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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Protein Aggregation and Proteinopathies
edited by Hongyu Hu
submission deadline 20 Mar 2026 | 2 articles | Viewed by 8667 | Submission Open
Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy
(This special issue belongs to the Section Molecular Biology)
Cutting-Edge Research on Nanosensors and Microsensors submission deadline 20 Mar 2026 | 2 articles | Viewed by 8603 | Submission Open
Keywords: nanosensors and microsensors; innovations; nanomaterials; nanotechnology; biomedical devices; point-of-care and point-of-use testing; environmental control
(This special issue belongs to the Section Materials Science)
Molecular Research and Insight into Endocannabinoid System submission deadline 20 Mar 2026 | 3 articles | Viewed by 8262 | Submission Open
Keywords: endocannabinoid system; molecular research; biomarker; translational
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research in Retina: 3rd Edition submission deadline 20 Mar 2026 | 4 articles | Viewed by 8066 | Submission Open
Keywords: glaucoma; age-related macular degeneration; diabetic retinopathy; neurodegenerative diseases; diagnostic techniques; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Molecular Research in Leukemia submission deadline 20 Mar 2026 | 2 articles | Viewed by 7273 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML); hairy cell leukemia (HCL); T-cell prolymphocytic leukemia (T-PLL); large granular lymphocytic leukemia; measurable residual disease (MRD)
(This special issue belongs to the Section Molecular Oncology)
Induced Pluripotent Stem and Extracellular Vesicles in Biomedicine submission deadline 20 Mar 2026 | 2 articles | Viewed by 7189 | Submission Open
Keywords: induced pluripotent stem; embryonic stem cells; extracellular vesicles; tissue development; translational medicine
(This special issue belongs to the Section Molecular Biology)
Parkinson’s Disease and Related Diseases: Mechanisms, Genetic Factors and Treatments
edited by
submission deadline 20 Mar 2026 | 3 articles | Viewed by 7187 | Submission Open
Keywords: Parkinson’ s disease; neurodegenerative disorders; α -synuclein aggregation; neuroinflammation; gene therapy; biomarkers
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Natural Products in Treating Human Diseases
edited by Luís R. Silva
submission deadline 20 Mar 2026 | 5 articles | Viewed by 7177 | Submission Open
Keywords: natural products; phytochemicals; biological potential; pharmacological activity; health promoters; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Advances and Challenges in Colorectal Cancer: From Molecular Research to Treatment submission deadline 20 Mar 2026 | 1 articles | Viewed by 7053 | Submission Open
Keywords: tumor biology; tumor heterogeneity; molecular mechanism involved in cancer initiation; progression; and metastasis; compensatory pathways; cancer screening; cancer biomarkers discovery; tumor molecular profiling methods; early cancer diagnosis; novel therapeutic strategies; targeted therapies; drug resistance
(This special issue belongs to the Section Molecular Oncology)
The Discovery, Extraction, Synthesis, and Application of Natural Products
edited by , Kang Hyun Lee and
submission deadline 20 Mar 2026 | 2 articles | Viewed by 7009 | Submission Open
Keywords: antibiotics; antioxidants; biomass; bioactive molecule; biological activity; biosynthesis; biosensor; biomedicine; biotechnology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Steatotic Liver Disease: From Bench to Bedside and Back
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 7000 | Submission Open
Keywords: MASLD; ALD; MetALD; fibrosis; hepatocellular carcinoma; molecular mechanisms; molecular markers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lymphoma: Molecular Pathologies and Therapeutic Strategies submission deadline 20 Mar 2026 | 2 articles | Viewed by 6892 | Submission Open
Keywords: targeted therapy; molecular pathway; Hodgkin’ s lymphoma; non-Hodgkin’ s lymphoma; hematopathology biomarker; new therapeutic approaches
(This special issue belongs to the Section Molecular Oncology)
Mechanism and Treatment Progress of Liver Disease
edited by Yohei Shirakami
submission deadline 20 Mar 2026 | 3 articles | Viewed by 6836 | Submission Open
Keywords: liver diseases; MASLD; alcoholic liver disease; liver cancer; viral hepatitis; sarcopenia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Discovery: Natural Products and Compounds submission deadline 20 Mar 2026 | 7 articles | Viewed by 6801 | Submission Open
Keywords: natural products; drug discovery; bioactive compounds; phytochemicals; marine natural compounds; microorganisms; structure– activity relationships (SARs); pharmacological activity; cheminformatics; metabolomics
(This special issue belongs to the Section Molecular Pharmacology)
Endocrinology of Pregnancy submission deadline 20 Mar 2026 | 2 articles | Viewed by 6696 | Submission Open
Keywords: pregnancy; endocrine system; fetal development; maternal health; metabolism
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Big Data in Multi-Omics submission deadline 20 Mar 2026 | 2 articles | Viewed by 6626 | Submission Open
Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Shona   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Informatics)
Cancer Biology and Epigenetic Modifications
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 6568 | Submission Open
Keywords: epigenetics; DNA methylation; epigenetic modifiers; histone acetylation; histone methylation; miRNA; ncRNA; chrmoatin remodelling
