Special Issues

Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cytokine and Growth Factor Signaling at the Interface between Immune Cells and Cancer submission deadline 15 Mar 2025 | Viewed by 51 | Submission Open
Keywords: cytokines; growth factors; chemokines; inflammation; oncogenic signaling; cancer initiation; cancer progression; tumor microenvironment; cancer immune suppression; antitumor immunity
(This special issue belongs to the Section Molecular Cancer Biology)
Oxidative Phosphorylation System Dysfunction Role and Mechanisms in Cancer and Its Therapies submission deadline 20 Mar 2025 | 4 articles | Viewed by 8780 | Submission Open
Keywords: OXPHOS; respiratory complex; cancer; metastasis; mtDNA mutations; ROS; apoptosis; mitophagy; metabolic remodeling; therapy; epigenetics
(This special issue belongs to the Section Molecular Cancer Biology)
Thermal Ablation in the Management for Colorectal Liver Metastases submission deadline 20 Mar 2025 | 5 articles | Viewed by 5598 | Submission Open
Keywords: image-guided therapies; colorectal liver metastases (CRLMs); thermal ablation; (non-)thermal and radiation-related treatment; interventional and radiation oncology
(This special issue belongs to the Section Cancer Metastasis)
Current Updates and Future Directions in Neuroendocrine Neoplams (NENs): Understanding Biology, Diagnosis, Management and Research Efforts in NENs
edited by and Aman Chauhan
submission deadline 20 Mar 2025 | 4 articles | Viewed by 5048 | Submission Open
Keywords: neuroendocrine neoplasms; NENs; neuroendocrine carcinomas; tumor biology; clinical management; therapeutic
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The New Challenge of Curing AML: Analysis of Mechanisms of Resistance of Target Drugs and Future Perspectives
edited by
submission deadline 20 Mar 2025 | 2 articles | Viewed by 2763 | Submission Open
Keywords: AML; FLT3 inhibitors; BCL2 inhibitor; MCL1; IDH1-2 inhibitors; venetoclax; CAR-T; anti-CD123 monoclonal antibodies; anti-CD33 monoclonal antibodies; anti-PD-1 and -PD-L1
(This special issue belongs to the Section Tumor Microenvironment)
Immunotherapy and Targeted Molecular Therapy in Thoracic Surgical Oncology
edited by and Ryan Albert John Campagna
submission deadline 20 Mar 2025 | Viewed by 117 | Submission Open
Keywords: immunotherapy; lung cancer; esophageal cancer; targeted therapy; thymic cancer; adjuvant therapy
(This special issue belongs to the Section Cancer Therapy)
Predictive Biomarkers for Colorectal Cancer
edited by Mitsukuni Suenaga
submission deadline 21 Mar 2025 | 7 articles | Viewed by 8680 | Submission Open
Keywords: colorectal cancer; biomarker; chemotherapy; precision medicine; genetic analysis
(This special issue belongs to the Section Cancer Biomarkers)
Involvement of RNA Polymerases I and III in Cancer Progression (Volume II)
edited by
submission deadline 21 Mar 2025 | 1 articles | Viewed by 1360 | Submission Open
Keywords: cancer; RNA polymerase I; RNA polymerase III; rRNA; tRNA
(This special issue belongs to the Section Cancer Therapy)
Advances in the Treatment of Upper Gastrointestinal Cancer
edited by Sang-ho Jeong and
submission deadline 21 Mar 2025 | Viewed by 59 | Submission Open
Keywords: upper gastrointestinal cancer; surgery therapy; chemotherapy therapy; radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Targeting the Sphingolipid Metabolic Pathway: Promotion from Benchwarmer to the Starting Lineup—a Themed Issue in Memory of Dr’s. Lina Obeid and Mark Kester
edited by
submission deadline 25 Mar 2025 | 4 articles | Viewed by 7073 | Submission Open
Keywords: sphingolipid metabolic pathways; targeted therapeutics; cancer; drug resistance; rational drug combinations
(This special issue belongs to the Section Tumor Microenvironment)
Bacterial Infections and Cancer Risk: From Biological Mechanisms to Clinical Realities
edited by and Shuai Hu
submission deadline 25 Mar 2025 | Viewed by 146 | Submission Open
Keywords: bacterial infections; cancer risk; biological mechanisms; treatment modalities; therapeutic strategies
(This special issue belongs to the Section Infectious Agents and Cancer)
Non-genomic Mechanism-Based Therapy against Melanoma
edited by Mickaël Ohanna
submission deadline 25 Mar 2025 | Viewed by 58 | Submission Open
