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Biology, Volume 12, Issue 9

2023 September - 118 articles

Cover Story: Cells are exposed to various extrinsic and intrinsic stressors like infections, oxidative stress, endoplasmic reticulum stress, chemotherapeutic agents and stressors in the tumor microenvironment (TME). Cells initiate the Integrated Stress Response (ISR) pathway to maintain cellular homeostasis in the presence of these stressors. The ISR pathway modulates the activation of regulated cell death (RCD) pathways to determine the live-or-die cell fate choice under stress. View this paper
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Articles (118)

  • Article
  • Open Access
11 Citations
3,185 Views
18 Pages

eDNA Metabarcoding- and Microscopic Analysis for Diet Determination in Waterfowl, a Comparative Study in Vejlerne, Denmark

  • Anna-Sofie Lützhøft Svendsen,
  • Louise Bach Nielsen,
  • Jakob Braüner Schmidt,
  • Dan Bruhn,
  • Line Holm Andersen and
  • Cino Pertoldi

21 September 2023

Understanding diets and structural food webs are keys to the apprehension of ecological communities, upon which conservation and management biology are based. The understanding of grazing and habitat choice for waterfowl is one of the most important...

  • Article
  • Open Access
6 Citations
2,667 Views
20 Pages

21 September 2023

This study investigated the species composition, distribution, and salinity tolerance of macrozoobenthos in 17 small rivers in the southern arid region of the East European Plain, which are characterized by a small channel gradient, slow-flowing or s...

  • Article
  • Open Access
6 Citations
7,068 Views
15 Pages

Maternal Cardiovascular Responses to Position Change in Pregnancy

  • Alys R. Clark,
  • Hanna Fontinha,
  • John Thompson,
  • Sophie Couper,
  • Devanshi Jani,
  • Ali Mirjalili,
  • Laura Bennet and
  • Peter Stone

21 September 2023

The maternal cardiovascular-circulatory system undergoes profound changes almost from the conception of a pregnancy until the postpartum period to support the maternal adaptions required for pregnancy and lactation. Maintenance of cardiovascular home...

  • Article
  • Open Access
4 Citations
4,517 Views
31 Pages

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

  • David Kartchner,
  • Kevin McCoy,
  • Janhvi Dubey,
  • Dongyu Zhang,
  • Kevin Zheng,
  • Rushda Umrani,
  • James J. Kim and
  • Cassie S. Mitchell

21 September 2023

Multiple studies have reported new or exacerbated persistent or resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates resistan...

  • Article
  • Open Access
4 Citations
2,602 Views
22 Pages

Isotopic Overlap of Invasive and Native Consumers in the Food Web of Lake Trasimeno (Central Italy)

  • Davide Cicala,
  • Maria Teresa Guerra,
  • Roberta Bardelli,
  • Cristina Di Muri,
  • Alessandro Ludovisi,
  • Salvatrice Vizzini and
  • Giorgio Mancinelli

21 September 2023

An advanced characterization of the trophic niche of non-indigenous species (NIS) may provide useful information on their ecological impact on invaded communities. Here, we used carbon and nitrogen stable isotopes to estimate pairwise niche overlaps...

  • Review
  • Open Access
82 Citations
8,489 Views
22 Pages

From Alpha to Omicron: How Different Variants of Concern of the SARS-Coronavirus-2 Impacted the World

  • Mickensone Andre,
  • Lee-Seng Lau,
  • Marissa D. Pokharel,
  • Julian Ramelow,
  • Florida Owens,
  • Joseph Souchak,
  • Juliet Akkaoui,
  • Evan Ales,
  • Harry Brown and
  • Nazira El-Hage
  • + 6 authors

21 September 2023

SARS-CoV-2, the virus that causes COVID-19, is prone to mutations and the generation of genetic variants. Since its first outbreak in 2019, SARS-CoV-2 has continually evolved, resulting in the emergence of several lineages and variants of concern (VO...

