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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on the Immunomodulatory Role of Macrophages

edited by

Daniel Paparini

submission deadline 31 Oct 2026 | Viewed by 22 | Submission Open

Keywords: disease models; immunometabolism; extracellular vesicles; biomarkers; inflammation; therapeutic targets; pregnancy

(This special issue belongs to the Section Molecular Immunology)

Inherited Metabolic Disorders: Genetic Insights and Therapeutic Strategies

edited by

Fabiano Poswar

and Kristiane Michelin-Tirelli

submission deadline 31 Oct 2026 | Viewed by 21 | Submission Open

Keywords: inherited metabolic disorders; animal models; biomarkers; clinical laboratory techniques; tandem mass spectrometry; high-throughput nucleotide sequencing; cell- and tissue-based therapy; genetic therapy; enzyme replacement therapy; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Products and Functional Biomaterials in Wound Healing and Cancer Treatment

edited by Shaik Nyamathulla

submission deadline 31 Oct 2026 | Viewed by 21 | Submission Open

Keywords: cancer; wound healing; biomaterials; scaffolds; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein S in Coagulation, Inflammation, and Cancer

edited by

Rinku Majumder

submission deadline 31 Oct 2026 | Viewed by 21 | Submission Open

Keywords: Protein S; hemostasis; anticoagulation; inflammation; cancer biology; thrombotic disorders; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Microbial Infections and Novel Biological Molecules for Treatment: 2nd Edition

edited by Matthew Cheesman

submission deadline 31 Oct 2026 | Viewed by 21 | Submission Open

Keywords: microbial infections; infectious diseases; new antibiotics; antimicrobial resistance (AMR); antimicrobial drugs; active substance; bacterial; virus

(This special issue belongs to the Section Molecular Microbiology)

Molecular Immunology and Defenses: Oral and Periodontal Health

edited by Evangelos Papathanasiou

submission deadline 31 Oct 2026 | Viewed by 20 | Submission Open

Keywords: periodontal disease; immune response; host defense; inflammation; immune regulation

(This special issue belongs to the Section Molecular Immunology)

The Multiple Roles of RNA and RNases

edited by

Ester Boix

submission deadline 31 Oct 2026 | Viewed by 20 | Submission Open

Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA-binding proteins; RNA recognition patterns; RNA catalysis

(This special issue belongs to the Section Molecular Biology)

Bioactive Lipid Signaling in Cardiovascular and Metabolism-Associated Diseases

edited by

Nathalie Mercier

submission deadline 31 Oct 2026 | Viewed by 20 | Submission Open

Keywords: bioactive lipids; inflammation; lipid metabolism; lipid signaling pathways; cardiovascular and metabolism-associated diseases; cellular phenotype; lipid receptors; cardiovascular treatments; lipidomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nanotechnology in Precision Medicine for Pancreatic Cancer

edited by Virendar Kumar

submission deadline 31 Oct 2026 | Viewed by 19 | Submission Open

Keywords: nanotechnology; precision medicine; pancreatic cancer; pancreatic ductal adenocarcinoma (PDAC); tumor microenvironment; desmoplasia / stromal barrier; targeted drug delivery; stimuli-responsive nanocarriers; theranostics; nucleic acid therapeutics (siRNA / mRNA); cancer immunotherapy; translational nanomedicine/clinical translation

(This special issue belongs to the Section Molecular Nanoscience)

Multi-Omics and AI-Driven Discovery of Abiotic Stress Resilience in Crops

edited by

Romit Seth

submission deadline 31 Oct 2026 | Viewed by 19 | Submission Open

Keywords: genomics; pangenome; abiotic stress; multi-omics; artificial intelligence; climate extremes; predictive breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Gene and Nucleic Acid-Based Therapeutics: From Molecular Innovations to Potential Misuse

edited by

Teruaki Tozaki

submission deadline 31 Oct 2026 | Viewed by 18 | Submission Open

Keywords: gene therapy; nucleic acid therapeutics; mRNA therapeutics; lipid nanoparticles (LNPs); genome editing (CRISPR/Cas); gene delivery systems; cell therapy; pharmacokinetics and safety; gene doping; detection methods

