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Nutrients
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The Effect of Bioactive Compounds in Anti-inflammation
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The Effect of Bioactive Compounds in Anti-inflammation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 December 2024) | Viewed by 6357

Special Issue Editor

Dr. Ewa Piątkowska

E-Mail Website
Guest Editor
Department of Human Nutrition and Dietetics, Faculty of Food Technology, University of Agriculture, 30-149 Krakow, Poland
Interests: human nutrition; antioxidant and anti-inflammatory properties; plant food
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive food ingredients are understood as compounds that can enhance, weaken, or modify the body’s physiological and metabolic functions. The effects of such ingredients may be beneficial or unfavorable. The use of research strategies such as genomics, proteomics, and metabolomics, as well as access to large amounts of data (e.g., collected in databases) and tools for their processing, provide unprecedented expansion possibilities with regard to knowledge about bioactive food ingredients.

Chronic inflammation is a symptom accompanying many non-communicable diseases. It seems reasonable to create and use an anti-inflammatory dietary pattern in the prevention and treatment of these diseases. It is a known fact that food can influence the body's inflammation through immunomodulation. Various foods or nutritional and bioactive food ingredients may have pro- or anti-inflammatory effects. However, it is the overall diet that has the greatest impact on the functioning of the body. An anti-inflammatory diet therefore includes both many food components and food products with anti-inflammatory potential, and eliminates or recommends limiting the consumption of pro-inflammatory foods. It is considered particularly important when planning a diet to take into account the large supply of raw materials and plant products. The combination of these strategies allows for a cumulative positive effect of the diet on reducing inflammation in the body and thus reducing the risk of the occurrence or severity of lifestyle diseases.

Dr. Ewa Piątkowska
Guest Editor

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Keywords

  • inflammation
  • plant origin food
  • antioxidants
  • human health
  • non-communicable diseases

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Published Papers (5 papers)

