Special Issue "Complex Genetic Loci"

A special issue of Genes (ISSN 2073-4425).

Deadline for manuscript submissions: 31 October 2017

Special Issue Editor

Guest Editor
Dr. Santiago Rodriguez

MRC Integrative Epidemiology Unit,School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove Bristol BS8 2BN, UK
Website | E-Mail
Interests: Human Genetics; Genetic Epidemiology; Population Genetics; Molecular Genetics; Complex genetic loci; Complex human traits

Special Issue Information

Dear Colleagues,

The study of genetic variation is key to understand genes, genetics and genomics. In previous decades, genetic analyses have been successful in many areas. One of these areas is the understanding of the influence of genetics on “complex traits”, i.e., phenotypes that are not a direct reflection of genotypes. Current genetic studies are mainly focussed on binary genetic variants such as single nucleotide polymorphisms (SNPs) and mutations. However, genomes contain many other types of genetic variants. The use of these “complex loci” in genetics is currently underexplored compared to binary genetic variants.

In this Special Issue, we welcome reviews, new methodologies and original articles covering aspects of complex loci relevant to genes, genetics and genomics. These include, but are not limited to, copy number variants (telomere length variation, mitochondrial DNA copy number, etc.), repeat polymorphisms (microsatellites, minisatellites, etc.), insertion-deletion variants, chromosomal abnormalities (irregular karyotype, structural modifications of chromosomes, etc.), transposable elements (LINEs, SINES, etc.). This Special Issue has a special emphasis on the relation between complex loci and complex traits, although studies relating complex loci to Mendelian traits are also welcome.

Dr. Santiago Rodriguez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Genetic variation
  • Complex loci
  • Copy number variants
  • Telomere length
  • Microsatellites
  • Minisatellites
  • Transposable elements
  • Chromosomal abnormalities
  • Complex traits
  • Mendelian traits

Published Papers (1 paper)

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Research

Open AccessArticle Identification of the Ovine Keratin-Associated Protein 26-1 Gene and Its Association with Variation in Wool Traits
Genes 2017, 8(9), 225; doi:10.3390/genes8090225
Received: 11 July 2017 / Revised: 1 September 2017 / Accepted: 6 September 2017 / Published: 13 September 2017
PDF Full-text (1317 KB) | HTML Full-text | XML Full-text
Abstract
Keratin-associated proteins (KAPs) are structural components of wool and hair fibres, and are believed to play a role in defining the physico-mechanical properties of the wool fibre. In this study, the putative ovine homologue of the human KAP26-1 gene (KRTAP26-1) was
[...] Read more.
Keratin-associated proteins (KAPs) are structural components of wool and hair fibres, and are believed to play a role in defining the physico-mechanical properties of the wool fibre. In this study, the putative ovine homologue of the human KAP26-1 gene (KRTAP26-1) was sequenced and four variants (named A–D) were identified. The sequences shared some identity with each other and with other KRTAPs, but they had the greatest similarity with the human KRTAP26-1 sequence. This suggests they represent different variants of ovine KRTAP26-1. The association of these KRTAP26-1 variants with wool traits was investigated in the 383 Merino-Southdown cross sheep. The presence of B was associated (p < 0.05) with an increase in mean fibre diameter (MFD), mean fibre curvature, and prickle factor (PF). The presence of C was found to be associated (p < 0.05) with an increase in wool yield (Yield) and mean staple length (MSL), and a decrease in MFD, fibre diameter standard deviation (FDSD), and PF. The results suggest that sheep with C have, on average, higher wool quality. These results may be useful in the future development of breeding programs based on decreasing wool MFD and FDSD, or on increasing wool MSL. Full article
(This article belongs to the Special Issue Complex Genetic Loci)
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Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Tentative Title: Strategies for Identifying Putative Quantitative Trait Genes in Model Animals
Authors: Akira Ishikawa (Nagoya University, Japan)
Abstract:Large numbers of quantitative trait loci (QTLs) affecting complex diseases and other quantitative traits have been reported in humans and model animals. However, the genetic architecture of these traits remains elusive due to the difficulty of identifying causal quantitative trait genes (QTGs) for typical QTLs with relatively small phenotypic effects. For QTG identification,a standard approachbased on DNA sequencinghas been long and widely used in combination with gene expression analysisin model animals.However, the standard approach doesnotalways allow the identification of a single candidate gene for a QTL of interest, because it is rare to narrow a target genomic region of the QTLdownto a very small region harboring only one gene. An alternativeapproach uses a combination of gene expression analysisandstatistical causal inference tests. This combined approach can dramatically reduce the number of candidate genes and can provide causal evidence that one of the candidate genes is a putative QTG for the QTL. Using this approach, I have recently succeeded in identifying a single putative QTG for resistance to obesity in mice. Here, I provide overviews of the standard and combined approaches and discuss the usefulness of the combined approach using my successful report as an example.

 

Tentative Title: MHC-Dependent Mate Selection within the Health and Retirement Study
Authors: Zhen Qiao, Joseph Powell, David M. Evans
Abstract: Disassortative mating refers to the phenomenon in which individuals with dissimilar genotypes and/or phenotypes mate with one another more frequently than would be expected by chance. Although the existence of disassortative mating is well established in plant and animal species, the only documented example of negative assortment in humans involves dissimilarity at the Major Histocompatability (MHC) locus. Unfortunately previous studies investigating mating patterns at the MHC have been hampered by limited sample size and contradictory findings. Inspired by the sparse and conflicting evidence, we investigated the role that the MHC region played in human mate selection using genome-wide association data from 597 European American spouses from the Health and Retirement Study (HRS). First we treated the MHC region as a whole, and investigated genomic similarity between spouses using three levels of genomic variation: SNPs, classical HLA alleles (both 4-digit and 2-digit classifications), and amino acid polymorphisms. The extent of MHC dissimilarity between spouses was assessed using a permutation approach. Second, we investigated fine scale mating patterns by testing for deviations from random mating at individual SNPs, HLA genes, and amino acids in HLA molecules. Third, we assessed how extreme the spousal relatedness at the MHC region was compared to the rest of the genome, to distinguish the MHC-specific effects from genome-wide effects. The multi-locus relatedness analyses showed no significant difference in MHC relatedness between spouses and non-spouse pairs at either the level of SNPs (relatedness coefficient, R=0.013, one-sided p=0.638) or classical MHC alleles (R=-0.025, p=0.258); however, analyses based on HLA amino acid polymorphisms revealed stronger evidence of dissimilarity (R=-0.046, p=0.095). In terms of fine mapping, we did not find evidence of excess dissimilarity between spousal pairs at individual SNPs, classical HLA genes or amino acids after adjustment for multiple testing. However, the MHC dissimilarity among spouses was extreme relative to the rest of genome (i.e. only 1.6% of the randomly sampled genomic windows exhibited more extreme dissimilarity than the MHC region), but was as extreme in opposite-sex non-spousal pairs, and therefore the dissimilarity could not be attributed to mate selection. Despite the long-standing controversy, our analyses did not support a significant role of MHC dissimilarity in human mate choice.

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