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Nutrients
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Effects of Nutraceuticals on Intestinal Inflammation
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Effects of Nutraceuticals on Intestinal Inflammation

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 11608

Special Issue Editors

Dr. Efstathia Papada

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Guest Editor
Division of Medicine, University College London, London WC1E 6JF, UK
Interests: gut health; inflammatory bowel disease; Inflammation; nutraceuticals; phytochemicals; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Dr. Anastasia Z. Kalea

E-Mail Website
Guest Editor
1. Institute of Liver and Digestive Health, Division of Medicine, Institute of Cardiovascular Science, University College London, London, UK
2. Division of Medicine, University College London, Rayne Building, London WC1E 6JF, UK
Interests: cardiovascular disease; metabolic disease; inflammation; obesity; diet; micronutrients; personalised nutrition
Special Issues, Collections and Topics in MDPI journals
Dr. Charalampia Amerikanou

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Guest Editor
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, 70 El. Venizelou Ave., 17676 Kallithea, Athens, Greece
Interests: molecular nutrition; inflammation; oxidative stress; phytochemicals; nutraceuticals; functional foods; clinical trials; obesity; epigenetics; microRNAs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutraceuticals include a wide range of foods or food components such as isolated nutrients, herbal products, dietary supplements, novel foods, and processed food ingredients that provide medical or health benefits. They include several biological properties such as antioxidant, antihypertensive, antiproliferative, antimicrobial, and anti-inflammatory. Although, several research endeavors have been undertaken to understand their effects on the prevention and treatment of inflammation-mediated gastrointestinal diseases, their effectiveness, safety, side effects, and interactions with other nutrients or medications are not yet known. Thus, further research is required to expand our understanding about the possible usage of nutraceuticals as a novel approach against intestinal inflammation.

This Special Issue titled ‘Effects of Nutraceuticals on Intestinal Inflammation’ aims to collate papers that highlight the latest findings on the effects of different nutraceuticals for the prevention and management of intestinal inflammation, including conditions such as Crohn’s disease, ulcerative colitis and others. We invite submissions of relevant review articles, systematic reviews, meta-analyses, as well as original papers.

Dr. Efstathia Papada
Dr. Anastasia Z. Kalea
Dr. Charalampia Amerikanou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutraceuticals
  • inflammation
  • gastrointestinal disease
  • intestinal health
  • supplements
  • nutrients

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Published Papers (5 papers)