(This special issue belongs to the Section Molecular Oncology)
Blueprints of Enzymatic Function and Structure in Biocatalysis submission deadline 20 Mar 2026 | 2 articles | Viewed by 6543 | Submission Open
Keywords: enzyme; biocatalysis; enzyme structure; enzyme kinetics and thermodynamics; enzyme engineering; synthetic biology applications; sustainable biocatalyst design
(This special issue belongs to the Section Biochemistry)
Latest Advances in Oxidative Stress and Brain Injury
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 6462 | Submission Open
Keywords: measurement of ROS; pathology of brain injuries; traumatic brain injuries; hypoxic– ischemic brain damage; experimental models of brain injury; targeted therapy of brain injuries; drug abuse and ROS; histological diagnosis of brain injuries; epigenetics of brain injuries; miRNA and prognosis of neural damage; novel approaches and proofs of principle in therapy; quality of life after brain injury
(This special issue belongs to the Section Molecular Neurobiology)
Exploring the Molecular Basis of Cellular Responses to Microgravity-Induced Oxidative Stress submission deadline 20 Mar 2026 | 2 articles | Viewed by 6346 | Submission Open
Keywords: microgravity; reactive oxygen species (ROS); oxidative damage; cellular antioxidant systems; cell metabolism; cell responses; molecular pathways; simulated microgravity; protective countermeasures
(This special issue belongs to the Section Molecular Biology)
Molecular Perspective in Autoimmune Diseases
edited by Andrés González-García and
submission deadline 20 Mar 2026 | 3 articles | Viewed by 6322 | Submission Open
Keywords: interferon; cytokines; lupus nephritis; lupus; type I interferon; vasculitis; IgG4-related disease; B cell; NETs; IL-6; biomarkers
(This special issue belongs to the Section Molecular Immunology)
New Trends and Challenges in Chronic Diseases
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 6251 | Submission Open
Keywords: chronic diseases; ER stress; oxidative stress; immune regulation; new pathways of pathogenesis; cancer development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic Analysis Based on CRISPR/Cas9 Technology: 2nd Edition
edited by and
submission deadline 20 Mar 2026 | 2 articles | Viewed by 6126 | Submission Open
Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Melanin Pigmentation: Physiology and Pathology submission deadline 20 Mar 2026 | 7 articles | Viewed by 6099 | Submission Open
Keywords: eumelanin; pheomelanin; melanogenesis; photoprotection; pigmentary disorders; depigmenting agents; extracutaneous melanins
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches submission deadline 20 Mar 2026 | 3 articles | Viewed by 6079 | Submission Open
Keywords: eye diseases; genetic; biochemical; proteomic; cellular and physiological level; innovative therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Molecules from Food or Other Natural Sources Against Cancer: 2nd Edition submission deadline 20 Mar 2026 | 3 articles | Viewed by 6019 | Submission Open
Keywords: cancer; natural bioactive molecules; natural products; tumor
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Signalling Pathways in Metabolic Diseases and Cancers
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 5728 | Submission Open
Keywords: cancer; prostate cancer; molecular signalling pathway; metabolic diseases; diabets; immunotherapy; immunological diseases
(This special issue belongs to the Section Biochemistry)
Cutaneous Biology, Molecular Dermatology and Dermatopathology, 2nd Edition
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 5726 | Submission Open
Keywords: molecular dermatology; targeted therapy; cutaneous oncology; immunodermatology; cutaneous biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular and Molecular Study of Neurodevelopmental and Neurological Disorders
edited by
submission deadline 20 Mar 2026 | 1 articles | Viewed by 5683 | Submission Open
Keywords: autism spectrum disorder; ADHD; schizophrenia; intellectual disability; Alzheimer’ s disease; Parkinson’ s disorder; traumatic brain injury; epilepsy; neurodevelopmental disorders; neurological diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Adapter CAR T Cells: From the Idea to the Clinic submission deadline 20 Mar 2026 | 2 articles | Viewed by 5679 | Submission Open
Keywords: CAR T cell therapy; chimeric antigen receptor; bispecific antibody; target module; autoimmune diseases; solid tumors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Pathophysiology of Cystic Fibrosis
edited by and George M. Solomon
submission deadline 20 Mar 2026 | 2 articles | Viewed by 5549 | Submission Open
Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Unraveling the Genetic Background of Neurological Disorders: 2nd Edition submission deadline 20 Mar 2026 | 3 articles | Viewed by 5446 | Submission Open
Keywords: neurological disorders; neurogenetics; personalized treatments; gene-association studies; genetics; genome-wide association studies; genetic linkage studies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioactive Natural Compounds: Protecting Plants and Promoting Human Health, 2nd Edition submission deadline 20 Mar 2026 | 3 articles | Viewed by 5385 | Submission Open
Keywords: natural products; molecular biology; chemical characterization; bioactivity; mechanism of action; plant protection; human health promotion; antioxidant; anti-inflammation; biopesticides; biostimulants; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Sepsis: Pathogenesis, Biomarkers, Treatments and Prognosis
edited by Francesca Innocenti
