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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Editorial Board Members’ Collection Series: Genome Stability

edited by

Tae-Hong Kang

and

Lasse Lindahl

submission deadline 20 Mar 2025 | 3 articles | Viewed by 3898 | Submission Open

Keywords: genome stability; DNA damage response; DNA repair; DNA replication; DNA recombination; ATR/ATM pathway; GENOTOXINS

(This special issue belongs to the Section Molecular Genetics and Genomics)

Polyphenols Hazard and Safety Assessment in Human Health and Food Systems

edited by

Lidia Magerusan

and

Dana Alina Magdas

submission deadline 20 Mar 2025 | 2 articles | Viewed by 3694 | Submission Open

Keywords: polyphenols; food safety; health risk evaluation; graphenes-based sensors; electrochemical detection; chemometrics; artificial intelligence; metabolomics

(This special issue belongs to the Section Biochemistry)

Applications of Biomaterials in Drug Development

edited by

Sung Giu Jin

submission deadline 20 Mar 2025 | 2 articles | Viewed by 3640 | Submission Open

Keywords: drug delivery systems; nanomaterials; pharmaceutical engineering; targeting; solubilization technology; controlled release; microneedle; biopolymers

(This special issue belongs to the Section Materials Science)

Functional and Structural Genomics Studies for Plant Breeding

edited by

Andrea Cavallini

, Tommaso Giordani and Alberto Vangelisti

submission deadline 20 Mar 2025 | 4 articles | Viewed by 3595 | Submission Open

Keywords: plant transcriptomics; genome sequencing; plant gene function; molecular plant breeding; structural genomics

(This special issue belongs to the Section Molecular Plant Sciences)

DNA Damage, Oxidative Stress and Related Metabolic By-Products in Cancer and Environmental Studies 3.0

edited by

Marco E. M. Peluso

submission deadline 20 Mar 2025 | 1 articles | Viewed by 3392 | Submission Open

Keywords: DNA Damage; Oxidative Stress; By-Products

(This special issue belongs to the Section Molecular Toxicology)

Molecular Studies on Plant and Plant In Vitro Systems Secondary Metabolism

edited by

Andrey Marchev

submission deadline 20 Mar 2025 | 2 articles | Viewed by 3098 | Submission Open

Keywords: plants; plant in vitro systems; secondary metabolism; sustainable production; elicitation; metabolic engineering; CRISPR/Cas; molecular targets

(This special issue belongs to the Section Molecular Plant Sciences)

Proteasomes and Cellular Senescence: An Age-Related Connection

edited by

Aniruddha Das

submission deadline 20 Mar 2025 | 2 articles | Viewed by 3082 | Submission Open

Keywords: proteasomes; aging; proteasome receptors; post-translational modification

(This special issue belongs to the Section Molecular Biology)

New Advances in Epigenetics and Epigenomics

edited by Vicki Maltby

submission deadline 20 Mar 2025 | 3 articles | Viewed by 2852 | Submission Open

Keywords: epigenetics; epigenomics; multi-omics; epitranscriptomics; single cell

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Products as Multitarget Agents in Human Diseases

edited by

Andrey Marchev

and

Nikolina Mihaylova

submission deadline 20 Mar 2025 | 2 articles | Viewed by 2820 | Submission Open

Keywords: natural products; bioactive compounds; human health; disease prevention and treatment; molecular and physiological mechanism; inflammatory diseases; cancer; arthritic diseases

(This special issue belongs to the Section Molecular Pharmacology)

Nanomaterials and Biomaterials in Biomedicine Application

edited by

Filipa Mascarenhas-Melo

submission deadline 20 Mar 2025 | 3 articles | Viewed by 2817 | Submission Open

Keywords: nanomaterials; biomaterials; biomedicine; drug delivery; regenerative medicine; healthcare technologies; biocompatible platforms

(This special issue belongs to the Section Materials Science)

Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition

edited by

Elia Ranzato

and

Simona Martinotti

submission deadline 20 Mar 2025 | 3 articles | Viewed by 2785 | Submission Open

Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Liposomes as Membrane Models in Drug-Lipid Interactions

edited by

Carla Matos

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2766 | Submission Open

Keywords: liposomes; membrane interactions; drug development

(This special issue belongs to the Section Molecular Pharmacology)

