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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Metabolic Insights into Liver Disease submission deadline 15 Nov 2024 | 1 articles | Viewed by 925 | Submission Open
Keywords: alcoholic liver disease; NAFLD; viral hepatitis; chronic liver disease; pathophysiology and treatment
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Radiation, Oxidative Stress and Damage Related Normal Tissue Complications: Mechanisms and Strategies to Mitigate submission deadline 15 Nov 2024 | 1 articles | Viewed by 770 | Submission Open
Keywords: free radicals; oxidative stress; inflammation; regenerative medicine; effects of space radiation on the CNS; stem cell and exosome therapies; neuroscience; FLASH radiotherapy; tissue toxicity; high-energy radiation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Multifunctional Application of Biopolymers and Biomaterials 2.0
edited by
submission deadline 15 Nov 2024 | 1 articles | Viewed by 702 | Submission Open
Keywords: biopolymers; nanomaterials; biomaterials; functional materials; bioactive natural compounds; essential oil emulsion; natural colorant; plant extract; bioactive compounds; nanocomposite; functional composite; composite film and coatings
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms Regulating Plant Development and Cell Function
edited by
submission deadline 15 Nov 2024 | Viewed by 397 | Submission Open
Keywords: cell function; cell polarity; tissue organization; transporter; localization
(This special issue belongs to the Section Molecular Plant Sciences)
Metabolomics in the Field of Autoimmune Diseases submission deadline 15 Nov 2024 | Viewed by 215 | Submission Open
Keywords: metabolomics; proteomics; genomics; transcriptomics; biomarkers; autoimmune diseases; inflammatory diseases; nuclear magnetic resonance spectroscopy; mass spectrometry; precision medicine
(This special issue belongs to the Section Molecular Immunology)
Advances in Molecular Research of Kidney Diseases
edited by Andrea Angioi
submission deadline 15 Nov 2024 | Viewed by 161 | Submission Open
Keywords: molecular genetics; kidney disease; biomarkers; cellular signaling; target therapeutics; innovative treatments
(This special issue belongs to the Section Molecular Biology)
Spleen: Crossroad between Immune System, Metabolic Asset and Endocrine Function 2.0
edited by
submission deadline 15 Nov 2024 | Viewed by 103 | Submission Open
Keywords: cytokines; neurotransmitters; hormones/growth factors; vitamin D and spleen; mechanisms linking spleen and obesity-related diseases (NAFLD; OSAS; PCOS); trace elements/immunity and spleen; environmental particulate matter/immunity and spleen; spleen-organ axes
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Signalling Pathways in Metabolic Diseases and Cancers
edited by
submission deadline 15 Nov 2024 | Viewed by 102 | Submission Open
Keywords: cancer; prostate cancer; molecular signalling pathway; metabolic diseases; diabets; immunotherapy; immunological diseases
(This special issue belongs to the Section Biochemistry)
Research on Mitochondria and Cell Death in Disease Diagnosis and Treatment submission deadline 20 Nov 2024 | 12 articles | Viewed by 24994 | Submission Open
Keywords: mitochondrial dysfunction; reactive oxygen species; oxidative stress; lipid peroxidation; mitochondrial dynamics; mitophagy; mitochondrial biogenesis; apoptosis; neurodegeneration; metabolic syndrome; mitochondria-targeted antioxidants; diseases associated with mitochondrial dysfunction; diagnosis and treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Micronutrients in Metabolic Health submission deadline 20 Nov 2024 | 5 articles | Viewed by 23372 | Submission Open
Keywords: micronutrients; vitamin B12; vitamin D; epigenetics; obesity; type 2 diabetes; gestational diabetes; insulin resistance; cardiovasular disease; maternal and fetal programming
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Mitochondria in Human Health and Disease 2.0
edited by
submission deadline 20 Nov 2024 | 9 articles | Viewed by 17705 | Submission Open
Keywords: OXPHOS; mitochondrial transcription; mitochondrial– nuclear interactions; mitochondrial– ER interactions; mitochondrial bioenergetics; mitochondrial fusion/fission; apoptosis; mitophagy; ROS– mitochondrial oxidative defense systems; neurodegenerative diseases; mitochondrial myopathies; mitochondrial diseases; mitochondrial disorders in cancer; mitochondria and inflammation; Ca2+ signaling
