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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Targets in Gastrointestinal Diseases

edited by

Changwon Yang

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3374 | Submission Open

Keywords: molecular pathways; gastrointestinal cancers; inflammatory bowel disease; targeted therapies; microbiota; gene editing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Understanding Plant-Microbe Interactions

edited by

Tomislav Radić

and

Katarina Hančević

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3296 | Submission Open

Keywords: phytomicrobiome; symbiosis; pathogen resistance; microbial signalling

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Clostridial and Related Neurotoxins, 3rd Edition

edited by

Sabine Pellett

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3280 | Submission Open

Keywords: botulinum neurotoxin; BoNT; toxicity; molecular mechanisms; recombinant; derivative; clostridium botulinum

(This special issue belongs to the Section Molecular Toxicology)

Molecular Dynamics Simulations of Protein Structures

edited by Alfonso Trezza

submission deadline 20 Jan 2026 | 3 articles | Viewed by 3268 | Submission Open

Keywords: molecular dynamics simulations; protein structure analysis; computational methods in structural biology; bioinformatics and drug discovery; protein– ligand interactions

(This special issue belongs to the Section Molecular Biophysics)

Genomics of Human Disease

edited by

Sungkyoung Choi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3219 | Submission Open

Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Hematologic Diseases: Molecular Insights and Novel Methods

edited by

Simona Soverini

and Samantha Bruno

submission deadline 20 Jan 2026 | 1 articles | Viewed by 3200 | Submission Open

Keywords: hematologic malignancies; high-throughput technologies; omics data; biomarkers; drug resistance; minimal residual disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research of Cartilage: 2nd Edition

edited by

Laura Mangiavini

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2994 | Submission Open

Keywords: articular cartilage; cartilage lesions; tissue engineering; cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms: New Insights into the Pathogenesis of Neonatal Disorders

edited by

Rozeta Sokou

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2968 | Submission Open

Keywords: neonate; neonatal infections; molecular and cellular mechanisms; necrotizing enterocolitis; immature immune system; neonatal inflammation; epigenetic modification; regulatory RNAs; bronchopulmonary dysplasia; neonatal hypoxic– ischemic injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches

edited by Magaly Martinez-Ferrer

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2941 | Submission Open

Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker

(This special issue belongs to the Section Molecular Oncology)

Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies

edited by Hanna Mysliwiec

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2893 | Submission Open

Keywords: psoriasis; pathogenesis; lipid metabolism disturbances; metabolic syndrome; systemic comorbidities; epigenetics; therapeutic strategies; biologic treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Envelope Biogenesis and, Molecular Strategies to Maintain Cellular Homeostasis in Bacteria

edited by

Satish Raina

and

Gracjana Klein

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2806 | Submission Open

Keywords: LpxC and the regulation of LPS; periplasmic protein folding; disulfide bond formation; BAM proteins and assembly of outer membrane proteins; periplasmic protease DegP (HtrA); lipopolysaccharide assembly; LPS modifications and diversity; LPS and phospholipid trafficking; bacterial virulence factors; antibiotic resistance; extracytoplasmic function sigma factors; regulatory RNAs; two-component systems; lipid A and its modification

(This special issue belongs to the Section Molecular Microbiology)

Dysregulation of Bone Health–a Matter of Several Culprits

edited by Ana Gomes

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2760 | Submission Open

Keywords: bone metabolism; osteoporosis; osteopenia; low-impact fractures; osteoimmunology; leptin; lung disorders; cancer; renal disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Lymphocytic Leukemia: Molecular Pathologies and Therapeutic Strategies

edited by Tang Her Jaing

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2759 | Submission Open

Keywords: chronic lymphocytic leukemia; genomic landscapes; precision medicine; clinical trials; biomarker

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Resistance Mechanisms in Biotechnology: From Extremes to Applications

edited by Giovanni Gallo and

Martina Aulitto

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2726 | Submission Open

Keywords: microorganism resistance systems; extreme environments; molecular adaptation; genetic pathways; biotechnological applications; industrial biotechnology; environmental remediation; extremophiles; stress tolerance; evolutionary adaptations

(This special issue belongs to the Section Molecular Microbiology)

Exploring New Field in Hydrocolloids Research and Applications

edited by

Mihaela Violeta Ghica

, Cristina Elena Dinu-Pirvu and

Lacramioara Popa

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2705 | Submission Open

Keywords: drug delivery systems; controlled-release; targeted delivery; wound healing; tissue engineering; bioadhesive agents; transdermal patches; mucoadhesive hydrogels; ophthalmic preparations; oral disintegrating films; gastroretentive systems; rheology modifiers; textural characteristics; stabilizing agents; encapsulation for protection and stability (drugs; probiotics and bioactive compounds); 3D bioprinting; nutraceutical delivery