Heartfulness: Contributors of Healthy and Unhealthy Cardiac Aging

edited by

Susana P. Pereira

and Laura A. Cox

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2590 | Submission Open

Keywords: cardiac development; gene regulation; epigenetics; genomics; integrated omics; accelerated aging; cardiac metabolism; cardiac regeneration and repair; cardiovascular diseases; cutting-edge techniques; cardiac imaging; regenerative mechanisms; pathophysiology of cardiovascular disease; cardiac endothelium; cardiomyocytes; cardiovascular computational modeling; cardiovascular informatics; transgenerational inheritance; life expectancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fatty Acid Oxidation, Lipid Mediators and Dietary Fatty Acids in the Molecular Mechanisms of Diseases

edited by

Cinzia Signorini

submission deadline 20 Mar 2025 | 3 articles | Viewed by 2529 | Submission Open

Keywords: fatty acid oxidation; inflammation; lipid mediators; lipid metabolism; omega-3 fatty acids; oxidative stress; dietary supplementation; animal models; human diseases

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms of Neuromuscular Transmission in Health and Disease

edited by

Michele Salanova

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2499 | Submission Open

Keywords: neuromuscular junction; muscle atrophy; muscle postsynaptic signaling; muscle myopathy; NMJ in vitro models

(This special issue belongs to the Section Molecular Neurobiology)

Application of Fluorescence Imaging and Super-Resolution Imaging in Molecular Biology

edited by

Keigo Kohara

submission deadline 20 Mar 2025 | 2 articles | Viewed by 2441 | Submission Open

Keywords: fluorescence imaging; super-resolution imaging; molecular biology; disease; biomolecules; organelles; morphologies of cells; iPS cells; organoids; molecular biology

(This special issue belongs to the Section Molecular Biophysics)

Mucopolysaccharidoses: Diagnosis, Treatment and Management 4.0

edited by

Shunji Tomatsu

Grzegorz Wegrzyn

and Roberto Giugliani

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2396 | Submission Open

Keywords: mucopolysaccharidoses; glycosaminoglycans; proteoglycans; lysosomal dysfunction; cell function; metabolic disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanotechnology in Targeted Drug Delivery 2.0

edited by

Antonio Di Stefano

and

Marilisa Pia Dimmito

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2365 | Submission Open

Keywords: pharmaceutical materials; functionalization; nanoformulations; drug release

(This special issue belongs to the Section Molecular Nanoscience)

DNA Damage in Neurological Disorders: Etiological and Therapeutical Aspects

edited by Tam Quach, Ilaria Palmisano and Anne-Marie Duchemin

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2352 | Submission Open

Keywords: neurological disorders; peripheral neuropathies; DNA damage; epigenetic dynamism; 3D chromatin organization/remodeling; therapeutic targets for DNA repair

(This special issue belongs to the Section Molecular Neurobiology)

The Evolution, Genetics and Pathogenesis of Viruses

edited by

Marta Szabat

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2200 | Submission Open

Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents

(This special issue belongs to the Section Molecular Microbiology)

Immunology of Infectious Disease and Transplantation: A Symbiotic Dance

edited by

Alessandro Perrella

submission deadline 20 Mar 2025 | 2 articles | Viewed by 2166 | Submission Open

Keywords: organ transplantation; infectious disease; immune responses; immunology; personalized medicine; transplantation medicine

(This special issue belongs to the Section Molecular Immunology)

Flavonoids and Their Impact on Human Health: 2nd Edition

edited by

Davide Barreca

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2158 | Submission Open

Keywords: flavonoids; antioxidants; activation/block of signal cascade; modulation of key metabolic enzymes; oxidative stress; biological potentials; antimicrobial activity; antiviral potential; anticancer activity; anti-aggregative activity; anti-inflammatory activity

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Applications of Nanocomposites in Gas Sensors

edited by

Valeriy Krivetskiy

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2147 | Submission Open

Keywords: nanocomposite; gas sensor; nano architecture; solid state

(This special issue belongs to the Section Molecular Nanoscience)

Innovative Molecular Strategies in Biomedicine

edited by

Rui Vitorino

submission deadline 20 Mar 2025 | 2 articles | Viewed by 2104 | Submission Open

Keywords: bioprinting; organ-on-chip; venom-derived therapeutics; 3D in vitro models; skeletal muscle models; toxic peptides; peptide expression; nanoparticles in medicine; protein and peptide drug delivery; peptide-based biomaterials; self-assembled hydrogels; molecular therapeutics; nanotechnology in drug delivery; regenerative medicine; tissue engineering

(This special issue belongs to the Section Materials Science)

The Use of Molecular Markers in Forensic Field as an Element of Scientific Evidence

edited by

Angelo Montana

and

Margherita Neri

submission deadline 20 Mar 2025 | 2 articles | Viewed by 2070 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