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
RNA Virus Mechanisms: From Molecular Insights to Therapeutic Strategies
edited by
submission deadline 20 Nov 2024 | 5 articles | Viewed by 16685 | Submission Open
Keywords: RNA virus mechanisms; viral pathogenesis; host– virus interactions; antiviral drug discovery; vaccine development; RNA virus epidemiology; RNA virus structure; RNA virus evolution
(This special issue belongs to the Section Molecular Microbiology)
Latest Review Papers in Molecular Neurobiology 2024
edited by
submission deadline 20 Nov 2024 | 7 articles | Viewed by 14092 | Submission Open
Keywords: neurobiology; neurochemistry; neurology; neuropathology; neurophysiology; neuropharmacology; neurogenetics; neuro-oncology; aging neuroscience; neurotrauma; neurogenesis; neurotransmitter; neuroinflammation; neuroendocrine tumor; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
The Advances in Antimicrobial Biomaterials submission deadline 20 Nov 2024 | 7 articles | Viewed by 13614 | Submission Open
Keywords: biomaterials; biopolymers production; antimicrobial agents; antimicrobial activity; natural antibiotics; antioxidants; bioelastomers; food packaging
(This special issue belongs to the Section Materials Science)
Recent Approaches for Wound Treatment—2nd Edition submission deadline 20 Nov 2024 | 7 articles | Viewed by 13003 | Submission Open
(This special issue belongs to the Section Molecular Pharmacology)
Bioactive Lipids: From the Perspective of Cellular and Molecular Mechanisms submission deadline 20 Nov 2024 | 6 articles | Viewed by 12720 | Submission Open
Keywords: lipids; polyunsaturated fatty acids; lipid metabolism; lipid mediators; inflammation; neuroprotection
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Essential Molecules in Life: Regulation, Defense, and Longevity submission deadline 20 Nov 2024 | 7 articles | Viewed by 12326 | Submission Open
Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab
(This special issue belongs to the Section Molecular Biology)
Mechanism of Redox Signal Transduction in Plants
edited by and
submission deadline 20 Nov 2024 | 3 articles | Viewed by 12215 | Submission Open
Keywords: reactive oxygen species; reactive nitrogen species; hydrogen sulfide; persulfidation; nitrosation; sulfenylation; redox modification; redox signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of mRNA Transcriptional Regulation: 2nd Edition submission deadline 20 Nov 2024 | 5 articles | Viewed by 12082 | Submission Open
Keywords: transcriptoion factors (TFs); cis-regulatory elements (CREs); long non-coding RNAs (lncRNAs); short non-coding RNAs (sncRNAs); small nuclear RNAs (snRNAs); microRNA (miRNA); circular RNA (circRNA); DNA methylation; chromatin regulators
(This special issue belongs to the Section Biochemistry)
Advanced Progress and Application of Photodynamic Therapy submission deadline 20 Nov 2024 | 4 articles | Viewed by 11855 | Submission Open
Keywords: photodynamic therapy; photobiology; light sources; illumination; light emitting diodes (LED); laser; photosensitizer; methylamoninolevunlic acid; delta aminolevulinic acid
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomaterials: From Design, Synthesis and Characterization to Application
edited by and
submission deadline 20 Nov 2024 | 6 articles | Viewed by 11788 | Submission Open
Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis
(This special issue belongs to the Section Materials Science)
Lysophosphatidic Acid Signaling in Health and Disease
edited by and
submission deadline 20 Nov 2024 | 8 articles | Viewed by 11742 | Submission Open
(This special issue belongs to the Section Biochemistry)
Epilepsy: From Molecular Basis to Therapy submission deadline 20 Nov 2024 | 10 articles | Viewed by 10877 | Submission Open
Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial
(This special issue belongs to the Section Molecular Neurobiology)
Neuromodulatory Effects of Serotonin
edited by
submission deadline 20 Nov 2024 | 7 articles | Viewed by 10154 | Submission Open
Keywords: neuromodulation; Serotonin; pain research; cognition; emotions; depression; anxiety; GBM
(This special issue belongs to the Section Molecular Neurobiology)
Atherosclerosis 2.0: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches
edited by