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Biofunctionalization of Metals for Medical Application: Molecular Aspects

edited by

Luca Scotti

and Xiaoming Zhang

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2675 | Submission Open

Keywords: biofunctionalization; medical applications; nanomaterials; nanofunctionalized materials; molecular mechanisms; bacterial membranes; membrane polarity; bacterial resistance

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Epilepsy and Epileptogenesis—2nd Edition

edited by

Stanisław Jerzy Czuczwar

and Barbara Miziak

submission deadline 20 Jan 2026 | 3 articles | Viewed by 2659 | Submission Open

Keywords: epilepsy; antiseizure; anti-epileptogenic drugs; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

The Multiple Faces of Non-Small Cell Lung Cancer: Targeted Therapies and Recent Developments

edited by Angelo Delmonte and Alberto Verlicchi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2654 | Submission Open

Keywords: non-small cell lung cancer; tyrosine-kinase inhibitors; next generation sequencing; immunoconjugates; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Innovative Strategies in the Design and Development of Anticancer Agents

edited by Sanjay Kumar

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2642 | Submission Open

Keywords: chemotherapy; biomimetic; natural product analogs; prodrugs; nanodrugs; drug release

(This special issue belongs to the Section Molecular Pharmacology)

Bone Development and Regeneration—4th Edition

edited by

Kazuo Yudoh

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2624 | Submission Open

Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials

(This special issue belongs to the Section Molecular Biology)

Autophagy and Kidney Diseases

edited by Francesco Reggiani

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2599 | Submission Open

Keywords: autophagy; kidney diseases; cellular homeostasis; molecular signaling; autophagy biomarkers; renal homeostasis; autophagy modulators

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structure, Function and Dynamics in Proteins: 3rd Edition

edited by

Luigi Russo

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2588 | Submission Open

Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray

(This special issue belongs to the Section Molecular Biology)

Protein Networks and Their Signaling

edited by

Ashok Kumar

and

Vladimir N. Uversky

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2507 | Submission Open

Keywords: protein-protein interaction; chromatin/nucleosome; signaling; protein structure; drug design

(This special issue belongs to the Section Molecular Biology)

Latest Advances in Nanoparticles for Modern Biomedicine (2nd Edition)

edited by

Sebastian Schwaminger

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2474 | Submission Open

Keywords: nanoparticles; nanotherapeutics; nanomedicine; biomedicine; selective targeting of nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Molecular Mechanisms of Bacterial Resistance and Antibiotic Therapy

edited by

Xinyi Yang

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2458 | Submission Open

Keywords: bacterial resistance; antibiotics; antimicrobials; “ superbugs” ; clinical strains; laboratory induced-bacteria; antimicrobial peptides; antimicrobial combinations; hybrid antibiotics; repurposing drugs; anti-virulence agents; immune modulators; toxin neutralizers

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms of Bone Injury and Bone Tissue Regeneration

edited by Nasim Golafshan

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2350 | Submission Open

Keywords: bone formation; osteoblast diffrentiation; cell-based materials

(This special issue belongs to the Section Materials Science)

Research in Alzheimer’s Disease: Advances and Perspectives

edited by

Silvia Boschi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2239 | Submission Open

Keywords: neuroinflammation; synaptic dysfunction; oxidative stress; neurofibrillary tangles; mitochondrial dysfunction; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Precision Medicine Approaches to Antifibrotic Therapy

edited by Karim Daliri

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2237 | Submission Open

Keywords: fibrotic diseases; antifibrotic therapy; antifibrotic drug; multi-omics data; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Signal Transduction in the Nucleus

edited by Jaekyung Shim

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2159 | Submission Open

Keywords: inner nuclear membrane protein; protein network; LEM-domain proteins; nuclear lamina; signal transcription; transcriptional regulation

(This special issue belongs to the Section Molecular Biology)

The Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by

Mrigya Babuta

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2112 | Submission Open

Keywords: alcohol-associted hepatitis; acute kidney injury; hepatic encephalopathy; adaptive immune response; innate immune response; neutrophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Tumor Suppressor Proteins

edited by Jie Liu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 2064 | Submission Open

Keywords: DNA repair; genome stability; tumor suppressor; BRCA1; BRCA2; PALB2; RAD51C

(This special issue belongs to the Section Molecular Oncology)

Advanced Research on the Physiology and Toxicology of Aquatic Animals

edited by Xin Zhang

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2040 | Submission Open

Keywords: aquatic ecosystem; physiology of aquatic animals; toxicology of aquatic animals; environmental adaptability; environmental pollutants; ecotoxicology; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Biology)

Role of Cell Metabolism in Cancer Biology

edited by

Silvia Filippi

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1988 | Submission Open

Keywords: cancer cells metabolism; target therapy; PI3K/Akt/mTOR pathway; hypoxia

(This special issue belongs to the Section Molecular Oncology)

