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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Lung Cancers: An Update on Molecular Diagnostics and Therapy

edited by

Mariusz Chabowski

submission deadline 20 Mar 2026 | 6 articles | Viewed by 22691 | Submission Open

Keywords: lung cancer; cancer cachexia; prognosis; anti-lung cancer agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Infections and Immune Responses

edited by

Alessandra Ruggiero

and

Marco Iannetta

submission deadline 20 Mar 2026 | 8 articles | Viewed by 21055 | Submission Open

Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralizing activity

(This special issue belongs to the Section Molecular Immunology)

Beyond Digestion: The Role of Gut Microbiota in Metabolism, Immunity and Brain Function

edited by

Alip Borthakur

submission deadline 20 Mar 2026 | 5 articles | Viewed by 21034 | Submission Open

Keywords: gut dysbiosis; gut microbiota; metabolism

(This special issue belongs to the Section Molecular Immunology)

Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications

edited by Jung-Hyun Lee

submission deadline 20 Mar 2026 | 7 articles | Viewed by 20650 | Submission Open

Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems

(This special issue belongs to the Section Biochemistry)

Molecular and Cellular Perspectives on Wound Healing

edited by

Ermelindo C. Leal

and

Eugenia Carvalho

submission deadline 20 Mar 2026 | 7 articles | Viewed by 20532 | Submission Open

Keywords: chronic wound healing; scarring; biomarkers; inflammation; angiogenesis; infection; extracellular matrix; biomaterials; tissue regeneration; therapeutic targets; innovative therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Obesity and Obesity Related Disorders: 3rd Edition

edited by

Grażyna Nowicka

submission deadline 20 Mar 2026 | 7 articles | Viewed by 20106 | Submission Open

Keywords: biochemistry and molecular medicine; molecular and cellular mechanisms of disease pathogenesis; pathogenesis of metabolic disorders; the role of interaction between genetic and environmental factors in the pathogenesis of non-communicable diseases; atherosclerosis; obesity; obesity-related metabolic diseases and cancers

(This special issue belongs to the Section Molecular Biology)

Natural Product-Based Strategy for Skin Inflammatory Disorders and Regeneration

edited by

Mi Young Lee

submission deadline 20 Mar 2026 | 6 articles | Viewed by 19481 | Submission Open

Keywords: inflammatory skin disorders; skin wound healing and regeneration; skin aging; bioactive natural compound; derivative and conjugate; plant extract; beneficial effect and application; molecular mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in RNA Drug Development

edited by Hidenori Tani

submission deadline 20 Mar 2026 | 3 articles | Viewed by 18960 | Submission Open

Keywords: RNA therapeutics; drug development; antisense oligonucleotides; siRNA; miRNA; aptamers; CRISPR-Cas9; delivery systems; clinical applications; emerging technologies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Translational Bioinformatics: Second Edition

edited by

Camelia Quek

submission deadline 20 Mar 2026 | 5 articles | Viewed by 18922 | Submission Open

Keywords: translational research; sequencing; single cell; spatial biology; treatment; diagnostics; machine learning; artificial intelligence; model; computational biology

(This special issue belongs to the Section Molecular Informatics)

Molecular Insights into Zoonotic Diseases

edited by

Vishwanath Venketaraman

submission deadline 20 Mar 2026 | 6 articles | Viewed by 17240 | Submission Open

Keywords: mycobacterial diseases; bubonic and pneumonic plague; Q fever; cat scratch disease; Mediterranean fever; HIV; malaria; ADIS; SARS-CoV-2; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Microbiology)

Innovative Molecular Strategies in Biomedicine

edited by

Rui Vitorino

submission deadline 20 Mar 2026 | 4 articles | Viewed by 16986 | Submission Open

Keywords: bioprinting; organ-on-chip; venom-derived therapeutics; 3D in vitro models; skeletal muscle models; toxic peptides; peptide expression; nanoparticles in medicine; protein and peptide drug delivery; peptide-based biomaterials; self-assembled hydrogels; molecular therapeutics; nanotechnology in drug delivery; regenerative medicine; tissue engineering

(This special issue belongs to the Section Materials Science)

Hormone Replacement Therapy

edited by

Marco Antonio Botelho

and

Raouf A. Khalil

submission deadline 20 Mar 2026 | 2 articles | Viewed by 16093 | Submission Open

Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Latest Advances in Reproduction Biology

edited by Clara Malo

submission deadline 20 Mar 2026 | 9 articles | Viewed by 15858 | Submission Open

Keywords: gamete formation; fertilization; embryo formation; embryo implantation; fertility; infertility; molecular markers; reproductive biology

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Diabetes and Obesity

edited by

Shin-Da Lee

submission deadline 20 Mar 2026 | 5 articles | Viewed by 15832 | Submission Open

Keywords: obesity; diabetes; hypothalamus; insulin resistance; glucose homeostasis; lipid metabolism; adipose tissue; cardiovascular tissue

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Mitochondria: Transport of Metabolites Across Biological Membranes

edited by

Graziantonio Lauria

and

Rosita Curcio

submission deadline 20 Mar 2026 | 3 articles | Viewed by 15602 | Submission Open

Keywords: mitochondria; mitochondrial transporters; mitochondrial metabolism; transport proteins; translocases carriers; mitochondrial carriers; mitochondrial diseases; mitochondrial permeability; apoptosis

(This special issue belongs to the Section Molecular Biology)

