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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neuroblastoma: Molecular Pathology, Diagnostics and Therapeutics

edited by

Simona Dedoni

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1947 | Submission Open

Keywords: neuroblastoma; solid cancer; immature nerve cells; molecular mechanism; biomarker; tumor heterogeneity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plasma-Based Technologies for Food Safety and Health Enhancement

edited by

Ihn Han

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1860 | Submission Open

Keywords: plasma-based technologies; food safety; microbial pathogens; oxidative stability; nutrient preservation

(This special issue belongs to the Section Biochemistry)

Cancer Immunotherapy Biomarkers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Apostolos Zaravinos

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1849 | Submission Open

Keywords: tumor microenvironment; tumor immunology; cancer biomarkers; immunotherapy; immunohistochemistry; pathology; personalized medicine; omics technologies; prognosis and therapy; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Toxicity Research of Biological Venoms

edited by

Karla De Castro Figueiredo Bordon

and Suely Vilela Sampaio

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1842 | Submission Open

Keywords: neurotoxicity assays; insect models; electrophysiology; screening assays; ion channels; therapeutic molecules; animal venoms; antitumoral activity; enzyme activity; biotechnological application

(This special issue belongs to the Section Molecular Toxicology)

Molecular Biological Determination of Physical Injury

edited by

Sorin Hostiuc

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1728 | Submission Open

Keywords: molecular markers; physical injury; micro-RNA; dating of traumatic injuries

(This special issue belongs to the Section Molecular Biology)

Unravelling Functional Biology in Retinal Dystrophies and Eye Disease

edited by

Luigi Donato

and

Simona Alibrandi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 1062 | Submission Open

Keywords: precision ophthalmology; inherited retinal diseases; functional genomics; multi-omics approaches; photoreceptor degeneration; retinal organoids and iPSC models; bioinformatics and systems biology; genotype– phenotype correlations; RNA therapeutics and gene editing; early and late biomarkers of retinal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Significance and Challenges of Plant-Derived Natural Compounds in Cancers

edited by Ba Vinh Le

submission deadline 30 Jan 2026 | 1 articles | Viewed by 955 | Submission Open

Keywords: metabolomic; bioactive compound; pharmacognosy; oriental medicine; drug discovery; pharmacology; anti-cancer; pharmacological effects

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Biogenesis, Structure, Function and Division of Plastids

edited by

Xiaomin Liu

and Li'na Yin

submission deadline 30 Jan 2026 | Viewed by 938 | Submission Open

Keywords: plastid; chloroplast; chlorophyll; endosymbiotic cyanobacteria; photosynthesis; genetic engineering

(This special issue belongs to the Section Biochemistry)

Exosomes and Non-Coding RNA Research in Health and Disease—2nd Edition

edited by Stergios Boussios

submission deadline 30 Jan 2026 | 1 articles | Viewed by 896 | Submission Open

Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetics of Metabolic Diseases

edited by

Makrina Karaglani

submission deadline 30 Jan 2026 | 1 articles | Viewed by 819 | Submission Open

Keywords: epigenetics; metabolic diseases; DNA methylation; histone modifications; non-coding RNAs; obesity; diabetes; metabolic syndrome

(This special issue belongs to the Section Molecular Genetics and Genomics)

KRAS-Mutant Cancers: From Basic Biology to Clinical Translation

edited by

Mirela Sedic

Sérgia Velho

and Luka Bočkor

submission deadline 30 Jan 2026 | Viewed by 807 | Submission Open

Keywords: KRAS mutations; KRAS signalling; cancer; KRAS inhibitors; drug resistance; tumour microenvironment; cellular metabolism

(This special issue belongs to the Section Molecular Oncology)

Latest Advances in Aquatic Genetic Improvement

edited by Jun Qiang,

Yifan Tao

and Wenjing Tao

submission deadline 30 Jan 2026 | 1 articles | Viewed by 706 | Submission Open

Keywords: aquaculture genetic breeding; genomic selection; gene editing; disease-resistant breeding; multi-omics analysis; stress resistance enhancement; smart aquaculture; artificial intelligence

(This special issue belongs to the Section Molecular Genetics and Genomics)