Keywords: melanoma; skin cancer; oncoepigenetics; single cell; omics; microenvironment; tumor heterogeneity; metabolic heterogeneity; circulating cells; residual disease biomarkers; immunotherapy; new therapies; molecular and pharmacological strategies
(This special issue belongs to the Section Cancer Therapy)
Study on Clinical Treatment of Brain Tumors
edited by Shinya Watanabe
submission deadline 28 Mar 2025 | Viewed by 60 | Submission Open
Keywords: brain tumors; clinical treatment; anti-tumor drugs; clinical trials
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Genetic Studies on Leukemia
edited by
submission deadline 30 Mar 2025 | Viewed by 220 | Submission Open
Keywords: hematologic neoplasms; leukemia; cancer genetics; precision medicine; target therapy
(This special issue belongs to the Section Molecular Cancer Biology)
The Evaluation of Cancer Treatment Patterns and Quality of Care across the World
edited by Monica Pinto
submission deadline 30 Mar 2025 | Viewed by 158 | Submission Open
Keywords: cancer care; delivery strategies; barriers; opportunities; prevention strategies; acute treatment phase; rehabilitation; survivorship
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Ovarian Cancer Biomarkers, Diagnostic, and Therapeutic Technologies 2nd Edition
edited by
submission deadline 30 Mar 2025 | Viewed by 78 | Submission Open
Keywords: diagnostic; prognostic; theranostic; therapy; metastasis; biomarker; regression; chemoresistance; invasion
(This special issue belongs to the Section Cancer Biomarkers)
Advances in Anal Cancer
edited by and Cristina B. Sanger
submission deadline 30 Mar 2025 | Viewed by 69 | Submission Open
Keywords: anal cancer; prevention; therapeutics; risk stratification
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy with Checkpoint Inhibitors for Non-small Cell Lung Cancer submission deadline 31 Mar 2025 | 7 articles | Viewed by 12588 | Submission Open
Keywords: immune-checkpoint inhibitors; non-small cell lung cancer; neoadjuvant therapy; adjuvant therapy; primary resistance; acquired resistance; biomarkers; immune-related adverse events
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Novel Combinatorial Approaches for Immunotherapy and Targeted Therapies in Cancer submission deadline 31 Mar 2025 | 5 articles | Viewed by 12121 | Submission Open
Keywords: antibody-based therapeutics; antitumor immunity; active cancer targeting; aptamer-based targeted therapies; aptamer-based immunotherapeutics
(This special issue belongs to the Section Cancer Therapy)
Targeted Therapies for Pediatric Solid Tumors (2nd Edition)
edited by
submission deadline 31 Mar 2025 | 4 articles | Viewed by 10575 | Submission Open
Keywords: pediatric solid tumors; targeted therapies; immunotherapies; CAR T cells; nanomedicine; rhabdomyosarcoma; Ewing sarcoma; neuroblastoma; medulloblastoma; osteosarcoma; diffuse intrinsic pontine glioma (DIPG); high-grade glioma; Wilms tumor
(This special issue belongs to the Section Cancer Therapy)
Neurofibromatosis Type 1 (NF1) Related Tumors submission deadline 31 Mar 2025 | 4 articles | Viewed by 5150 | Submission Open
Keywords: NF1; tumorigenesis; cancer stem cells; targeted therapy; tumor microenvironment; epigenetics; case report; metastasis; clinical trials
(This special issue belongs to the Section Tumor Microenvironment)
Advanced Research on Spine Tumor
edited by
submission deadline 31 Mar 2025 | 1 articles | Viewed by 1050 | Submission Open
Keywords: diagnosis; treatment strategy; prognostic factors and scoring systems; pain management; surgical techniques; spondylectomy/vertebrectomy; stereotactic body radiotherapy; particle beam radiation therapy; minimum invasive treatment
(This special issue belongs to the Section Cancer Therapy)
Mathematical Models in Cancer
edited by Eric A. Stahlberg
submission deadline 31 Mar 2025 | 1 articles | Viewed by 984 | Submission Open
Keywords: virtual human models; predictive oncology; cancer systems biology; machine learning; artificial intelligence; mechanistic models; digital twins; precision oncology; precision medicine; computational oncology; cancer
(This special issue belongs to the Section Cancer Informatics and Big Data)
Intratumoral Heterogeneity in Brain Cancers
edited by Michael Oldham
submission deadline 31 Mar 2025 | 1 articles | Viewed by 741 | Submission Open
