Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor Stroma Interaction
edited by
submission deadline 25 Mar 2025 | Viewed by 69 | Submission Open
Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma
Therapeutic Targets in Glioblastoma
edited by Candice Mazewski and
submission deadline 28 Mar 2025 | Viewed by 41 | Submission Open
Keywords: glioblastoma; signaling targets; blood-brain-barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
Kinases in Cancer: Advancing Targeted Therapies and Their Implications in Cancer Immunity
edited by Zamal Ahmed and John A. Tainer
submission deadline 30 Mar 2025 | 1 articles | Viewed by 1120 | Submission Open
Keywords: kinase targets; proliferation; cell cycle checkpoints; DNA damage responses; inflammation; cancer immune response; phosphatase targets; adaptor and scaffold targets
(This special issue belongs to the Section Cellular Immunology)
Cellular Differentiation in Health and Disease
edited by Christine K. C. Loo and
submission deadline 30 Mar 2025 | Viewed by 141 | Submission Open
Keywords: cellular differentiation; tumour microenvironment; human development; regeneration/healing; cell signaling pathways; tumour differentiation
Male Reproductive Health and Infertility: A Look towards the Future II submission deadline 31 Mar 2025 | 6 articles | Viewed by 10799 | Submission Open
Keywords: sperm; male infertility; spermatogenesis; epigenetics; fertilization; exosomes; cell communication; oxidative stress; biomarkers
(This special issue belongs to the Section Reproductive Cells and Development)
New Insights into Vascular Biology in Health and Disease
edited by Bashir M. Rezk
submission deadline 31 Mar 2025 | 2 articles | Viewed by 4910 | Submission Open
Keywords: vascular diseases; cardiovascular; cancer; hyperhomocyteinemia; endothelial dysfunction; vascular smooth muscle cell; autophagy; alcohol; galectins; angiogenesis; neovascularization
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular and Molecular Basis of Alkaptonuria submission deadline 31 Mar 2025 | 2 articles | Viewed by 4331 | Submission Open
Keywords: Alkaptonuria; AKU; pathophysiology; post-genomics; histopathology; bioinformatics
(This special issue belongs to the Section Cellular Pathology)
Inflammatory Pathways in Psychiatric Disorders
edited by Teresa Femenía
submission deadline 31 Mar 2025 | 1 articles | Viewed by 4307 | Submission Open
Keywords: inflammation; immune system; psychiatry; emotion; cognition
(This special issue belongs to the Section Cells of the Nervous System)
Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities submission deadline 31 Mar 2025 | 1 articles | Viewed by 3623 | Submission Open
Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities
(This special issue belongs to the Section Tissues and Organs)
Antioxidants in Redox Homeostasis of Plant Development submission deadline 31 Mar 2025 | 1 articles | Viewed by 2548 | Submission Open
Keywords: reactive oxygen species; radical scavenging; oxidative stress; plant growth and development; primary and secondary metabolites
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Microbe–Heavy Metal Interactions
edited by
submission deadline 31 Mar 2025 | 1 articles | Viewed by 2347 | Submission Open
Keywords: horizontal gene transfer (HGT); gene duplication; natural selection; mutation; heavy metal resistance genes (MRGs); antibiotic resistance genes (ARGs); acid mine drainage (AMD); heavy metals; plasmids; mobile genetic elements (MGEs); transposons; extreme environments; bioremediation
Remyelination: From Basic Science to Therapies submission deadline 31 Mar 2025 | 1 articles | Viewed by 1421 | Submission Open
Keywords: myelin disease; neurodegeneration; CNS therapy; stem cells; regenerative therapies
(This special issue belongs to the Section Cells of the Nervous System)
Signaling Regulation of Bone and Tooth Development
edited by Xiaofang Wang
submission deadline 31 Mar 2025 | 1 articles | Viewed by 1224 | Submission Open
Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis
Flow Cytometry in Immunology Research
edited by and Ekaterina Kopitman
submission deadline 31 Mar 2025 | 1 articles | Viewed by 1023 | Submission Open
Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays
(This special issue belongs to the Section Cell Methods)
Adipose Tissue, Obesity, and Metabolic Diseases
edited by Takafumi Miyamoto
submission deadline 31 Mar 2025 | 1 articles | Viewed by 685 | Submission Open
Keywords: adipose tissue; obesity; metabolic diseases; stress; inflammation; gut microbiota
(This special issue belongs to the Section Cellular Metabolism)
Ca2+ Signaling and Calcium-Binding Proteins in Human Disease
edited by Nordine Helassa
submission deadline 31 Mar 2025 | Viewed by 343 | Submission Open
Keywords: calcium signaling; calcium-binding protein; calmodulin; ion channels; cardiac arrhythmia; neurodegenerative disease
Membrane Damage and Repair in Organelles
edited by Yoko Shiba
submission deadline 31 Mar 2025 | Viewed by 286 | Submission Open
Keywords: membrane damage; organelle; pathogen; inorganic material; galectin
(This special issue belongs to the Section Intracellular and Plasma Membranes)
New Insights of TGF-Beta Signaling in Cancer
edited by
submission deadline 31 Mar 2025 | Viewed by 258 | Submission Open
Keywords: cancer; TGF-beta; signaling crosstalk; smad signaling; non-Smad signaling; TGF-beta receptors; TGF-beta signaling inhibitors; TGF-beta paradox; epithelial-mesenchymal transition (EMT); mesenchymal-epithelial transition (MET)
Organellar Ca2+ Transport in Plant versus Animal Cells: Can We Learn from Each Other?
edited by Shey-Shing Sheu and Marc Freichel
submission deadline 31 Mar 2025 | Viewed by 243 | Submission Open
Keywords: organellar calcium transport; plant cells; animal cells; intracellular organelle communication; calcium signaling; mitochondria; organelle-targeted florescent Ca2+ indicators; super-resolution imaging
(This special issue belongs to the Section Cell Microenvironment)
State of the Art in Computational Modeling of Cancer Immunotherapy submission deadline 31 Mar 2025 | Viewed by 192 | Submission Open
Keywords: oncoimmunology; modeling immune– tumor interactions; modeling combination immunotherapies; modeling adoptive cell therapies; mathematical modeling; data-driven models
Biomolecular Condensates in Oncology and Immunology submission deadline 31 Mar 2025 | Viewed by 177 | Submission Open
Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis
(This special issue belongs to the Section Cellular Immunology)
Cell Death: Cell–Cell Interactions and Signaling Networks
edited by , Sun Chul Kang and
submission deadline 31 Mar 2025 | Viewed by 161 | Submission Open
Keywords: apoptosis; necrosis; pyroptosis; autophagic cell death; lysosome-dependent cell death; parthanatos; ferroptosis; anoikis; entosis; necroptosis; NETosis; mitotic catastrophe; healthy cell death tissue homeostasis
Advances in Neurogenesis: 3rd Edition submission deadline 31 Mar 2025 | Viewed by 148 | Submission Open
Keywords: neurogenesis; gliogenesis; cell plasticity; neurophysiology; behavior; neural circuits; cytogenic regulators; neuropsychiatric disorders; neurodegenerative disorders
Pathogenic Mechanisms of Chronic Inflammation-Associated Cancer
edited by Emiko Mizoguchi
submission deadline 31 Mar 2025 | Viewed by 131 | Submission Open
Keywords: chronic inflammation; dysplasia; neoplasia; oncogene; cytokine; colitis-associated cancer
(This special issue belongs to the Section Cellular Pathology)
Molecular and Cellular Mechanisms of Liver Regeneration: From Biology to Therapy
edited by
submission deadline 31 Mar 2025 | Viewed by 123 | Submission Open
Keywords: liver regeneration; hepatocytes; chemokines; growth factors; liver diseases; signaling pathways; inflammation; liver immunobiology; fibrosis; cirrhosis
(This special issue belongs to the Section Tissues and Organs)
