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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Heavy Metal and Fluoride Stress: Toxicity and Tolerance Mechanisms in Plants

edited by

Hatem Rouached

submission deadline 20 Apr 2026 | Viewed by 185 | Submission Open

Keywords: heavy metal toxicity; fluoride stress; stress tolerance mechanisms; phytoremediation; oxidative stress response

(This special issue belongs to the Section Molecular Plant Sciences)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 20 Apr 2026 | Viewed by 184 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

Autosomal Dominant Polycystic Kidney Disease (ADPKD): Molecular Mechanism, Management and Therapy

edited by

Maria Teresa Sciarrone Alibrandi

submission deadline 20 Apr 2026 | Viewed by 183 | Submission Open

Keywords: autosomal dominant polycystic kidney disease; ADPKD progression; cystic kidney disease; cardiovascular complications in ADPKD; biomarkers of ADPKD; genetics of polycystic kidney disease; renal imaging; targeted therapies in ADPKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Impact of Circulating Biomarkers and Metabolites on Cardiometabolic Disease and Cancer: New Insights and Therapeutic Opportunities

edited by Melania Gaggini and

Cristina Vassalle

submission deadline 20 Apr 2026 | Viewed by 183 | Submission Open

Keywords: lipidomic; metabolomic; lipotoxicity; oxidative stress; amino acids; metabolic disease; cardiovascular risk; tumorigenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeting Receptor Tyrosine Kinases and Related Signalling Pathways in Cancer: Mechanisms, Resistance, and Therapeutic Advances

edited by

Athina-Myrto Chioni

and

Richard Grose

submission deadline 20 Apr 2026 | Viewed by 180 | Submission Open

Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Intercellular Adhesion and Inflammatory Response in Cancer

edited by Anna Pryczynicz

submission deadline 20 Apr 2026 | Viewed by 175 | Submission Open

Keywords: adhesion; cancer; cancer therapy; inflammation; microenvironment

(This special issue belongs to the Section Molecular Biology)

Viral Biology: Infection and Pathology, Diagnosis and Treatment

edited by

Gergana Zahmanova

submission deadline 20 Apr 2026 | Viewed by 174 | Submission Open

Keywords: viral infection; viral pathogenesis; diagnostics; antiviral therapy; host– virus interactions; emerging viruses; zoonotic viruses; one health; vaccine development; CRISPR antivirals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism and Pharmacological Target of Neuroprotection

edited by

Pietro Cacialli

submission deadline 20 Apr 2026 | Viewed by 174 | Submission Open

Keywords: neurodegeneration; animal model; brain regeneration; pharmacological drug; molecular analysis

(This special issue belongs to the Section Molecular Neurobiology)

The Influence of Genetics on Lymphatic System Diseases

edited by

Tomomi Watanabe-Asaka

submission deadline 20 Apr 2026 | Viewed by 174 | Submission Open

Keywords: lymphatic system; gene expression; disease model; medical application; lymphatic development; lymphatic function

(This special issue belongs to the Section Molecular Genetics and Genomics)

Bioactive Compounds in Bee Products: Chemistry, Mechanisms of Action and Nutritional Applications

edited by

Jarosław Widelski

and

Ioanna Chinou

submission deadline 20 Apr 2026 | Viewed by 174 | Submission Open

Keywords: honey; propolis; royal jelly; polyphenols; nutritional properties; bioactivity; analytical and isolation methods; bee pollen

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 20 Apr 2026 | Viewed by 171 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Transcription Factors in Cancer

edited by

Tomasz Wilanowski

submission deadline 20 Apr 2026 | Viewed by 169 | Submission Open

Keywords: transcription factor; oncogene; tumor suppressor; nuclear receptor; genetic regulation; post-translational regulation; biomarker; drug target

(This special issue belongs to the Section Molecular Oncology)

Metabolic Dependencies of the Influence of Intestinal Microbiota During Pregnancy, Childbirth and Infancy

edited by Małgorzata Szczuko and Maciej Ziętek

submission deadline 20 Apr 2026 | Viewed by 169 | Submission Open

Keywords: microbiota; dysbiosis; intestinal microbiome; LPS; zonulin; calprotectin; occludin; SCFA; citrulline; glucagon-like peptide (GLP)-2; LPS binding protein (LBP); amyloid A; intestinal leakage