Spectral Control of Stress Response in Plants

edited by

Gábor Kocsy

and Zsolt Gulyás

submission deadline 30 Jan 2026 | 1 articles | Viewed by 678 | Submission Open

Keywords: spectral control; stress response; light spectrum; photoreceptor; reactive oxygen; plant hormone; antioxidant; plant growth and development

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Molecular and Cellular Approaches to Tuberculosis Pathogenesis, Treatment and Prevention

edited by

Selvakumar Subbian

submission deadline 30 Jan 2026 | 1 articles | Viewed by 650 | Submission Open

Keywords: tuberculosis (TB); animal models of mycobacterium infections; molecular pathogenesis; host-directed therapy (HDT); nanoparticle drug delivery; vaccine development; cellular immunology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Dialogues in the Tumor Microenvironment: Mechanisms, Methods and Therapeutic Implications

edited by

José M. Muñoz-Félix

submission deadline 30 Jan 2026 | 1 articles | Viewed by 612 | Submission Open

Keywords: tumor microenvironment; blood vessels; immune cells; spatial transcriptomics; histology

(This special issue belongs to the Section Molecular Oncology)

Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies

edited by Osha Roopnarine

submission deadline 30 Jan 2026 | Viewed by 600 | Submission Open

Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies

(This special issue belongs to the Section Molecular Pharmacology)

New Research Perspectives in Protein Glycosylation

edited by

Hirokazu Yagi

submission deadline 30 Jan 2026 | 1 articles | Viewed by 588 | Submission Open

Keywords: glycan function; glycan structural analysis; glycoproteomics; glycoengineering; systems glycobiology

(This special issue belongs to the Section Biochemistry)

Chemoinformatics and Bioinformatics Tools in Structure-Activity Modelling in Molecular Sciences: 3rd Edition

edited by

Bono Lučić

submission deadline 30 Jan 2026 | Viewed by 585 | Submission Open

Keywords: chemoinformatics tools and models; bioinformatics tools and models; structure– activity modeling; structure– property modeling; QSAR; QSPR; drug/structure identification in bioprospecting research; molecular docking; molecular interactions; protein– protein interactions; development of algorithms; databases and web servers; data mining in chemoinformatics and bioinformatics; structure representation and optimization; molecular descriptors; modeling of health and environmentally relevant endpoints (activities; properties); toxicity modeling and prediction; carcinogenicity modeling and prediction; computational methods in molecular sciences; model validation approaches; multivariate modeling; predictive modeling; descriptive modeling; continuous data modeling; classification data modeling; machine learning in molecular sciences; deep learning in molecular sciences; structure visualization tools

(This special issue belongs to the Section Molecular Informatics)

Molecular Research and Insights into Anti-Cancer Vaccines

edited by

Alfredo Martínez

submission deadline 30 Jan 2026 | 1 articles | Viewed by 564 | Submission Open

Keywords: anti-cancer vaccines; tumor antigens; molecular mechanisms; immunotherapy; molecular oncology

(This special issue belongs to the Section Molecular Oncology)

Protease and Carbonic Anhydrase Inhibitors: 3rd Edition

edited by

Alessio Nocentini

submission deadline 30 Jan 2026 | Viewed by 552 | Submission Open

Keywords: carbonic anhydrase; protease; inhibitor; antiviral drug; antitumor drug; drug design; serine protease; metalloprotease; aspartic protease

(This special issue belongs to the Section Biochemistry)

Experimental Models and Applications in Muscle Regeneration

edited by

Daiva Bironaite

submission deadline 30 Jan 2026 | Viewed by 546 | Submission Open

Keywords: stem cells; internal and external stimuli; scaffolds; signaling systems; muscle regeneration mechanisms

(This special issue belongs to the Section Molecular Biology)

Hepatocellular Carcinoma: From Pathophysiology to Innovative Therapeutic Approaches

edited by Andrea Martini

submission deadline 30 Jan 2026 | Viewed by 538 | Submission Open

Keywords: liver carcinogenesis; tumor microenvironment; immune surveillance; fibrogenesis; inflammation

(This special issue belongs to the Section Molecular Oncology)

Insights into Neurological and Psychiatric Diseases from Invertebrate Models

edited by

Efthimios M. C. Skoulakis

submission deadline 30 Jan 2026 | Viewed by 480 | Submission Open

Keywords: disease model development; disease model validation; GWAS validation; ameliorative approaches; pharmacogenetics; pharmacoproteomics; disease mechanisms; suppressor/enhancer genetic screens; synthetic lethality screens; biomarker screens and validation