Host Immunity to Bacterial Infections
edited by Karine Gloux
submission deadline 31 Mar 2025 | Viewed by 97 | Submission Open
Keywords: host immune systemsbacterial pathogens; innate and adaptive immune responses; pathogen evasion; bacterial infections
(This special issue belongs to the Section Cellular Immunology)
Retinal Pigmented Epithelium (RPE) and the Choroid: Players and Partners for Vision
edited by and Janet R. Sparrow
submission deadline 31 Mar 2025 | Viewed by 91 | Submission Open
Keywords: retinal pigment epithelium; photoreceptor cell; choroid; Bruch’ s membrane; neural retina; visual cycle; phagocytosis; secretion; organelles; mitochondria; retinoid; melanin; albinism; age-related macular degeneration
Modulation of P2X Receptors: Emerging Implications for Cellular Signaling and Disease Management
edited by Luca Antonioli and
submission deadline 31 Mar 2025 | Viewed by 81 | Submission Open
Keywords: purinergic receptors; purinergic signaling; adenosine; ATP; ADP
Glial Cells: Physiological and Pathological Perspective
edited by
submission deadline 31 Mar 2025 | Viewed by 80 | Submission Open
Keywords: neurodegeneration; oligodendrocytes; astrocytes; microglia; neuroinflammation; demyelination neuron– glial interactions; homeostasis; glia-targeted therapies
(This special issue belongs to the Section Cellular Pathology)
Cellular Senescence and Senotherapies in the Aging Retina
edited by
submission deadline 31 Mar 2025 | Viewed by 78 | Submission Open
Keywords: retina; senescence; aging; inflammasome; oxidative stress; antioxidant; gene therapy; senotherapies; glaucoma; diabetic retinopathy
(This special issue belongs to the Section Cellular Aging)
Organoids and Models from Stem Cells
edited by Tiziana A. L. Brevini and
submission deadline 31 Mar 2025 | Viewed by 72 | Submission Open
Keywords: cellular microenvironment; 3D culture; organoid
(This special issue belongs to the Section Stem Cells)
Cellular and Molecular Mechanisms of Liver Diseases
edited by Jieyun Jiang
submission deadline 31 Mar 2025 | Viewed by 71 | Submission Open
Keywords: liver; alcoholic liver disease (ALD); viral hepatitis; metabolic associated steatotic liver disease (MASLD); autoimmune hepatitis; drug-induced liver injury; liver fibrosis and cirrhosis; liver cancer; cellular and molecular mechanisms
(This special issue belongs to the Section Cellular Pathology)
CRISPR-Based Genome Editing Approaches in Cancer Therapy
edited by Martin Pal
submission deadline 31 Mar 2025 | Viewed by 61 | Submission Open
Keywords: CRISPR; genome editing; cancer therapy; precision medicine
(This special issue belongs to the Section Cell and Gene Therapy)
Development of PET Radiotracers for Imaging Alpha-Synuclein
edited by and Jamie Eberling
submission deadline 1 Apr 2025 | Viewed by 141 | Submission Open
Keywords: alpha-synuclein; Parkinson’ s disease; multiple system atrophy; positron emission tomography
(This special issue belongs to the Section Cellular Aging)
The Role of Secretory RNases and Extracellular RNAs in the Regulation of Inflammation and Organ Injury
edited by and
submission deadline 1 Apr 2025 | Viewed by 92 | Submission Open
Keywords: RNase; extracellular RNAs; inflammation; sepsis; organ injury; innate immunity; neutrophils; monocyte/macrophages; endothelial cells
(This special issue belongs to the Section Tissues and Organs)
Recent Advances in Astrocyte Neuron Communication submission deadline 10 Apr 2025 | Viewed by 506 | Submission Open
Keywords: astrocytes; calcium signaling; ion channels; gliotransmitters; brain circuits; reactive astrogliosis; astrocyte heterogeneity; astrocyte– neuron networks; synaptic plasticity
(This special issue belongs to the Section Cells of the Nervous System)
Sebaceous Gland in Skin Health and Disease
edited by and Monica Ottaviani
submission deadline 10 Apr 2025 | Viewed by 327 | Submission Open