Molecular Crosstalk in Breast Cancer Progression and Therapies

edited by Giuseppina Daniela Naimo

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1940 | Submission Open

Keywords: breast cancer; endocrine therapy; drug resistance; breast tumor microenvironment; targeted therapies; personalized therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress in Dermatology, Aesthetics and Regenerative Medicine

edited by

Eugenio Luigi Iorio

submission deadline 20 Jan 2026 | Viewed by 1920 | Submission Open

Keywords: oxidative stress; redox system; antioxidant chemical species; dermatology; aesthetics; regenerative medicine; inflammatory; degenerative skin diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Breeding and Genetic Regulation of Crops, 2nd Edition

edited by

Chiara Biselli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1897 | Submission Open

Keywords: molecular breeding; genetic regulation; genomics; genome-editing techniques; epigenetic modifications

(This special issue belongs to the Section Molecular Plant Sciences)

Modulating the Function of the Immune System by Thyrotropin and Thyroid Hormones

edited by Graciela Alicia Cremaschi and Claudia Gabriela Pellizas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1885 | Submission Open

Keywords: thyrotropin (TSH); thyroid hormones (THs); immune modulation; immunology; immune; autoimmune; immunoendocrinology; hypothalamic-pituitary-thyroid axis; antitumor immune response

(This special issue belongs to the Section Molecular Immunology)

The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment

edited by Fabricio Figueiro

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1844 | Submission Open

Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gluten/Wheat-Related Disorders: The Role of Nutrition, Gut Barrier, Microbiota, and New Therapeutic Strategies

edited by Lisa Lungaro

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1820 | Submission Open

Keywords: gluten-related disorders; celiac disease; non celiac gluten wheat sensitivity; gluten free diet; microbiota; gut barrier; probiotics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Ozone Therapy

edited by

Francisco Rodríguez-Esparragón

Bernadino Clavo

and

Jacob Lorenzo-Morales

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1754 | Submission Open

Keywords: antioxidant response; cellular stress responses; inflammatory signaling; mitochondrial function; molecular pathways; Nrf2; oxidative stress; ozone therapy; redox regulation; antimicrobial resistance; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Research in Photocatalysis

edited by

María Teresa Colomer

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1701 | Submission Open

Keywords: design; simulation; synthesis; properties; functionalities; reactions; photocatalysis

(This special issue belongs to the Section Biochemistry)

Advances and Applications in Molecular Enzymology

edited by

Gustavo Molina

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1661 | Submission Open

Keywords: microbial enzymes; biosynthesis and bioengineering; drug development and targets; enzymes in the environment; engineered enzymes; enzymes in agri-food; enzymatic formulations; enzyme engineering; enzymes in biomedical sciences; green chemistry/technology; glycans; molecular evolution; nanocatalyst and nanotechnology; pharma enzymes; recombinant proteins production and purification; system and synthetic biology

(This special issue belongs to the Section Biochemistry)

Molecular Research in Animal Nutrition

edited by Jie Fu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1643 | Submission Open

Keywords: animal nutrition; animal immunity; epigenetics; m6A methylation; gut microbiota; host– microbiome interaction; metabolic reprogramming

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights and Regulation Mechanisms of Tea Quality

edited by

Xujun Zhu

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1633 | Submission Open

Keywords: molecular ecology; spectroscopic techniques; tea quality; tea plant growth

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Plant Nematology Research

edited by

Sergei A. Subbotin

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1588 | Submission Open

Keywords: DNA barcoding; Molecular evolution; Genomes; Molecular systematics; Phylogenetics; Plant– nematode interactions; Transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Extracellular Histones in Patho(physio)logical Hemostasis

edited by Fabrizio Semeraro and

Mauro Coluccia

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1544 | Submission Open

Keywords: extracellular histones; hemostasis; platelets; coagulation; fibrinolysis; thrombosis; inflammation; extracellular traps

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endothelial Cells in Health and Disease

edited by

Alessia Ricci

and

Amelia Cataldi

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1517 | Submission Open

Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair

(This special issue belongs to the Section Molecular Biology)

Coagulation Factors and Natural Anticoagulants in Health and Disease

edited by

Zsuzsanna Bereczky

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1494 | Submission Open

Keywords: coagulation factor; natural anticoagulant; hemostasis; thrombosis; molecular studies; molecular interactions; structure; functional studies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Design and Engineering in Biochemistry

edited by Om Prakash Narayan

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1370 | Submission Open

Keywords: protein engineering; molecular biology; biochemical tools; computational protein design; directed evolution; CRISPR/Cas9; synthetic biology; biomaterials; protein therapeutics; regenerative medicine

(This special issue belongs to the Section Molecular Biology)

Fibrotic Disease: From Pathophysiology to Treatment

edited by Galina S. Bogatkevich

submission deadline 20 Jan 2026 | Viewed by 1365 | Submission Open

Keywords: lung; liver; heart; kidney; fibrosis; systemic sclerosis; mechanisms; pathophysiology; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 901-950 on page 19 of 66.

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