  • Article
  • Open Access
13 Citations
4,370 Views
25 Pages

Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes

  • Katharina Hartman,
  • Guido Steiner,
  • Michel Siegel,
  • Cary M. Looney,
  • Timothy P. Hickling,
  • Katharine Bray-French,
  • Sebastian Springer,
  • Céline Marban-Doran and
  • Axel Ducret

21 September 2023

A critical step in the immunogenicity cascade is attributed to human leukocyte antigen (HLA) II presentation triggering T cell immune responses. The liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based major histocompatibility comple...

  • Article
  • Open Access
2 Citations
2,364 Views
13 Pages

Chromosome-Level Genome Assembly of Protosalanx chinensis and Response to Air Exposure Stress

  • Yanfeng Zhou,
  • Xizhao Zhang,
  • Xuemei Tang,
  • Yifan Zhou,
  • Yuting Ding and
  • Hong Liu

21 September 2023

Protosalanx chinensis is a suitable particular species for genetic studies on nearly scaleless skin, transparency and high sensitivity to hypoxia stress. Here, we generated a high-quality chromosome-level de novo assembly of P. chinensis. The final d...

  • Article
  • Open Access
4 Citations
3,026 Views
18 Pages

Selective Noradrenaline Depletion in the Neocortex and Hippocampus Induces Working Memory Deficits and Regional Occurrence of Pathological Proteins

  • Chiara Prinzi,
  • Anna Kostenko,
  • Gioacchino de Leo,
  • Rosario Gulino,
  • Giampiero Leanza and
  • Antonella Caccamo

21 September 2023

Noradrenaline (NA) depletion occurs in Alzheimer’s disease (AD); however, its relationship with the pathological expression of Tau and transactive response DNA-binding protein 43 (TDP-43), two major hallmarks of AD, remains elusive. Here, incre...

  • Review
  • Open Access
6 Citations
3,320 Views
17 Pages

Matrix Metalloproteinases and the Pathogenesis of Recurrent Corneal Erosions and Epithelial Basement Membrane Dystrophy

  • Katarzyna Jadczyk-Sorek,
  • Wojciech Garczorz,
  • Beata Bubała-Stachowicz,
  • Tomasz Francuz and
  • Ewa Mrukwa-Kominek

21 September 2023

Matrix metalloproteinases (MMPs) are a group of proteolytic enzymes which are members of the zinc endopeptidase family. They have the ability to degrade extracellular matrix elements, allowing for the release of binding molecules and cell migration....

  • Article
  • Open Access
11 Citations
3,642 Views
16 Pages

Exploring Longitudinal Gut Microbiome towards Metabolic Functional Changes Associated in Atopic Dermatitis in Early Childhood

  • Preecha Patumcharoenpol,
  • Amornthep Kingkaw,
  • Massalin Nakphaichit,
  • Pantipa Chatchatee,
  • Narissara Suratannon,
  • Gianni Panagiotou and
  • Wanwipa Vongsangnak

20 September 2023

Atopic dermatitis (AD) is a prevalent inflammatory skin disease that has been associated with changes in gut microbial composition in early life. However, there are limited longitudinal studies examining the gut microbiome in AD. This study aimed to...

  • Article
  • Open Access
1,770 Views
13 Pages

BLTR1 Is Decreased in Steroid Resistant Pro-Inflammatory CD28nullCD8+ T Lymphocytes in Patients with COPD—The Spillover Hypothesis Explained?

  • Greg Hodge,
  • Hubertus Jersmann,
  • Mark Holmes,
  • Patrick Asare,
  • Eugene Roscioli,
  • Paul N. Reynolds and
  • Sandra Hodge

20 September 2023

Introduction: Pro-inflammatory CD8+ T cells are increased in the lungs and also in the peripheral circulation of both smokers and chronic obstructive pulmonary disease (COPD) patients. The reason for this is unclear but has been described as a spillo...