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Research

19 pages, 6915 KiB  
Article
Yerba Mate (Ilex paraguariensis) Reduces Colitis Severity by Promoting Anti-Inflammatory Macrophage Polarization
by Alexandra Olate-Briones, Sofía Albornoz-Muñoz, Francisca Rodríguez-Arriaza, Valentina Rodríguez-Vergara, Juan Machuca Aguirre, Chaohong Liu, Carlos Peña-Farfal, Noelia Escobedo and Andrés A. Herrada
Nutrients 2024, 16(11), 1616; https://doi.org/10.3390/nu16111616 - 25 May 2024
Cited by 1 | Viewed by 1709
Abstract
Yerba Mate (YM) (Ilex paraguariensis) is a natural herbal supplement with a well-described anti-inflammatory capacity and beneficial effects in different inflammatory contexts such as insulin resistance or obesity. However, whether YM could improve other inflammatory conditions such as colitis or the [...] Read more.
Yerba Mate (YM) (Ilex paraguariensis) is a natural herbal supplement with a well-described anti-inflammatory capacity and beneficial effects in different inflammatory contexts such as insulin resistance or obesity. However, whether YM could improve other inflammatory conditions such as colitis or the immune cell population that can be modulated by this plant remains elusive. Here, by using 61 male and female C57BL/6/J wild-type (WT) mice and the dextran sodium sulfate (DSS)-induced acute colitis model, we evaluated the effect of YM on colitis symptoms and macrophage polarization. Our results showed that the oral administration of YM reduces colitis symptoms and improves animal survival. Increasing infiltration of anti-inflammatory M2 macrophage was observed in the colon of the mice treated with YM. Accordingly, YM promoted M2 macrophage differentiation in vivo. However, the direct administration of YM to bone marrow-derived macrophages did not increase anti-inflammatory polarization, suggesting that YM, through an indirect mechanism, is able to skew the M1/M2 ratio. Moreover, YM consumption reduced the Eubacterium rectale/Clostridium coccoides and Enterobacteriaceae groups and increased the Lactobacillus/Lactococcus group in the gut microbiota. In summary, we show that YM promotes an immunosuppressive environment by enhancing anti-inflammatory M2 macrophage differentiation, reducing colitis symptoms, and suggesting that YM consumption may be a good cost-effective treatment for ulcerative colitis. Full article
(This article belongs to the Special Issue Effects of Nutraceuticals on Intestinal Inflammation)
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15 pages, 4861 KiB  
Article
Bifidobacterium longum Subsp. infantis Promotes IgA Level of Growing Mice in a Strain-Specific and Intestinal Niche-Dependent Manner
by Mengfan Ding, Bowen Li, Haiqin Chen, Reynolds Paul Ross, Catherine Stanton, Jianxin Zhao, Wei Chen and Bo Yang
Nutrients 2024, 16(8), 1148; https://doi.org/10.3390/nu16081148 - 12 Apr 2024
Viewed by 1419
Abstract
Throughout infancy, IgA is crucial for maintaining gut mucosal immunity. This study aims to determine whether supplementing newborn mice with eight different strains of Bifidobacterium longum subsp. infantis might regulate their IgA levels. The strains were gavaged to BALB/C female (n = 8) [...] Read more.
Throughout infancy, IgA is crucial for maintaining gut mucosal immunity. This study aims to determine whether supplementing newborn mice with eight different strains of Bifidobacterium longum subsp. infantis might regulate their IgA levels. The strains were gavaged to BALB/C female (n = 8) and male (n = 8) dams at 1–3 weeks old. Eight strains of B. longum subsp. infantis had strain-specific effects in the regulation of intestinal mucosal barriers. B6MNI, I4MI, and I10TI can increase the colonic IgA level in females and males. I8TI can increase the colonic IgA level in males. B6MNI was also able to significantly increase the colonic sIgA level in females. B6MNI, I4MI, I8TI, and I10TI regulated colonic and Peyer’s patch IgA synthesis genes but had no significant effect on IgA synthesis pathway genes in the jejunum and ileum. Moreover, the variety of sIgA-coated bacteria in male mice was changed by I4MI, I5TI, I8TI, and B6MNI. These strains also can decrease the relative abundance of Escherichia coli. These results indicate that B. longum subsp. infantis can promote IgA levels but show strain specificity. Different dietary habits with different strains of Bifidobacterium may have varying effects on IgA levels when supplemented in early infancy. Full article
(This article belongs to the Special Issue Effects of Nutraceuticals on Intestinal Inflammation)
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16 pages, 7016 KiB  
Article
Lactate Protects Intestinal Epithelial Barrier Function from Dextran Sulfate Sodium-Induced Damage by GPR81 Signaling
by Xiaojing Li, Zhijie Yao, Jin Qian, Hongling Li and Haitao Li
Nutrients 2024, 16(5), 582; https://doi.org/10.3390/nu16050582 - 21 Feb 2024
Cited by 4 | Viewed by 1786
Abstract
The dysregulation of the intestinal epithelial barrier significantly contributes to the inflammatory progression of ulcerative colitis. Recent studies have indicated that lactate, produced by gut bacteria or derived from fermented foods, plays a key role in modulating inflammation via G-protein-coupled receptor 81 (GPR81). [...] Read more.
