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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Trends and Challenges in Chronic Diseases

edited by

Guan-Jhong Huang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6320 | Submission Open

Keywords: chronic diseases; ER stress; oxidative stress; immune regulation; new pathways of pathogenesis; cancer development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic Analysis Based on CRISPR/Cas9 Technology: 2nd Edition

edited by

Yong-Gu Cho

and

Kwon-Kyoo Kang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 6174 | Submission Open

Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Tomasz Chorągiewicz

and

Joanna Dolar-Szczasny

submission deadline 20 Mar 2026 | 3 articles | Viewed by 6169 | Submission Open

Keywords: eye diseases; genetic; biochemical; proteomic; cellular and physiological level; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition

edited by

Alessandro Maugeri

and

Michele Navarra

submission deadline 20 Mar 2026 | 3 articles | Viewed by 6096 | Submission Open

Keywords: cancer; natural bioactive molecules; natural products; tumor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition

edited by

Bijan Safai

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5891 | Submission Open

Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Signalling Pathways in Metabolic Diseases and Cancers

edited by

Sabrina Bossio

submission deadline 20 Mar 2026 | 4 articles | Viewed by 5878 | Submission Open

Keywords: cancer; prostate cancer; molecular signalling pathway; metabolic diseases; diabets; immunotherapy; immunological diseases

(This special issue belongs to the Section Biochemistry)

Adapter CAR T Cells: From the Idea to the Clinic

edited by

Michael P. Bachmann

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5793 | Submission Open

Keywords: CAR T cell therapy; chimeric antigen receptor; bispecific antibody; target module; autoimmune diseases; solid tumors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders

edited by

Kazuhito Toyooka

submission deadline 20 Mar 2026 | 1 articles | Viewed by 5754 | Submission Open

Keywords: autism spectrum disorder; ADHD; schizophrenia; intellectual disability; Alzheimer’ s disease; Parkinson’ s disorder; traumatic brain injury; epilepsy; neurodevelopmental disorders; neurological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Pathophysiology of Cystic Fibrosis

edited by

Stefanie Krick

and George M. Solomon

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5603 | Submission Open

Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling the Genetic Background of Neurological Disorders: 2nd Edition

edited by

Vasileios Siokas

Efthimios Dardiotis

and

Ioannis Liampas

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5533 | Submission Open

Keywords: neurological disorders; neurogenetics; personalized treatments; gene-association studies; genetics; genome-wide association studies; genetic linkage studies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Medicinal Plant Resources—from Molecular Studies to Sustainable Use

edited by Ekaterina Kozuharova

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5478 | Submission Open

Keywords: genetic improvement of medicinal plants; sustainable use; bioactive compounds

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Sepsis: Pathogenesis, Biomarkers, Treatments and Prognosis

edited by Francesca Innocenti

submission deadline 20 Mar 2026 | 4 articles | Viewed by 5455 | Submission Open

Keywords: sepsis phenotypes; hemodynamic stabilization; fluids; vasopressors; diagnostic biomarkers; tailored approach; immune modulation; immunomodulatory therapy; prognostic stratification

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Hepatocellular Carcinoma: From Carcinogenesis to Liver Transplantation

edited by

Kevin Tak-Pan Ng

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5443 | Submission Open

Keywords: hepatocarcinogenesis; molecular pathogenesis; tumor microenvironment; metabolic dysfunction-associated fatty liver disease (MAFLD); metastasis; genetic and epigenetic alterations; biomarkers; precision oncology; targeted therapy; immunotherapy; therapy resistance; immune escape; tumor recurrence; transplant oncology

(This special issue belongs to the Section Molecular Oncology)

Bioactive Natural Compounds: Protecting Plants and Promoting Human Health, 2nd Edition

edited by

Gina Rosalinda De Nicola

submission deadline 20 Mar 2026 | 3 articles | Viewed by 5435 | Submission Open

Keywords: natural products; molecular biology; chemical characterization; bioactivity; mechanism of action; plant protection; human health promotion; antioxidant; anti-inflammation; biopesticides; biostimulants; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Immunosuppressive Therapy

edited by

Marta Grabowska

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5429 | Submission Open

Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Regenerative Medicine and Therapeutics

edited by

Diana Torge

submission deadline 20 Mar 2026 | 2 articles | Viewed by 5406 | Submission Open

Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Bone Diseases

edited by Gaia Palmini

submission deadline 20 Mar 2026 | 4 articles | Viewed by 5363 | Submission Open

Keywords: mineralization; bone diseases; rare bone diseases; non-coding RNAs; fibrous bone dysplasia; tumoral calcinosis; osteosarcoma; Ewing sarcoma; osteoporosis; Gorham-Stout disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Phage–Host Interactions: Novel Findings and Perspectives

edited by

Luís Melo

submission deadline 20 Mar 2026 | 4 articles | Viewed by 5171 | Submission Open

Keywords: bacteriophages; phage therapy; phage/bacteria interactions; genomics; transcriptomics; proteomics; metabolomics; biofilms

