Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Phytohormones 2024–2025
edited by Guzel Kudoyarova
submission deadline 31 Mar 2025 | Viewed by 68 | Submission Open
Keywords: plant hormones; auxins; cytokinins; gibberellins; abscisic acid; ethylene; salicylic acid; jasmonates
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Bioactive Molecules against Aging: Organism-, Cell-, and Mitochondria-Based Approaches
edited by and Lucia Biasutto
submission deadline 31 Mar 2025 | Viewed by 61 | Submission Open
Keywords: aging; bioactive molecules; healthy aging; cell signaling; mitochondria
Recent Advances in Fluorescent Probes: From Structure Design to Biological Applications
edited by Yalin Qi
submission deadline 31 Mar 2025 | Viewed by 59 | Submission Open
Keywords: fluorescent probes; organic small molecule fluorescent probes; drug discovery; disease detection
Inflammation Biology in Orthodontic Tooth Movement
edited by
submission deadline 31 Mar 2025 | Viewed by 52 | Submission Open
Keywords: orthodontic tooth movement; inflammation; cytokine; root resorption; accelerated orthodontic tooth movement; relapse
Thyroid Cancer: Molecular Mechanisms and Targeted Therapies submission deadline 31 Mar 2025 | Viewed by 45 | Submission Open
Keywords: differentiated thyroid cancer; medullary thyroid cancer; anaplastic thyroid carcinoma; advanced/metastatic thyroid cancer; refractory thyroid cancer; molecular biomarkers; oncogenic signaling pathways; thyroid cytology; targeted therapy; tyrosine kinase inhibitors; immune checkpoint inhibitors; therapeutic strategies; thyroid cancer prognosis; epigenomics in thyroid cancer
(This special issue belongs to the Section Molecular Medicine)
Experimental and Bioinformatic Approaches for Biomarker Discovery in Disease: From Molecular Mechanisms to Therapeutic Challenges
edited by
submission deadline 31 Mar 2025 | Viewed by 44 | Submission Open
Keywords: biomarker; molecular biology; bioinformatics
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Molecular and Cellular Mechanisms of Kidney Diseases
edited by and Maria Divani
submission deadline 1 Apr 2025 | Viewed by 174 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; kidney transplantation; glomerular diseases; ischemia– reperfusion injury; diabetic nephropathy
Advances in CRISPR/Cas Systems for Genome Editing Applications in Biomedical Research
edited by
submission deadline 10 Apr 2025 | 1 articles | Viewed by 2063 | Submission Open
Keywords: genome editing; CRISPR/Cas; gene therapy; cancer immunotherapy; diagnosis
(This special issue belongs to the Section Molecular Biology)
Advances in Nano-Based Drug Delivery: Unveiling the Next Frontier submission deadline 15 Apr 2025 | 1 articles | Viewed by 1771 | Submission Open
Keywords: targeted drug delivery; smart nanoformulation; controlled drug release; biocompatible nanocarriers; extracellular vesicles; immunotherapy
(This special issue belongs to the Section Biological and Bio- Materials)
Mechanisms of Schizophrenia: Insights to Unlock the Brain Puzzle and Generate Effective Antipsychotic Drugs
edited by Tatiana V. Lipina
submission deadline 15 Apr 2025 | 1 articles | Viewed by 916 | Submission Open
Keywords: animal models of schizophrenia; antipsychotic drugs; brain; genes; D2R
(This special issue belongs to the Section Molecular Biology)
Biomolecules and Materials Based Approaches in Biomedical Field: 2nd Edition submission deadline 15 Apr 2025 | Viewed by 204 | Submission Open
Keywords: biomolecules roles in biological processes and pathologies; therapeutic molecules; biomarkers; biomolecules for disease diagnostics; and pharmaceutical development; cell signaling biomolecules; biomaterials for biomedical applications; self-assembled biomaterials; biofunctionalization of materials; new fabrication technologies (e.g.; 3D printing); biosensors for disease diagnostics and/or prognosis; 3D scaffolds and hydrogels; 3D material-based tissue models; membrane bioreactors; bioartificial organs; materials for cell-/drug-delivery systems; in vitro material platforms for disease modeling/drug screening; materials for fabricating microfluidic systems
