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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances in Epigenetics and Epigenomics
edited by Vicki Maltby
submission deadline 20 Apr 2026 | 5 articles | Viewed by 13374 | Submission Open
Keywords: epigenetics; epigenomics; multi-omics; epitranscriptomics; single cell
(This special issue belongs to the Section Molecular Genetics and Genomics)
Boosting the Production of Bioactive Compounds: Biotechnology and Metabolic Engineering of Medicinal Plants submission deadline 20 Apr 2026 | 5 articles | Viewed by 13218 | Submission Open
Keywords: bioactive compounds; plant tissue culture; elicitors; metabolic engineering; gene expression; medicinal plants; metabolic pathway; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of RNAs in Cancers: Recent Advances
edited by Roman Beňačka
submission deadline 20 Apr 2026 | 5 articles | Viewed by 13184 | Submission Open
Keywords: cancer cells; carcinogenesis; mRNAs; ncRNAs; lncRNAs; miRNAs; circRNAs; piRNAs; RNA-based diagnostics; RNA-based therapy
(This special issue belongs to the Section Molecular Oncology)
The Role of Protein Kinase in Health and Diseases
edited by
submission deadline 20 Apr 2026 | 6 articles | Viewed by 12578 | Submission Open
Keywords: protein kinases; phosphorylation; cancer; neurological disorder; targeted therapies; metabolic diseases
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Antioxidant and Anti-Inflammatory Properties of Bioactive Compounds
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 11938 | Submission Open
Keywords: antioxidant; anti-inflammatory; bioactive compounds; artificial intelligence; multiomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Cytokines in Health and Diseases
edited by Hung-Jen Liu
submission deadline 20 Apr 2026 | 6 articles | Viewed by 11775 | Submission Open
Keywords: cytokines; immune regulation; disease management; signaling pathways; translational research; clinical applications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Prostate Cancer Research Update: Molecular Diagnostic Biomarkers
edited by Mikhail Baryshev
submission deadline 20 Apr 2026 | 4 articles | Viewed by 11683 | Submission Open
Keywords: prostate cancer; molecular biomarkers; cancer-specific DNA methylation; non-coding genes; gene fusions; lncRNA
(This special issue belongs to the Section Molecular Oncology)
Biomarkers in Cancer Immunology
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 11592 | Submission Open
Keywords: immunotherapy; adoptive cell transfer; CAR-T cells; immune checkpoint inhibitors; tumor microenvironment; extracellular vesicles; biomarkers; miRNA; DNA
(This special issue belongs to the Section Molecular Immunology)
Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases
edited by
submission deadline 20 Apr 2026 | 7 articles | Viewed by 11368 | Submission Open
Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Functions and Dynamics
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 10957 | Submission Open
Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro; cellular; and animal models; myopathies; mitochondria and immune system
(This special issue belongs to the Section Molecular Biology)
Genetic and Epigenetic Analyses in Cancer
edited by Jing Gong
submission deadline 20 Apr 2026 | 9 articles | Viewed by 10886 | Submission Open
Keywords: epigenetics; genetic mutations; chromosomal instability; DNA methylation; histone modifications; non-coding rnas; multi-omics; transcriptomics; proteomics; drug resistance in cancer; cancer biomarkers; therapeutic targets in cancer
(This special issue belongs to the Section Molecular Genetics and Genomics)
Research Advances in Reproductive Immunology
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 10719 | Submission Open
Keywords: reproductive immunology; immune regulation; fertility; pregnancy; immunocontraception
(This special issue belongs to the Section Molecular Immunology)
Small Molecule Drug Design and Research: 3rd Edition
edited by
submission deadline 20 Apr 2026 | 5 articles | Viewed by 10706 | Submission Open
Keywords: drug design; diversity-oriented synthesis; combinatorial chemistry; computationally guided synthesis; drug-like compounds; computer modeling techniques
