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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Interplay Between Aging, Dementia and Renal Function: Mechanisms, Biomarkers and Therapeutic Targets

edited by

Luca Soraci

submission deadline 31 Oct 2025 | Viewed by 156 | Submission Open

Keywords: aging; dementia; neuroinflammation; kidney– brain axis; translational research; biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Translational Neuroscience of Emotion, Cognition, and Behavior: From Mechanisms to Mental Health

edited by

Masaru Tanaka

submission deadline 31 Oct 2025 | Viewed by 151 | Submission Open

Keywords: translational neuroscience; emotion and cognition; neurobehavioral mechanisms; mental health biomarkers; Neuroimmunology; brain– gut axis; optogenetics and behavior; single-cell transcriptomics; psychiatric disorders; neuromodulation therapies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Skeletal Muscle Adaptation

edited by

Michele Salanova

submission deadline 31 Oct 2025 | Viewed by 149 | Submission Open

Keywords: skeletal muscle; adaptive responses; muscle physiology; genomics; transcriptomics; proteomics; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Angiogenesis—from Molecular Drivers to Clinical Implications

edited by

Claudiu N. Lungu

and

Subhash C. Basak

submission deadline 31 Oct 2025 | Viewed by 149 | Submission Open

Keywords: angiogenesis; pro-angiogenic molecules; vascular endothelial growth factor (VEGF); fibroblast growth factors (FGFs); angiopoietins; vascular morphogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Therapeutic Approaches to Endocrine Disorders

edited by

Gilberta Giacchetti

and

Emanuele-Salvatore Scarpa

submission deadline 31 Oct 2025 | Viewed by 147 | Submission Open

Keywords: endocrine disorders; osteoporosis; diabetes; obesity; synthetic drugs; nutraceuticals; biomarkers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton

edited by

Nikolas Nikolaidis

submission deadline 31 Oct 2025 | Viewed by 146 | Submission Open

Keywords: cellular stress response; molecular remodeling; lipid signaling; membrane dynamics; cytoskeletal reorganization; chaperones; heat shock proteins; proteostasis; membrane– protein interactions; stress-induced trafficking; mechano-transduction; cell survival signaling

(This special issue belongs to the Section Molecular Biology)

The Natural Products for Cancer Therapy

edited by María Jesus Rodríguez-Yoldi

submission deadline 31 Oct 2025 | Viewed by 146 | Submission Open

Keywords: apoptosis; antioxidant; anti-inflammatory; cancer; cell viability; food-by-products; natural products; polyphenols

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment

edited by Madan Mohan Kwatra

submission deadline 31 Oct 2025 | Viewed by 144 | Submission Open

Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tolerance Mechanisms of Plants Against Abiotic Stresses

edited by

Ilektra Sperdouli

submission deadline 31 Oct 2025 | Viewed by 143 | Submission Open

Keywords: abiotic stress; oxidative stress; plant adaptation; physiological mechanisms; molecular mechanisms; morphological mechanisms; biochemical mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic Regulation of Plant Growth and Protection (2nd Edition)

edited by

Yuxuan Hou

and

Zhiyong Li

submission deadline 31 Oct 2025 | Viewed by 143 | Submission Open

Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Environmental Stress-Induced Human Diseases

edited by

Silvia Cantara

submission deadline 31 Oct 2025 | Viewed by 141 | Submission Open

Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene– environment interactions; biomarkers of exposure and disease; systems biology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials: Molecular Design and Applications

edited by

Yuxin Zhang

submission deadline 31 Oct 2025 | Viewed by 141 | Submission Open

Keywords: biomaterials; molecular design; biomedical applications

(This special issue belongs to the Section Materials Science)

Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside

edited by Antonio Arnaiz-Villena

submission deadline 31 Oct 2025 | Viewed by 137 | Submission Open

Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV

(This special issue belongs to the Section Molecular Immunology)