(This special issue belongs to the Section Molecular Genetics and Genomics)

Aquaculture: Genomics, Genetics and Breeding

edited by Chunde Wang and Shaoxuan Wu

submission deadline 31 Oct 2026 | Viewed by 18 | Submission Open

Keywords: aquaculture; genetics; molecular breeding

(This special issue belongs to the Section Molecular Genetics and Genomics)

Collagen and Lipid-Based Nanoagents/Nanoparticles: Chemical Investigation and Delivery

edited by

Riyanto Teguh Widodo

submission deadline 31 Oct 2026 | Viewed by 18 | Submission Open

Keywords: collagen nanoparticles; lipid nanoparticles; drug delivery system; nanocarriers; liposomes; niosomes; nanostructured lipid carriers; biocompatibility; surface functionalisation; nanoagents; molecular characterisation; controlled release

(This special issue belongs to the Section Molecular Pharmacology)

Immune Defense Mechanisms of the External, Middle, and Inner Ear

edited by

Chul Ho Jang

submission deadline 31 Oct 2026 | Viewed by 18 | Submission Open

Keywords: ear immunology; mucosal immunity; autoimmune inner ear disease (AIED); innate immune response; blood– labyrinth barrier; middle ear immune defense

(This special issue belongs to the Section Molecular Immunology)

Acute Lymphoblastic Leukemia (ALL): From Molecular Drivers to Therapeutic Innovation

edited by Carmen Maldonado-Bernal

submission deadline 31 Oct 2026 | Viewed by 18 | Submission Open

Keywords: acute lymphoblastic leukemia; minimal residual disease; molecular drivers; genetic drivers treatment approaches; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Emulsion Systems in Pharmaceutical Science: Stability, Drug Delivery, and Biocatalytic Applications

edited by

Tomasz Siodmiak

submission deadline 31 Oct 2026 | Viewed by 18 | Submission Open

Keywords: emulsion systems; emulsion stability; drug delivery; pharmaceutical formulations; surfactants; supports; enzyme immobilization; biocatalysis; chiral drugs; kinetic resolution; enantioselective synthesis; lipolytic activity

(This special issue belongs to the Section Molecular Pharmacology)

Microbial Fermentation Optimization and Product Bioactivity

edited by

Wai Prathumpai

submission deadline 31 Oct 2026 | Viewed by 16 | Submission Open

Keywords: microbial processes; bioprocess engineering; bioreactor process optimization; engineering design; synthetic biology; metabolic engineering; metabolic regulation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Studies on Natural Products: Anti-Inflammatory, Immune Response, and Anti-Bacterial Activities

edited by Hicham Wahnou

submission deadline 31 Oct 2026 | Viewed by 16 | Submission Open

Keywords: natural products; anti-inflammatory; immune response; antibacterial; molecular mechanisms; phytochemicals; immunomodulation; probiotics; prebiotics; synbiotics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Ion Channel in Physiology

edited by Isaac E. García

submission deadline 31 Oct 2026 | Viewed by 16 | Submission Open

Keywords: ion channels; channel gating mechanisms; structure– function relationships; electrophysiology; cryo-electron microscopy (cryo-EM); connexin hemichannels and gap junctions; pannexin channels; ion transporters; cell signaling and homeostasis; channelopathies

(This special issue belongs to the Section Molecular Biophysics)

Bioactive Compounds from Microorganisms and Their Biotechnological Applications

edited by

Christian Anumudu

submission deadline 31 Oct 2026 | Viewed by 15 | Submission Open

Keywords: microbial bioactive compounds; secondary metabolites; natural products; antimicrobial agents; drug discovery; metabolomics; genomics; synthetic biology; fermentation biotechnology; bioprocessing; enzyme biotechnology; microbial peptides; polysaccharides; industrial biotechnology; biopharmaceuticals; anticancer compounds; anti-inflammatory agents; microbiome-derived compounds; sustainable production

