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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on Malaria: Molecular and Biochemical Perspectives submission deadline 30 Nov 2025 | Viewed by 297 | Submission Open
Keywords: malaria; vectors; therapies; resistance; cellular mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels
edited by
submission deadline 30 Nov 2025 | Viewed by 292 | Submission Open
Keywords: calcium-permeable channels in health and disease; calcium-permeable channels in calcium cycling; TRP channels; voltage-gated calcium channels; STIM / Orai complexes; intracellular IP3 calcium channels; intracellular RyR calcium channels; posttranslational calcium channel modifications; calcium-permeable channel inhibitors; calcium-permeable channel biophysics; calcium-permeable channel evolution
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in the Structure, Biological Activity and Structure–Activity Relationship of Polysaccharides submission deadline 30 Nov 2025 | 1 articles | Viewed by 279 | Submission Open
Keywords: natural polysaccharides; phytochemicals; nutraceuticals; structure– activity relationship; anticancer potential; immunomodulation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Markers and Genetic Diversity in Plants
edited by Eugenija Kupčinskienė
submission deadline 30 Nov 2025 | Viewed by 277 | Submission Open
Keywords: plant populations; genetic diversity; molecular diversity; invasion; invasive alien species; pollution; climate change; habitat; conservation; endangered and rare species; DNA markers; molecular markers; sequencing
(This special issue belongs to the Section Molecular Plant Sciences)
Supplements and Drug-Based Strategies in Neonatal and Paediatric Health submission deadline 30 Nov 2025 | Viewed by 268 | Submission Open
Keywords: neonatal pharmacology; paediatric supplements; nutraceuticals in early life; microbiota– host interactions; infectious diseases in children; neurodevelopmental disorders; drug– nutrient interactions; dosing and delivery routes; molecular paediatrics; critical analysis of paediatric interventions
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Natural Products on Neurological Diseases, Neuroinflammation and Neuropathic Pain
edited by Karin C. Calaza
submission deadline 30 Nov 2025 | Viewed by 262 | Submission Open
Keywords: natural products; neurological diseases; neuroinflammation; neuropathic pain; neuroprotection; anti-inflammatory compounds; pain modulation; plant-based therapies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Regulation of Brown Adipose Function submission deadline 30 Nov 2025 | Viewed by 232 | Submission Open
Keywords: brown adipose tissue; metabolic disorders; thermogenesis; endocrine function; cellular signaling
(This special issue belongs to the Section Biochemistry)
Recent Research on Glycosylation
edited by
submission deadline 30 Nov 2025 | Viewed by 222 | Submission Open
Keywords: protein glycosylation; protein folding; cell signaling; immune regulation; glycoproteins
(This special issue belongs to the Section Biochemistry)
Vitamin D and New Vitamin D Analogs
edited by
submission deadline 30 Nov 2025 | Viewed by 221 | Submission Open
Keywords: vitamin D; vitamin D receptor; vitamin D analogs; synthesis; clinical applications; cancer; anti-proliferation; therapeutic target
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research Progress on Photosensitizers and Photodynamic Therapy
edited by
submission deadline 30 Nov 2025 | Viewed by 221 | Submission Open
Keywords: photodynamic therapy; photosensitizers; tumor microenvironment; nanotechnology; immunotherapy; targeted drug delivery; reactive oxygen species; hypoxia; combination therapy; molecular mechanisms
(This special issue belongs to the Section Biochemistry)
New Insights into Intercellular Communication and Signal Transduction
edited by
submission deadline 30 Nov 2025 | Viewed by 215 | Submission Open
Keywords: intercellular communication; signal transduction; extracellular vesicles (EVs); exosomes; tunneling nanotubes (TNTs); cytokines; hormonal signaling; neurotransmitters; mechanotransduction; immune signaling
(This special issue belongs to the Section Molecular Biology)
Strategies and Molecular Mechanisms to Enhance Outcomes in Orthobiologics
edited by Leonardo Oliveira
submission deadline 30 Nov 2025 | Viewed by 207 | Submission Open
