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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Radiation Resistance in Extremophile Bacteria: Unraveling the Molecular Mysteries submission deadline 20 Mar 2025 | Viewed by 242 | Submission Open
Keywords: extremophiles; radiation resistance; genome analysis; RNAseq; proteome studies; comparative analysis; molecular mechanisms; genetic adaptation; metabolic shifts; evolutionary insights; eukaryotic resistance
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Cell Biology of Pancreatic Diseases
edited by Hirohito Ichii
submission deadline 20 Mar 2025 | Viewed by 241 | Submission Open
Keywords: pancreatic diseases; pancreas; cell and molecular biology; pathogenesis; islet; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroinflammation in the Pathogenesis of Alzheimer’s Disease and Related Dementias: 2nd Edition
edited by
submission deadline 20 Mar 2025 | Viewed by 241 | Submission Open
Keywords: Alzheimer’ s disease; neuroinflammation; drug development; microglia; astrocytes; cytokines; TREM2; risk factors; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Immune Responses to Viruses
edited by , Tarik Gheit and
submission deadline 20 Mar 2025 | Viewed by 238 | Submission Open
Keywords: viruses; innate immunity; cellular signaling; viral infections; cell– host interactions; virus-mediated cellular transformation; immune response; viral escape
(This special issue belongs to the Section Molecular Immunology)
Molecular Research of Nanocomposites: Design, Properties and Application
edited by
submission deadline 20 Mar 2025 | Viewed by 235 | Submission Open
Keywords: interfacial thermal resistance; polymer-based nanocomposites; polymers; thermal conductivity; thermal-interface materials
(This special issue belongs to the Section Materials Science)
Advances in Design, Synthesis and Applications of Peptide Nucleic Acid
edited by , Concetta Avitabile and
submission deadline 20 Mar 2025 | Viewed by 231 | Submission Open
Keywords: PNA; nucleic acid analog; molecular design; synthesis; delivery system; therapeutics; diagnostic
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnostic and Treatment Methods in Socially Significant Diseases in Urology
edited by
submission deadline 20 Mar 2025 | Viewed by 229 | Submission Open
Keywords: prostate cancer; bladder cancer; renal-cell cancer; risk stratification; urolithiasis; chronic UTIs; BPH; clinical decision-making
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Streptococcus pneumoniae
edited by Lok-To Sham
submission deadline 20 Mar 2025 | Viewed by 227 | Submission Open
Keywords: respiratory pathogen; Streptococcus pneumoniae; host– pathogen interactions; gene function
(This special issue belongs to the Section Molecular Microbiology)
Molecular and Cellular Research in Pregnancy-Related Complications, 2nd Edition submission deadline 20 Mar 2025 | Viewed by 226 | Submission Open
Keywords: pregnancy loss/miscarriage; pregnancy complications; pre-eclampsia; maternal– placental– fetal interactions; trophoblast; immune cells; immune tolerance; red blood cells; oxidative stress; blood and fetal proteins; DNA; RNA; stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Oxidative Stress in Kidney Disease
edited by Stefanos Roumeliotis
submission deadline 20 Mar 2025 | Viewed by 221 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; hemodialysis; peritoneal dialysis; oxidative stress; pro-oxidants; inflammation; atherosclerosis; cardiovascular disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Intracellular Trafficking and Catabolism of Free Heme: Physiological Roles and Relevance to Pathological Mechanisms
edited by Junichi Taira
submission deadline 20 Mar 2025 | Viewed by 219 | Submission Open
Keywords: heme oxygenase; heme metabolism; heme chaperon; free heme (labile heme); cytochrome P450 reductase; reactive oxygen species; carbon monoxide  
(This special issue belongs to the Section Biochemistry)
Pathogenesis and Molecular Treatment of Primary Liver Cancer
edited by
submission deadline 20 Mar 2025 | Viewed by 211 | Submission Open
Keywords: primary liver cancer; cholangiocarcinoma; hepatocellular carcinoma; hepatoblastoma; molecular pathogenesis; targeted therapies; anticancer drug
(This special issue belongs to the Section Molecular Oncology)