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 20 Apr 2026 | Viewed by 167 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Molecular-Scale Design, Synthesis, and Applications of (Photo)Electrochemical Materials for Sustainable Energy and Environmental Solutions

edited by

Shiwei Lin

and

Zhaohui Xiao

submission deadline 20 Apr 2026 | Viewed by 166 | Submission Open

Keywords: molecular-scale material engineering; photoelectrocatalysis/electrocatalysis; sustainable energy conversion; atomic-precision synthesis; environmental remediation technologies

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Role of Micronutrients in Cancer Prevention

edited by Jacek Baj

submission deadline 20 Apr 2026 | Viewed by 166 | Submission Open

Keywords: micronutrient; metallomics; metallomic analysis; nutrient; ICP-MS; ICP-OES; prevention; carcinogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Surfactant Sciences: Design, Synthesis, and Applications

edited by Zakaria Hafidi

submission deadline 20 Apr 2026 | Viewed by 163 | Submission Open

Keywords: surfactants; synthesis; biodegradation; catalysis; biological activity; nanoparticles; design; green chemistry; self-assembly; surface chemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Latest Molecular Research in Plant Secondary Metabolism

edited by

Andrey Marchev

submission deadline 20 Apr 2026 | Viewed by 160 | Submission Open

Keywords: plants; plant in vitro systems; secondary metabolism; metabolite profiling and fingerprinting; sustainable production; elicitation; metabolic engineering; CRISPR/Cas; molecular targets

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Research on Probiotics: Molecular Mechanisms and Health Applications

edited by

Ying Zhang

submission deadline 20 Apr 2026 | Viewed by 157 | Submission Open

Keywords: probiotics; molecular signaling; microbial– host crosstalk; metabolomic profiling; microbiome modulation; metabolite– receptor interaction

(This special issue belongs to the Section Molecular Microbiology)

Advances in Plant–Pathogen Interactions (4th Edition)

edited by

Fucheng Lin

submission deadline 20 Apr 2026 | Viewed by 156 | Submission Open

Keywords: host; effection; pathogenicity; pathogen; plant immunity; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Unraveling the Molecular Crosstalk Between Ferroptosis and Tumorigenesis

edited by

Ji Hoon Jung

submission deadline 20 Apr 2026 | Viewed by 151 | Submission Open

Keywords: tumorigenesis; ferroptosis; cancer biology; tumor development

(This special issue belongs to the Section Molecular Oncology)

Antimicrobial Agents and the Quest for Resistance Breakthroughs

edited by

Inês Bártolo

submission deadline 20 Apr 2026 | Viewed by 148 | Submission Open

Keywords: drug resistance; antimicrobial resistance (AMR); drug-resistant bacteria; drug-resistant viruses; drug-resistant fungi; drug-resistant parasite; drug resistance biomolecular studies; mechanism of resistance; novel antimicrobial agents; treatment of infectious diseases

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Techniques to Study Food Safety Challenges

edited by

María J. Andrade

and

Micaela Álvarez

submission deadline 20 Apr 2026 | Viewed by 147 | Submission Open

Keywords: food safety; hazards; foodborne pathogens; advanced microbial detection technologies; omics techniques; preventive measures

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Andrology

edited by Elikanah Olusayo Adegoke

submission deadline 20 Apr 2026 | Viewed by 147 | Submission Open

Keywords: fertilty; assisted reproduction technology; endocrine disrupting chemicals; hormones; male reproductive aging; semen analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanomedicine: Application of Nanostructured Biomaterials in the Biomedical Field

edited by

Yaser Dahman

submission deadline 20 Apr 2026 | Viewed by 144 | Submission Open

Keywords: nanomedicine; nanostructured biomaterials; targeted drug delivery; tissue regeneration; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

New Advances in Reversing Cancer Therapy Resistance

edited by

Tae Woo Kim

submission deadline 20 Apr 2026 | Viewed by 137 | Submission Open

Keywords: cancer; natural compound; cell death; radioresistance; chemoresistance

(This special issue belongs to the Section Molecular Pharmacology)

Pleiotropic NME Proteins: Nucleoside Diphosphate Kinases and Histidine-Protein Kinases

edited by

Krisztina Takács-Vellai

submission deadline 20 Apr 2026 | Viewed by 135 | Submission Open

Keywords: NDPK ; NME ; NM23 ; AWD ; protein-histidine kinase ; cancer ; metastasis ; bioenergetics ; cell signaling ; cardiovascular diseases