Keywords: platelet-rich plasma; adipose-derived stem cells; microfragmented fat; nutrition; exercise; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Glyco-Based Anticancer Agents
edited by Pedro Colinas
submission deadline 30 Nov 2025 | Viewed by 200 | Submission Open
Keywords: carbohydrates; cancer; Warburg effect; glycolysis; enzyme inhibitors; transporters inhibitors; docking simulations; tumor microenvironment
(This special issue belongs to the Section Biochemistry)
Targeting Epigenetic Complexes and Alternative Protein Degradation Pathways in Medicinal Chemistry
edited by Jean Leandro Dos Santos
submission deadline 30 Nov 2025 | Viewed by 198 | Submission Open
Keywords: protein degradation; LYTAC; AUTAC; ATTEC; epigenetics; NuRD; HDAC; BRD; SWI/SNF; PRC2; chromatin; conjugates; lysosome; autophagy; drug discovery
(This special issue belongs to the Section Biochemistry)
AI and Machine Learning in Molecular Biomarker Discovery and Mechanisms of Neurodegenerative Disorders submission deadline 30 Nov 2025 | Viewed by 195 | Submission Open
Keywords: artificial intelligence (AI); machine learning (ML); biomarker discovery; neurodegenerative disorders; Alzheimer’ s disease (AD); Parkinson’ s disease (PD); dementia; risk prediction models; multi-omics integration; translational bioinformatics
(This special issue belongs to the Section Molecular Neurobiology)
Biomaterials for Bone Treatment, Replacement and Regeneration: Focus on Regeneration and Inflammation
edited by
submission deadline 30 Nov 2025 | Viewed by 189 | Submission Open
Keywords: biomaterials  ; bone substitute  ; inflammation  ; foreign body response  ; bone regeneration
(This special issue belongs to the Section Materials Science)
Molecular Design and Engineering of Carbon-Based Materials for Environmental Remediation and Bioenergy
edited by Hilda Elizabeth Reynel-Ávila
submission deadline 30 Nov 2025 | Viewed by 187 | Submission Open
Keywords: adsorption; catalysis; functionalization; molecular design; environmental; sustainable energy; tailoring
(This special issue belongs to the Section Materials Science)
Plant Molecular Ecology and Genomic Perspectives
edited by
submission deadline 30 Nov 2025 | Viewed by 186 | Submission Open
Keywords: genome assembly and annotaion; genomic structure and function of plants; plant molecular ecology; genome prediction and GWAS; gene-editing technologies; transcriptomics and metabolomics; nuclear and organelle genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Lectins: Structural Diversity, Molecular Recognition and Emerging Applications submission deadline 30 Nov 2025 | Viewed by 184 | Submission Open
Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications
(This special issue belongs to the Section Biochemistry)
ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy
edited by Ilaria Marrocco and
submission deadline 30 Nov 2025 | Viewed by 182 | Submission Open
Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Application of Biomaterials in Bone Tissue Repair and Regeneration, 2nd Edition
edited by
submission deadline 30 Nov 2025 | Viewed by 181 | Submission Open
Keywords: allograft; autograft; autologous bone; bone; graft materials; mineral substitutes; regeneration
(This special issue belongs to the Section Materials Science)
Sustainable Material Development Through Waste Utilization: From Molecular Insights to Functional Applications
edited by
submission deadline 30 Nov 2025 | Viewed by 180 | Submission Open
Keywords: sustainable materials; waste-derived materials; biodegradable polymers; green chemistry; functionalization; structure– property relationships; chemical modification; recycling; valorization; circular economy; composites; analytical techniques; industrial waste; agricultural waste
(This special issue belongs to the Section Materials Science)
Plant Extracts: Molecular Insights and Functional Potential
edited by Abdelaziz Yasri
submission deadline 30 Nov 2025 | Viewed by 179 | Submission Open
Keywords: plant extract; phytochemistry; plant secondary metabolites; plant extraction techniques; product valorization
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in Pediatric Neuromuscular Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 179 | Submission Open
Keywords: pediatric neuromuscular disorders; gene therapy; biomarkers; molecular pathophysiology; muscular dystrophy; motor neuron disease; translational medicine; neuromuscular therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Recent Research on Natural Compounds: From Biosynthesis to Application