Advanced Molecular Research on Pregnancy Complication Mechanisms

edited by

Aleksandra Stefanović

submission deadline 31 Oct 2025 | Viewed by 136 | Submission Open

Keywords: hypertensive pregnancy disorders; gestational diabetes; intrauterine growth restriction; maternal metabolism in pregnancy complications; genetic and epigenetic mechanisms in pregnancy complications; immunology in pregnancy complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms of Genetic and Acquired Acid-Base Disorders

edited by

Manoocher Soleimani

submission deadline 31 Oct 2025 | Viewed by 135 | Submission Open

Keywords: acid– base balance; bicarbonate transport; metabolic acidosis; metabolic alkalosis; renal tubular acidosis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Vector–Pathogen–Host Interaction, Vaccines and Immunobiologicals

edited by Carlo José Freire Oliveira and

Marcos Vinícius Da Silva

submission deadline 31 Oct 2025 | Viewed by 131 | Submission Open

Keywords: host– pathogen– vector interactions; active biomolecules; immunomodulation; vaccines; binding molecules; immunobiologicals

(This special issue belongs to the Section Molecular Immunology)

The Gene, Genomics, and Molecular Breeding in Cruciferae Plants (3rd Edition)

edited by

Maoteng Li

submission deadline 31 Oct 2025 | Viewed by 130 | Submission Open

Keywords: Cruciferae plants; genome analysis; genetic dissection; gene function; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Blood–Brain Barrier Dysfunction in Neurodegenerative Disorders

edited by

Amal Kaddoumi

submission deadline 31 Oct 2025 | Viewed by 130 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; Alzheimer’ s disease; amyotrophic lateral sclerosis; Parkinson's disease; BBB as a therapeutic target; neuroinflammation; molecular mechanisms; cerebral blood flow

(This special issue belongs to the Section Molecular Neurobiology)

Neuropeptides in Brain Health and Disease: From Molecular Mechanisms to Therapeutic Potential

edited by

Alessandro Castorina

submission deadline 31 Oct 2025 | Viewed by 129 | Submission Open

Keywords: neuropeptides; brain function; neuroinflammation; regeneration; neurodegeneration; biomarkers; therapy; CNS; brain disorders; demyelination

(This special issue belongs to the Section Molecular Neurobiology)

Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement

edited by

Amelia Salimonti

submission deadline 31 Oct 2025 | Viewed by 128 | Submission Open

Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Perineuronal Nets and Fear Memories Erasure: State of the Art and Future Directions

edited by

Andrea Poli

submission deadline 31 Oct 2025 | Viewed by 127 | Submission Open

Keywords: perineuronal nets (PNNs); extracellular matrix (ECM); fear erasure; traumatic memories; PTSD; translation research; clinical treatment; therapeutical strategies

(This special issue belongs to the Section Molecular Neurobiology)

3D Printing in Pharmaceutical Drug Delivery

edited by

Sagar Narala

and

Dinesh Nyavanandi

submission deadline 31 Oct 2025 | Viewed by 126 | Submission Open

Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing

(This special issue belongs to the Section Molecular Pharmacology)

Current and Emerging Therapeutic Approaches for MASLD

edited by

Chrysoula Boutari

submission deadline 31 Oct 2025 | Viewed by 123 | Submission Open

Keywords: MASLD; MASH; GLP-1 agonists; anti-inflammatory agents; anti-obesity drugs; FGF-21

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Omics Approaches to Unravel Plant Responses to Habitat Stresses

edited by

Claudia Uhde-Stone

submission deadline 31 Oct 2025 | Viewed by 123 | Submission Open

Keywords: omics; multi-omics; high-throughput technologies; biotic stress; abiotic stress; environmental stress; crosstalk; translational biology; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition

edited by

Joanna Filipowska

submission deadline 31 Oct 2025 | Viewed by 122 | Submission Open

Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode

(This special issue belongs to the Section Molecular Pharmacology)

miRNA in Human Diseases

edited by

Anna Valentino

submission deadline 31 Oct 2025 | Viewed by 120 | Submission Open

Keywords: microRNA; gene regulation; disease biomarkers; miRNAs expression profiling; miRNA-based therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Functional Adsorption Materials: From Design to Application

edited by Qi Liu

submission deadline 31 Oct 2025 | Viewed by 118 | Submission Open

Keywords: functional adsorption materials; molecular design; selective adsorption