(This special issue belongs to the Section Molecular Medicine)
Role of Dopamine Receptors and Dopamine Transporter in Brain Function: Quantitative Approach submission deadline 15 Apr 2025 | Viewed by 25 | Submission Open
Keywords: algorithm; animal model; dopamine receptor; dopamine transporter; mathematical modeling; simulation
(This special issue belongs to the Section Biomacromolecules: Proteins)
Natural Bioactives as Leading Molecules for Drug Development
edited by , and
submission deadline 16 Apr 2025 | 1 articles | Viewed by 764 | Submission Open
Keywords: drug discovery; natural products; leading molecules; isolation and identification; phytochemical investigation; omics approaches
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Dysregulated Cytokine Signals in Human Disease
edited by
submission deadline 25 Apr 2025 | Viewed by 39 | Submission Open
Keywords: cytokine; signaling; dysregulation; immunity; development; disease
(This special issue belongs to the Section Molecular Medicine)
Neurological Disorders: From Molecular Mechanisms to Therapy Strategies submission deadline 30 Apr 2025 | 8 articles | Viewed by 27818 | Submission Open
Keywords: neurodegeneration; neuroprotection; novel therapies; natural molecules
(This special issue belongs to the Section Molecular Biology)
Nutrition, Metabolism, and Obesity: Novel Strategies and Molecular Mechanisms—Future Perspectives submission deadline 30 Apr 2025 | 7 articles | Viewed by 14867 | Submission Open
Keywords: diet; nutrients; obesity; inflammation; fat; glucose intolerance; insulin resistance; fatty liver disease; metabolic syndrome
(This special issue belongs to the Section Molecular Medicine)
Novel Insights into Autoimmune/Autoinflammatory Skin Diseases submission deadline 30 Apr 2025 | 5 articles | Viewed by 7865 | Submission Open
Keywords: autoimmune/autoinflammatory skin diseases; omics; bioinformatics; pathogenesis; tailored medicine
(This special issue belongs to the Section Molecular Medicine)
Advances in Metabolites Produced by Microbiota submission deadline 30 Apr 2025 | 2 articles | Viewed by 3569 | Submission Open
Keywords: microbiota; metabolites; short-chain fatty acids; amino acids; vitamins
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Diagnosis and Regulation of Mitochondrial Dysfunction
edited by
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1602 | Submission Open
Keywords: metabolic conditions; neurological conditions; genetic diseases; mitochondrial dysfunction; mitochondrial disorders; diagnostics; therapies
(This special issue belongs to the Section Biological Factors)
Recent Trends in Kidney and Cardiovascular Diseases
edited by
submission deadline 30 Apr 2025 | 1 articles | Viewed by 1594 | Submission Open
Keywords: chronic kidney disease; cardiovascular risk; albuminuria; epidemiology; estimated glomerular filtration rate
(This special issue belongs to the Section Molecular Medicine)
Glial Cross-Talk in Central Nervous System Health and Disease submission deadline 30 Apr 2025 | 1 articles | Viewed by 1429 | Submission Open
Keywords: glial physiology; glial cross-talk in CNS homeostasis; glial cross-talk in neuroinflammation; glial cross-talk in CNS diseases
(This special issue belongs to the Section Molecular Biology)
New Insights into the Membranes of Anoxygenic Phototrophic Bacteria submission deadline 30 Apr 2025 | 1 articles | Viewed by 1122 | Submission Open
Keywords: anoxygenic phototrophs; light harvesting; membrane dynamics; molecular evolution; reaction centers
(This special issue belongs to the Section Molecular Structure and Dynamics)
Plant-Microbe-Insect Interactions
edited by and Xueke Gao
submission deadline 30 Apr 2025 | Viewed by 330 | Submission Open
Keywords: plant– microbe– insect interactions; plant defense; insects; pest control; microbiology
