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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Molecular Research of Animal Genetics and Genomics

edited by Congjiao Sun

submission deadline 28 Feb 2026 | 1 articles | Viewed by 628 | Submission Open

Keywords: animal genetics; animal genomics; molecular breeding; genetic improvement; molecular evolution; genomic selection; genome-wide association studies (GWAS); CRISPR; multiomics analysis; animal conservation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Design, Synthesis, Application and Mechanism of Functional Polymers

edited by Jingyuan Liu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 599 | Submission Open

Keywords: functional polymers; polymer synthesis; structure– property relationship; molecular mode of actions; interfacial interaction; molecular design; smart materials; functional coatings; biomedical applications; energy storage

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Toxicity Caused by Environmental Pollutants

edited by Ivan Girón-Perez

submission deadline 28 Feb 2026 | 1 articles | Viewed by 561 | Submission Open

Keywords: environmental pollutant; molecular toxicity; immunotoxicology; neurotoxicity

(This special issue belongs to the Section Molecular Toxicology)

Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants: 3rd Edition

edited by

Shanfa Lu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 552 | Submission Open

Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Imprinting Technologies for Biological and Biomedical Applications

edited by

Urtė Prentice

and

Simonas Ramanavičius

submission deadline 28 Feb 2026 | 1 articles | Viewed by 552 | Submission Open

Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications

(This special issue belongs to the Section Molecular Informatics)

Role of Integrins in Cytokine Signaling

edited by

Yoshikazu Takada

submission deadline 28 Feb 2026 | 1 articles | Viewed by 528 | Submission Open

Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation

(This special issue belongs to the Section Molecular Biology)

Brain–Immune Crosstalk and Ischemic Injury

edited by

Yvonne Couch

submission deadline 28 Feb 2026 | 1 articles | Viewed by 485 | Submission Open

Keywords: stroke; ischemia; haemorrhage; inflammation; cytokines; macrophages; neutrophils; microglia; immunity

(This special issue belongs to the Section Molecular Immunology)

Flowers: Molecular and Genetic Regulation of Growth and Development

edited by Yaqin Wang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 448 | Submission Open

Keywords: flower; growth and development; molecular regulation; genetic breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

edited by

Eric Santoni-Rugiu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 437 | Submission Open

Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance

(This special issue belongs to the Section Molecular Oncology)

Molecular Research and Utilization of Environmental Microbial Resources

edited by

Hikmate Abriouel

submission deadline 28 Feb 2026 | 1 articles | Viewed by 416 | Submission Open

Keywords: environmental microbiology; molecular microbial resources; microbial metabolites; microbial diversity; microbial ecology; bioremediation; agricultural microbiology; omics technologies; biofilm formation; microbiome applications

(This special issue belongs to the Section Molecular Microbiology)

Oral and Dental Infectious Diseases: Molecular Pathology, Diagnosis and Therapy (2nd Edition)

edited by

Keiji Murakami

and

Hiromichi Yumoto

submission deadline 28 Feb 2026 | 1 articles | Viewed by 413 | Submission Open

Keywords: oral; dental; periodontitis; tooth decay; periodontal diseases; gingivitis; oral microorganism; oral infections; dental infections; dental caries; microbial pathogenicity; porphyromonas gingivalis; antimicrobials; oral biofilm

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Peptides: Discovery, Synthesis, and Therapeutic Applications

edited by

Chuan-Mu Chen

submission deadline 28 Feb 2026 | 1 articles | Viewed by 413 | Submission Open

Keywords: bioactive peptides; functional food-derived peptides; antimicrobial and antiviral peptides; peptide drug design and delivery; anticancer peptides; peptide-based therapeutics; regenerative medicine; immunomodulatory peptides; structure– function relationships; translational peptide research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Electromagnetic Field Interactions with Biomolecules

edited by

Svetlana Jovanović

submission deadline 28 Feb 2026 | 1 articles | Viewed by 413 | Submission Open

Keywords: nonionizing electromagnetic fields; biomolecules; proteins; oxidative stress; Fe metabolism; amyloid-β peptide

