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14 Results Found

  • Article
  • Open Access
1 Citations
1,416 Views
16 Pages

The Potential of Cardiac Biomarkers in Differentiating Disease Subtypes in Patients with Systemic Sclerosis: Focus on GDF15, MR-pro ANP, and suPAR

  • Olga Gumkowska-Sroka,
  • Anna Chudek,
  • Aleksander Owczarek,
  • Kornelia Kuźnik-Trocha,
  • Kacper Kotyla,
  • Jan Kurdybacha,
  • Jerzy Chudek,
  • Katarzyna Komosińska-Vassev,
  • Katarzyna Winsz-Szczotka and
  • Przemysław Kotyla
  • + 1 author

Systemic sclerosis, a connective tissue disease of unknown etiology and unpredictable outcomes, is characterized by the fibrosis of the skin and internal organs, vasculopathy, and immune system dysregulation. The disease is classified into two main s...

  • Article
  • Open Access
2 Citations
1,768 Views
15 Pages

Effectiveness of Copeptin, MR-proADM and MR-proANP in Predicting Adverse Outcomes, Alone and in Combination with Traditional Severity Scores, a Secondary Analysis in COVID-19 Patients Requiring Intensive Care Admission

  • Emanuele Varaldo,
  • Francesca Rumbolo,
  • Nunzia Prencipe,
  • Fabio Bioletto,
  • Fabio Settanni,
  • Giulio Mengozzi,
  • Silvia Grottoli,
  • Ezio Ghigo,
  • Luca Brazzi and
  • Alessandro Maria Berton
  • + 1 author

30 March 2024

Objective: To investigate whether copeptin, MR-proADM and MR-proANP, alone or integrated with the SOFA, MuLBSTA and SAPS II scores, are capable of early recognition of COVID-19 ICU patients at increased risk of adverse outcomes. Methods: For this pre...

  • Article
  • Open Access
723 Views
21 Pages

28 October 2025

Background/Objectives: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) and chronic obstructive pulmonary disease (COPD) are linked to multi-organ vulnerability involving the lungs, heart, and kidneys. This study aimed to compare the...

  • Article
  • Open Access
1 Citations
1,076 Views
12 Pages

27 November 2024

Objectives: Adrenomedullin (AM) and natriuretic peptide levels are elevated in pre-eclampsia. The aim of the present study was to determine AM and natriuretic peptide concentrations before 20 weeks of pregnancy in women who later developed gestationa...

  • Article
  • Open Access
4 Citations
2,443 Views
13 Pages

An Integrated Imaging and Circulating Biomarker Approach for Secondary Tricuspid Regurgitation

  • Georg Spinka,
  • Philipp E. Bartko,
  • Gregor Heitzinger,
  • Eliza Teo,
  • Suriya Prausmüller,
  • Henrike Arfsten,
  • Noemi Pavo,
  • Max-Paul Winter,
  • Julia Mascherbauer and
  • Georg Goliasch
  • + 2 authors

16 November 2020

Secondary tricuspid regurgitation (sTR) is frequent among patients with heart failure with reduced ejection fraction (HFrEF), however it confers considerable diagnostic challenges. The assessment of neurohumoral activation may constitute a valuable s...

  • Article
  • Open Access
1 Citations
1,147 Views
13 Pages

Natriuretic Peptides and Soluble ST2 Improve Echocardiographic and Invasive Long-Term Survival Prediction in Patients Evaluated for Diastolic Dysfunction

  • Horațiu Suciu,
  • Paul-Adrian Călburean,
  • Adina Huțanu,
  • Mădălina Oprica,
  • Diana Roxana Opriș,
  • Anda-Cristina Scurtu,
  • Alexandru Stan,
  • David Aniței,
  • Klara Brînzaniuc and
  • Marius Harpa
  • + 1 author

This study aimed to investigate the impact of long-term survival on cardiac serum biomarkers such as natriuretic peptides (mid-regional pro-atrial natriuretic peptide [MR-proANP], B-type natriuretic peptide [BNP], N-terminal prohormone BNP [NT-proBNP...

  • Article
  • Open Access
1 Citations
2,291 Views
10 Pages

The Association between Echocardiographic Parameters of Heart Failure with Preserved Ejection Fraction and Fluid Status Biomarkers in Hemodialysis Patients

  • Mariusz Lupa,
  • Agnieszka Pardała,
  • Anna Bednarek,
  • Jolanta Mrochem-Kwarciak,
  • Regina Deja,
  • Katarzyna Mizia-Stec and
  • Aureliusz Kolonko

Overhydration and cardiac function abnormalities are common in hemodialysis patients. The association of N-terminal prohormone for brain natriuretic peptide (NT-proBNP) and other fluid status biomarkers with echocardiographic parameters of heart fail...