(This special issue belongs to the Section Cellular Biochemistry)
Advances in Cancer and Glycosylation
edited by
submission deadline 30 Apr 2025 | Viewed by 250 | Submission Open
Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases
(This special issue belongs to the Section Molecular Medicine)
Stem Cells in Musculoskeletal Tissue Engineering
edited by and
submission deadline 30 Apr 2025 | Viewed by 230 | Submission Open
Keywords: tissue regeneration; stem cell; cell reporgramming; iPSCs
(This special issue belongs to the Section Synthetic Biology and Bioengineering)
Image-Guided Cancer Therapy
edited by
submission deadline 30 Apr 2025 | Viewed by 185 | Submission Open
Keywords: MRI; PET; CT; US; oncology; cancer immunotherapy
Pluripotent Stem Cell Models of Human Disease
edited by Satish Kumar
submission deadline 30 Apr 2025 | Viewed by 171 | Submission Open
Keywords: pluripotent stem cells; cellular reprogramming; cellular differentiation; 2D and 3D cell models of human disease; cellular phenotypes; biomarkers; disease gene; multi-omics approaches; genome editing; drug screening and discovery
(This special issue belongs to the Section Cellular Biochemistry)
Microbial Biocontrol and Plant-Microbe Interactions
edited by
submission deadline 30 Apr 2025 | Viewed by 132 | Submission Open
Keywords: endophytic microbiome for disease management; plant– microbe interactions; plant– insect– pathogen interactions; microbial and plant metabolites against pathogens; pathogen signaling; microbial communities shift for disease prevention; omics approaches; abiotic stress response
(This special issue belongs to the Section Cellular Biochemistry)
Design and Synthesis of Bioactive Compounds for Therapeutic Applications submission deadline 30 Apr 2025 | Viewed by 126 | Submission Open
Keywords: drug design and discovery; synthesis of bioactive molecules; biological evaluations and applications; diagnostics; drug delivery
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Non-invasive Biomarkers in Saliva or Urine: Technical and Biological Variability
edited by
submission deadline 30 Apr 2025 | Viewed by 125 | Submission Open
Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Novel Mechanisms of Bacterial Antibiotic Resistance submission deadline 30 Apr 2025 | Viewed by 119 | Submission Open
Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches
(This special issue belongs to the Section Biological Factors)
Molecular Basis and Oxidative Stress of Thyroid Diseases submission deadline 30 Apr 2025 | Viewed by 113 | Submission Open
Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease
(This special issue belongs to the Section Biological Factors)
Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges
edited by
submission deadline 30 Apr 2025 | Viewed by 106 | Submission Open
Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials
The Role of Alarmins and Innate Lymphoid Cells in Allergic Immune Responses
edited by Yasutomo Imai
submission deadline 30 Apr 2025 | Viewed by 73 | Submission Open
Keywords: innate lymphoid cells; biologics; alarmin; atopic dermatitis; psoriasis; asthma; food allergy; allergic conjunctivitis; allergic rhinitis
(This special issue belongs to the Section Molecular Biology)
Pathogenesis and Neuropathology of Alzheimer's Disease submission deadline 30 Apr 2025 | Viewed by 53 | Submission Open
Keywords: Alzheimer disease; pathogenesis; neuropathology; diagnosis; neurodegenerative diseases; microRNA as diagnostic marker; the important modulatory action of DNA repair enzyme DNA-PKcs in synaptic plasticity
(This special issue belongs to the Section Molecular Medicine)
Unveiling Molecular Pathways Involved in the Gut–Brain Axis in Autism
edited by and John Scott
submission deadline 30 Apr 2025 | Viewed by 52 | Submission Open
Keywords: neurodevelopment; autism; genetic; molecular pathways; gastrointestinal
(This special issue belongs to the Section Molecular Biology)
