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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein Folding 2.0

edited by

Salvador Ventura

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4983 | Submission Open

Keywords: amyloid; calorimetry; chaperones; crowding and folding; downhill folding; energy lanscape; folding in biomembranes; folding in the cell; folding intermediates; folding kinetics; intrinsically disordered proteins; molecular dynamics simulation of folding; oxidative folding; protein aggregation; protein folding and design; protein folding and docking; protein folding and evolution; protein misfolding; single molecule folding; transition state analysis

(This special issue belongs to the Section Biochemistry)

Reproductive Endocrinology Research

edited by

Tsung-Hsien Lee

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4933 | Submission Open

Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on Adenosine Receptors: From Cell Biology to Human Diseases

edited by

Federica Mannino

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4785 | Submission Open

Keywords: adenosine; ARs; AR agonists; chronic diseases; therapeutic strategy; AR antagonists

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Growth Hormone and Human Disease

edited by

Joanna Smyczyńska

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4738 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Experimental and Clinical Aspects of Allergies and Autoimmunity

edited by

Krzysztof Bryniarski

and

Katarzyna Nazimek

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4657 | Submission Open

Keywords: advanced diagnostics; extracellular vesicles; hypersensitivity; immune regulation; long noncoding RNA; miRNA; novel therapeutics; research models of allergy and autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Exercise and Health: Cellular and Molecular Perspectives

edited by

Annamaria Mancini

submission deadline 20 Feb 2025 | 2 articles | Viewed by 4656 | Submission Open

Keywords: promoting health; anti-inflammatory action; anti-ageing action; mental health; mitochondrial adaptation; cellular function; regulation of gene expression; metabolic response to exercise

(This special issue belongs to the Section Molecular Biology)

Evolution, Maintenance and Molecular/Cellular Mechanisms of Totipotency, Pluripotency and Cell Stemness

edited by

Malgorzata Kloc

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4612 | Submission Open

Keywords: stemness; totipotent; self-renewal; asymmetric division

(This special issue belongs to the Section Molecular Biology)

Recent Advances of Proteomics in Human Health and Disease

edited by

Ekaterina Poverennaya

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4607 | Submission Open

Keywords: proteomics; biomarkers; drug target; disease mechanism; signalling pathways; interactomics; omics; proteoforms; bioinformatics; technology development

(This special issue belongs to the Section Molecular Informatics)

Advanced Research on the Immune Microenvironment in Tumors

edited by

Abeer Shaaban

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4577 | Submission Open

Keywords: cancer; tumor microenvironment; TILs; tumor-associated macrophages; PD-L1

(This special issue belongs to the Section Molecular Immunology)

Heart-Brain Interaction: Atrial Fibrillation and Stroke

edited by

Tihamér Molnár

and Giovanna Mercurio

submission deadline 20 Feb 2025 | 3 articles | Viewed by 4538 | Submission Open

Keywords: stroke; atrial fibrillation; cerebrovascular disease; heart– brain interaction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidant, Anti-inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights

edited by

Ramona Suharoschi

Oana Lelia Pop

and

Adriana Fodor

submission deadline 20 Feb 2025 | 2 articles | Viewed by 4344 | Submission Open

Keywords: phytochemicals; antioxidant activities; anti-inflammatory properties; antimicrobial effects; molecular mechanisms; clinical applications; traditional medicine; bioavailability; safety and toxicology and regulatory aspects of phytochemicals; pharmacological interaction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Skeletal Muscle Diseases

edited by

Olga Karpicheva

and

Yurii Borovikov

submission deadline 20 Feb 2025 | 4 articles | Viewed by 4308 | Submission Open

Keywords: muscle contraction; calcium regulation; desease-causing mutations; cross-bridge cycling and kinetics; thin filament; ATPase activity; actin– myosin interaction; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding the Mechanisms of Mitochondrial Stress and Its Association with Human Diseases

edited by

Jaeseok Han

submission deadline 20 Feb 2025 | 4 articles | Viewed by 4135 | Submission Open

Keywords: mitochondrial stress; mitochondrial quality control; mitophagy; mitochondrial unfolded protein response; mitochondrial fission and fusion; mitochondria-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Cytokines and Their Receptors in Human Tumors and Immune-Regulation

edited by

Spaska Stanilova

submission deadline 20 Feb 2025 | 2 articles | Viewed by 4059 | Submission Open

Keywords: cytokines; cytokine receptors; immune regulation; cytokine expression regulation; tumorogenesis; tumor development

