Table of Contents
Nutrients, Volume 9, Issue 8 (August 2017)
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Cover Story Microbial communities of gut are well known to play vital roles in mammalian physiology. During [...] Read more. Microbial communities of gut are well known to play vital roles in mammalian physiology. During last decade scientists in field of metabolic, neurological and other chronic diseases have published huge amounts of evidence to show that disturbances in gut microbial flora, known as dysbiosis, may initiate and contribute to pathologies of multiple chronic diseases. Dietary habits directly related to human health. High fat and high carb diets cause immense effects on gut microbial composition. The changes in gut microbiome and the metabolic products of these altered flora both play different and important roles in development of chronic diseases. Host interaction with the altered gut microbiome impair homeostatic mechanisms that regulate health and can activate multiple pathways leading to CVD risk factor progression. Dysbiosis has been implicated in the development of atherosclerosis through metabolism-independent and metabolite-dependent pathways.