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Journals
Processes
Special Issues
Feature Review Papers in Section “Pharmaceutical Processes”
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Feature Review Papers in Section “Pharmaceutical Processes”

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: 10 June 2025 | Viewed by 3664

Special Issue Editor

Dr. Paolo Trucillo

E-Mail Website
Guest Editor
The Sustainable Technologies for Pollution Control Laboratory (STPC Laboratory), Department of Chemical, Material and Industrial Production Engineering, University of Naples Federico II, Piazzale V. Tecchio, 80125 Napoli, Italy
Interests: drug delivery systems; foams; material science; pharmaceutical material science
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are excited to announce the launch of a Special Issue dedicated to “Feature Review Papers in Section “Pharmaceutical Processes””. This special edition aims to bring together the latest insights and comprehensive reviews from leading experts in the field, focusing on innovative techniques, advancements, and challenges within pharmaceutical processes. Covering a wide spectrum of topics, from drug formulation and delivery to quality control and regulatory compliance, this collection of feature review papers will serve as an invaluable resource for researchers, practitioners, and policymakers. Submit your review paper to this Special Issue and be part of the efforts to shape the future of pharmaceutical science and engineering. By curating this collection, we aim to improve knowledge sharing about innovative solutions in this field. We invite you to contribute your expertise and perspectives, thereby advancing the understanding and application of pharmaceutical processes. The participation of all experts in topics related to drug release is welcome, driving the quest for safer, more effective, and more efficient pharmaceutical solutions.

Dr. Paolo Trucillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • plants for drug delivery
  • materials for drug delivery
  • liposomes
  • niosomes
  • biocompatible polymers