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Immunotherapy of Soft Tissue and Bone Sarcomas

edited by

Minggui Pan

and

Nam Quoc Bui

submission deadline 20 Feb 2025 | 1 articles | Viewed by 3851 | Submission Open

(This special issue belongs to the Section Molecular Oncology)

Transcription Factors in Plant Gene Expression Regulation

edited by

Piotr Szymczyk

submission deadline 20 Feb 2025 | 4 articles | Viewed by 3836 | Submission Open

Keywords: plant trans-factor; cis-active sequence; post-translational modification; dimerization and oligomerization; DNA modules

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances: Heterocycles in Drugs and Drug Discovery 2.0

edited by

Ivana Pibiri

and

Carla Rizzo

submission deadline 20 Feb 2025 | 3 articles | Viewed by 3827 | Submission Open

Keywords: aromatic heterocycles; non-aromatic heterocycles; bioactive compounds; drug design; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Redox Biomarkers in the Evaluation of the Antioxidant Profile In Vitro and In Vivo

edited by

Dimitrios Kouretas

and

Fotios Tekos

submission deadline 20 Feb 2025 | 2 articles | Viewed by 3670 | Submission Open

Keywords: antioxidants; redox biomarkers; redox biology

(This special issue belongs to the Section Biochemistry)

Current Research on G Protein-Coupled Receptors

edited by Francis Galibert

submission deadline 20 Feb 2025 | 2 articles | Viewed by 3570 | Submission Open

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Allergy and Asthma: 3rd Edition

edited by

Bilal Alashkar Alhamwe

and

Daniel P. Potaczek

submission deadline 20 Feb 2025 | 4 articles | Viewed by 3570 | Submission Open

Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology

(This special issue belongs to the Section Molecular Biology)

Insulin Resistance and Metabolic Syndrome

edited by

Marcia Hiriart

submission deadline 20 Feb 2025 | 2 articles | Viewed by 3551 | Submission Open

Keywords: metabolic syndrome; insulin resistance; IRS; protein phosphorylation; insulin receptor; AKT; mTOR

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Kidney Diseases: Molecular Pathogenesis and Therapeutic Strategies—2nd Edition

edited by

Gábor Kökény

submission deadline 20 Feb 2025 | 2 articles | Viewed by 3493 | Submission Open

Keywords: kidney fibrosis; chronic kidney disease; gene expression; acute kidney injury; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Small Molecules with Spiro-Conjugated Cycles: Advances in Synthesis and Applications, 2nd Edition

edited by

Elena K. Beloglazkina

submission deadline 20 Feb 2025 | 3 articles | Viewed by 3475 | Submission Open

Keywords: bioactivity; carbocycles; cyclization; cycloaddition; heterocycles; low molecular weight materials; spiro-compounds; synthetic methods

(This special issue belongs to the Section Biochemistry)

Mechanisms Underlying Antioxidant Potency of Bioactive Compounds

edited by

Ana Amić

Antonio González-Sarrías

and

Dimitra Hadjipavlou-Litina

submission deadline 20 Feb 2025 | 1 articles | Viewed by 3325 | Submission Open

Keywords: natural compounds; radical scavenging; antioxidant potency; antioxidants; free radicals; reaction mechanisms; functional groups; ion chelation; thermodynamics; kinetics; DFT; computational chemistry; molecular docking; molecular modelling