  • Article
  • Open Access
5 Citations
3,921 Views
14 Pages

Circulating Levels of the Cardiovascular Biomarkers ST2 and Adrenomedullin Predict Outcome within a Randomized Phase III Lung Cancer Trial (RASTEN)

  • Emelie Gezelius,
  • Pär-Ola Bendahl,
  • Widet Gallo,
  • Kelin Gonçalves de Oliveira,
  • Lars Ek,
  • Bengt Bergman,
  • Jan Sundberg,
  • Olle Melander and
  • Mattias Belting

3 March 2022

Cardiovascular comorbidity is common in small cell lung cancer (SCLC) and may significantly affect treatment tolerability and patient outcome. Still, there are no established biomarkers for objective and dynamic assessment as a tool for improved trea...

  • Article
  • Open Access
2 Citations
1,825 Views
13 Pages

Features of Heart Failure with Preserved Ejection Fraction in Patients with Chronic Obstructive Pulmonary Disease and Systemic Sclerosis-Associated Interstitial Lung Diseases

  • Lyazat Ibrayeva,
  • Meruyert Aubakirova,
  • Irina Bacheva,
  • Assel Alina,
  • Nazira Bazarova,
  • Aizhan Zhanabayeva,
  • Olga Avdiyenko,
  • Seda Borchashvili,
  • Saltanat Tazhikhanova and
  • Askhat Murzabaeyev

Background/Objectives: This study aims to investigate the potential etiopathogenesis of HFpEF development and identify possible different phenotypes of HFpEF in patients with chronic obstructive pulmonary disease (COPD) and systemic sclerosis-associa...

  • Review
  • Open Access
14 Citations
3,922 Views
11 Pages

Natriuretic Peptides, Cognitive Impairment and Dementia: An Intriguing Pathogenic Link with Implications in Hypertension

  • Giovanna Gallo,
  • Franca Bianchi,
  • Maria Cotugno,
  • Massimo Volpe and
  • Speranza Rubattu

16 July 2020

The natriuretic peptides (NPs) belong to a family of cardiac hormones that exert relevant protective functions within the cardiovascular system. An increase of both brain and atrial natriuretic peptide levels, particularly of the amino-terminal pepti...

  • Review
  • Open Access
59 Citations
8,927 Views
23 Pages

Natriuretic Peptides in Heart Failure with Preserved Left Ventricular Ejection Fraction: From Molecular Evidences to Clinical Implications

  • Daniela Maria Tanase,
  • Smaranda Radu,
  • Sinziana Al Shurbaji,
  • Genoveva Livia Baroi,
  • Claudia Florida Costea,
  • Mihaela Dana Turliuc,
  • Anca Ouatu and
  • Mariana Floria

The incidence of heart failure with preserved ejection fraction (HFpEF) is increasing and its challenging diagnosis and management combines clinical, imagistic and biological data. Natriuretic peptides (NPs) are hormones secreted in response to myoca...

  • Review
  • Open Access
37 Citations
14,797 Views
32 Pages

Cardiovascular Biomarkers: Tools for Precision Diagnosis and Prognosis

  • Vasudeva Reddy Netala,
  • Tianyu Hou,
  • Yanbo Wang,
  • Zhijun Zhang and
  • Sireesh Kumar Teertam

The present study provides a detailed review of cardiovascular biomarkers critical for the diagnosis, prognosis, and pathophysiology of cardiovascular diseases, the leading cause of global morbidity and mortality. These biomarkers aid in detecting di...

  • Review
  • Open Access
1,232 Views
16 Pages

Optimum Patient’s Selection for Atrial Fibrillation Ablation Using Echocardiography

  • Matteo Cameli,
  • Maria Concetta Pastore,
  • Francesco Morrone,
  • Giulia Elena Mandoli,
  • Giovanni Benfari,
  • Federica Ilardi,
  • Matteo Lisi,
  • Alessandro Malagoli,
  • Simona Sperlongano and
  • Antonello D’Andrea
  • + 7 authors

4 November 2025

Catheter ablation (CA) has become a validated technique for treating patients with symptomatic or paroxysmal atrial fibrillation (AF), as recommended by the latest 2024 European society of cardiology (ESC) guidelines, class II level A. The procedure...