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Review

21 pages, 1284 KiB  
Review
Recent Advances in Pharmaceuticals Biosorption on Microbial and Algal-Derived Biosorbents
by Zdravka Velkova, Kristiana Lazarova, Gergana Kirova and Velizar Gochev
Processes 2025, 13(2), 561; https://doi.org/10.3390/pr13020561 - 17 Feb 2025
Viewed by 259
Abstract
The removal of pharmaceuticals from aqueous environments has become a critical ecological challenge. Biosorption has emerged as a promising and cost-effective solution for pharmaceutical removal. This review examines the potential of microbial and algal-derived biosorbents, including fungi, bacteria, and algae, in the biosorption [...] Read more.
The removal of pharmaceuticals from aqueous environments has become a critical ecological challenge. Biosorption has emerged as a promising and cost-effective solution for pharmaceutical removal. This review examines the potential of microbial and algal-derived biosorbents, including fungi, bacteria, and algae, in the biosorption of pharmaceuticals from water. The removal efficiency of various types of biosorbents is discussed in relation to the chemical structure and functional groups presented on the biosorbent surfaces at various process parameters, such as pH, contact time, biosorbent dosage, and initial pharmaceutical concentration. Additionally, the benefits of chemical and physical modifications, immobilization techniques, and the reusability of biosorbents are highlighted. The major goal of the present review is not just to gather and discuss information about possible mechanisms of biosorption, which to some extent are still speculative, and to explain the effect of process parameters on the removal but also to highlight the advantages and disadvantages of various types of microbial/algal biosorbents and to ease the selection of proper biosorbents for pharmaceuticals removal. In this way, the review will benefit and induce more technological studies in the field of biosorption. Full article
(This article belongs to the Special Issue Feature Review Papers in Section “Pharmaceutical Processes”)
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26 pages, 1328 KiB  
Review
Modeling the Analysis Process of a Lipid-Based, Multi-Compartment Drug Delivery System
by Eliza Wolska and Małgorzata Sznitowska
Processes 2025, 13(2), 460; https://doi.org/10.3390/pr13020460 - 8 Feb 2025
Viewed by 363
Abstract
Solid lipid microparticles (SLMs) are multi-compartment lipid drug carriers that can be used in various forms via many routes of administration, primarily to obtain prolonged release, protect the drug substance or mask its taste. It is practically impossible to theoretically predict the effectiveness [...] Read more.
Solid lipid microparticles (SLMs) are multi-compartment lipid drug carriers that can be used in various forms via many routes of administration, primarily to obtain prolonged release, protect the drug substance or mask its taste. It is practically impossible to theoretically predict the effectiveness of the incorporation and distribution of active pharmaceutical ingredients (APIs) in SLMs, and these are fundamental features that determine the key properties of the dosage form. The possibility of an effective assessment of these features by selecting or developing sensitive, universal methods, therefore, conditions further development and practical use of this carrier. Therefore, unlike the already available review papers on SLMs, the aim of this mini-review is to focus solely on the issues of API distribution in SLMs and their release. For this purpose, the most important observations and results of our own research were collected and summarized, and then an attempt was made to confront them with the available literature data. Among the methods describing the critical attributes of SLMs, instrumental methods (DSC, AFM, Raman spectroscopy and NMR), quantitative studies for assessing API distribution in SLMs (including entrapment efficiency and drug-loading parameters) as well as different release techniques (without a membrane, in a dialysis bag and in horizontal chambers, taking into account physiological factors) were characterized and compared. The aim of this review is to facilitate the understanding of the SLM properties and to assess their ability to achieve the intended effect in vivo, as well as to standardize studies of such carriers, facilitating a comparison of the results between centers. Full article
(This article belongs to the Special Issue Feature Review Papers in Section “Pharmaceutical Processes”)
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30 pages, 740 KiB  
Review
Volatile Organic Compound–Drug Receptor Interactions: A Potential Tool for Drug Design in the Search for Remedies for Increasing Toxic Occupational Exposure
by John Onyebuchi Ogbodo, Simeon Ikechukwu Egba, Gavin Chibundu Ikechukwu, Promise Chibuike Paul, Joseph Obinna Mba, Okechukwu Paul-Chima Ugwu and Tobechukwu Christian Ezike
Processes 2025, 13(1), 154; https://doi.org/10.3390/pr13010154 - 8 Jan 2025
Viewed by 788
Abstract
Volatile organic compounds (VOCs) can impact the actions of drugs due to their effects on drug receptors and the activities of enzymes involved in various metabolic processes, especially those relating to gene regulation. They can disrupt cellular functions and potentially affect human drug [...] Read more.
Volatile organic compounds (VOCs) can impact the actions of drugs due to their effects on drug receptors and the activities of enzymes involved in various metabolic processes, especially those relating to gene regulation. They can disrupt cellular functions and potentially affect human drug metabolism and utilization receptors. They mimic or inhibit the actions of endogenous ligands, leading to carcinogenesis, neurotoxicity, endocrine disruption, and respiratory disorders. Chronic exposure to VOCs due to human occupation can lead to an increased generation of reactive oxygen species (ROS), which could lead to oxidative stress and damage to lipids, affecting the formation and proper functioning of gene regulation, enzyme activity, and cell membranes. The presence of oxidative stress could interfere with drug activity and potentially impact the body’s ability to process and utilize drugs effectively. This is because drugs such as antioxidant drugs play an essential role in cell protection against oxidative damage. Therefore, disruptions in their metabolism could distort the overall health condition through the breakdown of antioxidant defense mechanisms. In this study, the aim is to assess the effect of VOC exposure on drug receptors and the way forward in designing and maintaining optimal drug activity for workers’ overall well-being. Full article
(This article belongs to the Special Issue Feature Review Papers in Section “Pharmaceutical Processes”)
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19 pages, 3066 KiB  
Review
Role of Natural Phytoconstituents as a Potential Bioenhancer of Anti-Cancer and Anti-Microbial Agents: Spotlight on the Mechanism of Action, Clinical Studies and Patents
by Dhanalekshmi Unnikrishnan Meenakshi, Gurpreet Kaur Narde, Alka Ahuja, Md Jawaid Akhtar and Shah Alam Khan
Processes 2024, 12(10), 2060; https://doi.org/10.3390/pr12102060 - 24 Sep 2024
Cited by 1 | Viewed by 1313
Abstract
A drug design strategy with reduced side effects and economic feasibility is desirable for fatal diseases. Increasing the bioavailability of a drug using a bioenhancer is a smart strategy. Herbal/natural bioenhancers with no probable side effects are an ideal choice to enhance the [...] Read more.
A drug design strategy with reduced side effects and economic feasibility is desirable for fatal diseases. Increasing the bioavailability of a drug using a bioenhancer is a smart strategy. Herbal/natural bioenhancers with no probable side effects are an ideal choice to enhance the pharmacokinetics of a therapeutic drug synergistically. The mechanism of bioenhancers relies on the retention of the drug molecule in the cell without causing any changes in the metabolic activity. Most of the herbal bioenhancers achieve this feat by inhibiting metabolic enzymes such as cytochrome P450 and Uridine 5′-diphospho-glucuronosyltransferase. The efflux pump p-glycoprotein, responsible for removal of xenobiotics, is also inhibited by herbal/natural bioenhancers. The increased bioavailability because of the higher Cmax and tmax of chemotherapeutics or anti-infectious agents such as rifampicin can result in a lower drug dosage regimen. The reduction in drug dosage is directly linked to fewer side effects and economic viability. Further, there is a significant effort in clinical trials to incorporate bioenhancers in drug regimens for cancer. The role of herbal/natural bioenhancers and their potential to augment the bioavailability of therapeutics used in cancer and infectious diseases, with a focus on the mechanisms of action, clinical studies and patents, have been summarized in this review article. Full article
(This article belongs to the Special Issue Feature Review Papers in Section “Pharmaceutical Processes”)
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