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Stem Cells and Cardiovascular Diseases—More than Just about Cells

edited by

Katherine Sattler

submission deadline 20 Feb 2025 | 2 articles | Viewed by 3262 | Submission Open

Keywords: somatic stem cells or iPS-derived cells; paracrine cell function; secretome modeling; microvascular repair; tissue regeneration; genome editing of stem cells; environmental interference with stem cell function; in vitro and preclinical model

(This special issue belongs to the Section Molecular Biology)

Computational Molecular Biology of Metabolic Pathways and Signal Transduction Pathways

edited by Ralf Herwig

submission deadline 20 Feb 2025 | 3 articles | Viewed by 3191 | Submission Open

Keywords: computational genomics; computational structural and molecular biology; molecular dynamics simulations; artificial intelligence; AI-driven drug design and development; molecular modeling; computer-aided drug design; computational proteomics; computational and theoretical chemistry

(This special issue belongs to the Section Molecular Biology)

Immunotherapy versus Immune Modulation of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2025 | 2 articles | Viewed by 3062 | Submission Open

Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Applications of Spectrophotometric Determination

edited by

Kiril Gavazov

submission deadline 20 Feb 2025 | 3 articles | Viewed by 3016 | Submission Open

Keywords: molecular spectroscopy; UV-Vis spectrophotometry; determination; molecular mechanisms; molecular research; molecular modeling; complex formation; sample preparation; speciation analysis; green analytical chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Oxidative Stress and Mitochondrial Dysfunction

edited by

Giuseppe Lazzarino

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2978 | Submission Open

Keywords: oxidative/nitrosative stress; mitochondrial dysfunction; gene and protein expressions; neuroinflammation; stroke; traumatic brain injury; Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis; multiple sclerosis; acute and chronic neurodegenerations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Pain and Analgesia

edited by

Dong-Ho Youn

and Hee Young Kim

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2972 | Submission Open

Keywords: pain; analgesia; sensory transmission and integration; molecular pathways; pain genes; drug targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Effects of Bioactive Compounds in Oxidative Stress and Inflammation

edited by

Paul-Mihai Boarescu

and

Raluca Maria Pop

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2932 | Submission Open

Keywords: natural products; antioxidant effects; anti-inflammatory effects; molecular targets; health beneficial effect; bioactive compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Understanding Sepsis: Pathophysiology, Diagnostics and Early Intervention

edited by Erika Bosio

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2856 | Submission Open

Keywords: biomarkers; inflammation; coagulation; endothelial dysfunction; sepsis; septic shock; organ failure; resuscitation; antibiotics; infection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology of the Endocannabinoid System 2.0

edited by

Deanne H. Hryciw

submission deadline 20 Feb 2025 | 1 articles | Viewed by 2758 | Submission Open

Keywords: cannabinoid receptors; cannabinoid signalling; cannabinoid therapeutics; physiology; development; disease; organs

(This special issue belongs to the Section Molecular Biology)

Ribbon Synapses: Molecular Mechanisms of Synaptic Signaling and Involvement in Diseases 2.0

edited by

Ruth Heidelberger

Frank Schmitz

and

David Zenisek

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2718 | Submission Open

Keywords: ribbon synapses; molecular anatomy and physiology of ribbon synapses; retina; inner ear ribbon synapses; pineal gland; synaptic ribbon; exocytosis; endocytosis; neuronal networks; circadian rhythms and circadian signaling

(This special issue belongs to the Section Molecular Neurobiology)

Versatility of Protein Synthesis in a Test Tube

edited by

Tamás Mészáros

submission deadline 20 Feb 2025 | 3 articles | Viewed by 2700 | Submission Open

Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation

(This special issue belongs to the Section Molecular Biology)

Dipeptidyl Peptidases: From Structure to Function

edited by

Mihaela Matovina

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2676 | Submission Open

Keywords: dipeptidyl peptidase; protein structure; inhibitors; protein-protein interactions; cell signaling; oxidative stress; cancer; immune control

(This special issue belongs to the Section Biochemistry)

