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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Lipids in Health and Diseases

edited by

Yutang Wang

submission deadline 31 Dec 2025 | 5 articles | Viewed by 14601 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

Phyto-Functional Nanomaterials: Synthesis, Characterization and Application

edited by

Maria G. P. M. S. Neves

Carla Isabel Madeira dos Santos

and

Nuno M. M. Moura

submission deadline 31 Dec 2025 | 8 articles | Viewed by 13978 | Submission Open

Keywords: phyto-functional nanomaterials; green synthesis; hydrogen generation; pollutant degradation/removal; fine chemistry; photoinactivation; cancer; microorganisms

(This special issue belongs to the Section Molecular Nanoscience)

Editorial Board Members’ Collection Series: Cancer Metastasis

edited by

Carlos Cabañas

and

Sung-Hoon Kim

submission deadline 31 Dec 2025 | 4 articles | Viewed by 13381 | Submission Open

Keywords: biomarkers; liquid biopsy; premetastatic niche; angiogenesis; immune evasion and suppression; genetic and epigenetic determinants; chemoresistance; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

Natural Products in Drug Discovery and Development

edited by Tian-Le Gao

submission deadline 31 Dec 2025 | 10 articles | Viewed by 13235 | Submission Open

Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

The Impact of Natural Bioactive Compounds on Human Health and Disease

edited by

Yeong-geun Lee

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12154 | Submission Open

Keywords: natural product chemistry; nuclear magnetic resonance; structural elucidation; herbal drug

(This special issue belongs to the Section Molecular Pharmacology)

Abiotic Stress Tolerance and Genetic Diversity in Plants, 2nd Edition

edited by

Andrés J. Cortés

submission deadline 31 Dec 2025 | 6 articles | Viewed by 9783 | Submission Open

Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Bamboo, Tree, Grass, and Other Forest Products

edited by

Huayu Sun

submission deadline 31 Dec 2025 | 8 articles | Viewed by 8991 | Submission Open

Keywords: bamboo; tree; grass; molecular biology; gene function

(This special issue belongs to the Section Molecular Plant Sciences)

25th Anniversary of IJMS: Updates and Advances in Molecular Neurobiology

edited by

Kiminobu Sugaya

submission deadline 31 Dec 2025 | 6 articles | Viewed by 8656 | Submission Open

Keywords: molecular neurobiology; neural signaling and gene regulation; synaptic plasticity; neurodevelopment; neurodegeneration; neuroregeneration; neuroinflammation; epigenetics in neuroscience; non-coding RNAs; protein misfolding and aggregation; exosomes and extracellular vesicles; stem cells and neural repair; biomarkers of neurological disease; translational neuroscience; neuropharmacology; brain omics (genomics; proteomics; transcriptomics); neuronal-glial interactions; mitochondrial dysfunction in the nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Coordination Complexes: From Molecular Design to Functional Applications

edited by

Sanaa Musa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7570 | Submission Open

Keywords: coordination complexes; organometallic complexes; functional materials; metal– ligand interactions; homogenous catalysis; sensing; magnetic materials; ligand tunability

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

25th Anniversary of IJMS: Updates and Advances in Molecular Oncology

edited by

Peter J. K. Kuppen

submission deadline 31 Dec 2025 | 9 articles | Viewed by 7449 | Submission Open

Keywords: molecular oncology; cancer epigenetics; tumour heterogeneity; tumour microenvironment; precision oncology; liquid biopsy; cancer immunotherapy

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Advances in Molecular Endocrinology and Metabolism

edited by

José L. Quiles

submission deadline 31 Dec 2025 | 5 articles | Viewed by 7237 | Submission Open

Keywords: molecular endocrinology; metabolic diseases; hormonal regulation; systems biology; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

25th Anniversary of IJMS: Updates and Advances in Macromolecules

edited by

Haiyang Gao

Salah-Eddine Stiriba

and

Zhongzhou Chen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5867 | Submission Open

