Table of Contents
Processes, Volume 5, Issue 2 (June 2017)
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Cover Story (view full-size image) “Physiologically relevant” in vitro models are designed to better mimic in vivo conditions. Besides [...] Read more. “Physiologically relevant” in vitro models are designed to better mimic in vivo conditions. Besides flow and 3D architecture, they also require the control of environmental parameters to ensure that the in vivo physico-chemical milieu is recapitulated. The SUITE platform – consisting of a pump, modular bioreactors and a mixing chamber, along with sensing, actuation, and control components – was engineered as a free-standing fluidic cell culture system able to measure and regulate cell culture parameters (e.g. temperature, pH, pressure) “on-line”. SUITE can be used for generating pathophysiological biomimetic in-vitro models, with applications in disease modelling or toxicity testing. View this paper