The Roles of Mesenchymal Stem/Stromal Cells in Tumor Therapies
edited by Francesco Agostini
submission deadline 20 Mar 2025 | Viewed by 200 | Submission Open
Keywords: mesenchymal stem cells; tumor; cancer patients; ex vivo cell modification; cell and gene therapy; targeted drug delivery; homing; migration; current regulatory guidelines; MSC therapeutic potential
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Artificial Reproduction and Female Health: From Molecular Diagnosis to the Treatment of Gynecological Diseases
edited by Liselotte Mettler
submission deadline 20 Mar 2025 | Viewed by 192 | Submission Open
Keywords: gynecological diseases; molecular diagnostic technologies; reproductive medicine; artificial reproduction; gynecological endocrinology; adnexal tumors; genital and breast cancer; urogynecology; uterine fibroids
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Roles of Mast Cells in Immune-Induced Diseases
edited by Paul L.A. Van Daele and Willem A. Dik
submission deadline 20 Mar 2025 | Viewed by 189 | Submission Open
Keywords: mast cell; fibrosis; inflammation; autoinflammation; autoimmunity; transplantation; gastrointestinal; pulmonary; cytokines; MRGPRX2; rejection
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms Underlying Pancreatic Cancer Progression and Drug Resistance
edited by Daoyan Wei and Robert S. Bresalier
submission deadline 20 Mar 2025 | Viewed by 187 | Submission Open
Keywords: pancreatic cancer; cancer progression; therapeutic resistance; targeted therapies; oncogenic pathways; molecular pathogenesis; tumor heterogeneity; tumor microenvironment; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications
edited by Jung-Hyun Lee
submission deadline 20 Mar 2025 | Viewed by 181 | Submission Open
Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Latest Advances in Protein-Ligand Interactions
edited by
submission deadline 20 Mar 2025 | Viewed by 179 | Submission Open
Keywords: protein– ligand interaction; molecular mode of actions; target identification; drug discovery; bioactive agents
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research on Advanced Optical Materials 2.0: From Materials to Applications
edited by and Won Yeop Rho
submission deadline 20 Mar 2025 | Viewed by 178 | Submission Open
Keywords: metal materials; plasmonic materials; SERS substrates; fluorescence materials; dye-doped materials; quantum dots; up-conversion materials; carbon materials; meta materials; bioapplications; energy applications; LED applications; bioimaging; molecules; molecular dynamic simulations; molecular materials
(This special issue belongs to the Section Materials Science)
New Insights into Airway Smooth Muscle: From Function to Dysfunction
edited by
submission deadline 20 Mar 2025 | Viewed by 176 | Submission Open
Keywords: contraction; proliferation; migration; airway hyperresponsiveness; airway remodeling; β 2-adrenergic receptors; muscarinic receptor; Th2 inflammation; non-Th2 inflammation; oxidative stress; lysophospholipids; intracellular signal transduction processes; Ca2+ signaling; interactions with other cells (inflammatory cells and epithelium); asthma; COPD
(This special issue belongs to the Section Molecular Biology)
Novel Molecular Insights into the Most Common Muscular Dystrophy, Motor Neuron and Neuromuscular Junction Diseases

 

edited by Mendell Rimer
submission deadline 20 Mar 2025 | Viewed by 176 | Submission Open
Keywords: ALS; DMD; CMS; NMJ; motor neuron disease; muscular dystrophy; neuromuscular junction; motor neuron; skeletal muscle
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Hypoxia, Normoxia and Hyperoxia in Cancer Initiation and Propagation
edited by Mary M. Salvatore
submission deadline 20 Mar 2025 | Viewed by 173 | Submission Open
Keywords: hypoxia; normoxia; hyperoxia; cancer initiation; cancer propagation
(This special issue belongs to the Section Molecular Biology)
Microsatellite Instability (MSI) and Mismatch Repair Deficient (dMMR)-Related Diseases: From Detection Methods to Practice
edited by Federica Zito Marino
submission deadline 20 Mar 2025 | Viewed by 172 | Submission Open
Keywords: microsatellite instability (MSI); mismatch repair deficient (dMMR); immunotherapy; next-generation sequencing (NGS); immunohistochemistry (IHC); polymerase chain reaction (PCR); MSI-positive tumors
(This special issue belongs to the Section Molecular Biology)