edited by
submission deadline 30 Nov 2025 | Viewed by 170 | Submission Open
Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery
(This special issue belongs to the Section Biochemistry)
Molecular Research on Ataxia submission deadline 30 Nov 2025 | Viewed by 168 | Submission Open
Keywords: ataxia; molecular mechanisms; repeat expansion disorders; gene discovery; biomarkers; RNA biology; protein aggregation; epigenetics; gene therapy; neurodegeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Contemporary Perspective of Cardio-Kidney Metabolic Syndrome: From Prevention to Management
edited by Alberto Palazzuoli, and
submission deadline 30 Nov 2025 | Viewed by 166 | Submission Open
Keywords: cardiovascular risk factors; metabolic syndrome; chronic kidney disease; heart failure; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Gynecologic Oncology: Tumor Microenvironment and Novel Therapeutics submission deadline 30 Nov 2025 | Viewed by 161 | Submission Open
Keywords: tumor microenvironment; peritoneal-cancer cell interactions; extracellular matrix; ascites; immune cells; cancer-associated fibroblasts; immunotherapy; novel therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Genomics and Epigenetics of Stem Cell: An Update
edited by
submission deadline 30 Nov 2025 | Viewed by 161 | Submission Open
Keywords: stem cells; epigenetics; genomics; cell fate; self-renewal; differentiation; regenerative medicine; transcription factors
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research on Autoimmune Diseases and Rheumatology
edited by
submission deadline 30 Nov 2025 | Viewed by 159 | Submission Open
Keywords: rheumatology; molecular immunology; autoimmune diseases; biomarkers; transcriptomics; proteomics; epigenetics; single-cell analysis; cytokine signaling; precision medicine; exosomes; microRNA; immune metabolism; fibroblast activation; translational research
(This special issue belongs to the Section Molecular Immunology)
Drug and Non-Drug Treatment of Cerebral Ischemia
edited by
submission deadline 30 Nov 2025 | Viewed by 159 | Submission Open
Keywords: cerebral ischemia; neonatal hypoxic-ischemic encephalopathy (HIE); neuroprotection; therapeutic hypothermia; neurorehabilitation; oxidative stress; stem cell therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oral Potentially Malignant Disorders and Oral Cancers: From Molecular Pathology to Therapeutic Approaches
edited by and Nicholas Kalavrezos
submission deadline 30 Nov 2025 | Viewed by 158 | Submission Open
Keywords: oral cancer; oral potentially malignant disorders; molecular mechanisms in oral cancer; detection of oral cancer; pathogenic mechanisms of oral cancer; immune system; translational oral cancer; microbiota oral cancer; therapy for oral cancer
(This special issue belongs to the Section Molecular Oncology)
Unraveling Bioactive Peptides: Structure, Function, and Applications
edited by
submission deadline 30 Nov 2025 | Viewed by 156 | Submission Open
Keywords: bioactive peptides; peptide structure– activity relationship; peptidomics; bioactivity assays; human health
(This special issue belongs to the Section Macromolecules)
Stress Signaling and Horticultural Crops Quality Control
edited by and
submission deadline 30 Nov 2025 | Viewed by 155 | Submission Open
Keywords: stress tolerance; molecular mechanisms; quality traits; redox regulation; postharvest physiology; signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Perspectives in Tissue Engineering and Regenerative Medicine
edited by
submission deadline 30 Nov 2025 | Viewed by 154 | Submission Open
Keywords: 3D scaffolds; personalized regenerative therapies; tissue engineering; stem cells; bone regeneration; regenerative biomarkers; cell– scaffold interactions; nanomaterials
(This special issue belongs to the Section Molecular Biology)
Biometallic Nanoparticles: Synthesis, Functionalization and Multidisciplinary Applications
edited by
submission deadline 30 Nov 2025 | Viewed by 153 | Submission Open
Keywords: biogenic nanomaterials; antibacterial agents; plant extracts; biogenic silver nanoparticles; biofilms; cytotoxicity
(This special issue belongs to the Section Molecular Nanoscience)
Rheumatoid Arthritis: From Molecular Mechanism to Emerging Therapeutic Target
edited by Elisa Gremese and Costantino Pitzalis