(This special issue belongs to the Section Biochemistry)

Novel Therapeutic Strategies and Targets in Rheumatoid Arthritis

edited by David Fox and

James J. Moon

submission deadline 20 Apr 2026 | Viewed by 135 | Submission Open

Keywords: RA; synovium; FLS; synovial fluid; microbiome; autoimmunity; DMARD; joint inflammation; joint damage; nanoparticle

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondria-Associated Non-Coding RNAs

edited by

Verónica A. Burzio

, Jaime E. Villegas and

Sam Das

submission deadline 20 Apr 2026 | Viewed by 134 | Submission Open

Keywords: mitochondrial-encoded ncRNAs; mitochondrial miRNAs; mitochondrial lncRNAs; mitochondrial circRNAs; nuclear-encoded mitochondrial ncRNAs

(This special issue belongs to the Section Molecular Biology)

Hydrogels and Nanogels: Revolutionizing Drug Delivery and Disease Detection

edited by Enrico Gallo

submission deadline 20 Apr 2026 | Viewed by 128 | Submission Open

Keywords: hydrogel and nanogel networks; supramolecular systems; hydrogel synthesis and analysis; nanogel preparation and characterization; nanostructured fibers; multiphase gels; biomedicine applications; supramolecular probes for imaging; hydrogels and nanogels as drug release systems; coatings and surface treatments; polymeric systems; peptide-based supramolecular systems

(This special issue belongs to the Section Materials Science)

Eco-Conscious Therapeutics: Molecular Foundations and Future Directions in Green Medicine

edited by

Adi Lahat

and

Kassem Sharif

submission deadline 20 Apr 2026 | Viewed by 127 | Submission Open

Keywords: green medicine; molecular therapeutics; sustainable healthcare; biomarker profiling; predictive toxicology; eco-friendly drug design; environmental impact; biodegradable materials

(This special issue belongs to the Section Molecular Toxicology)

Magnetic Nanoparticles: From Synthesis and Modification to Biomedical Applications

edited by

Ahmet Kertmen

submission deadline 20 Apr 2026 | Viewed by 126 | Submission Open

Keywords: magnetite nanoparticles; colloidal interactions; X-ray characterizations; biomedical applications; method development; imaging

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research in Leukemia

edited by Juan Manuel Mejia-Arangure

submission deadline 20 Apr 2026 | Viewed by 123 | Submission Open

Keywords: leukemia; molecular biology; genetic testing; epigenomics; targeted therapy; precision medicine; diagnostic techniques; molecular pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Antimicrobial Agents and Resistance Mechanisms

edited by

Julieta Luna-Herrera

submission deadline 20 Apr 2026 | Viewed by 118 | Submission Open

Keywords: acquired resistance; antibiotic inactivation; antibiotic modifications; antibiotic uptake; antibiotics; antimicrobial agents; bacterial dormancy; efflux pumps; extrachromosomal elements; genomic mutations; novel antimicrobial molecules; resistant mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Nano-Biomaterials for Biomedicine and Tissue Regeneration

edited by

Silvia Barbon

and

Elena Stocco

submission deadline 20 Apr 2026 | Viewed by 116 | Submission Open

Keywords: nanostructured biomaterials; cell-scaffold interactions; drug delivery systems; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

Genome Editing in Autologous Stem Cells: From Bench to Bedside

edited by

Edina Poletto

submission deadline 20 Apr 2026 | Viewed by 114 | Submission Open

Keywords: genome editing; gene therapy; autologous transplant; preclinical studies; process development; scalability; quality control; manufacturing; regulatory compliance; IND-enabling studies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Antimicrobial Nanoparticles

edited by

Lide Arana

and

Ianire Mate

submission deadline 20 Apr 2026 | Viewed by 112 | Submission Open

Keywords: antimicrobial nanoparticles; resistant pathogens; antimicrobial resistance; lipid nanoparticles; biomimetic nanostructures; combined therapy; antimicrobial strategies

(This special issue belongs to the Section Molecular Nanoscience)

Nanocomposite Fibers: Current Status and Applications

edited by

Mourad Krifa

submission deadline 20 Apr 2026 | Viewed by 109 | Submission Open

Keywords: advanced fibrous and particulate materials; nano-enhanced textiles; natural fiber utilization; fiber quality; textile processing