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Research

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18 pages, 1731 KiB  
Article
The Phytochemical Composition and Antioxidant Activity of Matricaria recutita Blossoms and Zingiber officinale Rhizome Ethanol Extracts
by Anca Elena But, Raluca Maria Pop, Georg Friedrich Binsfeld, Floricuța Ranga, Meda Sandra Orăsan, Andra Diana Cecan, Iulia Ioana Morar, Elisabeta Ioana Chera, Teodora Irina Bonci, Lia Oxana Usatiuc, Mădălina Țicolea, Florinela Adriana Cătoi, Alina Elena Pârvu and Mircea Constantin Dinu Ghergie
Nutrients 2025, 17(1), 5; https://doi.org/10.3390/nu17010005 - 24 Dec 2024
Viewed by 473
Abstract
Background: Inflammation-induced oxidative stress is a pathophysiological mechanism of inflammatory diseases. Treatments targeting oxidative stress can reduce inflammatory tissue damage. Objectives: This study aimed to conduct phytochemical analysis and evaluate the antioxidant effects of the hydroalcoholic extract of Matricaria recutita blossoms (M. [...] Read more.
Background: Inflammation-induced oxidative stress is a pathophysiological mechanism of inflammatory diseases. Treatments targeting oxidative stress can reduce inflammatory tissue damage. Objectives: This study aimed to conduct phytochemical analysis and evaluate the antioxidant effects of the hydroalcoholic extract of Matricaria recutita blossoms (M. recutita) and Zingiber officinale rhizomes (Z. officinale). Materials and Methods: The phytochemical analysis was carried out by measuring the total polyphenol content, total flavonoid content, and polyphenolic compounds’ HPLC-ESI MS. The antioxidant activity was evaluated in vitro through H2O2 DPPH, FRAP, and NO scavenging assays. An in vivo experiment was performed on rats with turpentine oil-induced acute inflammation. Treatments were administrated orally for 10 days, with three dilutions of each extract (100%, 50%, 25%), and compared to the CONTROL, inflammation, Diclofenac, and Trolox groups. In vivo, the antioxidant activity was evaluated by measuring the total antioxidant capacity (TAC), total oxidative status (TOS), oxidative stress index (OSI), malondialdehyde (MDA), nitric oxide (NO), advanced oxidation protein products (AOPP), and total thiols (SH). Results: The phytochemical analysis found a high content of phenolic compounds in both extracts, and the in vitro antioxidant activity was significant. In vivo, M. recutita and Z. officinale extracts proved to be effective in increasing TAC and lowering oxidative stress markers, respectively, the TOS, OSI, MDA, and NO levels. The effects were dose-dependent, with the lower concentrations being more efficient antioxidants. Matricaria recutita and Z. officinale extract effects were as good as those of trolox and diclofenac. Conclusions: Treatment with M. recutita and Z. officinale alleviated inflammation-induced oxidative stress. These findings suggest that M. recutita and Z. officinale extracts could be a promising adjuvant antioxidant therapy in inflammatory diseases. Full article
(This article belongs to the Special Issue The Effect of Bioactive Compounds in Anti-inflammation)
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13 pages, 644 KiB  
Article
Biological Effect of Food for Special Medical Purposes (NutramilTM Complex) on Melanoma Cells in In Vitro Study
by Aneta Koronowicz, Katarzyna Krawczyk, Aleksandra Such, Ewelina Piasna-Słupecka, Mariola Drozdowska and Teresa Leszczyńska
Nutrients 2024, 16(24), 4287; https://doi.org/10.3390/nu16244287 - 12 Dec 2024
Viewed by 528
Abstract
Background/Objectives: Melanoma malignum is considered the most dangerous form of skin cancer, characterized by the exceptional resistance to many conventional chemotherapies. The aim of this study was to evaluate the effect of NutramilTM Complex (NC)—Food for Special Medical Purpose (FSMP), on two [...] Read more.
Background/Objectives: Melanoma malignum is considered the most dangerous form of skin cancer, characterized by the exceptional resistance to many conventional chemotherapies. The aim of this study was to evaluate the effect of NutramilTM Complex (NC)—Food for Special Medical Purpose (FSMP), on two types of melanoma cell lines, primary WM115 and malignant WM266-4. Methods: At 24 h after seeding, growth medium was replaced with a medium containing encoded treatments of NC or NC-CC (NutramilTM Complex without calcium caseinate) at various concentrations. Cells were treated for 24, 48, and 72 h. Results: Our results showed that NutramilTM Complex reduces proliferation of malignant melanoma WM266-4 cells but did not affect the proliferation of WM115 primary melanoma. This was followed by measured down-regulation of selected pro-survival proteins expression in WM266-4 cells, specifically ERK1/2, AKT-1, HSP27, Survivin, and TAK1. Interestingly, our results showed elevated levels of some pro-apoptotic proteins in both cell lines, including Bad, Smad2, p38MAPK, cleaved forms of Caspase-3/7, as well as cleaved PARP. Conclusions: Taken together, our results indicate that various melanoma cancer cell lines may respond in a different way to the same compound. They also suggest induction of apoptotic pathway by NutramilTM Complex as the most likely mechanism of its anticarcinogenic activity. Full article
(This article belongs to the Special Issue The Effect of Bioactive Compounds in Anti-inflammation)
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21 pages, 2887 KiB  
Article
Iodine Bioavailability and Biochemical Effects of Brassica oleracea var. sabellica L. Biofortified with 8-Hydroxy-7-iodo-5-quinolinesulfonic Acid in Wistar Rats
by Joanna Krzemińska, Ewa Piątkowska, Aneta Kopeć, Sylwester Smoleń, Teresa Leszczyńska and Aneta Koronowicz
Nutrients 2024, 16(21), 3578; https://doi.org/10.3390/nu16213578 - 22 Oct 2024
Viewed by 1189
Abstract
Background: Iodine is one of the essential trace elements for human life. The main objective of the biofortification of plants with iodine is to obtain food with a higher content of this element compared to conventional food. Biofortification of plants with iodine can [...] Read more.
Background: Iodine is one of the essential trace elements for human life. The main objective of the biofortification of plants with iodine is to obtain food with a higher content of this element compared to conventional food. Biofortification of plants with iodine can increase the intake of this trace element by different populations. In addition, it may reduce the risk of iodine deficiency diseases. Objectives: The aim of the study was to investigate the effect of kale biofortified with 8-hydroxy-7-iodo-5-quinolinesulfonic acid (8-OH-7-I-5QSA) on iodine bioavailability and biochemical effects in Wistar rats. Methods: Kale biofortified with (8-OH-7-I-5QSA) was tested for iodine levels in urine, feces, and selected tissues using the ICP-MS/MS technique. The feeding experiment was designed to investigate potential changes in selected thyroid-regulated biochemical parameters in blood serum of Wistar rats. Results: The dietary intake of Wistar rats fed kale biofortified with (8-OH-7-I-5QSA) from both the “Oldenbor F1” and “Redbor F1” cultivars for 8 weeks resulted in significantly (p ≤ 0.05) higher iodine concentrations in the urine and kidneys of rats, which proves iodine bioavailability. Rats’ diets with “Oldenbor F1” and “Redbor F1” kale non- and -biofortified with 8-OH-7-I-5QSA had a significantly (p ≤ 0.05) lower or a tendency for lower concentration of TSH, triglyceride, total and direct bilirubin, TBARs, uric acid, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations in serum. Dietary intake of “Oldenbor F1” and “Redbor F1” kale biofortified with 8-OH-7-I-5QSA significantly (p ≤ 0.05) increased the total antioxidant status (TAS). Conclusions: Our study confirms that kale biofortified with iodine in organic form iodoquinoline 8-OH-7-I-5QSA is bioavailable and well absorbed by the Wistar rat and has a positive effect on selected biochemical parameters. The results obtained in this study may be highly predictive for further studies in humans. Full article
(This article belongs to the Special Issue The Effect of Bioactive Compounds in Anti-inflammation)
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Review