submission deadline 30 Nov 2025 | Viewed by 153 | Submission Open
Keywords: rheumatoid arthritis; molecular mechanisms; emerging therapeutic targets; precision medicine; synovial tissue
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Sarcomas: From Molecular Signatures to Morphologic Patterns
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 153 | Submission Open
Keywords: sarcomas; histopathology; molecular pathology; FISH; gene fusion in sarcomas
(This special issue belongs to the Section Molecular Oncology)
DNA Repair, Genome Stability and Diseases
edited by Melike Caglayan
submission deadline 30 Nov 2025 | Viewed by 153 | Submission Open
Keywords: DNA damage; DNA repair; genomic stability; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Genetics and Genomics)
Combined and Mixture Exposure Toxicology of Cancer
edited by and Quentin Felty
submission deadline 30 Nov 2025 | Viewed by 152 | Submission Open
Keywords: combined exposure; mixture exposure; toxicology of cancer; omics of cancer; AI in carcinogenesis; machine learning use in cancer; cancer biomarkers; pollutants of cancer; agrochemicals; endocrine-disruptive chemicals
(This special issue belongs to the Section Molecular Oncology)
Kidney Diseases: Molecular Research and Novel Therapies
edited by Niels Olsen Saraiva Camara
submission deadline 30 Nov 2025 | Viewed by 152 | Submission Open
Keywords: kidney disease; immunology and inflammation; zebrafish models; therapeutic targets; modern-era drivers of renal pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroinflammation: Emerging Insights and Advances in Drug Development submission deadline 30 Nov 2025 | Viewed by 148 | Submission Open
Keywords: neuroinflammation; drugs; neurodegenerative; Parkinson’ s disease; Alzheimer’ s disease; multiple scleroris; stroke
(This special issue belongs to the Section Molecular Neurobiology)
Molecular, Genetic, and Omics Approaches to Disorders in Bone–Inflammation Crosstalk submission deadline 30 Nov 2025 | Viewed by 147 | Submission Open
Keywords: bone physiology; inflammatory; epigenetic regulation; molecular signaling pathways; cellular interactions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Lipopolysaccharides submission deadline 30 Nov 2025 | Viewed by 146 | Submission Open
Keywords: LPS structural diversity; lipid A; amino arabinose and phosphoethanolamine; TLR4; antibiotic resistance; Lpt transport system; phospholipids and fatty acids; cell envelope stress; lipid A acyltransferases
(This special issue belongs to the Section Molecular Biology)
Stem Cell and Epigenetic Regulation in Regenerative Medicine
edited by
submission deadline 30 Nov 2025 | Viewed by 146 | Submission Open
Keywords: mesenchymal stem cells; regenerative medicine; stemness genes; stem cell differentiation; molecular regulation; gene expression; cell– environment interactions; conditioned medium; secreted factors; epigenetic modification
(This special issue belongs to the Section Molecular Biology)
Molecular Modeling in Pharmaceutical Sciences
edited by
submission deadline 30 Nov 2025 | Viewed by 145 | Submission Open
Keywords: molecular modeling; computer-aided drug design; molecular docking; drug discovery; quantum chemistry; molecular dynamics simulations; virtual screening; computational pharmacology; pharmacy; in silico methods
(This special issue belongs to the Section Molecular Pharmacology)
Natural Product as Therapeutic Agent: From Molecular Targets to Cellular and Functional Modulation
edited by Su-Yun Lyu
submission deadline 30 Nov 2025 | Viewed by 144 | Submission Open
Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Horizons in Antiviral and Antibacterial Agent Discovery submission deadline 30 Nov 2025 | Viewed by 143 | Submission Open
Keywords: antimicrobial resistance; multidrug-resistant infections; new antimicrobial drug development; natural and synthetic an-timicrobial agents; drug repurposing
(This special issue belongs to the Section Molecular Microbiology)
Kidney Disease: Molecular Insights and Emerging Therapies
edited by
submission deadline 30 Nov 2025 | Viewed by 141 | Submission Open
Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Informatics and AI in Cancer Research
edited by and
submission deadline 30 Nov 2025 | Viewed by 139 | Submission Open
Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data
(This special issue belongs to the Section Molecular Informatics)
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