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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment

edited by

Stefania Grimaudo

and

Rosaria Maria Pipitone

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2298 | Submission Open

Keywords: MAFLD; MASH; metabolic syndrome; steatosis; lipid droplets; SNPs; GWAS; therapeutc target; fatty liver; steatohepatitis; HCC; EpigEnetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Drug Treatment and Cancer Cell Drug Resistance

edited by

Juan Sebastian Yakisich

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2278 | Submission Open

Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Gastrointestinal Disease: Exploring the Interplay Between Inflammation, Autoimmunity, and Cancer

edited by Spyridon Siakavellas and

Stavros P. Papadakos

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2221 | Submission Open

Keywords: gastrointestinal disease; inflammation; autoimmunity; gut microbiota

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Nature to Medicine: Exploring Natural Products for New Therapies

edited by

Alejandro Madrid

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2191 | Submission Open

Keywords: secondary metabolites; flavonoids; terpenes; hemisynthetic compounds; cytotoxic activity; antimicrobial activity; antioxidant activity; natural products; essential oil; resinous exudate

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Veterinary Science

edited by

JeongWoo Kang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2132 | Submission Open

Keywords: forensic pathology and necropsy; forensic toxicology; DNA analysis in veterinary forensics; the role of veterinarians in legal investigations; case studies in veterinary forensics

(This special issue belongs to the Section Molecular Toxicology)

Systemic Sclerosis: New Insight into Pathogenesis, Molecular and Immune Mechanisms

edited by

Przemysław Kotyla

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2073 | Submission Open

Keywords: systemic sclerosis; autoimmunity; inflammation; fibrosis; pathophysiology and treatment; profibrotic signaling; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lipid Metabolism and Biomarkers in Neural and Cardiometabolic Health

edited by

Elena Vianello

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2014 | Submission Open

Keywords: lipid species; cardiovascular health; neural health; inflammation; cardiac biomarkers; neural biomarkers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Thyroid Hormone in Health and Disease

edited by Sandra Incerpi and Jens Z. Pedersen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1995 | Submission Open

Keywords: nongenomic effects; integrin α vβ 3; crosstalk; signal transduction; metabolites; 3; 5-diiodothyronine; tetraiodothyrocetic acid (tetrac); antioxidant; oxidative stress; stilbene derivatives

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Cell Cycle-Related Proteins: Biochemical Regulative/Deregulative Mechanisms

edited by

Emanuela Stampone

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1981 | Submission Open

Keywords: cell cycle; cell division; cyclins; cyclin-dependent kinases (CDKs); biochemical regulative mechanisms

(This special issue belongs to the Section Biochemistry)

Anticancer and Chemopreventive Activity of Natural Products and Its Derivatives

edited by

Magdalena Bartnik

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1967 | Submission Open

Keywords: coumarins; coumarin derivatives; anticancer activity; chemopreventive activity; therapy adjuvant; mechanism of action; in vitro and in vivo studies; molecular research; metabolic pathway; phytochemicals; natural products; apoptosis; bioactivity assessment; chemical composition; therapeutic targets

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Diseases in Humans and Animals: From Emergence to Translational Medicine

edited by

Pawel Kordowitzki

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1947 | Submission Open

Keywords: animal diseases; human diseases; viruses; bacteria; translational medicine; environment; zoonosis; One Health; disease models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Radiopharmaceuticals and Radiotherapy

edited by Feifei An

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1828 | Submission Open

Keywords: positron emission tomography; single photon emission computed tomography; boron neutron capture therapy; alfa-particle; radiopharmaceutical; radiotherapy; radiosensitizer; Cu-67; Lu-177; I-131; Ac-225; Pb-212; At-211

(This special issue belongs to the Section Molecular Pharmacology)

Understanding and Treating Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases

edited by

Patrick Vourc'h

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1804 | Submission Open

Keywords: neurodegenerative; ALS; motor neuron; genetics; molecular pathways; biomarkers; models; treatments

(This special issue belongs to the Section Molecular Neurobiology)

Histopathological and Cytological Biomarkers for Breast and Gynecologic Cancers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Yosep Chong

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1801 | Submission Open

Keywords: pathology; cytopathology; malignant effusions; biomarker; breast cancer; ovarian cancer; endometrial cancer; cervical cancer; metastasis; immunohistochemistry; immunocytochemistry; immunotherapy; genomics; proteomics; personalized medicine; prognosis and therapy; digital pathology; artificial intelligence; machine learning

(This special issue belongs to the Section Molecular Oncology)

Integrating Molecular Insights on Plant Microbes and Insect Pests

edited by

Xifeng Wang

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1790 | Submission Open

Keywords: pathogenic microbes; resistance mechanisms; signaling pathways; omics technologies; plant and insect interactions