(This special issue belongs to the Section Materials Science)

Recent Advances in Antitumor Agents from Natural Source

edited by Fábio Ferreira Perazzo

submission deadline 31 Oct 2025 | 1 articles | Viewed by 115 | Submission Open

Keywords: natural products; cancer; medicinal plants; phytochemistry; fermented compounds; isolated compounds; tumor; in vitro; in vivo; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 31 Oct 2025 | Viewed by 113 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nano-Biomaterials and Biotechnology for Biomedicine and Tissue Regeneration

edited by

Laura Giannotti

submission deadline 31 Oct 2025 | Viewed by 113 | Submission Open

Keywords: nano-biomaterials; regenerative medicine; tissue engineering; drug delivery systems; bioactive interfaces

(This special issue belongs to the Section Materials Science)

Development, Characterization and Applications of Novel Polymeric Materials and Composites: 2nd Edition

edited by

Daniel Dumitru Banciu

and

Xiao Hu

submission deadline 31 Oct 2025 | Viewed by 110 | Submission Open

Keywords: diagnosis; therapy; polymers; composite materials; theoretical model

(This special issue belongs to the Section Materials Science)

Quantum Chemical Intelligence: New Horizons of Molecular Structure and Reactivity

edited by

Mihai V. Putz

submission deadline 31 Oct 2025 | Viewed by 108 | Submission Open

Keywords: chemical bond and bonding; quantum states and measurements; chemical reactivity; valence models; complex coordination; reaction coordinates and paths; bio-nano-materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Insights into Porous Polymers

edited by Bolin Ji

submission deadline 31 Oct 2025 | Viewed by 104 | Submission Open

Keywords: porous organic polymer; covalent organic framework; adsorption and separation of gases; energy storage materials; water treatment; antimicrobial; fluorescence imaging; tumor treatment

(This special issue belongs to the Section Materials Science)

Latest Molecular Research in Plant Secondary Metabolism

edited by

Andrey Marchev

submission deadline 31 Oct 2025 | Viewed by 104 | Submission Open

Keywords: plants; plant in vitro systems; secondary metabolism; metabolite profiling and fingerprinting; sustainable production; elicitation; metabolic engineering; CRISPR/Cas; molecular targets

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms in Rare and Hereditary Vascular Diseases

edited by

Antonino Tuttolomondo

submission deadline 31 Oct 2025 | Viewed by 95 | Submission Open

Keywords: Klippel– Trenaunay syndrome; Parkes– Weber syndrome; CLOVES syndrome; Proteus syndrome; hereditary hemorrhagic telangiectasia; blue rubber bleb nevus syndrome; COL4A1/A2-related disorders; CADASIL; Fabry disease; cerebral amyloid angiopathy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Mitochondria-Associated Non-Coding RNAs

edited by

Verónica A. Burzio

, Jaime E. Villegas and

Sam Das

submission deadline 31 Oct 2025 | Viewed by 94 | Submission Open

Keywords: mitochondrial-encoded ncRNAs; mitochondrial miRNAs; mitochondrial lncRNAs; mitochondrial circRNAs; nuclear-encoded mitochondrial ncRNAs

(This special issue belongs to the Section Molecular Biology)

Molecular Targets of Disease—Changing Treatment Strategies for Parkinson's Disease

edited by

Chung-Yin Lin

submission deadline 31 Oct 2025 | Viewed by 93 | Submission Open

Keywords: Parkinson’ s disease; therapeutic targets; potential treatments; molecular targets; drug delivery; neurodegenerative disease