(This special issue belongs to the Section Molecular Pharmacology)
Plant Breeding and Genetics: New Findings and Perspectives
edited by
submission deadline 20 Apr 2026 | 11 articles | Viewed by 10685 | Submission Open
Keywords: quantitative genetics; classical plant breeding; marker-assisted selection; genomic selection; speed breeding; gene editing and biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Gynecologic Oncology: Molecular Mechanisms and Therapies
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 10620 | Submission Open
Keywords: cervical cancer; endometrial cancer; ovarian cancer; vulvar cancer; carcinogenesis; microinvairment; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: “Selenium and Sulfur Chemistry” submission deadline 20 Apr 2026 | 3 articles | Viewed by 10556 | Submission Open
Keywords: selenium; sulfur; redox; catalysis; selenoproteins; green chemistry; materials; stereoselective synthesis
(This special issue belongs to the Section Biochemistry)
Pathophysiology and Pharmacology in Psychiatry
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 10495 | Submission Open
Keywords: psychiatric disorders; mental health; pathophysiology; neuropsychopharmacology; brain
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Epigenetics of Mental Disorders
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 10443 | Submission Open
Keywords: mental disorders; epigenetic; epigenomic; gene– environment interactions
(This special issue belongs to the Section Molecular Neurobiology)
Plant Chloroplasts and Mitochondria: Key Organelles for Sustainable Agriculture
edited by
submission deadline 20 Apr 2026 | 5 articles | Viewed by 10403 | Submission Open
Keywords: ‘ omics’ ; photosynthesis; energy production; crops; climate change; sustainable agriculture; stress response; inter-organelle crosstalk; signaling networks; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Biomarkers, Treatments, and Clinical Outcomes for Meningiomas and Other Skull Base Tumors
edited by and Philip David Tatman
submission deadline 20 Apr 2026 | 3 articles | Viewed by 10251 | Submission Open
Keywords: skull base tumor; meningioma; biomarkers; diagnosis; prognosis; radiology; surgery; pharmacotherapy; immunology
(This special issue belongs to the Section Molecular Oncology)
Recent Progress in Molecular Mechanisms of Sperm Metabolism and Development
edited by Karl Kerns
submission deadline 20 Apr 2026 | 4 articles | Viewed by 9985 | Submission Open
Keywords: sperm development  ; germ cell proliferation  ; sperm cell metabolism  ; seminal fluid biochemical composition  ; spermatogenesis  ; epididymal maturation  ; sperm capacitation  ; oocyte activation  
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Advances in Blood Disorders
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 9940 | Submission Open
Keywords: acquired and inherited blood disorders; diagnostic; prognostic and predictive biomarkers; molecular profiling; molecular monitoring; targeted therapy; leukaemia; lymphoma; disorders of haemostasis and thrombosis; genetic predisposition; germline pathogenic variants; molecular mechanisms; (epi)genomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanofibrous Biomaterials for Biomedicine and Medical Applications
edited by Jong-Young Kwak
submission deadline 20 Apr 2026 | 3 articles | Viewed by 9853 | Submission Open
Keywords: nanofibers; biomaterials; 3D scaffold; 3D cell culture; tissue engineering; drug release
(This special issue belongs to the Section Materials Science)
Editorial Board Members’ Collection Series: “Molecular Dynamics” submission deadline 20 Apr 2026 | 4 articles | Viewed by 9803 | Submission Open
Keywords: quantum mechanics; classical mechanics; hybrid QM/MM; molecular dynamics at the atomic level; steered molecular dynamics; coarse-graining; docking(protein– protein; protein– ligand); the molecular dynamics of protein– ligand interactions; drug design; virtual screening
(This special issue belongs to the Section Molecular Biophysics)
Musculoskeletal Diseases: Advances in Molecular Mechanisms and Therapeutic Approaches
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 9553 | Submission Open
Keywords: bone; muscle; tendon; cartilage; osteoporosis; sarcopenia; tendinopathy; osteoarthritis; musculoskeletal pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Therapy Using Human Mesenchymal Stem Cells (MSCs) and MSC Extracellular Vesicles
