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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Developing Methods and Molecular Basis in Plant Biotechnology: 2nd Edition

edited by

Wojciech Makowski

submission deadline 30 Jan 2026 | Viewed by 274 | Submission Open

Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress

(This special issue belongs to the Section Molecular Plant Sciences)

Artificial Intelligence Advancing Computer-Aided Drug Discovery

edited by

Raju Dash

submission deadline 30 Jan 2026 | 1 articles | Viewed by 259 | Submission Open

Keywords: machine learning; deep learning; computer-aided drug design; target identification; AI-assisted molecular diagnosis; AI-driven pharmacokinetic profiling; virtual screening; network pharmacology; drug repurposing; molecular dynamics simulation; computational chemistry; AI in nanotechnology

(This special issue belongs to the Section Molecular Informatics)

Photosensitizers for Photodynamic Therapy: From Molecular Design to Application

edited by

Carlos Monteiro

M. Amparo F. Faustino

and

Leandro M. O. Lourenço

submission deadline 30 Jan 2026 | Viewed by 235 | Submission Open

Keywords: photodynamic therapy (PDT); photosensitizers (PS); reactive oxygen species (ROS); molecular design; nanocarriers; porphyrins and analogs; targeted drug delivery; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Post-Mortem Toxicology

edited by

Rafał Skowronek

submission deadline 30 Jan 2026 | Viewed by 212 | Submission Open

Keywords: post-mortem toxicology; fatal poisoning; new psychoactive substances; opioids; analytical methods; interpretation of test results

(This special issue belongs to the Section Molecular Toxicology)

Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches

edited by Yuehling Hsieh

submission deadline 30 Jan 2026 | Viewed by 203 | Submission Open

Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Oral Health: Disease and Medicine

edited by Norio Sogawa

submission deadline 30 Jan 2026 | Viewed by 163 | Submission Open

Keywords: oral health; disease; molecular medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Interaction of Gut Microbiota and Food Bioactive Compounds

edited by

Yiming Feng

and

Xiaohong Sun

submission deadline 30 Jan 2026 | Viewed by 161 | Submission Open

Keywords: gut microbiome; molecular mechanisms; metabolomics; transcriptomics; bioactive compounds; microbial enzymes; host– microbe signaling; personalized nutrition; systems biology; functional genomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Synthesis and Molecular Applications of Nanomaterials

edited by

Fernando J. Pereira

A. Javier Aller

and

Roberto Lopez

submission deadline 30 Jan 2026 | Viewed by 161 | Submission Open

Keywords: nanomaterials; synthesis; molecular applications

(This special issue belongs to the Section Molecular Nanoscience)

Plant–Rhizobium Interaction

edited by Rujin Chen

submission deadline 30 Jan 2026 | Viewed by 152 | Submission Open

Keywords: legume; rhizobia; symbiotic nitrogen fixation

(This special issue belongs to the Section Molecular Plant Sciences)

Research on Immune Mechanisms in Kidney Disease

edited by Niels Olsen Saraiva Câmara

submission deadline 30 Jan 2026 | Viewed by 151 | Submission Open

Keywords: kidney disease; molecular sensors; kidney metabolism; immunity; AKI to CKD transition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Endometriosis Pathophysiology and Pharmacological Treatment (2nd Edition)

edited by

René Wenzl

submission deadline 30 Jan 2026 | Viewed by 148 | Submission Open

Keywords: endometriosis; pathophysiology; pharmacological treatment; estrogen

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rewriting Medicine: Stem Cells and Regeneration

edited by

Tadahisa Sugiura

submission deadline 30 Jan 2026 | Viewed by 136 | Submission Open

Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Application of Platelet-Rich Plasma

edited by

Jorge U. Carmona

submission deadline 30 Jan 2026 | Viewed by 136 | Submission Open

Keywords: platelet-rich plasma; fibrin scaffold; regenerative medicine; molecular biology; translational medicine