Keywords: macromolecules; monomers; lipids; peptides; proteins; carbohydrates; polysaccharides; nucleic acids; modification; functionalization; structure– property relationship

(This special issue belongs to the Section Macromolecules)

Recent Progress in Metabolic Diseases

edited by

Dariusz Chlubek

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5331 | Submission Open

Keywords: metabolic diseases; enzymes related to metabolic disorders; inborn errors of metabolism; inherited single-gene anomalies; molecular diagnostics in metabolic disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeted Delivery of Nucleic Acids

edited by Yong-Serk Park

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4906 | Submission Open

Keywords: nucleic acid delivery; gene delivery; pDNA delivery; siRNA delivery; miRNA delivery; mRNA delivery; CRISPR-Cas delivery; nanoparticle; lipid nanoparticle; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Animal Models for Human Diseases

edited by Yuning Song

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4633 | Submission Open

Keywords: animal models; translational research; preclinical studies; biomedical innovation; reproducibility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pro-Inflammatory and Anti-Inflammatory Cytokines

edited by

Juliann G. Kiang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4358 | Submission Open

Keywords: pro-inflammation cytokine; anti-inflammation cytokine; chemotherapy; radiotherapy; signal transduction; microbiome– host response; sepsis; bone marrow; GI; brain

(This special issue belongs to the Section Molecular Immunology)

Advancements in Diagnostic and Preventive Pharmacogenomics

edited by Alireza Tafazoli

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4061 | Submission Open

Keywords: genome profiling; pharmacogenetic analysis; diagnostic pharmacogenomics; pre-emptive pharmacogenomics; advanced genotyping technologies

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Relationship Between Diet and Insulin Resistance

edited by

Domenico Sergi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3956 | Submission Open

Keywords: insulin resistance; lipotoxicity; lipid metabolism; type 2 diabetes mellitus; dietary lipids; lipidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

25th Anniversary of IJMS: Updates and Advances in Molecular Nanoscience

edited by Qi Zhang,

Marilena Carbone

and

André F. Moreira

submission deadline 31 Dec 2025 | 6 articles | Viewed by 3847 | Submission Open

Keywords: nanotechnology; nanomaterials; nanomedicine; nanostructures; 2D materials; smart nanomaterials; nanocatalysts; nanozymes

(This special issue belongs to the Section Molecular Nanoscience)

25th Anniversary of IJMS: Updates and Advances in Molecular Genetics and Genomics

edited by

Francesco Sessa

Lasse Lindahl

and

Apostolos Zaravinos

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3763 | Submission Open

Keywords: molecular genetics; genomics; precision medicine; genetic diagnostics; gene therapy; next-generation sequencing (NGS); pharmacogenomics; epigenetics; forensic genomics; translational genomics; genome replication; gene expression; cell stress; cell cycle; cell signaling; macromolecular surveillance and turnover; molecular evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Dietary Supplements: A Delicate Balance Between Benefit and Harm

edited by

Carmen Cantisani

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3451 | Submission Open

Keywords: dietary supplements; antioxidants; skin; ageing; wellness

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutting-Edge Insights into Bacterial Infection and Host Immune Response

edited by

Pablo C. Baldi

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3416 | Submission Open

Keywords: bacteria– host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers

edited by

Alessandro Mannucci

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3311 | Submission Open

Keywords: gastrointestinal cancers; liquid biopsy; circulating biomarkers; minimal residual disease; early cancer detection; tumor-agnostic assays; molecular diagnostics; precision oncology; predictive biomarkers; translational research

(This special issue belongs to the Section Molecular Oncology)

Molecular Biomarkers for Targeted Therapies

edited by Vija Lavinia

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3076 | Submission Open

Keywords: biomarkers; molecular targeted radiotherapies; prognostic biomarkers; predictive biomarkers; single or composite biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ion and Molecule Transport in Membrane Systems, 6th Edition

edited by

Victor V. Nikonenko

and

Dmitrii Butylskii

submission deadline 31 Dec 2025 | 4 articles | Viewed by 3024 | Submission Open

Keywords: ion and molecular transport; physical chemistry; chemical physics; transport mechanisms; living systems; biological and artificial membranes; biomimetic structure; structure– property relationships; thermodynamics; irreversible thermodynamics; equilibriums; kinetics