Keywords: sebaceous gland; sebocytes; sebaceous lipid; sebum; inflammation; sebaceous gland disease; skin diseases; pathophysiology; biomarkers; therapeutics
(This special issue belongs to the Section Cellular Pathology)
Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration submission deadline 10 Apr 2025 | Viewed by 132 | Submission Open
Keywords: soft/hard tissue regeneration; therapeutical approaches; cell culture studies; inflammation-based diseases; degenerative diseases
Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies
edited by
submission deadline 15 Apr 2025 | Viewed by 130 | Submission Open
Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches
(This special issue belongs to the Section Cellular Immunology)
Recent Progress on Fibrosis and Cardiac Dysfunction submission deadline 15 Apr 2025 | Viewed by 112 | Submission Open
Keywords: regeneration; cardiac fibrosis; cardiac dysfunction; ischemic heart disease; hypertension; atrial fibrillation; inflammation
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 15 Apr 2025 | Viewed by 102 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Stem Cells)
Advances in Bone Biology and Diseases: Pathophysiology, Mechanisms, and Therapeutic Innovations
edited by Baohong Zhao
submission deadline 15 Apr 2025 | Viewed by 59 | Submission Open
Keywords: bone diseases; osteoimmunology; inflammation; osteoporosis; osteoarthritis; Paget’ s disease; bone cancer; bone resorption; bone formation; cytokines; immune cells; pathophysiology; biomarkers; therapeutic strategies; molecular mechanisms; bone metabolism; inflammation-mediated pathways; bone remodeling; diagnostic tools; cellular interactions
Computational Biophysics in Cellular Biological Systems
edited by and Wenhan Guo
submission deadline 15 Apr 2025 | Viewed by 47 | Submission Open
Keywords: cellular process; protein– protein interactions; single-cell analysis; drug design; molecular dynamics simulations
Spatial Proteomics and Transcriptomics in Cells
edited by Elizabeth Neumann
submission deadline 15 Apr 2025 | Viewed by 31 | Submission Open
Keywords: spatial proteomics; lipomics; cellular architecture; biomolecular interactions; bioinformatics; integrative biology
Immune Functions and Therapeutic Potential of B Lymphocytes in Autoimmune Disorders
edited by
submission deadline 20 Apr 2025 | 1 articles | Viewed by 1249 | Submission Open
Keywords: engineered immune cells; autoimmune disease; B lymphocyte; animal models; immune tolerance
(This special issue belongs to the Section Cellular Immunology)
pH Sensing, Signaling, and Regulation in Cellular Processes
edited by Maike Glitsch
submission deadline 20 Apr 2025 | Viewed by 117 | Submission Open
Keywords: extra- and intracellular pH; pH sensing; signaling; and regulation; pH-dependent receptors; proton signaling; ion channels; G-protein-coupled receptors; cell biology and function; physiological and pathological processes; aging; cancer; inflammation; and so on; novel therapeutic strategies and targets
Mechanotransduction: Understanding the Cellular and Tissue Communication Mechanisms of Mechanical Forces
edited by
submission deadline 20 Apr 2025 | Viewed by 18 | Submission Open
Keywords: mechanotransduction; cell/tissue mechanics; physical communication
Targeting Hallmarks of Cancer submission deadline 25 Apr 2025 | 1 articles | Viewed by 855 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
Gene Therapy for Rare Diseases
edited by
submission deadline 30 Apr 2025 | 3 articles | Viewed by 5597 | Submission Open
Keywords: gene therapy; gene editing; rare diseases; CRISPR; viral vectors; base editing; prime editing
(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)
The Pivotal Role of Tumor Stem Cells in Glioblastoma
edited by and Silvano J. Santini
submission deadline 30 Apr 2025 | 3 articles | Viewed by 4843 | Submission Open
Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment
(This special issue belongs to the Section Stem Cells)
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