; hepatocellular carcinoma; cholangiocarcinoma; molecular mechanisms; translational research; 3D models and organoids; biomarkers and therapeutic strategies; MASH/MASLD: pathogenesis; diagnosis; and management; primary liver cancer: pathogenesis; detection; and treatment; inflammation in liver disease; 3D liver models; microbiota and liver disease; mechanisms of damage and repair: ischemia-reperfusion injury; cellular pathology in acute and chronic liver damage of different origin; biomarkers in liver disease: emerging methods and potential applications; immunology in the liver— from homeostasis to disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Plant Biotechnology: From Pathogen Diagnostics to Disease Management submission deadline 25 Dec 2026 | 1 articles | Viewed by 1236 | Submission Open
Keywords: plant pathogens; diagnostic; isothermal; biosensor; RNAi; CRISPRi; QTL mapping; GWAS; MAS or MABC
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer
edited by
submission deadline 25 Dec 2026 | Viewed by 1227 | Submission Open
Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of Reproduction and Reproductive Diseases
edited by
submission deadline 25 Dec 2026 | 1 articles | Viewed by 963 | Submission Open
Keywords: reproduction; implantation; fertilization; gametogenesis; preimplantation genetic testing; in vitro fertilization; infertility; miscarriage; reproductive aging; endometriosis; premature ovarian failure; menopause; preeclampsia; preterm birth; placenta; testis; azoospermia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Clinical Advances in Ophthalmic Inflammation, Infection, and Degeneration
edited by Hyun Jin Shin
submission deadline 25 Dec 2026 | Viewed by 660 | Submission Open
Keywords: ophthalmic inflammation; ocular infection; ocular degeneration; molecular mechanisms; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes
edited by Maria Victoria Preciado
submission deadline 25 Dec 2026 | Viewed by 649 | Submission Open
Keywords: virus evolution; immune response; host– virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics
(This special issue belongs to the Section Molecular Immunology)
Identification of Predictive Molecular Markers for Cancer Progression, Response to Therapy, and Disease Outcome
edited by
submission deadline 25 Dec 2026 | Viewed by 443 | Submission Open
Keywords: predictive biomarkers; cancer progression; therapy response; molecular signatures; precision oncology
(This special issue belongs to the Section Molecular Oncology)
HPV Infection and Immune Escape Mechanisms
edited by and Elisa Lepore
submission deadline 25 Dec 2026 | Viewed by 437 | Submission Open
Keywords: HPV; persistence; natural molecules; vaccination; genotypes; anal infection; oral infection; co-infection
(This special issue belongs to the Section Molecular Immunology)
Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications
edited by
submission deadline 25 Dec 2026 | Viewed by 401 | Submission Open
Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation
(This special issue belongs to the Section Molecular Pharmacology)
Decoding the Pediatric Brain Tumor Microenvironment: A Molecular Perspective
edited by
submission deadline 25 Dec 2026 | Viewed by 316 | Submission Open
Keywords: pediatric brain tumor; precision immunotherapy; pediatric neuro-oncology; tumor microenvironment (TME); single-cell RNA sequencing; whole transcriptomics; mass spectrometry-based proteomics; mass cytometry; cellular and molecular architecture; organoid
(This special issue belongs to the Section Molecular Oncology)
Advances in the Design, Synthesis, and Characterization of Metal Complexes with Multifaceted Biological Activities
edited by
submission deadline 25 Dec 2026 | Viewed by 277 | Submission Open
Keywords: metal complexes; molecular design; biological activity; structure– activity relationships; therapeutic applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Biocatalysis: Mechanisms of Proteolytic Enzymes, 3rd Edition
edited by
submission deadline 25 Dec 2026 | Viewed by 229 | Submission Open
Keywords: aspartic proteases; cryptic ligand binding sites; cysteine proteases; metalloproteases; non-canonical amino acids; prodrugs; protease ligases; SARS-CoV-2 proteases; serine proteases; threonine proteases
(This special issue belongs to the Section Molecular Biophysics)
Advances in Growth, Development and Secondary Metabolism in Microorganisms submission deadline 25 Dec 2026 | Viewed by 201 | Submission Open
Keywords: secondary metabolites; signal transduction; molecular regulation; microbial growth; morphogenesis; microbial metabolites; biotechnological applications; omics technologies
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Treatment Strategies in Diabetic Kidney Disease submission deadline 25 Dec 2026 | Viewed by 190 | Submission Open