submission deadline 20 Nov 2024 | 8 articles | Viewed by 10126 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathophysiology to Novel Therapeutic Approaches for Leukemia
edited by
submission deadline 20 Nov 2024 | 5 articles | Viewed by 9842 | Submission Open
Keywords: acute myeloid leukemia; acute lymphoblastic leukemia; molecular pathophysiology; new therapeutic approaches; immunotherapy; cellular therapy; allogenic bone marrow transplantation
(This special issue belongs to the Section Molecular Oncology)
The Microbiota-Gut-Brain Axis in Relation to Non-communicable Diseases submission deadline 20 Nov 2024 | 4 articles | Viewed by 9792 | Submission Open
Keywords: gut– brain axis; gut microbiota; behavior; bioactive molecules; cognitive health; diabetes; in vitro models; in vivo models; hormones; intestine; obesity; probiotics; prebiotics; synbiotics
(This special issue belongs to the Section Molecular Microbiology)
Resistance to Therapy in Ovarian Cancers
edited by
submission deadline 20 Nov 2024 | 3 articles | Viewed by 9692 | Submission Open
Keywords: ovarian cancers; therapy response; biomarkers; innovative drugs; drug resistance; drug metabolism; drug delivery; platinum-based chemotherapy; PARP inhibitors; intratumor heterogeneity; microenvironment; homologous recombination deficiency
(This special issue belongs to the Section Molecular Oncology)
Advanced Therapy Medicinal Products: From Mechanism to Production submission deadline 20 Nov 2024 | 3 articles | Viewed by 9254 | Submission Open
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Somatic Cell Cloning and Other Assisted Reproductive Technologies in Mammals submission deadline 20 Nov 2024 | 5 articles | Viewed by 9252 | Submission Open
Keywords: somatic cell nuclear transfer (SCNT); SCNT-based cloning; assisted reproductive technology (ART); in vitro embryo production (IVP); in vitro fertilization (IVF); intracytoplasmic sperm injection (ICSI); in vivo embryo production
(This special issue belongs to the Section Molecular Biology)
Molecular Pharmacology of Antidepressants submission deadline 20 Nov 2024 | 5 articles | Viewed by 9066 | Submission Open
Keywords: depression; pharmacotherapy of depression; molecular mechanisms of depression; mood; pharmacology of depression; antidepressants; drug-drug interactions; in vitro mechanism for antidepressants; side effects of antidepressants
(This special issue belongs to the Section Molecular Pharmacology)
Pathogenesis and Therapy of Oral Carcinogenesis, 2nd Edition
edited by and
submission deadline 20 Nov 2024 | 7 articles | Viewed by 9000 | Submission Open
Keywords: oral cancer; oral premalignant disorders; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis
(This special issue belongs to the Section Molecular Oncology)
Molecular Studies of Natural Compounds and Plant Extracts—2nd Edition submission deadline 20 Nov 2024 | 7 articles | Viewed by 8702 | Submission Open
Keywords: bioactive substances; plant extracts; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic
(This special issue belongs to the Section Biochemistry)
Plant Phylogenomics and Genetic Diversity (2nd Edition)
edited by
submission deadline 20 Nov 2024 | 8 articles | Viewed by 7721 | Submission Open
Keywords: plant phylogenomics; genome; gene evolution; species diversity; speciation; ecogenomics
(This special issue belongs to the Section Molecular Plant Sciences)
Valorization of Lignocellulosic Biomass submission deadline 20 Nov 2024 | 4 articles | Viewed by 7684 | Submission Open
Keywords: lignocellulosic biomass; biorefinery; biomass conversion; bioenergy; biofuels; bioproducts; platform chemicals; cellulose nanomaterials; lignin nanoparticles; functional materials
(This special issue belongs to the Section Materials Science)
Parasite Biology and Host-Parasite Interactions: 2nd Edition submission deadline 20 Nov 2024 | 7 articles | Viewed by 7675 | Submission Open
Keywords: parasite; immunity; immunomodulation; helper T cells; IgA; IgE; eosinophils; mast cells; regulatory T cells; galectin
(This special issue belongs to the Section Molecular Biology)
Novel Targeted Therapies and Drugs in Cancer submission deadline 20 Nov 2024 | 4 articles | Viewed by 7671 | Submission Open
Keywords: targeted therapies; genetic mutation; PARP inhibitors; immunotherapy; drug development; cancer molecular analysis; drug response; molecular-targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis 2.0