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Pathogenesis of Gynecologic Diseases: Focus on Uterine and Ovarian Dysfunction

edited by

Seung-Yup Ku

submission deadline 30 Jan 2026 | Viewed by 136 | Submission Open

Keywords: molecular pathogenesis; uterine diseases; ovarian dysfunction; cellular mechanisms; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Therapy for Human Haemoglobinopathy

edited by Alex Felice and

Joseph Borg

submission deadline 30 Jan 2026 | Viewed by 132 | Submission Open

Keywords: haemoglobin (Hb); hemoglobinopathy (Hbpy); globin; thalassaemia; sickle cell; stem cell; gene therapy/editing; therapeutics; HbF inducing agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research on Gut Microbiota in Health and Disease

edited by Li Cui

submission deadline 30 Jan 2026 | Viewed by 129 | Submission Open

Keywords: microbiota-host crosstalk; HMA models; microbial metabolites; gut– brain axis; translational microbiome

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances of Osteomuscolar Conditions

edited by

Nicola Veronese

submission deadline 30 Jan 2026 | Viewed by 129 | Submission Open

Keywords: osteomuscular conditions; musculoskeletal disorders; bone; cartilage; and muscle degeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Updates and Advances in Molecular Toxicology

edited by

Marco E. M. Peluso

submission deadline 30 Jan 2026 | Viewed by 129 | Submission Open

Keywords: molecular toxicology; biomarkers; mechanisms of toxicity; xenobiotics; cancer diagnosis

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Brain Cancers: Second Edition

edited by

Monika Gudowska-Sawczuk

and

Karolina Orywal

submission deadline 30 Jan 2026 | Viewed by 125 | Submission Open

Keywords: brain tumors; malignant brain tumor; advanced cancer biology

(This special issue belongs to the Section Molecular Oncology)

Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML

edited by

Albrecht Reichle

submission deadline 30 Jan 2026 | Viewed by 118 | Submission Open

Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine; decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML

(This special issue belongs to the Section Molecular Oncology)

DNA Damage, Genome Stability and the Human Disease

edited by

Fiammetta Verni

submission deadline 30 Jan 2026 | Viewed by 114 | Submission Open

Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Tumor Viruses: Infection, Carcinogenesis, and Treatment

edited by

Sherif T.S. Hassan

submission deadline 30 Jan 2026 | Viewed by 111 | Submission Open

Keywords: tumor viruses; viral oncogenesis; EBV; HPV; KSHV; HBV; HCV; HTLV-1; and MCPyV; virus-associated cancers; merging oncoviruses; viral latency; immune evasion; antiviral therapy; immunotherapy; cancer vaccines; gene-editing technologies

(This special issue belongs to the Section Molecular Microbiology)

Cardiovascular Diseases: From Molecular Diagnosis to Treatment

edited by

Li Wang

submission deadline 30 Jan 2026 | Viewed by 104 | Submission Open

Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Genetic Insights into Neuropsychiatric Disorders: From Mechanisms to Management

edited by

James Alan Bourgeois

submission deadline 30 Jan 2026 | Viewed by 91 | Submission Open

Keywords: psychiatry; neurology; psychotic disorders; depressive disorders; neurocognitive disorders; neuropsychiatry; genetics; psychopharmacology; neuromodulation; genome-wide association studies (GWAS); transcriptomics; epigenetics; gene-environment interactions

(This special issue belongs to the Section Molecular Neurobiology)

Neural Signaling: The Perspective of Molecular Genetics

edited by

Chunlai Wu

submission deadline 30 Jan 2026 | Viewed by 83 | Submission Open

Keywords: molecular neurogenetics; neural signaling; gene editing; neural circuits; neural plasticity; neurodegenerative disorders; single-cell technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Sarcomeric Proteins in Health and Disease: Progress and Prospects

edited by

Thomas C. Irving

submission deadline 30 Jan 2026 | Viewed by 81 | Submission Open

Keywords: sarcomeric proteins; muscle contraction; sarcomere

(This special issue belongs to the Section Molecular Biophysics)