The Role of Choroid Plexus in Neurological Health
edited by
submission deadline 20 Mar 2025 | Viewed by 171 | Submission Open
Keywords: choroid plexus; cerebrospinal fluid; neurological health; blood– CSF barrier; central nervous system
(This special issue belongs to the Section Molecular Neurobiology)
Novel Insights into Reproductive Toxicology
edited by Maria Cristina Budani
submission deadline 20 Mar 2025 | Viewed by 156 | Submission Open
Keywords: endocrine disruptors; environmental toxicants; fertility; heavy metals; lifestyle habits; molecular mechanisms; pregnancy; teratology; teratogenic compounds; reproductive toxicology
(This special issue belongs to the Section Molecular Toxicology)
Physics and Chemistry of Molecular Materials for Optoelectronic Applications submission deadline 20 Mar 2025 | Viewed by 147 | Submission Open
Keywords: polarization of matter; non-linear optics and non-linear optical phenomena; optical phenomena; quantum chemistry; density functional theory; physics and chemistry of molecular materials; molecular-based optoelectronics
(This special issue belongs to the Section Materials Science)
Arrhythmias: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 20 Mar 2025 | Viewed by 146 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; ventricular arrhythmia; electrophysiologic alternation; ion channel; connexin; autonomic nerve system dysfunction; sleep-disordered breathing; obstructive sleep apnea
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Pathogens: Advances in Genomic and Proteomic Research
edited by Alejandro Yáñez and Vinicius Maracaja-Coutinho
submission deadline 20 Mar 2025 | Viewed by 144 | Submission Open
Keywords: genomics and proteomics; reverse vaccinology; pathogen biology; molecular pathogenesis; infectious diseases; host– pathogen interactions; non-coding DNAs and RNAs; omics technologies
(This special issue belongs to the Section Molecular Informatics)
Bone Development and Growth, 3rd Edition
edited by
submission deadline 20 Mar 2025 | Viewed by 136 | Submission Open
Keywords: bone development; osteogenesis; bone cells; bone matrix; intramembranous bone; endochondral bone; periosteum; mineralization; growth plate; bone structure; bone remodeling; histomorphometry; growth factors; bone morphogenic protein; bone metabolism markers; fracture repair; bone defects; bone quality; heterotopic bone formation; biograft; new bone formation
(This special issue belongs to the Section Biochemistry)
Modulation of Protein Structure and Function by Lipids: 2nd Edition submission deadline 20 Mar 2025 | Viewed by 131 | Submission Open
Keywords: protein modulation by lipids; phosphoinositides; cholesterol; sterols; fatty acids; G protein-coupled receptors; ion channels; transporters
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Transplantation and Machine Perfusion submission deadline 20 Mar 2025 | Viewed by 98 | Submission Open
Keywords: transplantation (liver; kidney; and other organs); primary failure; ischemia-reperfusion injury; static graft preservation; HOPE; NMP; cell signaling; glycocalyx; metabolomics; mitochondria; sterile inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Agents: Synthesis and Design
edited by
submission deadline 20 Mar 2025 | Viewed by 82 | Submission Open
Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles
(This special issue belongs to the Section Materials Science)
Plant Resistance to Biotic and Abiotic Stresses
edited by and
submission deadline 20 Mar 2025 | Viewed by 74 | Submission Open
Keywords: biotic stress; abiotic stress; resistance; molecular mechanisms; molecular biology; plant disease; plant pathogens; drought; salinity; extreme temperatures
(This special issue belongs to the Section Molecular Plant Sciences)
Neuronal Differentiation: From Pathology to Therapeutic Strategies
edited by
submission deadline 20 Mar 2025 | Viewed by 68 | Submission Open
Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells
(This special issue belongs to the Section Molecular Neurobiology)
Potential Health Benefits of Resveratrol: Laboratory-Confirmed Mechanisms of Action
edited by
submission deadline 20 Mar 2025 | Viewed by 54 | Submission Open