  • Article
  • Open Access
7 Citations
3,299 Views
15 Pages

Effects of Diet Consistency on Rat Maxillary and Mandibular Growth within Three Generations—A Longitudinal CBCT Study

  • Ioannis A. Tsolakis,
  • Christos Verikokos,
  • Despoina Perrea,
  • Paula Perlea,
  • Konstantina-Eleni Alexiou,
  • Zafeiroula Yfanti,
  • Ioannis Lyros,
  • Maria Georgaki,
  • Erofili Papadopoulou and
  • Apostolos I. Tsolakis

20 September 2023

Background: In this study, wistar rats were used to examine the impact of diet consistency on maxillary and mandibular growth over three generations. Methods: In this investigation, a breeding sample of 60 female and 8 male wistar rats was used. Meas...

  • Article
  • Open Access
1,811 Views
15 Pages

IFNγ-Producing B Cells Play a Regulating Role in Infection-Mediated Inhibition of Allergy

  • Sai Qiao,
  • Ying Peng,
  • Chunyan Zhang,
  • Rony Thomas,
  • Shuhe Wang and
  • Xi Yang

20 September 2023

The hygiene hypothesis suggests that some infections may inhibit the development of allergic diseases, but the mechanism remains unclear. Our previous study has shown that Chlamydia muridarum (Cm) lung infection can inhibit local eosinophilic inflamm...

  • Review
  • Open Access
15 Citations
4,809 Views
17 Pages

20 September 2023

Cardiovascular disease (CVD) is one of the leading causes of death worldwide. One of the most common implications of CVD is myocardial infarction (MI). Following MI, the repair of the infarcted heart occurs through three distinct, yet overlapping pha...

  • Review
  • Open Access
8 Citations
4,729 Views
24 Pages

Functional Implications of Protein Arginine Methyltransferases (PRMTs) in Neurodegenerative Diseases

  • Efthalia Angelopoulou,
  • Efstratios-Stylianos Pyrgelis,
  • Chetana Ahire,
  • Prachi Suman,
  • Awanish Mishra and
  • Christina Piperi

20 September 2023

During the aging of the global population, the prevalence of neurodegenerative diseases will be continuously growing. Although each disorder is characterized by disease-specific protein accumulations, several common pathophysiological mechanisms enco...

  • Article
  • Open Access
2,590 Views
13 Pages

Obstetrical and Perinatal Outcomes Are Not Associated with Advanced Paternal Age in IVF or ICSI Pregnancies with Autologous Oocytes

  • Ana Navarro-Gomezlechon,
  • María Gil Juliá,
  • Rosa María Pacheco-Rendón,
  • Irene Hervás,
  • Laura Mossetti,
  • Rocío Rivera-Egea and
  • Nicolás Garrido

20 September 2023

Background: In recent years, there has been an evident delay in childbearing and concerns have been raised about whether this increase in age affects reproductive outcomes. This study aimed to evaluate the effect of paternal age on obstetrical and pe...

  • Article
  • Open Access
5 Citations
4,796 Views
15 Pages

Genetic Monitoring of Grey Wolves in Latvia Shows Adverse Reproductive and Social Consequences of Hunting

  • Agrita Žunna,
  • Dainis Edgars Ruņģis,
  • Jānis Ozoliņš,
  • Alda Stepanova and
  • Gundega Done

19 September 2023

Nowadays, genetic research methods play an important role in animal population studies. Since 2009, genetic material from Latvian wolf specimens obtained through hunting has been systematically gathered. This study, spanning until 2021, scrutinizes t...

  • Article
  • Open Access
5 Citations
6,484 Views
13 Pages

Effect of Sugar Beet Pulp on the Composition and Predicted Function of Equine Fecal Microbiota

  • Tamara Ford,
  • Zachary L. McAdams,
  • Kile S. Townsend,
  • Lynn M. Martin,
  • Philip J. Johnson and
  • Aaron C. Ericsson

19 September 2023

The purpose of this study is to determine the effect of the partial replacement of dietary hay with sugar beet pulp (SBP) on the composition and predicted function of the fecal microbiota of healthy adult horses. Fecal samples were collected daily fo...