(This special issue belongs to the Section Molecular Neurobiology)

Autoimmune and Inflammatory Diseases: Latest Advances and Prospects

edited by

Paola Galozzi

submission deadline 30 Jan 2026 | Viewed by 479 | Submission Open

Keywords: autoimmunity; autoimmune disease; inflammation; inflammatory disease; cellular pathways; molecular mechanisms; pathogenesis; therapy

(This special issue belongs to the Section Molecular Immunology)

Inflammation and Metabolic Response in Mitochondrial Diseases

edited by

Guido Primiano

submission deadline 30 Jan 2026 | Viewed by 418 | Submission Open

Keywords: mitochondrial diseases; mitochondria; mtDNA; metabolic remodeling; inflammation; immunity; cell death; neurodegenration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence in Human Disease: Current and Future Perspectives in Digital Medicine

edited by

Dumache Raluca-Oana

submission deadline 30 Jan 2026 | Viewed by 399 | Submission Open

Keywords: molecular genetics; artificial intelligence; pharmacogenomics; internet of things; molecular pathology; genomic medicine

(This special issue belongs to the Section Molecular Informatics)

New Insights in Nanomaterials and Electroactive Molecules—in Memory of Prof. Royce W. Murray

edited by

Zeev Porat

submission deadline 30 Jan 2026 | Viewed by 374 | Submission Open

Keywords: nanomaterials; organic electrochemistry; macromolecules and polymers; analytical chemistry

(This special issue belongs to the Section Molecular Nanoscience)

Tumor Specific Immunotherapeutic Targets

edited by

Roberto Perris

submission deadline 30 Jan 2026 | Viewed by 364 | Submission Open

Keywords: immunotherapy; immunotherapeutics; tumour-specific antigens; immunotherapeutic targets; multi-omics approaches

(This special issue belongs to the Section Molecular Immunology)

Plant Cell/Organ Structure and Function Research

edited by

Bartosz Płachno

submission deadline 30 Jan 2026 | Viewed by 324 | Submission Open

Keywords: leaf development; root development; plant cell ultrastructure; plant morphogenesis; plant organs and bacteria; fungi and animal interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Nutritional Modulators of Healthy Longevity: Mechanisms and Interventions

edited by

Shaokang Wang

submission deadline 30 Jan 2026 | Viewed by 304 | Submission Open

Keywords: aging; healthspan; nutrient signaling; oxidative stress; inflammation; autophagy; sarcopenia; bioactive compounds; molecular nutrition; protein metabolism

(This special issue belongs to the Section Molecular Biology)

Developing Methods and Molecular Basis in Plant Biotechnology: 2nd Edition

edited by

Wojciech Makowski

submission deadline 30 Jan 2026 | Viewed by 261 | Submission Open

Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress

(This special issue belongs to the Section Molecular Plant Sciences)

Photosensitizers for Photodynamic Therapy: From Molecular Design to Application

edited by

Carlos Monteiro

M. Amparo F. Faustino

and

Leandro M. O. Lourenço

submission deadline 30 Jan 2026 | Viewed by 225 | Submission Open

Keywords: photodynamic therapy (PDT); photosensitizers (PS); reactive oxygen species (ROS); molecular design; nanocarriers; porphyrins and analogs; targeted drug delivery; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Post-Mortem Toxicology

edited by

Rafał Skowronek

submission deadline 30 Jan 2026 | Viewed by 203 | Submission Open

Keywords: post-mortem toxicology; fatal poisoning; new psychoactive substances; opioids; analytical methods; interpretation of test results

(This special issue belongs to the Section Molecular Toxicology)

Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches

edited by Yuehling Hsieh

submission deadline 30 Jan 2026 | Viewed by 188 | Submission Open

Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis and Molecular Applications of Nanomaterials

edited by

Fernando J. Pereira

A. Javier Aller

and

Roberto Lopez

submission deadline 30 Jan 2026 | Viewed by 158 | Submission Open

Keywords: nanomaterials; synthesis; molecular applications

(This special issue belongs to the Section Molecular Nanoscience)