(This special issue belongs to the Section Molecular Nanoscience)

Metal Toxicity and Particle Toxicity

edited by Alicja Piotrowska-Niczyporuk

submission deadline 20 Apr 2026 | Viewed by 103 | Submission Open

Keywords: metals; particles; toxicity; microplastic; environment pollution; animals; plants; algae

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms and Pathways of Epithelial-Mesenchymal Transition

edited by

Noemi Monti

submission deadline 20 Apr 2026 | Viewed by 102 | Submission Open

Keywords: metastasis; fibrosis; tumor microenvironment; molecular pathways; EMT reversion

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Genetics of Head and Neck Cancer

edited by

Jacek Kabziński

submission deadline 20 Apr 2026 | Viewed by 101 | Submission Open

Keywords: head and neck cancer; molecular genetics; tumor heterogeneity; driver mutations; epigenetic alterations; non-coding RNAs; oncogenes and tumor suppressors; gene expression profiling; genomic instability; biomarkers for diagnosis and therapy

(This special issue belongs to the Section Molecular Oncology)

Dynamic Nanoarchitectonics in Supramolecular Assemblies and Nanosystems: From Synthesis to Applications

edited by

Vicente Martí-Centelles

submission deadline 20 Apr 2026 | Viewed by 99 | Submission Open

Keywords: supramolecular chemistry; synthetic chemistry; nanoscale materials; nanostructured materials; molecular self-assembly; nanoparticles; nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Biomaterials for Dental and Orthopedic Applications, 2nd Edition

edited by

Lia Rimondini

submission deadline 20 Apr 2026 | Viewed by 62 | Submission Open

Keywords: personalized biomaterials; dental and orthopedic applications; tissue regeneration; 3D biorinting

(This special issue belongs to the Section Materials Science)

Tumor Markers and Tumor Microenvironment

edited by Tamás Micsik

submission deadline 20 Apr 2026 | Viewed by 59 | Submission Open

Keywords: tumor markers; tumor environment; molecular and genetics; omics; artificial intelligence; digital pathology; computational pathology; individualized therapy; prognostication

(This special issue belongs to the Section Molecular Oncology)

Latest Research on Drug-Diagnostics Co-Development in Oncology

edited by

Laxmi Swetha Karanam

submission deadline 20 Apr 2026 | Viewed by 54 | Submission Open

Keywords: companion diagnostics; tumor; drug– diagnostic co-development; molecular profiling; biomarker; theranostics

(This special issue belongs to the Section Molecular Oncology)

Plant Responses to Abiotic and Biotic Stresses: 2nd Editon

edited by

Longxing Tao

and

Tingting Chen

submission deadline 20 Apr 2026 | Viewed by 45 | Submission Open

Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Obstetrical and Gynaecological Disorders: 2nd Edition

edited by

Panagiotis Christopoulos

submission deadline 20 Apr 2026 | Viewed by 35 | Submission Open

Keywords: gynaecological disorders; obstetrical disorders; gynaecological diseases; genetic markers; molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research on Natural Compounds: Biosynthesis, Analysis, and Application

edited by

Aleksandar Shkondrov

submission deadline 20 Apr 2026 | Viewed by 30 | Submission Open

Keywords: phytochemicals; natural compounds; chromatography; MS; NMR; analysis; identification; extraction; standardisation; quantitation; activity; moleabular mechanism; biosynthesis

(This special issue belongs to the Section Biochemistry)

From Molecular Mechanisms to Precision Medicine in Gastrointestinal Cancers: (Epi)genetics, Pharmacogenomics, and Emerging Biomarkers

edited by

Kostas A. Triantaphyllopoulos

submission deadline 20 Apr 2026 | Viewed by 28 | Submission Open

Keywords: gastrointestinal and colorectal cancer; genetic and epigenetic regulation; multi-omics and computational biology; molecular pathology and biomarker discovery; translational and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetic and Post-Transcriptional Regulation of Gene Expression

edited by Lidia Borkiewicz

submission deadline 20 Apr 2026 | Viewed by 21 | Submission Open

Keywords: epigenome; DNA methylation; chromatin remodeling; histone modifications; non-coding RNA; epitranscriptome; alternative splicing; RNA methylation; RNA edition

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2951-3000 on page 60 of 69.

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