Genetic and Molecular Susceptibility in Human Diseases: 2nd Edition

edited by

Roberto Madeddu

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2627 | Submission Open

Keywords: genetic susceptibility; proteomics; gene expression; apoptosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Different Functions and Roles of microRNAs in Human Disease—Development, Progress and Challenges 2.0

edited by

Nitin Saksena

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2603 | Submission Open

Keywords: micro-RNA; infectious diseases; immune system; cancer; neurodegeneration; metabolic diseases; biomarkers; miRNA diagnostics

(This special issue belongs to the Section Molecular Biology)

Inflammaging and Brain Aging

edited by

Babak Baban

and David C. Hess

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2597 | Submission Open

Keywords: inflammaging; brain aging; aging; senescence; CNS; immunobiography; age-related diseases

(This special issue belongs to the Section Molecular Neurobiology)

Bacterial Adaptation Strategies to the Host: From Acute, Aggressive to Chronic, Dormant Infections, 2nd Edition

edited by

Bettina Löffler

and

Lorena Tuchscherr

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2586 | Submission Open

Keywords: dormancy; phenotype switching; bacterial stress; survival strategies; persisters; resuscitation; starvation; cell cycle arrest; ATP homeostasis

(This special issue belongs to the Section Molecular Microbiology)

RNA-Based Therapies for Lung Diseases

edited by

Marcella Barbarino

submission deadline 20 Feb 2025 | 1 articles | Viewed by 2526 | Submission Open

Keywords: RNA-based therapy; pulmonary diseases; lung cancer; COPD; fibrosis

(This special issue belongs to the Section Molecular Biology)

Application of Biomolecular Materials in Tissue Engineering

edited by

István Hornyák

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2516 | Submission Open

Keywords: biomolecular materials; tissue engineering; material science; in vitro and in vivo biodegradation; cell culture; tissue regeneration; cell scaffold; biocompatible materials

(This special issue belongs to the Section Materials Science)

Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition

edited by

Naoufal Lakhssassi

submission deadline 20 Feb 2025 | 1 articles | Viewed by 2516 | Submission Open

Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insight into Plant Bioactive Compounds

edited by

Karolina Wojtunik-Kulesza

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2505 | Submission Open

Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Human Microbiome 2.0

edited by

Maria Teresa Mascellino

submission deadline 20 Feb 2025 | 1 articles | Viewed by 2356 | Submission Open

Keywords: microbiome; microbial population; inflammatory bowel disease; bacterial translocation; Clostridium difficile infection

(This special issue belongs to the Section Molecular Microbiology)

Cell Motility and Its Underlying Cellular and Molecular Mechanisms

edited by

Maria Giulia Lionetto

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2348 | Submission Open

Keywords: cell motility; cell migration; cytoskeleton; adhesion; signaling; imaging; microscopy; molecular biology

(This special issue belongs to the Section Biochemistry)

Iron Dyshomeostasis

edited by

Carlo Marya Thomas Marobbio

and Sara Anjomani Virmouni

submission deadline 20 Feb 2025 | 1 articles | Viewed by 2231 | Submission Open

Keywords: iron metabolism; iron dyshomeostasis; ferroptosis; oxidative stress; mitochondrial disease

(This special issue belongs to the Section Biochemistry)

Molecular Research on the Neurodegenerative Diseases

edited by

Laszlo Bodai

and Nora Zsindely

submission deadline 20 Feb 2025 | 2 articles | Viewed by 2211 | Submission Open

Keywords: neurodegeneration; neurodegenerative disorders; Alzheimer’ s disease; Parkinson’ s disease; polyglutamine diseases; amyotrophic lateral sclerosis; multiple sclerosis; molecular pathomechanisms; pathogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular Biomarkers in Liver Diseases

edited by

Toshiaki Nakano

submission deadline 20 Feb 2025 | 1 articles | Viewed by 2199 | Submission Open

Keywords: acute rejection; animal models; biliary complications; chronic rejection; cirrhosis; fatty liver; fibrosis; hepatitis; hepatocellular carcinoma; jaundice; NASH; omics; tolerance

(This special issue belongs to the Section Molecular Immunology)

Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition

edited by