edited by
submission deadline 20 Nov 2024 | 6 articles | Viewed by 7632 | Submission Open
Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Peripheral Nerve Regeneration
edited by
submission deadline 20 Nov 2024 | 5 articles | Viewed by 7444 | Submission Open
Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth
(This special issue belongs to the Section Molecular Neurobiology)
Focus on Bacterial Pathogens: Host Cell Defense Pathways and Innovative Therapeutic Strategies submission deadline 20 Nov 2024 | 4 articles | Viewed by 7234 | Submission Open
Keywords: bacterial pathogenesis and virulence factors; host immune response to bacterial infection; innate and adaptive immunity against bacterial pathogens; immune evasion strategies employed by bacterial pathogens; innovative therapeutic strategies against bacterial pathogens; antimicrobial resistance and novel treatment strategies
(This special issue belongs to the Section Molecular Microbiology)
Inflammation and Endothelial Dysfunction in Cardio-Cerebrovascular Disease submission deadline 20 Nov 2024 | 4 articles | Viewed by 7056 | Submission Open
Keywords: endothelial dysfunction; inflammation; cytokines; atherosclerosis; arterial stiffness; stroke; myocardial infarction; cardiovascular risk; microRNA; miRNA
(This special issue belongs to the Section Molecular Immunology)
Molecular and Cellular Mechanisms of Epilepsy—3rd Edition
edited by
submission deadline 20 Nov 2024 | 5 articles | Viewed by 6986 | Submission Open
Keywords: epilepsy; epilepsy models; epileptogenesis; preventing epilepsy; neuroinflammation; neuroprotection; synaptic plasticity; neuron– astrocyte interaction
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insight into Novel Coatings: Design, Synthesis, and Applications submission deadline 20 Nov 2024 | 3 articles | Viewed by 6981 | Submission Open
Keywords: composite coatings; protective coatings; antibacterial coatings; superhydrophobic coatings; superhydrophilic coatings; anti-icing coatings; bioactive coatings; photocatalytic coatings  
(This special issue belongs to the Section Materials Science)
Cellular and Molecular Biology of Cardiac Hypertrophy and Heart Failure: Pathogenesis, Diagnostics and Treatment
edited by
submission deadline 20 Nov 2024 | 5 articles | Viewed by 6852 | Submission Open
Keywords: cardiac hypertrophy; myocardial remodelling; heart failure; cellular mechanisms; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Therapeutics against Eukaryotic Pathogens
edited by
submission deadline 20 Nov 2024 | 4 articles | Viewed by 6794 | Submission Open
Keywords: medicinal chemistry; parasitology; pathogen; drug-target; NTD; cryptosporidia; Giardia; helminths; Leishmania; Naegleria; Plasmodium; Schistosoma; Toxoplasma; Trichomonas; Trypanosoma  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Toxicity Mechanism of Emerging Pollutants submission deadline 20 Nov 2024 | 6 articles | Viewed by 6783 | Submission Open
Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms
(This special issue belongs to the Section Molecular Toxicology)
Kynurenic Acid: Emerging Research Advances and Therapeutic Implications
edited by Piotr Paluszkiewicz and Monika Turska-Kozłowska
submission deadline 20 Nov 2024 | 6 articles | Viewed by 6691 | Submission Open
Keywords: kynurenic acid; kynurenine pathway; kynurenine; therapeutic use; supply and distribution
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Lung Cancers: An Update on Molecular Diagnostics and Therapy
edited by
submission deadline 20 Nov 2024 | 4 articles | Viewed by 6667 | Submission Open
Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metal-Based Drugs and Research on Mechanisms of Action submission deadline 20 Nov 2024 | 3 articles | Viewed by 6660 | Submission Open
Keywords: transition metals; metal complexes; metallodrugs; drug development; synthesis; imaging agents; structure– activity ratio
(This special issue belongs to the Section Molecular Pharmacology)
Structural Dynamics of Macromolecules
edited by
submission deadline 20 Nov 2024 | 3 articles | Viewed by 6602 | Submission Open
Keywords: Structural biology; Structural dynamics; Serial crystallography; X-ray crystallography; Cryo-EM time-resolved studies; Molecular dynamics
(This special issue belongs to the Section Molecular Biophysics)
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