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research in Leukemia

edited by Juan Manuel Mejia-Arangure

submission deadline 31 Oct 2025 | Viewed by 93 | Submission Open

Keywords: leukemia; molecular biology; genetic testing; epigenomics; targeted therapy; precision medicine; diagnostic techniques; molecular pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Nano-Based Drug Delivery and Theranostic Systems

edited by

Mukesh Meher

and

Yapei Zhang

submission deadline 31 Oct 2025 | Viewed by 91 | Submission Open

Keywords: nanoparticles; smart drug/gene delivery; multifunctional nanoparticles; theranostics; targeted therapy; molecular imaging; cancer

(This special issue belongs to the Section Molecular Nanoscience)

The Involvement of the Ubiquitin Proteasome System in the Healthy and Diseased Heart

edited by

Ofer Binah

submission deadline 31 Oct 2025 | Viewed by 90 | Submission Open

Keywords: UPS; ubiquitin; proteasome; cardiac pathophysiology; coronary ischemia/reperfusion injury; heart failure; cardiomyopathies; E334K mutation; cMyBPC; electrophysiological dysfunction; hypertrophic cardiomyopathy; pharmacological targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regenerative Medicine for Tendon: Harnessing Stem Cell Potential

edited by

Maria Camilla Ciardulli

submission deadline 31 Oct 2025 | Viewed by 88 | Submission Open

Keywords: stem cells; endogenic differentiation; three-dimensional in vitro tendon models; immunomodulation; biomimetic scaffolds; in vivo tendon models; dynamic cultures

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Treatments in Aging-Related Cerebrovascular Diseases

edited by

Aurel Popa-Wagner

submission deadline 31 Oct 2025 | Viewed by 86 | Submission Open

Keywords: aging; cerebrovascular diseases; therapeutic tools; senolytic drugs; gene editing technologies; RNA-based therapies

(This special issue belongs to the Section Molecular Neurobiology)

Novel Therapeutic Strategies and Targets in Rheumatoid Arthritis

edited by David Fox and

James J. Moon

submission deadline 31 Oct 2025 | Viewed by 86 | Submission Open

Keywords: RA; synovium; FLS; synovial fluid; microbiome; autoimmunity; DMARD; joint inflammation; joint damage; nanoparticle

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Sex Hormones

edited by

Cheryl Anne Frye

submission deadline 31 Oct 2025 | Viewed by 85 | Submission Open

Keywords: neurosteroids; selective estrogen receptor β modulators (SERMs); selective androgen receptor modulators (SARMs); non-genomic; estriol; gut health; cardiovascular disease; stroke; lordosis; prostate; cognition; addiction; nutrition; oxytocin

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Genetics in the Pathogenesis of Neurological Disorders

edited by Jeannette Hübener-Schmid

submission deadline 31 Oct 2025 | Viewed by 84 | Submission Open

Keywords: ataxia; genetic modifier; genetic landscape; genomics; long-read sequencing; neurodegeneration; personalized medicine; personalized treatmen; polymorphisms; single cell sequencing

(This special issue belongs to the Section Molecular Neurobiology)

Fish and Amphibians: Exploring Genetic, Developmental, and Endocrine Mechanisms

edited by

Gad Degani

submission deadline 31 Oct 2025 | Viewed by 83 | Submission Open

Keywords: gene expression; fish physiology; amphibian development; endocrine regulation; comparative genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Unveiling the Functional Microbiomes of the Ocean: From Genes to Ecosystem Services

edited by

Sergey Dobretsov

and

Daniel Rittschof

submission deadline 31 Oct 2025 | Viewed by 82 | Submission Open

Keywords: microbiome; symbiosis; community organization; functional diversity; communication; microbial functions; metagenomics; metabolomics; transcriptomics; proteomics; biogeochemical cycling; biofouling; ocean health; marine biotechnology; microbial ecology

(This special issue belongs to the Section Molecular Microbiology)

Nano-Biomaterials for Biomedicine and Tissue Regeneration

edited by