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism and Therapeutic Strategy in Viral Infection

edited by Luisa Fernanda Duarte, Aracelly Gaete-Argel and Aldo Barrera

submission deadline 31 Oct 2026 | Viewed by 14 | Submission Open

Keywords: viral infections; immune evasion; inflammation; antiviral responses; vaccine; drug delivery systems; single-cell analysis; multi-omics approaches

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research and Insight in Plant Genetic Breeding

edited by

Bing He

submission deadline 31 Oct 2026 | Viewed by 14 | Submission Open

Keywords: plant genetic breeding; crop genomics; gene editing; molecular markers; functional genomics; germplasm enhancement; omics breeding; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Epigenetic Regulation in Health and Disease: From Molecular Mechanisms to Clinical Applications

edited by

Sara C. Zapico

submission deadline 31 Oct 2026 | Viewed by 12 | Submission Open

Keywords: epigenetic modifications; DNA methylation; histone modifications; chromatin remodeling; non-coding RNAs; environmental epigenetics; development and aging; disease epigenetics; translational epigenetics; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Calcium Channel Signaling: From Molecular Structure to Physiological Function

edited by

Dongki Yang

submission deadline 31 Oct 2026 | Viewed by 11 | Submission Open

Keywords: calcium signaling; ion channels; cell signaling; intracellular signaling; membrane proteins; electrophysiology; structural biology; cryo-electron microscopy; protein structure– function; signal transduction; calcium homeostasis; cellular physiology; molecular mechanisms; imaging techniques; live-cell imaging; systems biology; computational biology; pharmacology; drug discovery; therapeutic targets; translational research; disease mechanisms; cardiovascular diseases; neurological disorders; neurodegeneration; cancer biology; metabolism; inflammation; stem cells

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Reparative Therapeutic Strategies in Neurodegenerative Diseases

edited by

Cesar Borlongan

and Amir Hadanny

submission deadline 31 Oct 2026 | Viewed by 9 | Submission Open

Keywords: neurodegeneration; cell death signaling; oxidative stress; mitochondrial dysfunction; brain repair

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Docking Studies and Enzyme Inhibitory Assessment of Synthesized Heterocyclic Compounds

edited by

Mohamed Maatallah

submission deadline 31 Oct 2026 | Viewed by 6 | Submission Open

Keywords: heterocyclic compounds; molecular docking; enzyme inhibition; structure activity relationships (SAR); synthetic medicinal chemistry; computational chemistry; in silico drug design; ADMET prediction; molecular dynamics simulation

(This special issue belongs to the Section Biochemistry)

New Predictive Biomarkers for Ovarian Cancers

edited by

Olga Lilia Garibay-Cerdenares

submission deadline 31 Oct 2026 | Submission Open

Keywords: ovarian cancer; biomarkers; chemorresistance; nanotechnology; ovarian cancer signaling; metabolic plasticity in ovarian cancer; omics in ovarian cancer

(This special issue belongs to the Section Molecular Oncology)

Medicinal Plants and Natural Compounds in Health and Disease: Progresses, Challenges, Opportunities, 2nd Edition

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Nov 2026 | 3 articles | Viewed by 22955 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; oxidative stress; gene expression; protein expression; cellular signaling; ethnopharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 20 Nov 2026 | 5 articles | Viewed by 17552 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Emerging Therapies in Neurovascular Disease

edited by Leonidas D. Panos

submission deadline 20 Nov 2026 | 3 articles | Viewed by 16417 | Submission Open

Keywords: neurovascular diseases; blood– brain barrier; endothelial dysfunction; cellular signaling; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 20 Nov 2026 | 6 articles | Viewed by 10292 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition

edited by

Zhidong Zhou

submission deadline 20 Nov 2026 | 2 articles | Viewed by 8592 | Submission Open

Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies

(This special issue belongs to the Section Molecular Neurobiology)

Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition

edited by

Alessandro Fanzani

and

Silvia Codenotti

submission deadline 20 Nov 2026 | 3 articles | Viewed by 8339 | Submission Open

Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Diagnostics and Genomics of Tumors, 2nd Edition

edited by

Petra Korać

submission deadline 20 Nov 2026 | 8 articles | Viewed by 7466 | Submission Open

Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advancing Regenerative Medicine: Basic Research and Translation in Clinics

edited by

Dragan Primorac

submission deadline 20 Nov 2026 | 2 articles | Viewed by 7268 | Submission Open

Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics

(This special issue belongs to the Section Molecular Biology)