  • Article
  • Open Access
3,206 Views
14 Pages

Detection of Math6-Expressing Cell Types in Murine Placenta

  • Maren Brendel,
  • Marion Scharf,
  • Urs Kindler,
  • Satya Srirama Karthik Divvela and
  • Beate Brand-Saberi

19 September 2023

The transcription factor Math6, mouse atonal homolog 6, belongs to the family of highly conserved basic helix–loop–helix transcription factors. It plays an important role in embryonic development and shows a wide expression pattern in mur...

  • Perspective
  • Open Access
3 Citations
2,314 Views
18 Pages

19 September 2023

Activated CD4 T helper cells are required to activate B cells to produce antibody and CD8 T cells to generate cytotoxic T lymphocytes. In the absence of such help, antigens inactivate B cells and CD8 T cells. Thus, the activation or inactivation of C...

  • Article
  • Open Access
3 Citations
2,066 Views
14 Pages

18 September 2023

Seasonal and daily radius variations in the xylem (XRV) and inner bark (IBV) of mature Scots pine trees (Pinus sylvestris) were determined during April 2019–October 2021 at a drought-prone inner alpine site (c. 750 m asl; Tyrol, Austria) by app...

  • Article
  • Open Access
1,910 Views
14 Pages

Aberrant Water Structure Dynamics in B16 Melanoma-Bearing Mice by Time Domain Refractometry Analysis

  • Kahori Furuhata,
  • Haruchika Masuda,
  • Atsuko Sato,
  • Kumiko Miyata,
  • Naoki Shinyashiki,
  • Rio Kita,
  • Kotaro Imagawa,
  • Tadashi Akamatsu and
  • Shin Yagihara

18 September 2023

Living bodies comprise approximately 55–75% water to maintain homeostasis. However, little is known about the comprehensive differences in in vivo water molecule dynamics (water structure dynamics; WSD) between physiological and pathophysiologi...

  • Article
  • Open Access
2 Citations
2,672 Views
15 Pages

Ocean Acidification Affects the Response of the Coastal Coccolithophore Pleurochrysis carterae to Irradiance

  • Fengxia Wu,
  • Jia Guo,
  • Haozhen Duan,
  • Tongtong Li,
  • Yanan Wang,
  • Yuntao Wang,
  • Shiqiang Wang and
  • Yuanyuan Feng

18 September 2023

The ecologically important marine phytoplankton group coccolithophores have a global distribution. The impacts of ocean acidification on the cosmopolitan species Emiliania huxleyi have received much attention and have been intensively studied. Howeve...

  • Review
  • Open Access
16 Citations
3,721 Views
20 Pages

Lichens and Mosses as Biomonitors of Indoor Pollution

  • Luca Paoli,
  • Elena Bandoni and
  • Luigi Sanità di Toppi

18 September 2023

Biomonitoring in indoor environments is a recent application, and so far, indoor air quality (IAQ) has been investigated only in a few cases using photosynthesising biomonitors. On the whole, 22 studies have been selected and reviewed, being specific...

  • Article
  • Open Access
3 Citations
3,685 Views
12 Pages

Macroinvertebrate Response to Internal Nutrient Loading Increases in Shallow Eutrophic Lakes

  • Kai Peng,
  • Rui Dong,
  • Boqiang Qin,
  • Yongjiu Cai,
  • Jianming Deng and
  • Zhijun Gong

18 September 2023

In eutrophic lakes, even if external loading is controlled, internal nutrient loading delays the recovery of lake eutrophication. When the input of external pollutants is reduced, the dissolved oxygen environment at the sediment interface improves in...

  • Article
  • Open Access
7 Citations
2,703 Views
20 Pages

17 September 2023

The seawater microbiome is crucial in marine ecosystems because of its role in food chains and biogeochemical cycles; thus, we studied the composition of the pelagic marine microbiome collected in the upper 50 m on the opposite sides of Fram Strait:...