(This special issue belongs to the Section Materials Science)

Schiff Bases and Their Metal Complexes: Structure, Synthesis, and Biological Application

edited by Nenad Filipovic

submission deadline 28 Feb 2026 | Viewed by 393 | Submission Open

Keywords: hydrazones; (thio/seleno)semicarbazones; oximes; antimicrobial activity; anticancer activity; enzyme inhibition; metal complexes; diagnostic agents; photothermal therapy; photodynamic therapy

(This special issue belongs to the Section Biochemistry)

Advances in Plant Protein and Enzyme Inhibitors

edited by Yan Zhang

submission deadline 28 Feb 2026 | Viewed by 389 | Submission Open

Keywords: plant proteins; active substances; bioactive compounds; enzyme inhibitors

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Perspective on Skeletal Muscle Regeneration

edited by Xuhui Liu

submission deadline 28 Feb 2026 | 1 articles | Viewed by 382 | Submission Open

Keywords: skeletal muscle regeneration; satellite cells; stem cell niche; fibro/adipogenic progenitors; aging; muscle stem cells; cell– cell interactions; fibrosis and fatty infiltration; translational therapeutics

(This special issue belongs to the Section Molecular Biology)

Molecular Studies on Wnt Signaling

edited by Katalin Mészáros

submission deadline 28 Feb 2026 | 1 articles | Viewed by 378 | Submission Open

Keywords: Wnt signaling pathway; inhibitor; cancer; treatment; drugs

(This special issue belongs to the Section Molecular Biology)

Environmental Exposures and Chronic Obstructive Pulmonary Disease Pathogenesis

edited by

Abderrazzak Bentaher

submission deadline 28 Feb 2026 | Viewed by 317 | Submission Open

Keywords: chronic obstructive pulmonary disease; environmental exposures; disease pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidant and Antidiabetic Potential of Natural Products in the Management of Diabetes and Its Complications

edited by

Ochuko Lucky Erukainure

submission deadline 28 Feb 2026 | 1 articles | Viewed by 285 | Submission Open

Keywords: diabetes; natural products; obesity; medicinal plants; oxidative stress; antioxidants

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Molecular Insights in Oral Health and Disease

edited by

Iulia-Ioana Stanescu-Spinu

and

Tudor Claudiu Spînu

submission deadline 28 Feb 2026 | Viewed by 281 | Submission Open

Keywords: oral health; saliva; oral diseases; molecular insights; molecular targets; oral cavity physiology; wound healing; oral microbiome; oral biocompatibility; material interactions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Regenerative and Anti-Aging Medicine

edited by

Takayuki Yoshimoto

submission deadline 28 Feb 2026 | Viewed by 263 | Submission Open

Keywords: induced pluripotent stem cells (iPSCs); mesenchymal stem cells (MSCs); platelet-rich plasma (PRP); placenta; organoid; secretome; exosome; senolytics; nicotinamide mononucleotide (NMN); nicotinamide adenine dinucleotide+ (NAD+)

(This special issue belongs to the Section Molecular Biology)

The Role of Dietary Polyphenols and Dietary Polysaccharides in Human Diseases

edited by

Francisco Les

submission deadline 28 Feb 2026 | Viewed by 231 | Submission Open

Keywords: dietary polyphenols; dietary polysaccharides; bioactive compounds; chronic diseases prevention; functional foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Plant Abiotic Stress Tolerance: 3rd Edition

edited by

Michael Moustakas

submission deadline 28 Feb 2026 | Viewed by 220 | Submission Open

Keywords: acclimation; drought; salinity; pesticides; high–low temperature; high–low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Strategies for Enhancing Skeletal Muscle Recovery and Regeneration in Health and Disease Conditions

edited by

Elen Miyabara

and

Atsushi Asakura

submission deadline 28 Feb 2026 | Viewed by 218 | Submission Open

Keywords: skeletal muscle; regeneration; muscle wasting; aging; muscle diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Translational Insights in Neurological Disorders

edited by Tiago Santos

submission deadline 28 Feb 2026 | Viewed by 208 | Submission Open

Keywords: neurological disorders; molecular mechanisms; translational neuroscience; drug targets; biomarkers; neurodegenerative disorders; neuroinflammatory conditions; demyelinating conditions; cerebrovascular conditions; neurodevelopmental disorders; mood disorders; anxiety disorders; spinal cord injury; traumatic brain injury; precision neurology; therapeutic development