edited by Tong Ming Liu and Xiaoman Luo
submission deadline 20 Apr 2026 | 6 articles | Viewed by 9356 | Submission Open
Keywords: mesenchymal stem cells; extracellular vesicles; MSCs; MSC-EVs; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Advances in Antibody–Drug Conjugates
edited by Bing Sun
submission deadline 20 Apr 2026 | 2 articles | Viewed by 8659 | Submission Open
Keywords: antibody– drug conjugate (ADC); cancer treatment; non-oncology indications; antibody selection; payload; linker; conjugation chemistry
(This special issue belongs to the Section Molecular Immunology)
Natural Active Substances in Human Diseases
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 8549 | Submission Open
Keywords: natural active substances; bioactive compounds; molecular mechanisms; traditional medicine; metabolic disorders; inflammatory diseases; neurodegenerative diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Blood–Brain Barrier and Neuroprotection
edited by Aruna Sharma and Hari Shanker Sharma
submission deadline 20 Apr 2026 | 4 articles | Viewed by 8537 | Submission Open
Keywords: blood– brain barrier; neurodegenerative diseases; nanoformulations; drug development; delivery systems
(This special issue belongs to the Section Molecular Neurobiology)
Lifestyle Interventions in MASLD: Molecular and Clinical Perspectives
edited by Muhammad Y. Sheikh
submission deadline 20 Apr 2026 | 1 articles | Viewed by 8450 | Submission Open
Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Folding, Misfolding, and Related Diseases submission deadline 20 Apr 2026 | 3 articles | Viewed by 8440 | Submission Open
Keywords: protein folding; misfolding; amyloid; neurodegenerative diseases; chaperons; mechanisms; regulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbiome Modulation Through Probiotics: Molecular Insights and Therapeutic Applications
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 8286 | Submission Open
Keywords: live bacterial cells; prebiotic agents; synbiotic formulations; probiotic formulations; microbial dysbiosis; inflammation; oxidative stress; host– microbe interactions
(This special issue belongs to the Section Molecular Microbiology)
Molecular Microbiology in the Omics Era: Genomics, Metagenomics and Computational Insights
edited by
submission deadline 20 Apr 2026 | 2 articles | Viewed by 8157 | Submission Open
Keywords: microbial genomics; metagenomics; computational biology; antimicrobial resistance; host– microbe interactions; multi-omics integration; bioinformatics tools; machine learning in microbiology
(This special issue belongs to the Section Molecular Microbiology)
Micro-Nano Materials for Drug Delivery and Disease Treatment
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 8118 | Submission Open
Keywords: biomaterials; nanoparticle-loaded bacterial cells; nanoparticle-loaded cells; bioimaging and diagnosis; therapy
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Understanding of Allergen Exposome submission deadline 20 Apr 2026 | 4 articles | Viewed by 8040 | Submission Open
Keywords: allergen exposome; profile allergen exposures; climatic change; airborne allergens; molecular triggers; microbial allergens
(This special issue belongs to the Section Molecular Immunology)
Recent Research of Phytochemicals in Health and Disease
edited by Sachiko Koyama, and
submission deadline 20 Apr 2026 | 3 articles | Viewed by 7885 | Submission Open
Keywords: phytochemicals with bioactive properties; health; brain function; regeneration; wound healing; treatment; and prevention of diseases; delivery routes and delivery methods; formulation of phytochemicals to overcome their hydrophobic nature and enhance their stability; drugs; supplements to drugs; and supplements for health maintenance; nourishment and phytochemicals; drug side effects; COVID-19
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Signalling in Multitrophic Systems Involving Arthropods
edited by
submission deadline 20 Apr 2026 | 5 articles | Viewed by 7884 | Submission Open
Keywords: insects; plants; microorganisms; communication; symbioses; eavesdropping
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