New Insights into Satellite DNAs

edited by

Isidoro Feliciello

and

Đurđica Ugarković

submission deadline 20 Mar 2025 | 2 articles | Viewed by 2068 | Submission Open

Keywords: satellite DNA; satellitome; satellite DNA organization; satellite DNA evolution; satellite DNA origin; satellite DNA transcription; satellite DNA function; satellite DNA regulation; satellite RNA; heterochromatin; centromere; telomere; gene regulation; cancer; biomarkers; epigenetics; next-generation sequencing (NGS); nanopore sequencing; PacBio sequencing

(This special issue belongs to the Section Molecular Biology)

Redox Enzymes: Molecular Mechanisms, Structural Features, Physiological Roles

edited by

Vitaliy Borisov

submission deadline 20 Mar 2025 | 1 articles | Viewed by 2041 | Submission Open

Keywords: metalloenzyme; terminal oxidase; cytochrome; heme; respiratory chain; photosynthesis; enzyme activation and inhibition; ROS scavenging enzyme; reactive oxygen species; ROS defense mechanism; molecular bioenergetics; drug target

(This special issue belongs to the Section Molecular Biophysics)

New Progress in Extracellular Vesicles

edited by

Jorge Sanz-Ros

submission deadline 20 Mar 2025 | 2 articles | Viewed by 2029 | Submission Open

Keywords: extracellular vesicles; intercellular communication; biogenesis; uptake; disease pathogenesis; regenerative medicine; immunology; single-particle analysis

(This special issue belongs to the Section Molecular Biology)

Emerging Nanomaterials for New Energy Applications

edited by

Shaojun Yuan

and

Yuan Wang

submission deadline 20 Mar 2025 | 2 articles | Viewed by 1940 | Submission Open

(This special issue belongs to the Section Molecular Nanoscience)

Protein Unfolding Induced by Chemical Agents

edited by

Gyula Batta

and

Orsolya Tőke

submission deadline 20 Mar 2025 | 2 articles | Viewed by 1753 | Submission Open

Keywords: protein stability; chemical unfolding; denaturing conditions; protein folding; folding pathway; misfolding; conformational flexibility; disordered state; protein aggregation; protein drugs

(This special issue belongs to the Section Biochemistry)

RNA Vaccines and Therapeutics: Challenges and Opportunities

edited by

Seong-Wook Lee

submission deadline 20 Mar 2025 | 2 articles | Viewed by 1594 | Submission Open

Keywords: RNA-based therapy; RNA vaccine; mRNA; circRNA; saRNA; non-coding RNA/sRNA; microRNA/siRNA/antisense RNA; RNA aptamer; ribozyme; RNA editing/genome editing

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Search for Protective Agents against Amyloid β-Induced Brain Degeneration

edited by

Carlos Gutiérrez-Merino

submission deadline 20 Mar 2025 | 1 articles | Viewed by 1528 | Submission Open

Keywords: amyloid β -peptides; endogenous scavengers; antagonists; Alzheimer’ s disease; neurological disorders; brain neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Heterocycles

edited by

David StC Black

and

Naresh Kumar

submission deadline 20 Mar 2025 | 1 articles | Viewed by 1379 | Submission Open

Keywords: synthesis; reactions; applications; biological activity; medicinal chemistry; natural products; alkaloids; new methodology

(This special issue belongs to the Section Biochemistry)

New Advances in Neural Therapeutic Application of Mesenchymal Stem Cells

edited by

Giuliana Mannino

and

Debora Lo Furno

submission deadline 20 Mar 2025 | 1 articles | Viewed by 1354 | Submission Open

Keywords: mesenchymal stem cells; neural differentiation; nervous system injury; neurological diseases; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Biotechnology in Food

edited by

Josué Delgado Perón

submission deadline 20 Mar 2025 | 1 articles | Viewed by 1336 | Submission Open

Keywords: microbial biotechnology; nutrients; food; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

New Advances of the Molecular Mechanisms of Gonad Development, Gametogenesis, and Fertilization

edited by

Kenji Murata

submission deadline 20 Mar 2025 | 1 articles | Viewed by 1258 | Submission Open

Keywords: primordial germ cells; sex differentiation; extensive epigenetic reprogramming; Fertilization; oogenesis; spermatogenesis; vertebrate; imvertebrate; Sperm-egg interaction; folliculogenesis

(This special issue belongs to the Section Molecular Biology)

Redox Regulation and Drug Discovery

edited by

Junmin Zhang

submission deadline 20 Mar 2025 | 1 articles | Viewed by 1165 | Submission Open

Keywords: redox regulation; drug discovery; medical translation; redox biology and medicine; redox homeostasis; redox balance; natural products; redox signaling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Emerging Topics in Metal Complexes: Pharmacological Activity, 2nd Edition

edited by

Agnieszka Scibior

Juan Llopis

and

Manuel Aureliano

submission deadline 20 Mar 2025 | 1 articles | Viewed by 1103 | Submission Open

Keywords: metal complexes; polyoxometalates; biological activity; pharmacokinetic parameters; mechanistic analysis; cancer/neurodegenerative diseases; innovative strategies; laboratory diagnostics; clinical studies