Keywords: intratumoral heterogeneity; brain; clonal evolution; tumor microenvironment; multiomics
(This special issue belongs to the Section Molecular Cancer Biology)
Cancer Cell Motility submission deadline 31 Mar 2025 | Viewed by 332 | Submission Open
Keywords: cancer; EMT; invasion; metastasis; p53-related signaling; apoptosis; autophagy; cell cycle; anticancer drugs
(This special issue belongs to the Section Cancer Metastasis)
Surgery for Colorectal Cancer submission deadline 31 Mar 2025 | Viewed by 219 | Submission Open
Keywords: clinical and oncologic outcomes after new forms of therapy for colon– rectal cancer; colon cancer; rectal cancer; colorectal cancer
(This special issue belongs to the Section Cancer Therapy)
The Role of Ferroptosis in Cancer
edited by Wei Li
submission deadline 31 Mar 2025 | Viewed by 216 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Application of Biostatistics in Cancer Research
edited by and Han Yu
submission deadline 31 Mar 2025 | Viewed by 134 | Submission Open
Keywords: clinical trial design; nonparametric statistics; randomization and permutation tests; computational methods in statistics; Bayesian methods; computational biology; graphical models; network analysis; machine learning; artificial intelligence; predictive modeling
(This special issue belongs to the Section Cancer Informatics and Big Data)
Molecular Biology of Urological Cancers submission deadline 31 Mar 2025 | Viewed by 125 | Submission Open
Keywords: kidney cancer; prostate cancer; bladder cancer; therapies; cell signaling; resistance; gene profiling; hypoxia; metabolism
(This special issue belongs to the Section Molecular Cancer Biology)
Enhancing Cancer Treatments through Fluorescence-Guided Surgery
edited by Ibrahim Khot and Yazan Sulaiman Khaled
submission deadline 31 Mar 2025 | Viewed by 111 | Submission Open
Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine
(This special issue belongs to the Section Methods and Technologies Development)
The Oral Microbiome and Its Link to Oral Cancer: Exploring the Role of Infectious Agents
edited by
submission deadline 31 Mar 2025 | Viewed by 110 | Submission Open
Keywords: oral microbiome; oral cancer; infectious agents; microbial dysbiosis; host– microbe interactions
(This special issue belongs to the Section Infectious Agents and Cancer)
The Role of Viruses in the Development of Cancer
edited by
submission deadline 31 Mar 2025 | Viewed by 108 | Submission Open
Keywords: DNA and RNA tumour viruses; HPV; EBV; KSHV; HCV; HBV; HTLV1; McPyV
(This special issue belongs to the Section Infectious Agents and Cancer)
The Prevention and Treatment of Prostate Cancer
edited by Ning Wang and Kirsty Hodgson
submission deadline 31 Mar 2025 | Viewed by 98 | Submission Open
Keywords: prostate cancer; prevention; metastasis; drug resistance; tumor microenvironment; novel therapies; immunotherapy; androgen; hormone therapy
(This special issue belongs to the Section Cancer Therapy)
Hormones and Tumors
edited by Kiyoshi Takagi and
submission deadline 31 Mar 2025 | Viewed by 84 | Submission Open
Keywords: diagnosis; hormone; prognosis; progression; therapy; tumor
(This special issue belongs to the Section Molecular Cancer Biology)
Preclinical and Clinical Research on the Efficacy of Anticancer Drugs
edited by Andrzej Hellmann, Joanna Jakobkiewicz-Banecka and Jan Lica
submission deadline 31 Mar 2025 | Viewed by 77 | Submission Open
Keywords: clinical trials; preclinical research; anticancer drugs; drug efficacy; drug development; cancer therapy; therapeutic strategies; safety assessment; pharmacodynamics; pharmacokinetics
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in Spine Oncology: Research and Clinical Studies
edited by Oluwaseun O. Akinduro
submission deadline 31 Mar 2025 | Viewed by 58 | Submission Open
Keywords: metastatic spine cancer; targeted therapy; stereotactic body radiotherapy; proton radiotherapy; chordoma; chondrosarcoma; spondylectomy
(This special issue belongs to the Section Clinical Research of Cancer)
Advanced Glycation End-Products and Its Receptors in Cancer Progression
edited by Bhaumik B. Patel
submission deadline 31 Mar 2025 | Viewed by 55 | Submission Open
Keywords: advanced glycation end products; toxic advanced glycation end products; receptor for advanced glycation end products (RAGEs); glycosaminoglycans; cancer; cancer stem cells (CSCs); tumor immune microenvironment (TME)