New Advances in Environmental Carcinogenesis

edited by Grażyna Gromadzka

submission deadline 30 Jan 2026 | Viewed by 78 | Submission Open

Keywords: environmental carcinogenesis; molecular mechanisms; gene– environment interaction; endocrine disruptors; oxidative stress; epigenetics; cancer biomarkers; environmental pollutants; molecular epidemiology; cancer prevention; cancer treatment

(This special issue belongs to the Section Molecular Toxicology)

The Regulation of Metabolism by Sugars During Plant Responses to Environmental Factors and Their Function During Development

edited by

Iwona Morkunas

submission deadline 30 Jan 2026 | Viewed by 70 | Submission Open

Keywords: plant metabolism; sugar signalling; enzymes of sucrose metabolism; environmental factors; plant defense responses; developmental regulation; phytohormones; secondary metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Roles of Epithelial and Endothelial Cells

edited by

Lucie Germain

and

Stéphanie Proulx

submission deadline 31 Jan 2026 | 9 articles | Viewed by 18211 | Submission Open

Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier

(This special issue belongs to the Section Biochemistry)

Common Mechanisms in Gestational Diabetes, Preeclampsia, and Coronavirus Disease 2019

edited by

Sandor G. Vari

submission deadline 31 Jan 2026 | 6 articles | Viewed by 7482 | Submission Open

Keywords: gestational diabetes; preeclampsia; inflammation; immunoglobulins; glycolisation; platelet aggregation; microvascular thrombosis; coronavirus disease 2019

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches

edited by

Dimitrios Kanakis

submission deadline 31 Jan 2026 | 3 articles | Viewed by 7415 | Submission Open

Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma

(This special issue belongs to the Section Molecular Oncology)

Cytokines and Other Biomarkers of Health Status

edited by Anna Cywińska and

Ewelina Maculewicz

submission deadline 31 Jan 2026 | 5 articles | Viewed by 3745 | Submission Open

Keywords: cytokine concentration; cytokine gene expression; cytokine receptors; biomarkers; pathogenesis; adaptation; homeostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition

edited by

Yasemin M. Akay

submission deadline 31 Jan 2026 | 1 articles | Viewed by 3679 | Submission Open

Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis

(This special issue belongs to the Section Molecular Neurobiology)

Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 3rd Edition

edited by

Ilavenil Soundharrajan

submission deadline 31 Jan 2026 | 5 articles | Viewed by 3629 | Submission Open

Keywords: lactic acid bacteria; probiotics health benefits; gut microbiota modulation; functional foods with biological applications; immunomodulatory mechanisms; antimicrobial peptide production and its mechanisms; host-microbe interactions; functional dairy and meat products; inflammatory bowel diseases; metabolic health improvement; bioactive microbial metabolites; food safety and management; metabolic diseases and disorders; antibiotic-associated complications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research into Chronic Heart Failure

edited by

Velia Cassano

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3331 | Submission Open

Keywords: heart failure; oxidative stress; cardiac remodeling; cardiomyopathy; proteomic; molecular science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fish Nutrition, Biochemical Pathways, and Physiological Adaptations

edited by Paula Simó-Mirabet and Fernando Naya-Català

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3223 | Submission Open

Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture

(This special issue belongs to the Section Molecular Biology)

Antibody Engineering and Therapeutic Applications

edited by

Yong-Seok Heo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2571 | Submission Open

Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Mechanism in Neuroinflammation Research

edited by

Robert P. Ostrowski

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2458 | Submission Open

Keywords: non-coding RNA; nucleic acids; inflammatory cells; inflammatory mediators; neurotransmitters; neuroinflammation; immune cells; neurodegenerative diseases; cerebrovascular diseases; brain tumors