submission deadline 20 Mar 2026 | 4 articles | Viewed by 5364 | Submission Open
Keywords: sepsis phenotypes; hemodynamic stabilization; fluids; vasopressors; diagnostic biomarkers; tailored approach; immune modulation; immunomodulatory therapy; prognostic stratification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Hepatocellular Carcinoma: From Carcinogenesis to Liver Transplantation
edited by
submission deadline 20 Mar 2026 | 3 articles | Viewed by 5346 | Submission Open
Keywords: hepatocarcinogenesis; molecular pathogenesis; tumor microenvironment; metabolic dysfunction-associated fatty liver disease (MAFLD); metastasis; genetic and epigenetic alterations; biomarkers; precision oncology; targeted therapy; immunotherapy; therapy resistance; immune escape; tumor recurrence; transplant oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Regenerative Medicine and Therapeutics
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 5345 | Submission Open
Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Medicinal Plant Resources—from Molecular Studies to Sustainable Use
edited by Ekaterina Kozuharova
submission deadline 20 Mar 2026 | 3 articles | Viewed by 5334 | Submission Open
Keywords: genetic improvement of medicinal plants; sustainable use; bioactive compounds
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Immunosuppressive Therapy
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 5313 | Submission Open
Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling
(This special issue belongs to the Section Molecular Immunology)
Molecular Insight into Bone Diseases
edited by Gaia Palmini
submission deadline 20 Mar 2026 | 4 articles | Viewed by 5290 | Submission Open
Keywords: mineralization; bone diseases; rare bone diseases; non-coding RNAs; fibrous bone dysplasia; tumoral calcinosis; osteosarcoma; Ewing sarcoma; osteoporosis; Gorham-Stout disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Phage–Host Interactions: Novel Findings and Perspectives
edited by
submission deadline 20 Mar 2026 | 4 articles | Viewed by 5087 | Submission Open
Keywords: bacteriophages; phage therapy; phage/bacteria interactions; genomics; transcriptomics; proteomics; metabolomics; biofilms
(This special issue belongs to the Section Molecular Microbiology)
New Processes and Applications of Plasma in Liquids
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 4725 | Submission Open
Keywords: plasma in liquids; water decontamination; plasma-activated water; hydrogels; plasma medicine; polymerization in liquids; plasma agriculture
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Gut-Brain Axis: Genomic and Metagenomic Involvement
edited by and Elias Odusseas Tzavellas
submission deadline 20 Mar 2026 | 2 articles | Viewed by 4644 | Submission Open
Keywords: gut– brain axis; central nervous system; gastrointestinal tract; genomic; metagenomic
(This special issue belongs to the Section Molecular Neurobiology)
Regulation and Application of Bioactive Metabolites in Plants
edited by and
submission deadline 20 Mar 2026 | 2 articles | Viewed by 4637 | Submission Open
Keywords: medicinal plants; biosynthesis; biological activity; regulation; pharmacological mechanism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Antiviral Drugs Discovery
edited by
submission deadline 20 Mar 2026 | 2 articles | Viewed by 4612 | Submission Open
Keywords: antiviral agents; organic synthesis and medicinal chemistry; biological activity; drug design and computational chemistry; drug discovery and development
(This special issue belongs to the Section Molecular Pharmacology)
Molecular and Structural Research Advances in Model Plants (Second Edition) submission deadline 20 Mar 2026 | 3 articles | Viewed by 4605 | Submission Open
Keywords: A. thaliana; plant biology; model organisms; plant models; non-model plant models
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Protein Structure-Function and Drug Discovery
edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth
submission deadline 20 Mar 2026 | 5 articles | Viewed by 4486 | Submission Open
Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery
(This special issue belongs to the Section Macromolecules)
Gestational Diabetes Mellitus: Molecular Insights into Pathophysiology, Management and Therapy submission deadline 20 Mar 2026 | 2 articles | Viewed by 4476 | Submission Open
Keywords: GDM pathogenesis; health programming; pharmacogenomics; life-style interventions; fetal growth disorders; preeclampsia; polyhydramnios; placental origin of disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Fundamental and Translational Insights into Colorectal Cancer
edited by Giuseppe Broggi
submission deadline 20 Mar 2026 | 3 articles | Viewed by 4439 | Submission Open
Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanism and Therapeutic Approaches of Breast Cancer, Metastatic Breast Cancer, 3rd Edition
edited by
submission deadline 20 Mar 2026 | 3 articles | Viewed by 4377 | Submission Open
Keywords: breast cancer; metastatic breast cancer; epithelial-to-mesenchymal transition (EMT); epigenetic and post-translational modifications (PTM); tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Recent Research on Biomimetic Chromatography, QSAR and Chemoinformatics in Molecular Modeling and Drug Design submission deadline 20 Mar 2026 | 3 articles | Viewed by 4268 | Submission Open
Keywords: biomimetic chromatography; QSARs; QRARs; molecular modelling; chemoinformatics; pharmacokinetics
(This special issue belongs to the Section Molecular Informatics)
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