(This special issue belongs to the Section Tumor Microenvironment)
Medical Imaging and Artificial Intelligence in Cancer
edited by Debiao Li and
submission deadline 31 Mar 2025 | Viewed by 45 | Submission Open
Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization
(This special issue belongs to the Section Methods and Technologies Development)
Prediction of Melanoma
edited by
submission deadline 31 Mar 2025 | Viewed by 40 | Submission Open
Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Biomarkers for the Early Detection and Treatment of Cancers: 2nd Edition
edited by and Barbara Mroczko
submission deadline 31 Mar 2025 | Viewed by 3 | Submission Open
Keywords: cancer; tumor biomarkers; tumor progression; early cancers; inflammatory mediators; early diagnosis
(This special issue belongs to the Section Cancer Therapy)
Research Advances in Cancer Nanomedicine
edited by
submission deadline 1 Apr 2025 | Viewed by 186 | Submission Open
Keywords: cancer; nanotechnology; nanomedicine; drug delivery; biosensors; lab-on-chip; nanomechanics; nano-immuno therapy; CAR-T nano-technology
(This special issue belongs to the Section Methods and Technologies Development)
Screening, Early Detection and Prevention of Hepato-Pancreato-Biliary (HPB) Cancers
edited by Zaed Z.R. Hamady
submission deadline 1 Apr 2025 | Viewed by 156 | Submission Open
Keywords: hepatobiliary cancer; pancreatic cancer; early detection; diagnosis; screening; prevention
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Bridging the Gap: Integrating AI into Clinical Practice for Oncological PET/CT Imaging
edited by Fereshteh Yousefirizi
submission deadline 1 Apr 2025 | Viewed by 66 | Submission Open
Keywords: physician-in-the-loop; PET/CT; AI; foundation model; generalist model; tumor segmentation; outcome prediction; whole-body PET; cancers
(This special issue belongs to the Section Cancer Therapy)
Molecular Imaging Advances in Precision Oncology submission deadline 5 Apr 2025 | Viewed by 754 | Submission Open
Keywords: molecular imaging; hybrid imaging; oncologic imaging; PET/CT; SPECT/CT; PET radiotracers; precision medicine; theranostics; radiomics; machine learning
(This special issue belongs to the Section Methods and Technologies Development)
Endometrial Cancer—From Diagnosis to Management
edited by Mingxin Shi and
submission deadline 9 Apr 2025 | Viewed by 15 | Submission Open
Keywords: endometrial cancer; prognosis; diagnosis; novel biomarker; immunotherapy; targeted therapy; prevention
(This special issue belongs to the Section Cancer Therapy)
Novel Therapies of Salivary Gland Cancer
edited by Moritz Meyer
submission deadline 10 Apr 2025 | Viewed by 88 | Submission Open
Keywords: salivary gland cancer; treatment; targeted therapy; surgery; radiation therapy; survival; life quality; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Drug Targeting Therapy in Multiple Myeloma submission deadline 11 Apr 2025 | Viewed by 201 | Submission Open
Keywords: multiple myeloma; novel drug; novel targets; new therapeutic targets; prognosis
(This special issue belongs to the Section Cancer Drug Development)
Immunoediting in Cancer Therapies
edited by Vijay Kumar
submission deadline 13 Apr 2025 | Viewed by 88 | Submission Open
Keywords: cancer; cancer immunology; immunosurveillance; immunoediting; immunotherapy; immunomodulation; immunometabolism
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Cancer and Chronic Illness submission deadline 15 Apr 2025 | 5 articles | Viewed by 7588 | Submission Open
Keywords: cancer; chronic disease; inflammatory disease; cytokines; immune disease; radiotherapy-induced diseases; immunotherapy-induced disease; gastrointestinal chronic disorders; end-stage renal disease; lung cancer chronic disease
(This special issue belongs to the Section Cancer Pathophysiology)
Cervical Cancer: Study on Molecular Landscape and Protein Biomarkers. Current Diagnostic and Therapeutic Capabilities submission deadline 15 Apr 2025 | 2 articles | Viewed by 2382 | Submission Open
Keywords: cervical cancer; cervical dysplasia; human papilloma virus (HPV); tumor markers; cancerogenesis; genotyping
(This special issue belongs to the Section Molecular Cancer Biology)
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