(This special issue belongs to the Section Molecular Microbiology)

New Processes and Applications of Plasma in Liquids

edited by

Ricardo Molina

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4779 | Submission Open

Keywords: plasma in liquids; water decontamination; plasma-activated water; hydrogels; plasma medicine; polymerization in liquids; plasma agriculture

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Gut-Brain Axis: Genomic and Metagenomic Involvement

edited by

Maria Gazouli

and Elias Odusseas Tzavellas

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4694 | Submission Open

Keywords: gut– brain axis; central nervous system; gastrointestinal tract; genomic; metagenomic

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Protein Structure-Function and Drug Discovery

edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth

submission deadline 20 Mar 2026 | 5 articles | Viewed by 4684 | Submission Open

Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery

(This special issue belongs to the Section Macromolecules)

Molecular and Structural Research Advances in Model Plants (Second Edition)

edited by

Ioannis-Dimosthenis Adamakis

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4676 | Submission Open

Keywords: A. thaliana; plant biology; model organisms; plant models; non-model plant models

(This special issue belongs to the Section Molecular Plant Sciences)

Antiviral Drugs Discovery

edited by

Dongwei Kang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4660 | Submission Open

Keywords: antiviral agents; organic synthesis and medicinal chemistry; biological activity; drug design and computational chemistry; drug discovery and development

(This special issue belongs to the Section Molecular Pharmacology)

Regulation and Application of Bioactive Metabolites in Plants

edited by

Aoxue Luo

and

Yijun Fan

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4653 | Submission Open

Keywords: medicinal plants; biosynthesis; biological activity; regulation; pharmacological mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism and Therapeutic Approaches of Breast Cancer, Metastatic Breast Cancer, 3rd Edition

edited by

Mi Kyung Park

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4563 | Submission Open

Keywords: breast cancer; metastatic breast cancer; epithelial-to-mesenchymal transition (EMT); epigenetic and post-translational modifications (PTM); tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Gestational Diabetes Mellitus: Molecular Insights into Pathophysiology, Management and Therapy

edited by

Paweł Jan Stanirowski

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4517 | Submission Open

Keywords: GDM pathogenesis; health programming; pharmacogenomics; life-style interventions; fetal growth disorders; preeclampsia; polyhydramnios; placental origin of disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fundamental and Translational Insights into Colorectal Cancer

edited by Giuseppe Broggi

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4488 | Submission Open

Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Recent Research on Biomimetic Chromatography, QSAR and Chemoinformatics in Molecular Modeling and Drug Design

edited by

Małgorzata Janicka

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4383 | Submission Open

Keywords: biomimetic chromatography; QSARs; QRARs; molecular modelling; chemoinformatics; pharmacokinetics

(This special issue belongs to the Section Molecular Informatics)

Nanotechnology and Nanomedicine: Approaches, Challenges and Translation for Tissue Regeneration

edited by

Dinesh Kumar Srinivasan

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4308 | Submission Open

Keywords: nanotechnology; bone regeneration; skin regeneration; cardiac tissue regeneration; brain tissue regeneration; drug delivery system; targeted therapy

(This special issue belongs to the Section Molecular Nanoscience)

Advanced Molecular Research on Retinopathy and Protection

edited by

Jaeyon Won

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4298 | Submission Open

Keywords: retinopathy; neuroprotection; antioxidants; innovative therapy; emerging technology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Food Processing Industry’s 200th Anniversary: Bioactive Compounds, Antioxidants, and Potential Health Benefits (2nd Edition)

edited by

Vassilis Athanasiadis

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4277 | Submission Open

Keywords: antioxidants; bioactive compounds; food processing; functional foods; green processes; health potentials; molecular mechanisms; polyphenols; shelf life; vitamins

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pathogenesis of Preeclampsia: From a Molecular Perspective

edited by

Jezid Miranda

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4269 | Submission Open

Keywords: preeclampsia; immune system; molecular mechanisms in preeclampsia; angiogenic factors; gene regulation; epigenetics; transcription factors in preeclampsia; translational research in preeclampsia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism and Therapeutic Approach of Metal Toxicity

edited by Grażyna Gromadzka

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4239 | Submission Open

Keywords: metal toxicity; neurodegenerative disease; cancer; stroke; myocardial infarct; atherosclerosis; cardiovascular disease; metal chelators; therapeutic approach of metal toxicity; cobalt toxicity; copper toxicity; iron toxicity; aluminum toxicity; manganese toxicity; molybdenum toxicity; nickel toxicity; zinc toxicity; lead toxicity