Keywords: resveratrol; polyphenol; phytoalexin; phytoestrogen; natural compound; reactive oxygen species; antioxidant effects; anti-inflammatory effects; antiaging properties; antidiabetic properties; cardioprotective effects; neuroprotective effects; anticancer properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Design of Bioactive Agents and Interaction with Biological Systems
edited by
submission deadline 20 Mar 2025 | Viewed by 53 | Submission Open
Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry
(This special issue belongs to the Section Molecular Biology)
The Molecular Role of Platelets in Human Diseases submission deadline 20 Mar 2025 | Viewed by 43 | Submission Open
Keywords: platelet; biomarkers; platelet membrane proteins; platelet-derived microparticles; platelet-related diseases; thrombosis; inflammatory diseases; cardiovascular disease; cancer; tumor growth and metastasis
(This special issue belongs to the Section Molecular Biology)
Advances in Bioactive Peptides: Mechanisms of Action and Biosynthesis
edited by and
submission deadline 20 Mar 2025 | Viewed by 41 | Submission Open
Keywords: mechanisms of action; biosynthesis; bioactive peptides (BAPs); innate immunity; synthetic peptides; therapeutic applications; antimicrobial peptides (AMPs)
(This special issue belongs to the Section Biochemistry)
Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials
edited by
submission deadline 20 Mar 2025 | Viewed by 40 | Submission Open
Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Research Progress of Skin and Skin Diseases: 2nd Edition
edited by
submission deadline 20 Mar 2025 | Viewed by 28 | Submission Open
Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Endometrial Cancer
edited by Ursula Catena
submission deadline 20 Mar 2025 | Viewed by 27 | Submission Open
Keywords: endometrial cancer; risk factors; early detection; molecular profiling; targeted therapy; immunotherapy; surgical management; fertility-sparing treatment; quality of life
(This special issue belongs to the Section Molecular Oncology)
Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition submission deadline 20 Mar 2025 | Viewed by 21 | Submission Open
Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations
(This special issue belongs to the Section Molecular Oncology)
Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease
edited by Sophia Lavrentiadou
submission deadline 20 Mar 2025 | Viewed by 20 | Submission Open
Keywords: Alzheimer’ s disease; neuroinflammation; anti-inflammatory strategies; cell models
(This special issue belongs to the Section Molecular Neurobiology)
Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications
edited by Karim Daliri
submission deadline 20 Mar 2025 | Viewed by 18 | Submission Open
Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Research on Plant Bioactive Compounds submission deadline 25 Mar 2025 | Viewed by 257 | Submission Open
Keywords: plant bioactive compounds; extraction and analysis of plant bioactive compounds; bioactivity and pharmacokinetics of plant compounds; natural products and modern diseases; plant bioactive compounds and by-products; discovery and development of natural plant drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Blood Cells in Human Health and Disease
edited by Leonid Livshits
submission deadline 25 Mar 2025 | Viewed by 113 | Submission Open
Keywords: red blood cell; RBC membrane; RBC biophysical properties; RBC rheology; RBC mechanical properties; RBC membrane vesiculation; RBC clearance; RBC in diabetes; hemoglobinopathies; RBC storage TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Biochemistry)
Big Data in Multi-Omics submission deadline 25 Mar 2025 | Viewed by 108 | Submission Open
Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Shona   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Informatics)
Navigating Lung Cancer in the Era of Cancer Pharmacology and Precision Therapy
edited by
submission deadline 25 Mar 2025 | Viewed by 100 | Submission Open
Keywords: lung cancer; pharmacology; precision therapy; targeted therapy; immunotherapy; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases
edited by , and
submission deadline 25 Mar 2025 | Viewed by 83 | Submission Open
Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment
edited by
submission deadline 25 Mar 2025 | Viewed by 81 | Submission Open
Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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