  • Article
  • Open Access
3 Citations
2,215 Views
15 Pages

Molecular Diet Analysis of Asian Clams for Supplementary Biodiversity Monitoring: A Case Study of Nakdong River Estuary

  • Kanghui Kim,
  • Gea-Jae Joo,
  • Kwang-Seuk Jeong,
  • Jeong-Soo Gim,
  • Yerim Lee,
  • Donghyun Hong and
  • Hyunbin Jo

16 September 2023

Environmental DNA (eDNA) extracted from the gut contents of filter feeders can be used to identify biodiversity in aquatic ecosystems. In this study, we used eDNA from the gut contents of the Asian clam Corbicula fluminea to examine biodiversity with...

  • Article
  • Open Access
3 Citations
2,861 Views
26 Pages

16 September 2023

Tylosema esculentum, commonly known as the marama bean, is an underutilized legume with nutritious seeds, holding potential to enhance food security in southern Africa due to its resilience to prolonged drought and heat. To promote the selection of t...

  • Systematic Review
  • Open Access
21 Citations
6,308 Views
19 Pages

A549 as an In Vitro Model to Evaluate the Impact of Microplastics in the Air

  • Chman Shahzadi,
  • Alessandra Di Serafino,
  • Eleonora Aruffo,
  • Alessandra Mascitelli and
  • Piero Di Carlo

15 September 2023

Airborne microplastics raise significant concerns due to their potential health impacts. Having a small size, larger surface area, and penetrative ability into the biological system, makes them hazardous to health. This review article compiles variou...

  • Article
  • Open Access
8 Citations
2,866 Views
16 Pages

A New Chengjiang Worm Sheds Light on the Radiation and Disparity in Early Priapulida

  • Deng Wang,
  • Jean Vannier,
  • Jie Sun,
  • Chiyang Yu and
  • Jian Han

15 September 2023

The vast majority of early Paleozoic ecdysozoan worms are often resolved as stem-group Priapulida based on resemblances with the rare modern representatives of the group, such as the structure of the introvert and the number and distribution of scali...

  • Review
  • Open Access
19 Citations
9,025 Views
15 Pages

Attention Deficit-Hyperactivity Disorder (ADHD): From Abnormal Behavior to Impairment in Synaptic Plasticity

  • Gonzalo Ugarte,
  • Ricardo Piña,
  • Darwin Contreras,
  • Felipe Godoy,
  • David Rubio,
  • Carlos Rozas,
  • Marc Zeise,
  • Rodrigo Vidal,
  • Jorge Escobar and
  • Bernardo Morales

15 September 2023

Attention deficit-hyperactivity disorder (ADHD) is a neurodevelopmental disorder with high incidence in children and adolescents characterized by motor hyperactivity, impulsivity, and inattention. Magnetic resonance imaging (MRI) has revealed that ne...

  • Article
  • Open Access
6 Citations
3,147 Views
13 Pages

Evaluation of the Effectiveness of Boron Neutron Capture Therapy with Iodophenyl-Conjugated closo-Dodecaborate on a Rat Brain Tumor Model

  • Yoshiki Fujikawa,
  • Yusuke Fukuo,
  • Kai Nishimura,
  • Kohei Tsujino,
  • Hideki Kashiwagi,
  • Ryo Hiramatsu,
  • Naosuke Nonoguchi,
  • Motomasa Furuse,
  • Toshihiro Takami and
  • Masahiko Wanibuchi
  • + 8 authors

15 September 2023

High-grade gliomas present a significant challenge in neuro-oncology because of their aggressive nature and resistance to current therapies. Boron neutron capture therapy (BNCT) is a potential treatment method; however, the boron used by the carrier...

  • Article
  • Open Access
1 Citations
2,307 Views
16 Pages

14 September 2023

Scallop visceral mass and mantle are aquatic byproducts and waste, but they have high contents of protein. In this study, scallop visceral mass and mantle were used as supplements in the diet of juvenile sea cucumber (A. japonicus) and their effects...

  • Article
  • Open Access
2 Citations
2,477 Views
23 Pages

Phenotypic Characterization of Female Carrier Mice Heterozygous for Tafazzin Deletion

  • Michelle V. Tomczewski,
  • John Z. Chan,
  • Duaa M. Al-Majmaie,
  • Ming Rong Liu,
  • Alex D. Cocco,
  • Ken D. Stark,
  • Douglas Strathdee and
  • Robin E. Duncan

14 September 2023

Barth syndrome (BTHS) is caused by mutations in tafazzin resulting in deficits in cardiolipin remodeling that alter major metabolic processes. The tafazzin gene is encoded on the X chromosome, and therefore BTHS primarily affects males. Female carrie...