(This special issue belongs to the Section Molecular Toxicology)

Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities

edited by

Chuan Li

and

Jun Yang

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4238 | Submission Open

Keywords: multiomics technologies; functional foods; characterization; structures; biological activities; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antifungal Potential of Botanical Compounds

edited by Francisca Sempere-Ferre

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4207 | Submission Open

Keywords: botanical compounds; antifungal agents; natural products; secondary metabolites; fungal growth inhibition; bioactive plant extracts; eco-friendly antifungals; natural product chemistry; sustainable antifungal solutions; plant-derived bioactives

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Role of Anthranilic Acid in Neuropsychiatric Diseases

edited by

Gregory F. Oxenkrug

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4133 | Submission Open

Keywords: anthranilic acid; Alzheimer’ s disease; autism; schizophrenia; bipolar disorder; major depressive disorder; post-partum depression; COVID-19; interferons; attention deficit disorder; cognitive impairment; G-protein-coupled receptor 109A; microbiome; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Dynamics Simulation of Biomolecules

edited by

Pavel Rehak

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4093 | Submission Open

Keywords: molecular dynamics simulations; biochemical processes; biomaterial properties

(This special issue belongs to the Section Molecular Biophysics)

Advances in Molecular Therapeutics for HIV Co-Infections

edited by

Vishwanath Venketaraman

and

Selvakumar Subbian

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4082 | Submission Open

Keywords: HIV co-infections; molecular therapeutics; Mtb; ART; immune responses

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathogenesis and Therapeutic Innovations in Oral Diseases

edited by Tatsuji Nishihara

submission deadline 20 Mar 2026 | 4 articles | Viewed by 4067 | Submission Open

Keywords: molecular-based analysis; diagnosis of oral disease; oral disease treatment; regeneration therapy; drug therapy; periodontitis; implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dialogue Between Inflammation and Immunity: From Mechanism to Therapy

edited by

Nikolina Mihaylova

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4063 | Submission Open

Keywords: inflammation; immune activation; immunomodulation; tolerance; immunotherapy; autoimmune diseases; cancer

(This special issue belongs to the Section Molecular Immunology)

Drug Discovery and Development Focusing on Natural Products

edited by

Chung-Hsin Wu

and

Szu-Chuan Shen

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4051 | Submission Open

Keywords: natural products; drug R& D; herbal medicine; gut microbiota; mechanism of action; therapeutic targets

(This special issue belongs to the Section Molecular Pharmacology)

Macro- and Micronutrients in Health and Diseases

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4047 | Submission Open

Keywords: macronutrients; micronutrients; vitamins; macrominerals; trace elements; cancer; obesity; cardiovascular diseases; diabetes; osteoporosis; immune disorders; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

The Role of Natural Products in Inflammation

edited by

Antonia Cianciulli

submission deadline 20 Mar 2026 | 1 articles | Viewed by 4017 | Submission Open

Keywords: inflammation; natural products; immunomodulation; bioactive compounds; drug discovery; drug target identification; anti-inflammatory activity; antioxidant activity; cellular signalling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Kidney Disease/Renal Dysfunction

edited by

Hiroshi Nonoguchi

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4016 | Submission Open

Keywords: kidney disease/renal dysfunction; hypoxia-inducible factor-prolyl hydroxylase (HIF-PHD) inhibitors; renal anemia; chronic renal faikure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Biomarkers and Metabolic Vulnerabilities

edited by Francesca Bersani

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3982 | Submission Open

Keywords: cancer metabolism; cancer biomarkers; liquid biopsy; therapeutic targets; metabolic rewiring

(This special issue belongs to the Section Biochemistry)

Structure-Based Design of Drugs and Biologically Active Molecules Based on Computer-Aided Drug Discovery

edited by

Cleydson Breno Rodrigues dos Santos

submission deadline 20 Mar 2026 | 2 articles | Viewed by 3870 | Submission Open

Keywords: drug design; virtual screening; bioinformatics; chemoinformatics; quantum chemistry

(This special issue belongs to the Section Molecular Informatics)

Advances in Computational Biology: Molecular Dynamics Simulation of Biomolecules

edited by

Paulino Gómez-Puertas

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3835 | Submission Open

Keywords: computational biology; molecular dynamics; molecular simulation of rare diseases; computational design of antimicrobials; computational design of antivirals; molecular simulation of cancer-related processes; computational design of anti-cancer molecules; molecular simulation of biotechnology processes

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases

edited by

Debora Baroni

submission deadline 20 Mar 2026 | 3 articles | Viewed by 3800 | Submission Open

Keywords: genetic diseases; genotype– phenotype correlations; multi-omics approaches; current and investigational therapeutical approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Modelling in Material Science

edited by