(This special issue belongs to the Section Molecular Pharmacology)

Dietary Components in the Brain–Gut Axis: Exploring Nutrigenetic and Microbiome Interactions

edited by

Piotr Dobrowolski

submission deadline 20 Mar 2025 | 1 articles | Viewed by 1074 | Submission Open

Keywords: dietary components; carbohydrates; proteins; fats; fatty acids; vitamins; minerals; brain– gut axis; nutrigenetics; microbiome interactions; neurodegenerative disorders; metabolic pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protein Stability Research: 2nd Edition

edited by

Csaba Magyar

submission deadline 20 Mar 2025 | 1 articles | Viewed by 957 | Submission Open

Keywords: protein stability; protein degradation; conformational stability and flexibility; thermodynamic stability of proteins; mutation-induced changes in protein stability; stability of oligomeric proteins; stability of protein complexes; thermal adaptation of protein structures; protein aggregation; molten globules; heat shock proteins; chaperones

(This special issue belongs to the Section Molecular Biophysics)

Isolation, Characterization and Application of Lignin

edited by Edita Jasiukaitytė-Grojzdek

submission deadline 20 Mar 2025 | 1 articles | Viewed by 882 | Submission Open

Keywords: lignin; lignocellulose; renewable resources; biomass fractionation; lignin isolation; lignin fractionation; lignin valorization; biomaterials; biocomposites; biorefinery concept

(This special issue belongs to the Section Materials Science)

Molecular Research in Rheumatoid Arthritis

edited by Ângelo Calado

submission deadline 20 Mar 2025 | 1 articles | Viewed by 844 | Submission Open

Keywords: rheumatoid arthritis; synovium; autoimmunity; rheumatology; omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Periodontal Disease, Association with Systemic Conditions and Periodontal Pathogens: 2nd Edition

edited by Evangelos Papathanasiou

submission deadline 20 Mar 2025 | 1 articles | Viewed by 816 | Submission Open

Keywords: periodontal disease; periodontitis; periodontal medicine; periodontal– systemic interactions; immune response; periodontal pathogens

(This special issue belongs to the Section Molecular Immunology)

Advances and Challenges of Molecular Research on Disease in Animal Models in Biomedicine

edited by Minolfa C. Prieto

submission deadline 20 Mar 2025 | 1 articles | Viewed by 765 | Submission Open

Keywords: animal models; cardiovascular disease; renal disease; metabolic; neurological; behavioral; and oncological disorders; pathophysiology; cell and molecular research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches

edited by

Dimitrios Kanakis

submission deadline 20 Mar 2025 | Viewed by 724 | Submission Open

Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma

(This special issue belongs to the Section Molecular Oncology)

Natural Product-Based Strategy for Skin Inflammatory Disorders and Regeneration

edited by

Mi Young Lee

submission deadline 20 Mar 2025 | 1 articles | Viewed by 635 | Submission Open

Keywords: inflammatory skin disorders; skin wound healing and regeneration; skin aging; bioactive natural compound; derivative and conjugate; plant extract; beneficial effect and application; molecular mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Topoisomerase Inhibitors: Future Perspectives and Challenges

edited by

Ben Bax

and Mark Mitton-Fry

submission deadline 20 Mar 2025 | Viewed by 412 | Submission Open

Keywords: antibiotic; topoisomerase; inhibitor; anticancer; resistance; safety

(This special issue belongs to the Section Molecular Pharmacology)

Targeted Therapy and Molecular Strategies for Gynecological Cancer

edited by

Matin Sheriff

and

Stergios Boussios

submission deadline 20 Mar 2025 | Viewed by 385 | Submission Open

Keywords: gynecological cancer; targeted therapy; molecular markers; genomic profiling; immunotherapy; personalized medicine; multidisciplinary approach

(This special issue belongs to the Section Molecular Oncology)

Recent Research on Novel Lipid-Based Nano Drug Delivery Systems

edited by Eder Lilia Romero

submission deadline 20 Mar 2025 | Viewed by 340 | Submission Open

Keywords: lipids; nanoparticle; nanovesicle; algae; archaea; plant; bacteria; natural product

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Gestational Diabetes Mellitus

edited by Natasha Singh

submission deadline 20 Mar 2025 | Viewed by 311 | Submission Open

Keywords: metabolome; placental insulin signaling; DNA methylation; mitochondrial oxidation; MTOR; amino acids lipidomics; proteomics; gluconeogenesis; GDM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 3201-3250 on page 65 of 68.

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