Amyotrophic Lateral Sclerosis: From Molecular Basis to Therapies

edited by

Matteo Bordoni

submission deadline 20 Nov 2026 | 2 articles | Viewed by 5962 | Submission Open

Keywords: ALS; pathomechanisms; genetics; epigenetics; disease models; neuroinflammation; mithocondria; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Precision Medicine in Urological Cancers: Integrating Multi-Omics and Optimizing Therapeutic Approaches

edited by Magaly Martinez-Ferrer

submission deadline 20 Nov 2026 | 1 articles | Viewed by 4865 | Submission Open

Keywords: prostate cancer; proteomics; metabolomics; precision medicine; biomarker

(This special issue belongs to the Section Molecular Oncology)

Bioactive Natural Compounds in Neuroscience

edited by

Sarmistha Mitra

submission deadline 20 Nov 2026 | 3 articles | Viewed by 3703 | Submission Open

Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genomics, Genetics, and the Future of Fruit Improvement

edited by Zoe Hilioti

submission deadline 20 Nov 2026 | 2 articles | Viewed by 3437 | Submission Open

Keywords: fruit traits; genetics; genetic diversity; omics; new breeding techniques; fruit quality; shelf life

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research on Cancer Stem Cells

edited by

Ilze Štrumfa

and Inta Liepniece-Karele

submission deadline 20 Nov 2026 | 3 articles | Viewed by 3432 | Submission Open

Keywords: cancer stem cells; tumour microenvironment; pancreatic cancer; glioblastoma; gastric cancer; breast cancer; lung cancer; colorectal cancer; renal cancer; liver cancer; melanoma; leukemia; lymphoma

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Dyslipidemia

edited by

Aleksandra Zeljkovic

and

Jelena Vekić

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2892 | Submission Open

Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Nov 2026 | 1 articles | Viewed by 2804 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

Bioactives from Natural Products

edited by

Antía González Pereira

submission deadline 20 Nov 2026 | 2 articles | Viewed by 2429 | Submission Open

Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1885 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Next-Generation Therapeutic Polymers: From Molecular Design to Dual Antibacterial/Antithrombotic Action

edited by

Piotr Dobrzynski

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1781 | Submission Open

Keywords: antibacterial polymers; antifouling polymers; anticoagulant polymers; heparin-mimicking polymers; heparin-conjugated polymers; phosphorylcholine-based polymers; polymeric nitric oxide donors; polymers; loaded with silver ions; or antibiotics; antibacterial nano- and micro particles; anticoagulant layers

(This special issue belongs to the Section Materials Science)

Current Research on Colloidal Emulsions: Preparation and Applications

edited by Alexander Djerdjev

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1764 | Submission Open

Keywords: emulsion formulation and stability; nano-; micro-; and high-internal-phase emulsions; drug delivery; aerogels; pickering emulsions; food emulsions; oil– water interface; surfactants; zeta potential at hydrophobic interfaces; advances in emulsion technology

(This special issue belongs to the Section Materials Science)

Flow Cytometry as a Tool for Diagnostics and Biomarker Research

edited by

Leslie Chavez-Galan

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1606 | Submission Open

Keywords: biomarkers; flow cytometry; spectral cytometry; mass cytometry; translational research; human health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress in Synthesis, Properties, and Applications of Polyoxometalates and Their Nanocrystals

edited by

Xiang Ma

and

Pengtao Ma

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1412 | Submission Open

Keywords: polyoxometalates; POMs; metal cluster compound; inorganic chemistry; nanocrystals

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1265 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Marine Natural Products as a Source of Therapeutics—Recent Trends

edited by

Komal Anjum

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1177 | Submission Open

Keywords: marine natural products; marine-associated microbes; antimicrobial drug; antibiotics; marine-derived peptides; anti-inflammatory; molecular pharmacology; targeted therapies; extraction

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 2951-3000 on page 60 of 67.

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