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Functional Food Ingredients in Immunity Improvement

edited by

Prodromos Skenderidis

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2990 | Submission Open

Keywords: functional food ingredients; bioactive compounds; health potentials; food processing and immunomodulation; green extraction techniques; molecular mechanisms; nutritional immunology; dietary intervention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Biological Activities of Curcumin and Its Analogues

edited by Francis Johnson

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2723 | Submission Open

Keywords: curcumin; analogues; natural compounds; inflammation; tissue reconstruction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches

edited by

Whi-An Kwon

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2698 | Submission Open

Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanism Involved in Cancer Metastasis

edited by

Mohamed Jemaà

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2685 | Submission Open

Keywords: cell motility; cell migration; spheroid; metastasis; extracellular matrix; cell architecture; lamellipodia; epithelial-mesenchymal transition EMT; videomicroscopy; confocal microscopy; animal model

(This special issue belongs to the Section Molecular Oncology)

25th Anniversary of IJMS: Advances in Physical Chemistry and Chemical Physics

edited by

Mihai V. Putz

Hyotcherl Ihee

and

Carlos Miguel Costa

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2525 | Submission Open

Keywords: molecular dynamics; quantum chemistry; spectroscopic techniques; supramolecular interactions; computational modeling; AI in chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)

edited by

Yoshinori Marunaka

Masayuki Takahashi

Yusaku Iwasaki

, Atsushi Shiozaki and Akiyuki Taruno

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2348 | Submission Open

Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function

(This special issue belongs to the Section Biochemistry)

25th Anniversary of IJMS: Updates and Advances in "Materials Science" Section

edited by

Miklós Fried

and

Filippo Rossi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1875 | Submission Open

Keywords: nanomaterials; functional polymers; bio-inspired systems; complex intelligent; responsive materials

(This special issue belongs to the Section Materials Science)

Physicochemical Properties and Applications of Nanomaterials in Biology and Medicine

edited by

Gangho Lee

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1797 | Submission Open

Keywords: nanoparticle; nanomaterial; biomedicine; synthesis; physicochemical properties; imaging; therapy; contrast agent; therapeutic agent

(This special issue belongs to the Section Molecular Nanoscience)

Biomolecular Structure, Function and Interactions: 2nd Edition

edited by

Ivo Crnolatac

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1797 | Submission Open

Keywords: biophysical chemistry; protein– protein interactions; protein– DNA interactions; protein– ligand interactions; receptor– ligand interactions; biomolecular structure and function; protein folding and stability

(This special issue belongs to the Section Biochemistry)

25th Anniversary of IJMS: Updates and Advances in Molecular Informatics

edited by

M. Natália D.S. Cordeiro

and

Giulio Vistoli

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1713 | Submission Open

Keywords: AI-guided drug repurposing; virtual screening in personalized medicine; machine learning for toxicity prediction; network-based biomarkers in complex diseases; in silico pharmacokinetics and ADMET profiling; data-driven materials design; deep learning for molecular property prediction; AI-assisted nanomaterial synthesis; systems biology models for metabolic engineering

(This special issue belongs to the Section Molecular Informatics)

Plant Genome Evolution and Environmental Adaptation

edited by

Zhonghu Li

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1675 | Submission Open

Keywords: plant phylogeny; genome evolution; molecular evolution of cytoplasmic genomes; species divergence

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Technologies and Molecular Approaches in Brain Disease Diagnosis and Therapy

edited by

Furong Tian

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1646 | Submission Open

Keywords: neurodegenerative diseases; brain cancer; nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into RNA Diseases

edited by

Naoyuki Kataoka

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1617 | Submission Open

Keywords: RNA splicing; RNA modification; RNA processing; translation; RNA transport