  • Review
  • Open Access
14 Citations
4,619 Views
12 Pages

The Role of Mitochondrial Dysfunction in Idiopathic Pulmonary Fibrosis: New Perspectives for a Challenging Disease

  • Juan David Cala-Garcia,
  • German Jose Medina-Rincon,
  • Paula Andrea Sierra-Salas,
  • Julio Rojano and
  • Freddy Romero

14 September 2023

Mitochondrial biology has always been a relevant field in chronic diseases such as fibrosis or cancer in different organs of the human body, not to mention the strong association between mitochondrial dysfunction and aging. With the development of ne...

  • Article
  • Open Access
1 Citations
2,312 Views
16 Pages

13 September 2023

Chagas disease, caused by Trypanosoma cruzi and transmitted by triatomines, can lead to severe cardiac issues and mortality in many mammals. Recent studies have shown that systemic insecticide treatment of dogs is highly effective in killing triatomi...

  • Article
  • Open Access
3 Citations
1,873 Views
13 Pages

Using i-GONAD for Cell-Type-Specific and Systematic Analysis of Developmental Transcription Factors In Vivo

  • Christoph Wiegreffe,
  • Simon Ehricke,
  • Luisa Schmid,
  • Jacqueline Andratschke and
  • Stefan Britsch

13 September 2023

Transcription factors (TFs) regulate gene expression via direct DNA binding together with cofactors and in chromatin remodeling complexes. Their function is thus regulated in a spatiotemporal and cell-type-specific manner. To analyze the functions of...

  • Review
  • Open Access
2 Citations
2,669 Views
11 Pages

OMICS Approaches to Assess Dinoflagellate Responses to Chemical Stressors

  • Alice Roussel,
  • Vincent Mériot,
  • Thierry Jauffrais,
  • Véronique Berteaux-Lecellier and
  • Nicolas Lebouvier

13 September 2023

Dinoflagellates are important primary producers known to form Harmful Algae Blooms (HABs). In water, nutrient availability, pH, salinity and anthropogenic contamination constitute chemical stressors for them. The emergence of OMICs approaches propell...

  • Article
  • Open Access
5 Citations
2,757 Views
17 Pages

Head-to-Head Comparison of Tissue Factor-Dependent Procoagulant Potential of Small and Large Extracellular Vesicles in Healthy Subjects and in Patients with SARS-CoV-2 Infection

  • Marta Brambilla,
  • Roberto Frigerio,
  • Alessia Becchetti,
  • Alessandro Gori,
  • Marina Cretich,
  • Maria Conti,
  • Antonella Mazza,
  • Martino Pengo and
  • Marina Camera

13 September 2023

The relative contribution of small (sEVs) and large extracellular vesicles (lEVs) to the total plasma procoagulant potential is not yet well defined. Thus, we compared total and TFpos-sEVs and -lEVs isolated from healthy subjects and COVID-19 patient...

  • Review
  • Open Access
11 Citations
2,875 Views
21 Pages

13 September 2023

High-density lipoproteins (HDL) play an established role in protecting against cellular dysfunction in a variety of different disease contexts; however, harnessing this therapeutic potential has proved challenging due to the heterogeneous and relativ...

  • Article
  • Open Access
9 Citations
3,759 Views
23 Pages

12 September 2023

In recent years, the bacterial blight of cassava has caused substantial economic losses to the Chinese cassava industry. Chemical control methods have become the primary approach to control this disease; however, their widespread usage and harmful re...