(This special issue belongs to the Section Molecular Neurobiology)

Interactions and Functions Between Peptides and Polysaccharides

edited by

Kexue Zhu

and

Xianxiang Chen

submission deadline 28 Feb 2026 | Viewed by 200 | Submission Open

Keywords: polysaccharides; peptides; bioactivity; structural analysis; polysaccharide– peptide complexes; interactions; gut microbiota; immune regulation; interaction dynamics

(This special issue belongs to the Section Biochemistry)

New Progress in Peptidic Protease Inhibitors

edited by

Roberta Ettari

and Carla Di Chio

submission deadline 28 Feb 2026 | Viewed by 200 | Submission Open

Keywords: peptide inhibitors; infectious diseases; cancer; metabolic disorders; neurological disorders; inflammation

(This special issue belongs to the Section Biochemistry)

Molecular Mechanism in Cardiac Remodeling

edited by Xianming Lin and

Xiaobo Wu

submission deadline 28 Feb 2026 | Viewed by 199 | Submission Open

Keywords: cardiomyopathy; cardiac arrhythmias; ion channel; calcium transient

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurofibromatosis Type 1 and NF2-Related Schwannomatosis: Advances from Basic Research to Current Therapies

edited by

Bumjoon Park

and

Baehoon Kim

submission deadline 28 Feb 2026 | Viewed by 195 | Submission Open

Keywords: neurofibromatosis type 1 (NF1); neurofibromin; RAS/MAPK pathway; malignant peripheral nerve sheath tumor (MPNST); NF2-related schwannomatosis (NF2 syndrome); Merlin (Schwannomin); vestibular schwannoma; meningioma; ependymoma

(This special issue belongs to the Section Molecular Neurobiology)

Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition

edited by

Tao Sun

and

Xujin Bao

submission deadline 28 Feb 2026 | Viewed by 183 | Submission Open

Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis

(This special issue belongs to the Section Materials Science)

Role of Extracellular Vesicles in Immune Regulation

edited by Rachel Crossland

submission deadline 28 Feb 2026 | Viewed by 182 | Submission Open

Keywords: extracellular vesicle; immune regulation; immunomodulation; antigen presentation; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Abnormal Production and Structure of Hemoglobin Molecules

edited by Maria Dimopoulou

submission deadline 28 Feb 2026 | Viewed by 178 | Submission Open

Keywords: hemoglobin; hemoglobinopathies; thalassemias; sickle cell disease; structural hemoglobin variants; alpha globin; beta globin; globin chain genes; unstable hemoglobins; oxygen affinity

(This special issue belongs to the Section Biochemistry)

Neutrophil Extracellular Traps (NETs) in Human Disease: From Molecular Mechanisms to Therapeutic Translation

edited by

Michael Boettcher

and Julia Elrod

submission deadline 28 Feb 2026 | Viewed by 176 | Submission Open

Keywords: neutrophil extracellular traps (NETs); molecular mechanisms; human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Using Model Organisms to Study Complex Human Diseases—2nd Edition

edited by

Roberto Piergentili

submission deadline 28 Feb 2026 | Viewed by 169 | Submission Open

Keywords: model organism; Escherichia coli; yeast; Caenorhabditis elegans; Drosophila melanogaster; zebrafish; Arabidopsis thaliana; Xenopus laevis; rat and mouse model; human disease; inherited disease; cancer; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Functional Foods: Molecular Insights into Nutrition and Health

edited by Patroklos Vareltzis

submission deadline 28 Feb 2026 | Viewed by 165 | Submission Open

Keywords: functional foods; bioactive compounds; disease prevention; nutritional health; food innovation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Melatonin and Related Indolic Agents

edited by

Burkhard Poeggeler

submission deadline 28 Feb 2026 | Viewed by 159 | Submission Open

Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan

(This special issue belongs to the Section Molecular Pharmacology)