Interaction of Gut Microbiota and Food Bioactive Compounds

edited by

Yiming Feng

and

Xiaohong Sun

submission deadline 30 Jan 2026 | Viewed by 154 | Submission Open

Keywords: gut microbiome; molecular mechanisms; metabolomics; transcriptomics; bioactive compounds; microbial enzymes; host– microbe signaling; personalized nutrition; systems biology; functional genomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Plant–Rhizobium Interaction

edited by Rujin Chen

submission deadline 30 Jan 2026 | Viewed by 151 | Submission Open

Keywords: legume; rhizobia; symbiotic nitrogen fixation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insight into Oral Health: Disease and Medicine

edited by Norio Sogawa

submission deadline 30 Jan 2026 | Viewed by 151 | Submission Open

Keywords: oral health; disease; molecular medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Immune Mechanisms in Kidney Disease

edited by Niels Olsen Saraiva Câmara

submission deadline 30 Jan 2026 | Viewed by 141 | Submission Open

Keywords: kidney disease; molecular sensors; kidney metabolism; immunity; AKI to CKD transition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence Advancing Computer-Aided Drug Discovery

edited by

Raju Dash

submission deadline 30 Jan 2026 | Viewed by 136 | Submission Open

Keywords: machine learning; deep learning; computer-aided drug design; target identification; AI-assisted molecular diagnosis; AI-driven pharmacokinetic profiling; virtual screening; network pharmacology; drug repurposing; molecular dynamics simulation; computational chemistry; AI in nanotechnology

(This special issue belongs to the Section Molecular Informatics)

Recent Advances in Endometriosis Pathophysiology and Pharmacological Treatment (2nd Edition)

edited by

René Wenzl

submission deadline 30 Jan 2026 | Viewed by 136 | Submission Open

Keywords: endometriosis; pathophysiology; pharmacological treatment; estrogen

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and Application of Platelet-Rich Plasma

edited by

Jorge U. Carmona

submission deadline 30 Jan 2026 | Viewed by 133 | Submission Open

Keywords: platelet-rich plasma; fibrin scaffold; regenerative medicine; molecular biology; translational medicine

(This special issue belongs to the Section Molecular Biology)

Rewriting Medicine: Stem Cells and Regeneration

edited by

Tadahisa Sugiura

submission deadline 30 Jan 2026 | Viewed by 131 | Submission Open

Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Recent Research on Gut Microbiota in Health and Disease

edited by Li Cui

submission deadline 30 Jan 2026 | Viewed by 124 | Submission Open

Keywords: microbiota-host crosstalk; HMA models; microbial metabolites; gut– brain axis; translational microbiome

(This special issue belongs to the Section Molecular Microbiology)

Cellular and Molecular Pathogenesis of Gynecologic Diseases: Focus on Uterine and Ovarian Dysfunction

edited by

Seung-Yup Ku

submission deadline 30 Jan 2026 | Viewed by 122 | Submission Open

Keywords: molecular pathogenesis; uterine diseases; ovarian dysfunction; cellular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances of Osteomuscolar Conditions

edited by

Nicola Veronese

submission deadline 30 Jan 2026 | Viewed by 122 | Submission Open

Keywords: osteomuscular conditions; musculoskeletal disorders; bone; cartilage; and muscle degeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Therapy for Human Haemoglobinopathy

edited by Alex Felice and

Joseph Borg

submission deadline 30 Jan 2026 | Viewed by 122 | Submission Open

Keywords: haemoglobin (Hb); hemoglobinopathy (Hbpy); globin; thalassaemia; sickle cell; stem cell; gene therapy/editing; therapeutics; HbF inducing agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Updates and Advances in Molecular Toxicology

edited by

Marco E. M. Peluso

submission deadline 30 Jan 2026 | Viewed by 120 | Submission Open

Keywords: molecular toxicology; biomarkers; mechanisms of toxicity; xenobiotics; cancer diagnosis

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Brain Cancers: Second Edition

edited by

Monika Gudowska-Sawczuk

and

Karolina Orywal

submission deadline 30 Jan 2026 | Viewed by 114 | Submission Open

Keywords: brain tumors; malignant brain tumor; advanced cancer biology

(This special issue belongs to the Section Molecular Oncology)

Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML

edited by

Albrecht Reichle

submission deadline 30 Jan 2026 | Viewed by 111 | Submission Open

Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine; decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 901-950 on page 19 of 65.

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