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Epigenetics in Genome Maintenance and Its Relationship to Organismal Aging and Age-Related Diseases

edited by Berta Vázquez and Gerardo Ferrer

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1730 | Submission Open

Keywords: chromatin; DNA damage; DNA repair; gene transcription; DNA replication; chromosome segregation; genome integrity; chromosome organization

(This special issue belongs to the Section Molecular Genetics and Genomics)

Regulatory Mechanisms of Development and Abiotic Stress Response by Transcriptional Regulators in Plants: 2nd Edition

edited by

Yong-Hwan Moon

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1730 | Submission Open

Keywords: transcriptional regulator; transcription activation; transcription factor; transcription repression; plant development; abiotic stress response; epigenetic regulation; genome-wide analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Challenges in Molecularly Imprinted Materials

edited by

Monika Sobiech

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1667 | Submission Open

Keywords: molecularly imprinted polymer; ion imprinting; molecular recognition; artificial receptor; binding polymer; biomimetic sensor; computer simulation; hybrid materials; nanocomposites; modeling and optimization

(This special issue belongs to the Section Materials Science)

Biomarkers for Cardiovascular Risk Prediction

edited by

Sanja Stankovic

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1638 | Submission Open

Keywords: biomarker; cardiovascular disease; risk stratification; inflammation; vascular damage; micro-RNA; therapy; artificial intelligence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pharmacological Treatment of Neuroinflammation

edited by Beatrice Polini

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1580 | Submission Open

Keywords: microglia; neuroinflammation; neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; therapeutic; natural molecules

(This special issue belongs to the Section Molecular Neurobiology)

Toxicity Mechanism of Emerging Pollutants: 2nd Edition

edited by

Monika Naumowicz

and

Joanna Kotyńska

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1511 | Submission Open

Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Advances in Secondary Metabolites in Plants

edited by

Sławomir Dresler

submission deadline 20 Dec 2025 | 3 articles | Viewed by 1494 | Submission Open

Keywords: specialized metabolites; biosynthesis pathways; pharmacological applications; medicinal plants; plant stress resistance; abiotic and biotic elicitors; chemometric analysis; plant biotechnology; therapeutic potential; plant signaling and communication

(This special issue belongs to the Section Molecular Plant Sciences)

The Use of Molecular Biology in the Targeted Prevention, Diagnosis and Therapy of Microbial Infections

edited by

Maria D'Accolti

and

Elisabetta Caselli

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1478 | Submission Open

Keywords: microbial infections; AMR; molecular biology; One Health; microbiome

(This special issue belongs to the Section Molecular Microbiology)

Extraction, Isolation and Identification of Natural Chemicals

edited by Jiaozhen Zhang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1364 | Submission Open

Keywords: extraction; isolation; identification; natural chemicals; biological activities

(This special issue belongs to the Section Biochemistry)

Pregnancy-Related Complications: From Pathogenesis to Treatment

edited by

Ozlem Guzeloglu-Kayisli

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1362 | Submission Open

Keywords: adverse pregnancy outcomes; spontaneous preterm birth; idiopathic preterm birth; preeclampsia; fetal growth restriction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Insights into Ischemia/Reperfusion: 2nd Edition

edited by

Moo-Ho Won

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1310 | Submission Open

Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

A Commemorative Issue in Honor of Professor Peter A. Ward: World Expert in Sepsis

edited by Peter Ward

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1245 | Submission Open

Keywords: sepsis; neutrophils; macrophages; histones; chemical modifications; apoptosis; complement factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell

edited by Przemyslaw Bozko

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1189 | Submission Open

Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition

edited by

Jasmin Knopf

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1181 | Submission Open

Keywords: neutrophils; neutrophil functions; neutrophil extracellular traps (NETs); NET biology; NETs in autoimmune diseases; NETs in immune response; NETs in the development and progression of cancer diseases; NETs in immunothrombosis; degradation of NETs

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of Fish Stress

edited by

Tao Yin

Yong Long

and

Min Jin

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1172 | Submission Open

Keywords: fish stress; molecular biology; omics; apoptosis; inflammation

(This special issue belongs to the Section Molecular Biology)

New Insights into Photosystem I (Second Edition)

edited by

Stefano Santabarbara

and

Gary Hastings

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1163 | Submission Open

Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Anticancer Strategies

edited by

Yong Teng

submission deadline 20 Dec 2025 | Viewed by 1141 | Submission Open

Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress and Mitochondria in Human Diseases

edited by

Alejandra Espinosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1125 | Submission Open