(This special issue belongs to the Section Molecular Genetics and Genomics)

Research Progress in Cellular Senescence in Health and Disease

edited by

Gabriella Teti

and Mirella Falconi

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1563 | Submission Open

Keywords: senotherapy; cellular senescence; physiological relations; pathological relations; cell biology in aging; age-related diseases; senescence in mesenchymal stroma cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Ovarian Cancer Metastasis and Chemotherapy Resistance

edited by

Carmela Ricciardelli

and

Noor A. Lokman

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1476 | Submission Open

Keywords: ovarian cancer; metastasis; biomarkers; chemotherapy resistance; tumor microenvironment; peritoneal– cancer cell interactions; proteomics; novel therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Advances in Conventional Tree Breeding: Integrating Phenotypic Selection, Genetic Gain, and Sustainable Forest Management

edited by

Jingli Yang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1368 | Submission Open

Keywords: forest trees; genetic breeding; conventional tree breeding; forest management; forest tree varieties; modern molecular technology; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Melanoma: From Molecular Pathology to Therapeutic Approaches, 2nd Edition

edited by

Michael Eccles

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1354 | Submission Open

Keywords: melanoma; pathology; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Advances in Ocular Disease

edited by Da-Wen Lu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1239 | Submission Open

Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research of Plant-Pathogen Interaction

edited by

Hyong Woo Choi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1231 | Submission Open

Keywords: molecular plant-pathogen interactions; pathogen detection; secondary metabolism; multi-omics approaches; antibiotic resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Focus on Plant Biotechnology and Molecular Breeding

edited by

Magdalena Wróbel-Kwiatkowska

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1221 | Submission Open

Keywords: genetic engineering; plant transformation; applied biotechnology; functional genomics; crop plants; crop improvement; plant tissue cultures; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Forensic Molecular Biology and Genetics

edited by

Anna Barbaro

submission deadline 31 Dec 2025 | Viewed by 1138 | Submission Open

Keywords: nuclear and mt-DNA; rapid DNA analysis; next-generation sequencing; mRNA analysis; microbiome analysis; barcode DNA; time since deposition; fluid identification; DNA phenotyping; DNA ancestry

(This special issue belongs to the Section Molecular Biology)

Nanobiomaterials and Beyond: Innovations in Drug Delivery, Diagnostics, and Therapeutics

edited by

Alexandru Mihai Grumezescu

and

Adelina-Gabriela Niculescu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1112 | Submission Open

Keywords: nanobiomaterials; drug delivery systems; targeted drug delivery; controlled drug release; stimulus-responsive nanomaterials; biocompatibility; biodegradability; functionalized nanocarriers; theranostics; nanocarriers for cancer therapy; tumor-targeted drug delivery; organ-specific delivery systems; pH-responsive materials; temperature-sensitive nanobiomaterials; light-activated drug delivery; enzyme-responsive systems; multimodal nanomaterials; translational nanomedicine; computational modeling in nanobiomaterials; preclinical studies of nanomaterials

(This special issue belongs to the Section Materials Science)

Nature-Inspired and Synthetic Compounds: New Frontiers in Bioactivity and Drug Discovery

edited by

Alina Bora

and

Luminita Crisan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1078 | Submission Open

Keywords: natural and synthetic products; drug discovery and development; drug repurposing; artificial intelligence and machine learning; biological evaluation; healthcare; green and sustainable chemistry; natural and synthetic drug applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Inflammasomes

edited by

Roberto Negro

submission deadline 31 Dec 2025 | Viewed by 1042 | Submission Open

Keywords: inflammasome; pyroptosis; innate immunity; cancer; neurodegenerative diseases; microbiota; gasdermin; ninjurin; drug screening; personalized treatments; multi-omics analysis

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of Human Reproduction

edited by

Houda Amor

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1032 | Submission Open

Keywords: human reproduction; genomics; transcriptomics; proteomics; imaging technologies

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 901-950 on page 19 of 69.

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