The dysregulation of the intestinal epithelial barrier significantly contributes to the inflammatory progression of ulcerative colitis. Recent studies have indicated that lactate, produced by gut bacteria or derived from fermented foods, plays a key role in modulating inflammation via G-protein-coupled receptor 81 (GPR81). In this study, we aimed to investigate the potential role of GPR81 in the progression of colitis and to assess the impact of lactate/GPR81 signaling on intestinal epithelial barrier function. Our findings demonstrated a downregulation of GPR81 protein expression in patients with colitis. Functional verification experiments showed that Gpr81-deficient mice exhibited more severe damage to the intestinal epithelial barrier and increased susceptibility to DSS-induced colitis, characterized by exacerbated oxidative stress, elevated inflammatory cytokine secretion, and impaired expression of tight-junction proteins. Mechanistically, we found that lactate could suppress TNF-α-induced MMP-9 expression and prevent the disruption of tight-junction proteins by inhibiting NF-κB activation through GPR81 in vitro. Furthermore, our study showed that dietary lactate could preserve intestinal epithelial barrier function against DSS-induced damage in a GPR81-dependent manner in vivo. Collectively, these results underscore the crucial involvement of the lactate/GPR81 signaling pathway in maintaining intestinal epithelial barrier function, providing a potential therapeutic strategy for ulcerative colitis. Full article
(This article belongs to the Special Issue Effects of Nutraceuticals on Intestinal Inflammation)
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22 pages, 8209 KiB  
Article
Selenium- and/or Zinc-Enriched Egg Diet Improves Oxidative Damage and Regulates Gut Microbiota in D-Gal-Induced Aging Mice
by Qiaocui Liu, Yulin Wang, Yuan Wan, Yu Liang, Yali Tan, Mengya Wei and Tao Hou
Nutrients 2024, 16(4), 512; https://doi.org/10.3390/nu16040512 - 13 Feb 2024
Viewed by 2607
Abstract
Eggs, with their high nutritional value, are great carriers for enriching nutrients. In this study, selenium- and/or zinc-enriched eggs (SZE) were obtained and their effects on ameliorating oxidative stress injury, alleviating cognitive impairment, and maintaining intestinal flora balance in a D-gal-induced aging mice [...] Read more.
Eggs, with their high nutritional value, are great carriers for enriching nutrients. In this study, selenium- and/or zinc-enriched eggs (SZE) were obtained and their effects on ameliorating oxidative stress injury, alleviating cognitive impairment, and maintaining intestinal flora balance in a D-gal-induced aging mice model were investigated. As determined by the Y-maze test, SZE restored the learning and memory abilities and increased the Ach level and AChE activity of aging mice (p < 0.05). Meanwhile, supplementation of low-dose SZE increased antioxidant levels and decreased inflammation levels (p < 0.05). High-dose SZE increased anti-inflammatory levels but were less effective than low dose. Additionally, SZE maintained the intestinal flora balance and significantly increased the ratio of Firmicutes and Bacteroidota. Blautia, as a probiotic, was negatively correlated with pro-inflammatory factors and positively correlated with antioxidant levels (p < 0.05). These results suggest that SZE might improve organ damage and cognitive function by attenuating oxidative stress and inflammatory response and maintaining healthy gut flora. Full article
(This article belongs to the Special Issue Effects of Nutraceuticals on Intestinal Inflammation)
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11 pages, 798 KiB  
Article
The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome
by Cezary Chojnacki, Tomasz Poplawski, Aleksandra Blonska, Paulina Konrad, Jan Chojnacki and Janusz Blasiak
Nutrients 2023, 15(8), 1837; https://doi.org/10.3390/nu15081837 - 11 Apr 2023
Cited by 7 | Viewed by 3400
Abstract
(1) Background: A low-FODMAP diet is often recommended in the treatment of irritable bowel syndrome, but it does not improve abdominal symptoms in all patients, and an alternative diet is desirable. The purpose of this study was to evaluate the efficacy of a [...] Read more.
(1) Background: A low-FODMAP diet is often recommended in the treatment of irritable bowel syndrome, but it does not improve abdominal symptoms in all patients, and an alternative diet is desirable. The purpose of this study was to evaluate the efficacy of a low-FODMAP diet with a concomitant reduction in tryptophan (TRP) intake in irritable bowel syndrome with diarrhea predominance (IBS-D) in relation to its metabolism via the serotonin and kynurenine pathways. (2) Methods: 40 healthy people (Group I, Controls) and 80 patients with IBS-D were included in the study. IBS-D patients were randomly divided into two groups of 40 each (Groups IIA and IIB). In Group IIA, the low-FODMAP diet was recommended, while in Group IIB, the same diet was recommended but with limited TRP intake for 8 weeks. The TRP intake was analyzed with the use of the nutritional calculator. Abdominal complaints were assessed using the Gastrointestinal Symptom Rating Scale (GSRS-IBS), and psychological status was simultaneously determined using two scales: the Hamilton Anxiety Scale (HAM-A) and the Hamilton Depression Scale (HAM-D). TRP and its metabolites: 5-hydoxyindoleacetic acid (5-HIAA), kynurenine (KYN), kynurenic acid (KYNA), and quinolinic acid (QA) were measured in urine using liquid chromatography tandem mass spectrometry (LC-MS/MS). (3) Results: The consumption of TRP per mg/kg/b.w./24 h has decreased in Group IIA from 20.9 ± 2.39 to 17.45 ± 2.41 (16.5%) and in Group IIB from 21.3 ± 2.33 to 14.32 (34.4%). Significantly greater improvement was found after nutritional treatment in patients in Group IIB as compared to Group IIA (GSRS score: 38.1% vs. 49.8%; HAM-A: 38.7% vs. 49.9%; HAM-D: 13.8% vs. 35.0%; p < 0.01). Reducing TRP intake showed a negative correlation with the degree of improvement in the GSRS score. (4) Conclusions: Lowering the TRP content in a low-FODMAP diet may be useful in treating IBS-D. Full article
(This article belongs to the Special Issue Effects of Nutraceuticals on Intestinal Inflammation)
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