Alcohol Use Disorder: From Molecular Mechanisms to Therapeutics

edited by

Giampiero Ferraguti

submission deadline 28 Feb 2026 | Viewed by 157 | Submission Open

Keywords: alcohol; addiction; FASD; alcohol-related damage

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Molecules to Cognition: Biomarkers and Neuropsychological Tools in Neurological Disorders

edited by

Silvia Boschi

submission deadline 28 Feb 2026 | Viewed by 157 | Submission Open

Keywords: biomarkers; neuropsychological assessment; neurological disorders; neuroimaging; cognitive function; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Nanomaterials in Tissue Engineering and Regenerative Medicine: Recent Advances and Future Prospects

edited by

Kapil D. Patel

submission deadline 28 Feb 2026 | Viewed by 156 | Submission Open

Keywords: nanoparticles; nanofibers; nanotubes; nanocomposites; hydrogels; ceramics; bioactive glass nanoparticles; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

Dermatological Perspectives on Connective Tissue Diseases

edited by Yoshihide Asano

submission deadline 28 Feb 2026 | Viewed by 155 | Submission Open

Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjö gren’ s syndrome; skin immunology; fibrosis; cytokines; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Vascular Sclerosis

edited by Michishige Terasaki

submission deadline 28 Feb 2026 | Viewed by 151 | Submission Open

Keywords: atherosclerosis; genes; dyslipidemia; diabetes; macrophages; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Photodynamic Therapy in Cancer

edited by

Natalia Belén Rumie Vittar

submission deadline 28 Feb 2026 | Viewed by 148 | Submission Open

Keywords: tumor microenvironment; CAF; hypoxia; immune evasion; combined therapies; new cellular or molecular targets

(This special issue belongs to the Section Molecular Oncology)

Molecular Strategies for the Discovery, Optimization, and Efficient Use of Green Pesticides

edited by

Hongjian Song

submission deadline 28 Feb 2026 | Viewed by 148 | Submission Open

Keywords: natural-product-based pesticides; total synthesis; structural optimization; bioactivity evaluation; structure– activity relationship

(This special issue belongs to the Section Molecular Pharmacology)

Insights into Multiple Myeloma: Immune Microenvironment, Disease Mechanisms, and Therapeutic Innovations

edited by

Ichiro Hanamura

submission deadline 28 Feb 2026 | Viewed by 147 | Submission Open

Keywords: multiple myeloma; bone marrow microenvironment; disease biology; disease progression; treatment resistance; CAR-T cells; bispecific antibodies (BsAbs); antibody-drug conjugates (ADCs); tumor– host interaction

(This special issue belongs to the Section Molecular Oncology)

Cancer Nanomedicine: Imaging, Targeting and Therapeutic Applications

edited by

Marvin Xavierselvan

and

Steven Fiering

submission deadline 28 Feb 2026 | Viewed by 145 | Submission Open

Keywords: cancer nanomedicine; multimodal imaging; nanoparticle drug delivery; tumor targeting; theranostic nanoparticles; combination therapies

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research of Cognitive Impairment and Neuropsychiatric Symptoms in Late Life: From Pathogenesis to Treatment

edited by

Ioannis Liampas

submission deadline 28 Feb 2026 | Viewed by 144 | Submission Open

Keywords: dementia; Alzheimer’ s disease; mild cognitive impairment; mild behavioral impairment; movement disorders; Parkinson’ s disease; biomarkers; neurogenetics; molecular research

(This special issue belongs to the Section Molecular Neurobiology)

Liver Pathophysiology and Its Role in Systemic Diseases

edited by Vassilios Sevastianos

submission deadline 28 Feb 2026 | Viewed by 143 | Submission Open

Keywords: liver disease; endocrine functions; liver-targeted drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms and Applications of Heterosis in Plants

edited by