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25 pages, 7547 KiB  
Review
Polyphenols as Immunomodulators and Epigenetic Modulators: An Analysis of Their Role in the Treatment and Prevention of Breast Cancer
by Esmanur Eren, Jyotirmoyee Das and Trygve O. Tollefsbol
Nutrients 2024, 16(23), 4143; https://doi.org/10.3390/nu16234143 - 29 Nov 2024
Viewed by 939
Abstract
Breast cancer poses a substantial health challenge for women globally. Recently, there has been a notable increase in scholarly attention regarding polyphenols, primarily attributed to not only the adverse effects associated with conventional treatments but also their immune-preventive impacts. Polyphenols, nature-derived substances present [...] Read more.
Breast cancer poses a substantial health challenge for women globally. Recently, there has been a notable increase in scholarly attention regarding polyphenols, primarily attributed to not only the adverse effects associated with conventional treatments but also their immune-preventive impacts. Polyphenols, nature-derived substances present in vegetation, including fruits and vegetables, have received considerable attention in various fields of science due to their probable wellness merits, particularly in the treatment and hindrance of cancer. This review focuses on the immunomodulatory effects of polyphenols in breast cancer, emphasizing their capacity to influence the reaction of adaptive and innate immune cells within the tumor-associated environment. Polyphenols are implicated in the modulation of inflammation, the enhancement of antioxidant defenses, the promotion of epigenetic modifications, and the support of immune functions. Additionally, these compounds have been shown to influence the activity of critical immune cells, including macrophages and T cells. By targeting pathways involved in immune evasion, polyphenols may augment the capacity of the defensive system to detect and eliminate tumors. The findings suggest that incorporating polyphenol-rich foods into the diet could offer a promising, collaborative (integrative) approach to classical breast cancer remedial procedures by regulating how the defense mechanism interacts with the disease. Full article
(This article belongs to the Special Issue The Effect of Bioactive Compounds in Anti-inflammation)
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35 pages, 2745 KiB  
Review
Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management
by Seth Woodfin, Sierra Hall, Alexis Ramerth, Brooke Chapple, Dane Fausnacht, William Moore, Hana Alkhalidy and Dongmin Liu
Nutrients 2024, 16(17), 2996; https://doi.org/10.3390/nu16172996 - 5 Sep 2024
Viewed by 2554
Abstract
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration, resulting in significant disability and reduced quality of life. Current therapeutic strategies primarily target immune dysregulation, but limitations in efficacy and tolerability highlight the need for alternative treatments. Plant-derived [...] Read more.
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration, resulting in significant disability and reduced quality of life. Current therapeutic strategies primarily target immune dysregulation, but limitations in efficacy and tolerability highlight the need for alternative treatments. Plant-derived compounds, including alkaloids, phenylpropanoids, and terpenoids, have demonstrated anti-inflammatory effects in both preclinical and clinical studies. By modulating immune responses and promoting neuroregeneration, these compounds offer potential as novel adjunctive therapies for MS. This review provides insights into the molecular and cellular basis of MS pathogenesis, emphasizing the role of inflammation in disease progression. It critically evaluates emerging evidence supporting the use of plant-derived compounds to attenuate inflammation and MS symptomology. In addition, we provide a comprehensive source of information detailing the known mechanisms of action and assessing the clinical potential of plant-derived compounds in the context of MS pathogenesis, with a focus on their anti-inflammatory and neuroprotective properties. Full article
(This article belongs to the Special Issue The Effect of Bioactive Compounds in Anti-inflammation)
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