  • Article
  • Open Access
2 Citations
3,631 Views
21 Pages

Analysis of High-Risk Neuroblastoma Transcriptome Reveals Gene Co-Expression Signatures and Functional Features

  • Mónica Leticia Martínez-Pacheco,
  • Enrique Hernández-Lemus and
  • Carmen Mejía

12 September 2023

Neuroblastoma represents a neoplastic expansion of neural crest cells in the developing sympathetic nervous system and is childhood’s most common extracranial solid tumor. The heterogeneity of gene expression in different types of cancer is wel...

  • Article
  • Open Access
5 Citations
2,179 Views
12 Pages

A Novel Dual-Function Redox Modulator Relieves Oxidative Stress and Anti-Angiogenic Response in Placental Villus Explant Exposed to Hypoxia—Relevance for Preeclampsia Therapy

  • Diana Pintye,
  • Réka E. Sziva,
  • Maxim Mastyugin,
  • Brett C. Young,
  • Sonako Jacas,
  • Marianna Török,
  • Saira Salahuddin,
  • Prakash Jagtap,
  • Garry J. Southan and
  • Zsuzsanna K. Zsengellér

12 September 2023

Background: Preeclampsia (PE) is a severe, life-threatening complication during pregnancy (~5–7%), and no causative treatment is available. Early aberrant spiral artery remodeling is associated with placental stress and the release of oxygen ra...

  • Article
  • Open Access
2 Citations
1,998 Views
12 Pages

12 September 2023

To evaluate the relative importance of IGF-I expression in various cell types for endochondral ossification, we quantified the trabecular bone at the secondary spongiosa and epiphysis of the distal femur in 8–12-week-old male mice with a global...

  • Article
  • Open Access
1,961 Views
13 Pages

d-Serine Increases Release of Acetylcholine in Rat Submandibular Glands

  • Masanobu Yoshikawa,
  • Migiwa Okubo,
  • Kosuke Shirose,
  • Takugi Kan and
  • Mitsuru Kawaguchi

11 September 2023

d-serine has been observed in submandibular gland tissue in rats, but its functions remain to be clarified. Oral administration of d-serine, but not l-serine, increased its concentrations in the submandibular gland and pilocarpine-induced salivary se...

  • Article
  • Open Access
9 Citations
2,577 Views
33 Pages

The Designer Drug αPHP Affected Cell Proliferation and Triggered Deathly Mechanisms in Murine Neural Stem/Progenitor Cells

  • Elisa Roda,
  • Fabrizio De Luca,
  • Erica Cecilia Priori,
  • Daniela Ratto,
  • Silvana Pinelli,
  • Emilia Corradini,
  • Paola Mozzoni,
  • Diana Poli,
  • Giuliano Mazzini and
  • Daniele Bottai
  • + 5 authors

11 September 2023

Increasing reports of neurological and psychiatric outcomes due to psychostimulant synthetic cathinones (SCs) have recently raised public concern. However, the understanding of neurotoxic mechanisms is still lacking, particularly for the under-invest...

  • Article
  • Open Access
4 Citations
2,225 Views
9 Pages

Sex Variations in Retinal Microcirculation Response to Lower Body Negative Pressure

  • Adam Saloň,
  • Nikola Vladic,
  • Karin Schmid-Zalaudek,
  • Bianca Steuber,
  • Anna Hawliczek,
  • Janez Urevc,
  • Andrej Bergauer,
  • Vid Pivec,
  • Vishwajeet Shankhwar and
  • Nandu Goswami

11 September 2023

Introduction: Lower body negative pressure (LBNP) is routinely used to induce central hypovolemia. LBNP leads to a shift in blood to the lower extremities. While the effects of LBNP on physiological responses and large arteries have been widely repor...

  • Review
  • Open Access
13 Citations
5,603 Views
18 Pages

Exploring the Immune Response against RSV and SARS-CoV-2 Infection in Children

  • Rafaela Pires da Silva,
  • Bibiana Liberman Thomé and
  • Ana Paula Duarte da Souza

9 September 2023

Viral respiratory tract infections are a significant public health concern, particularly in children. RSV is a prominent cause of lower respiratory tract infections among infants, whereas SARS-CoV-2 has caused a global pandemic with lower overall sev...

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Biology - ISSN 2079-7737