edited by Rifaat Safadi and Johnny Amer
submission deadline 20 Apr 2026 | 6 articles | Viewed by 7879 | Submission Open
Keywords: MASLD (metabolic dysfunction-associated steatotic liver disease); lipotoxicity; inflammation; mitochondrial dysfunction; gut– liver axis; liver– spleen axis; fibrosis biomarkers; translational hepatology; precision liver medicine; insulin resistance; molecular therapeutics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Stem Cells in Health and Disease: 3rd Edition
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 7850 | Submission Open
Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity
(This special issue belongs to the Section Molecular Biology)
Wheat Genetics and Genomics: 3rd Edition
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 7809 | Submission Open
Keywords: wheat; genetics; molecular breeding; genome variation; multiomics
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Medicines and Functional Foods for Human Health
edited by Qiong Wang
submission deadline 20 Apr 2026 | 2 articles | Viewed by 7707 | Submission Open
Keywords: functional food; natural medicine; traditional Chinese medicine; memory; depression; dementia; Alzheimer’ s disease; Parkinson’ s disease; space medicine; sleeplessness; anti-inflammation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Newer Pharmacological Treatment Concepts for Patients with Acute Coronary Syndrome submission deadline 20 Apr 2026 | 2 articles | Viewed by 7685 | Submission Open
Keywords: acute coronary syndrome (ACS); molecular studies; antiplatelet; anticoagulant drugs; lipid-lowering therapies
(This special issue belongs to the Section Molecular Pharmacology)
Novel Approaches for Tissue Repair and Tissue Regeneration
edited by Srinivas Madduri
submission deadline 20 Apr 2026 | 2 articles | Viewed by 7622 | Submission Open
Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation
(This special issue belongs to the Section Molecular Biology)
Genetic, Epigenetic and Microbiota Molecular Insights for Crop Resilience to Abiotic Stress
edited by
submission deadline 20 Apr 2026 | 3 articles | Viewed by 7595 | Submission Open
Keywords: abiotic stress; tolerance; crop resilience; crop sustainability; environmental conditions; climate change; gene regulation; epigenetic mechanisms; microbiota communities; microbiome
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Molecular Breeding for Drought and Salt Stress Tolerance in Crops: 2nd Edition
edited by
submission deadline 20 Apr 2026 | 4 articles | Viewed by 7367 | Submission Open
Keywords: drought; salt; heat; cold; gene regulation; genomic research; multiomics; epigenetics; stress signal transduction
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Diagnosis and Treatments of Diabetes Mellitus: 2nd Edition submission deadline 20 Apr 2026 | 7 articles | Viewed by 7366 | Submission Open
Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights and Treatments for Gynecological Cancers submission deadline 20 Apr 2026 | 2 articles | Viewed by 7239 | Submission Open
Keywords: gynecological cancers; cancers; endometrial cancers; cervical cancer; tumor microenvironment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Plant Genomics and Genetics: 3rd Edition
edited by
submission deadline 20 Apr 2026 | 7 articles | Viewed by 7235 | Submission Open
Keywords: plant genomics; plant genetics; abiotic stresses; salt resistance; genome; next-generation sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Techniques and Strategies in Drug Design and Discovery, 3rd Edition submission deadline 20 Apr 2026 | 3 articles | Viewed by 7046 | Submission Open
Keywords: drug discovery; drug development; target identification; computational drug design; structure-based drug design; ligand-based drug design
(This special issue belongs to the Section Molecular Pharmacology)
Type 1 Diabetes: Molecular Mechanisms and Therapeutic Approach
edited by Preeti Chhabra
submission deadline 20 Apr 2026 | 3 articles | Viewed by 7008 | Submission Open
Keywords: type 1 diabetes; microbiome; proteomics; immunotherapy; β -cell replacement; single-cell sequencing; stem cells; gene editing technologies; tolerance
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
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