Nanoparticles for Cancer Therapy: Challenges and Opportunities submission deadline 30 Apr 2025 | Viewed by 45 | Submission Open
Keywords: nanoparticles; cancer; nanotheranostics; drug delivery; gene delivery
The Role of Extracellular Vesicles in Drug Delivery
edited by
submission deadline 30 Apr 2025 | Viewed by 37 | Submission Open
Keywords: extracellular vesicles; drug delivery systems; extracellular vesicle engineering; cancer treatment; gene therapy
(This special issue belongs to the Section Molecular Biology)
New Insight into Subphases of DNA Replication in Mammalian Cells
edited by
submission deadline 30 Apr 2025 | Viewed by 37 | Submission Open
Keywords: DNA content; chromosomal aberrations; replication peaks; subphases of replication
(This special issue belongs to the Section Molecular Reproduction)
Signaling Pathways as Therapeutic Targets for Cancer
edited by Fabian Benencia
submission deadline 10 May 2025 | Viewed by 66 | Submission Open
Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies
(This special issue belongs to the Section Molecular Biology)
Interface of Aging and Biomaterials: 2nd Edition
edited by
submission deadline 15 May 2025 | 3 articles | Viewed by 6836 | Submission Open
Keywords: aging; senescence; geroscience; biomolecules; biomaterials; biocompatibility; nanoparticles; hydrogels
(This special issue belongs to the Section Biological and Bio- Materials)
Genetic and Structural Analyses of SARS-CoV-2 and Its Variants
edited by
submission deadline 30 May 2025 | 1 articles | Viewed by 898 | Submission Open
Keywords: SARS-CoV-2 variants; protein variants; protein structure; virus evolution; mutations; structural bioinformatics; molecular phylogenesis; host– pathogen molecular interactions; molecular immunology; drug discovery
(This special issue belongs to the Section Molecular Structure and Dynamics)
Molecular Advances in Mechanism and Regulation of Lifespan and Aging
edited by Mark McCormick
submission deadline 31 May 2025 | 2 articles | Viewed by 4707 | Submission Open
Keywords: aging; lifespan; healthspan
(This special issue belongs to the Section Molecular Biology)
New Insights into Kidney Disease Development and Therapy Strategies submission deadline 31 May 2025 | 3 articles | Viewed by 3868 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products
edited by
submission deadline 31 May 2025 | 4 articles | Viewed by 3782 | Submission Open
Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Innate Immunomodulation and Inflammation: From Molecular Mechanisms to Pre-Clinical Insights
edited by Fabián Flores-Borja, and
submission deadline 31 May 2025 | 1 articles | Viewed by 718 | Submission Open
Keywords: innate immunity; therapy; immune checkpoints; cancer; autoimmunity; inflammation; infection; danger-associated molecular patterns; pattern recognition receptors
(This special issue belongs to the Section Molecular Medicine)
Molecular Basis of Mast Cells Activation and Medical Implications submission deadline 31 May 2025 | Viewed by 151 | Submission Open
Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms
(This special issue belongs to the Section Biological Factors)
Recent Advances in Cellular and Non-Cellular Treatment of Stroke
edited by
submission deadline 31 May 2025 | Viewed by 58 | Submission Open
Keywords: stroke; treatment; therapy; biomolecules; stem cells
Advances in Molecular Therapy Targeting DNA Damage and Repair Systems
edited by , and Anahita Mojiri
submission deadline 31 May 2025 | Viewed by 53 | Submission Open
Keywords: DNA repair; DNA repair inhibitors; homologous recombination; genome instability; inflammation; DNA damage; cell death; apoptosis
(This special issue belongs to the Section Biological Factors)
Pharmacology of Cardiovascular Diseases
edited by , Alexandra Gyongyosi and
submission deadline 31 May 2025 | Viewed by 50 | Submission Open
Keywords: cardioprotection autophagy; redox balance; heart faliure; cardiovascular pharmacotherapy
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