Keywords: mitochondrial dynamics; ROS; antioxidants; mitophagy; oxidative damage; lipid peroxidation; neurodegenerative diseases; cancer; obesity

(This special issue belongs to the Section Biochemistry)

Cardiac Repair and Regeneration: From Pathogenesis to Therapeutic Perspectives

edited by Marina Leone and Olaf Bergmann

submission deadline 20 Dec 2025 | Viewed by 1109 | Submission Open

Keywords: heart regeneration; cardiomyocyte proliferation; cell cycle; ischemic heart disease; myocardial infarction; stem cells; cardiac repair; polyploidization; tissue engineering; immune cells; metabolism; cell death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Type 2 Diabetes: Molecular Pathophysiology and Treatment

edited by

Edit Szabó

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1090 | Submission Open

Keywords: type 2 diabetes mellitus and comorbidity; bioinformatics; molecular pathways; genetic background; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Recent Advances in Organic Chemistry: Molecule Synthesis and Reactions (2nd Edition)

edited by

José Justicia

and

Rachid Chahboun

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1085 | Submission Open

Keywords: bioactive natural products; organocatalysis; photoredox reactions; free-radical reactions; organometallic reactions; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Osteoarthritis: From Pathophysiology to Novel Therapy

edited by

Paloma Guillem-Llobat

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1084 | Submission Open

Keywords: osteoarthritis; therapeutic targets; molecular mechanisms; biomarkers; bone degenerative disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1082 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Targeting Metabolic Reprogramming: From Pathogenesis to Therapeutic Strategies

edited by

Beatriz García-Díaz

, Alejandro Escamilla and

Raquel Sanchez-Varo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1050 | Submission Open

Keywords: metabolism; therapy; mitochondria; pathogenesis; bioenergetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Vegetable Breeding and Molecular Research

edited by

Ai-Sheng Xiong

and

Mengyao Li

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1035 | Submission Open

Keywords: vegetable breeding; gene editing; omics; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Rhizobia

edited by

Socorro Mesa

, María J. Delgado and

Germán Tortosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1033 | Submission Open

Keywords: biodiversity; environmental factors; plant– rhizobia interaction; nitrogen fixation; regulation; signaling; symbiosis

(This special issue belongs to the Section Molecular Microbiology)

Antimicrobial Peptides in Reproductive Health and Disease

edited by

Ga-Hyun Son

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1009 | Submission Open

Keywords: antimicrobial peptides; preterm birth; molecular mechanisms; microbiome; immune system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insight into Radiation Biology and Radiation Exposure

edited by Lynnette Cary

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1008 | Submission Open

Keywords: ionizing radiation; radiation biomarkers; radionuclide; medical countermeasure

(This special issue belongs to the Section Molecular Biology)

Phytochemicals of Natural Products: Source, Analysis, and Bioactivities

edited by

Yu-Kuo Chen

, Chi-I Chang and Chi-Chien Lin

submission deadline 20 Dec 2025 | 1 articles | Viewed by 981 | Submission Open

Keywords: phytochemicals; bioactive compounds; natural products; bioactivities; purification; chemoprevention; chemotherapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Mg Homeostasis in Disease: 2nd Edition

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 Dec 2025 | 1 articles | Viewed by 961 | Submission Open

Keywords: magnesium; chronic diseases; diabetes; bone disease; mineral metabolism; renal disease; inflammation; cardiovascular disease

(This special issue belongs to the Section Biochemistry)

Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine

edited by

Tomasz Urbanowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 942 | Submission Open

Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Nanomaterials: Approaches, Strategies and Applications

edited by

Andrea Bernardos

submission deadline 20 Dec 2025 | 1 articles | Viewed by 938 | Submission Open

Keywords: nanotechnology; biocides; antimicrobials; controlled release; drug delivery; antimicrobial agents; antimicrobial resistance; infection; nanoparticles

(This special issue belongs to the Section Materials Science)

Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds

edited by

Jianqiang Xu

and

Yanshuo Han

submission deadline 20 Dec 2025 | 1 articles | Viewed by 901 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Insights into Functional Nanomaterials: Application-Related Structural Analysis

edited by Zoltán Dudás

submission deadline 20 Dec 2025 | 1 articles | Viewed by 873 | Submission Open

Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials

(This special issue belongs to the Section Molecular Nanoscience)

Ovarian Cancer: Pathogenesis, Biomarkers and Treatment

edited by Alessandro Antonio Buda

submission deadline 20 Dec 2025 | 1 articles | Viewed by 873 | Submission Open

Keywords: ovarian cancer; radiotherapy; diagnosis; prevention; treatment; fertility sparing

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 2951-3000 on page 60 of 70.

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