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2380 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Oxidative and Redox Signalling in Neurological Diseases

edited by

Malamati Kourti

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2229 | Submission Open

Keywords: gasotransmitters; neurological diseases; oxidative stress; redox signalling; reactive oxygen species (ROS); neuroinflammation; mitochondrial dysfunction; cell death/apoptosis; nitrosative stress; endogenous gas signalling; neuromodulation; neurovascular coupling; therapeutic strategies; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutraceuticals and Healthy Aging: Molecular Mechanisms and Therapeutic Perspectives

edited by

Francesca Uberti

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1977 | Submission Open

Keywords: molecular mechanisms of the action of nutraceuticals on cellular aging; nutraceuticals and neuroprotection; effects of nutraceuticals on skin aging; nutraceuticals in the prevention or management of age-related metabolic diseases; interaction between nutraceuticals and gut microbiota in aging; nutraceuticals in bone and joint health; role of nutraceuticals in menopausal management; impact of nutraceuticals on BPH and prostate health; multi-target approaches of nutraceuticals in healthy aging; innovative nutraceutical delivery and formulation strategies to increase bioavailability; clinical and preclinical studies of nutraceuticals in the elderly population

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovative Strategies and Molecular Insights Into Wound Healing

edited by

Cheong Hoon Seo

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1860 | Submission Open

Keywords: wound healing; tissue regeneration; hypertrophic scar; biomaterials; stem cell therapy; gene therapy; exosomes; burn rehabilitation; inflammation; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Challenges and Future Perspectives in Treatment for Lung Cancer: 2nd Edition

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1773 | Submission Open

Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery

(This special issue belongs to the Section Molecular Oncology)

Th2-Mediated Inflammation in Dermatology: Mechanistic and Therapeutic Perspectives

edited by

Luca Mastorino

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1619 | Submission Open

Keywords: Th2 inflammation; inflammatory skin disease; immunology of the skin; type 2 inflammatory diseases; immunophenotype

(This special issue belongs to the Section Molecular Immunology)

Neuropharmacological Innovations in Treating Neurodegenerative Diseases

edited by

Gabriela Cioca

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1552 | Submission Open

Keywords: neuropharmacology; neurodegenerative disorders; targeted drug delivery; blood– brain barrier permeability; synaptic modulation; neuroprotective agents; disease-modifying therapies; molecular mechanisms of neurodegeneration; innovative drug targets; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

RNA-Based Regulation in Human Health and Disease

edited by

Alfredo Ciccodicola

and

Sudharshan Setra Janardhana Shetty

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1539 | Submission Open

Keywords: non-coding RNAs (ncRNAs); small nucleolar RNAs (snoRNAs); long non-coding RNAs (lncRNAs); microRNAs (miRNAs); piwi-interacting RNAs (piRNAs); circular RNAs (circRNAs); RNA modifications (m6A; pseudouridylation); RNA-protein interactions; post-transcriptional gene regulation; RNA interference (RNAi); antisense oligonucleotides (ASOs); RNA-binding proteins (RBPs); epitranscriptomics; RNA-based therapeutics; cancer-associated ncRNAs; neurodegenerative diseases and RNA regulation; cardiovascular RNA biology; metabolic disorders and RNA; ribosomal RNA modifications; RNA-targeted drug discovery

(This special issue belongs to the Section Molecular Genetics and Genomics)

25th Anniversary of IJMS: Updates and Advances in Molecular Biology

edited by

Irmgard Tegeder

Antonio Ieni

and

Costantino Balestra

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1490 | Submission Open

Keywords: next-generation sequencing (NGS); CRISPR-Cas9; liquid biopsy; molecular diagnostics; personalized medicine; genome-wide association studies (GWAS)

(This special issue belongs to the Section Molecular Biology)

New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside

edited by Irina Ivanova Stoyanova

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1417 | Submission Open

Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Pancreatic Diseases

edited by

Wasif Saif

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1372 | Submission Open

Keywords: pancreatic cancer; pancreatic neuroendocrine tumors; KRAS; KRAS inhibitors; KRASG12D inhibitor in pancreatic ductal adenocarcinoma; XPO1 inhibitor; PNET

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

HIV Infection, Pathogenesis and Treatment

edited by

Mudit Tyagi

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1349 | Submission Open

Keywords: HIV Infection; HIV; host immune responses; pathogenesis

(This special issue belongs to the Section Molecular Microbiology)

Displaying special issue 901-950 on page 19 of 66.

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