Keywords: diabetic kidney disease; oxidative stress; autophagy; inflammation; fibrosis; cell therapy; SGLT2 inhibitors and GLP-1 agonists; mesenchymal stem cells; gene therapy; translational nephrology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomass as Feedstock for the Production of High Value-Added Chemicals by Heterogeneous Catalysis submission deadline 25 Dec 2026 | Viewed by 189 | Submission Open
Keywords: biomass; heterogeneous catalysts; biofuels; bioproducts; platform molecules
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Insight in Reproductive Immunology
edited by Ruben Motrich
submission deadline 25 Dec 2026 | Viewed by 174 | Submission Open
Keywords: reproductive immunology; immune tolerance; male reproductive tract; female reproductive tract; fertility disorders; inflammation; pregnancy complications; immunoregulation
(This special issue belongs to the Section Molecular Immunology)
Stem Cell Innovations and Reproductive Biotechnologies
edited by
submission deadline 30 Dec 2026 | Viewed by 755 | Submission Open
Keywords: mammals; birds; stem cell research; pluri-/multipotency; differentiation/dedifferentiation; assisted reproductive technologies (ARTs); transgenic research; biomedicine
(This special issue belongs to the Section Molecular Biology)
Mitochondrial Function and Therapies
edited by
submission deadline 30 Dec 2026 | 1 articles | Viewed by 667 | Submission Open
Keywords: mitochondrial dysfunction; oxidative stress; antioxidants; biogenesis; transcription factors
(This special issue belongs to the Section Biochemistry)
Research Progress on Disease Models Based on Induced Pluripotent Stem Cells submission deadline 30 Dec 2026 | Viewed by 291 | Submission Open
Keywords: induced pluripotent stem cells; iPSC-derived cells; disease modeling; precision and regenerative medicine; genome editing; CRISP/Cas; organoid; cell sheet; personalized therapeutics; drug discovery
(This special issue belongs to the Section Molecular Biology)
Advances in Malnutrition and Infectious Diseases: Molecular Perspectives and Host-Pathogen Interactions
edited by
submission deadline 30 Dec 2026 | Viewed by 237 | Submission Open
Keywords: malnutrition; host-pathogen interactions; immunometabolism; micronutrient deficiency; innate and adaptive immunity; microbiome dysbiosis; infection-induced inflammation
(This special issue belongs to the Section Molecular Microbiology)
Advances in T Cell-Based Cancer Immunotherapy
edited by
submission deadline 30 Dec 2026 | Viewed by 150 | Submission Open
Keywords: T cell immunotherapy; CAR-T cell; immune checkpoint blockade; T cell exhaustion; tumor microenvironment
(This special issue belongs to the Section Molecular Immunology)
Molecular Interactions for Advanced Food Safety Biosensing
edited by and Yang Zhou
submission deadline 30 Dec 2026 | Viewed by 138 | Submission Open
Keywords: food safety; molecular interaction; biosensors; signal transduction; precise recognition
(This special issue belongs to the Section Biochemistry)
Molecular Synthesis, Properties, and Biomedical Applications of Bioceramics submission deadline 30 Dec 2026 | Viewed by 132 | Submission Open
Keywords: bioceramics; ceramic materials; dielectric materials; photocatalysis; perovskite ceramics; materials chemistry; solid-state materials; functional materials; environmental materials; energy materials
(This special issue belongs to the Section Materials Science)
Hybrid Materials: Antimicrobial Performance and Molecular Mechanisms
edited by and Kalina Ivanova
submission deadline 30 Dec 2026 | Viewed by 131 | Submission Open
Keywords: hybrid materials; molecular mechanisms; antimicrobial activity; nanomaterials; chemistry of ma-terials
(This special issue belongs to the Section Materials Science)
AI-Driven Molecular Modeling and Simulation in Biomedical Research and Biophysics
edited by
submission deadline 30 Dec 2026 | Viewed by 41 | Submission Open
Keywords: artificial intelligence (AI); machine learning (ML); biophysics; computational biology; molecular docking; molecular dynamics (MD); quantum mechanics; structure– activity relationships; computer-aided drug design (CADD); homology modeling
(This special issue belongs to the Section Molecular Informatics)
Advances in the Pathology and Pathogenetic Mechanisms of Diabetic Neuropathy
edited by
submission deadline 30 Dec 2026 | Viewed by 23 | Submission Open
Keywords: diabetic; neuroinflammation; neurovascular pathology; neuropathy; nerve injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Galectins (Gals), 2nd Edition
edited by
submission deadline 31 Dec 2026 | 10 articles | Viewed by 20471 | Submission Open
Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers
(This special issue belongs to the Section Molecular Biology)
Natural Products for Neuroprotection and Neurodegeneration
edited by
submission deadline 31 Dec 2026 | 6 articles | Viewed by 9397 | Submission Open
Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 6357 | Submission Open
Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liquid Biopsies in Oncology—3rd Edition submission deadline 31 Dec 2026 | 2 articles | Viewed by 4489 | Submission Open
Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles
(This special issue belongs to the Section Molecular Oncology)
Viral Biology: Infection and Pathology, Diagnosis and Treatment
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 3932 | Submission Open
Keywords: viral infection; viral pathogenesis; diagnostics; antiviral therapy; host– virus interactions; emerging viruses; zoonotic viruses; one health; vaccine development; CRISPR antivirals
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets
edited by Leonid Livshits
submission deadline 31 Dec 2026 | 1 articles | Viewed by 3759 | Submission Open
Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties
(This special issue belongs to the Section Molecular Biology)
Advances in HIV Research: Molecular Basis and Potential Therapies
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 3358 | Submission Open
Keywords: human immunodeficiency virus; HIV prevention; HIV therapeutics; HIV vaccines; antiretroviral therapies; long-acting ART; HIV genetic therapy; HIV animal models; HIV in vitro models; viral reservoirs; HIV latency; HIV persistence; HIV evolution; HIV quasispecies; HIV proteins; HIV cure; HIV immunopathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardiovascular and Metabolic Pharmacology
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 3073 | Submission Open
Keywords: cardiovascular pharmacology; metabolic pharmacology; hypertension; diabetes; obesity; atherosclerosis; hyperlipidemias; heart failure
(This special issue belongs to the Section Molecular Pharmacology)
Functional Proteomics: Insights from Biomedical Applications and Beyond
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 2988 | Submission Open
Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights into Sex Determination and Differentiation submission deadline 31 Dec 2026 | 3 articles | Viewed by 2553 | Submission Open
Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution
(This special issue belongs to the Section Molecular Biology)
Advances in Animal Molecular Genetics submission deadline 31 Dec 2026 | 3 articles | Viewed by 2414 | Submission Open
Keywords: epigenetics; functional genomics; gene expression; gene polymorphism; genetic diseases; genetic techniques and assays; genome-wide association; genetic markers; quantitative genetics
(This special issue belongs to the Section Molecular Genetics and Genomics)
ROS and Abiotic Stress in Plants, 3rd Edition submission deadline 31 Dec 2026 | 1 articles | Viewed by 2050 | Submission Open
Keywords: chilling and freezing; drought stress; heat stress; heavy metals stress; nutrient and mineral stress; oxidative stress; resurrection plants and desiccation tolerance; salinity
(This special issue belongs to the Section Molecular Plant Sciences)
Flowers: Molecular and Genetic Regulation of Growth and Development
edited by Yaqin Wang
submission deadline 31 Dec 2026 | 3 articles | Viewed by 1862 | Submission Open
Keywords: flower; growth and development; molecular regulation; genetic breeding
(This special issue belongs to the Section Molecular Plant Sciences)
PPAR Update: Molecular Mechanisms and Therapeutic Perspectives
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 1826 | Submission Open
Keywords: PPAR; PPARα ; SPPARMα ; pemafibrate; lipid metabolism; inflammation; fibrosis; nuclear receptor; translational research; precision medicine
(This special issue belongs to the Section Molecular Pharmacology)
Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 3 articles | Viewed by 1750 | Submission Open
Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication
(This special issue belongs to the Section Molecular Biology)
Biotransformation and Engineering of Fungals and Microalgae submission deadline 31 Dec 2026 | 1 articles | Viewed by 1515 | Submission Open
Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae– fungi synergy
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Translational Insights in Neurological Disorders
edited by Tiago Santos
submission deadline 31 Dec 2026 | 2 articles | Viewed by 1514 | Submission Open
Keywords: neurological disorders; molecular mechanisms; translational neuroscience; drug targets; biomarkers; neurodegenerative disorders; neuroinflammatory conditions; demyelinating conditions; cerebrovascular conditions; neurodevelopmental disorders; mood disorders; anxiety disorders; spinal cord injury; traumatic brain injury; precision neurology; therapeutic development
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms Linking Obesity to Atherosclerosis Pathogenesis
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1461 | Submission Open
Keywords: obesity; overweight; atherosclerosis; coronary artery disease; obesity paradox; body mass index; visceral fat
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1460 | Submission Open
Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance
(This special issue belongs to the Section Molecular Oncology)
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