Lipid Metabolism in Human Health and Diseases

edited by

Arianna Vignini

submission deadline 20 Mar 2026 | 5 articles | Viewed by 15401 | Submission Open

Keywords: lipids; fatty acids; lipid metabolism; metabolic disorders; cardiovascular diseases; neurodegenerative diseases; cancers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases

edited by

Abdullah Sheikh

submission deadline 20 Mar 2026 | 6 articles | Viewed by 15211 | Submission Open

Keywords: neurodegeneration; molecular pathways; protein aggregation; gene therapy; neuroprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Diabetes and Metabolic Dysfunction

edited by

Vasilis Tsimihodimos

submission deadline 20 Mar 2026 | 6 articles | Viewed by 15087 | Submission Open

Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Heart Failure: From Molecular Basis to Therapeutic Strategies

edited by

Michele Ciccarelli

submission deadline 20 Mar 2026 | 6 articles | Viewed by 14289 | Submission Open

Keywords: heart failure; cardiac metabolism; mitochondria; inflammatory pathway; neurohormonal system; therapeutical strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Plasticity and EMT in Cancer and Fibrotic Diseases

edited by

Sabrina Lisi

and

Margherita Sisto

submission deadline 20 Mar 2026 | 5 articles | Viewed by 14248 | Submission Open

Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases

(This special issue belongs to the Section Molecular Biology)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 20 Mar 2026 | 5 articles | Viewed by 14113 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Basis of Pancreatic Secretion and Metabolism

edited by

Dongki Yang

submission deadline 20 Mar 2026 | 5 articles | Viewed by 14052 | Submission Open

Keywords: exocrine of the pancreas; endocrine of the pancreas; acute pancreatitis; chronic pancreatitis; cystic fibrosis; pancreatic metabolic hormones; pancreatic metabolic disease; mechanism of pancreatic bicarbonate secretion; the sodium bicarbonate cotransporter (NBC); cystic fibrosis transmembrane conductance regulator (CFTR); regulators of the ion channels and ion transporters involved in secretion

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanism and Treatment of Diabetes Mellitus and Its Complications

edited by

Bernd Stratmann

submission deadline 20 Mar 2026 | 6 articles | Viewed by 13958 | Submission Open

Keywords: MODY; LADA; diabetes late complications; molecular mechanisms; omics; polyneuropathy; microvascular disease; macrovascular disease; liver disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

CNS Injuries: 2nd Edition

edited by

Sudhanshu Raikwar

submission deadline 20 Mar 2026 | 1 articles | Viewed by 13850 | Submission Open

Keywords: stroke; TBI; brain edema; SCI; spinal cord edema; neuroinflammation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases

edited by

Hirayuki Enomoto

submission deadline 20 Mar 2026 | 3 articles | Viewed by 13838 | Submission Open

Keywords: biomarker; genomic research; epigenomic research; molecular mechanisms; viral hepatitis; alcoholic-related liver disease; non-alcoholic fatty liver disease; autoimmune liver diseases; liver cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Zebrafish as a Model in Human Disease: 3rd Edition

edited by

Andrea Vettori

Nicola Facchinello

and

Marco G. Schiavone

submission deadline 20 Mar 2026 | 5 articles | Viewed by 13825 | Submission Open

Keywords: zebrafish; CRISPR/Cas9; transgenic lines; biosensors; endothelial cells; extracellular matrix; genetic mutant for human disease modeling; xenografts

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases

edited by Yi-Ming Arthur Chen

submission deadline 20 Mar 2026 | 3 articles | Viewed by 13596 | Submission Open

Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition

edited by

Ralf Kircheis

and

Oliver Planz

submission deadline 20 Mar 2026 | 8 articles | Viewed by 13544 | Submission Open

Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies

(This special issue belongs to the Section Molecular Immunology)

The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology

edited by

Katarzyna A. Lisowska

submission deadline 20 Mar 2026 | 8 articles | Viewed by 13275 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines

(This special issue belongs to the Section Molecular Immunology)

New Advances in Medical Microbiology

edited by

Alberto Rizzo

submission deadline 20 Mar 2026 | 4 articles | Viewed by 13012 | Submission Open

Keywords: clinical microbiology; clinical virology; SARS-CoV-2; HPV; sexually transmitted infections; respiratory viruses; emerging pathogens; opportunistic infections

(This special issue belongs to the Section Molecular Microbiology)

Molecular Genetics in Ovarian Cancer

edited by

Bruna Scaggiante

submission deadline 20 Mar 2026 | 7 articles | Viewed by 12977 | Submission Open

Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Exploring Biological Mechanisms and Therapeutic Strategies for Substance Use Disorders

edited by Thomas Paparrigopoulos

submission deadline 20 Mar 2026 | 3 articles | Viewed by 12779 | Submission Open

Keywords: addiction; alcohol use disorder; opioid use disorder; substance use disorders; physical exercise; physical activity; molecular mechanisms; neuroendocrine system

(This special issue belongs to the Section Molecular Neurobiology)

Inflammatory Bowel Disease and Microbiome

edited by Abigail Raffner Basson

submission deadline 20 Mar 2026 | 4 articles | Viewed by 12767 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker

(This special issue belongs to the Section Molecular Microbiology)

Toxicity of Metals, Metal-Based Drugs, and Microplastics

edited by

Agnieszka Scibior

Manuel Aureliano

and

Juan Llopis

submission deadline 20 Mar 2026 | 5 articles | Viewed by 12543 | Submission Open

Keywords: metal toxicity and pollution; microplastic toxicity and pollution; metal and microplastic bioaccumulation; metal-based drugs; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies

(This special issue belongs to the Section Molecular Toxicology)

Signaling Pathways and Novel Therapies in Heart Disease

edited by

Anindita Das

submission deadline 20 Mar 2026 | 4 articles | Viewed by 11912 | Submission Open

Keywords: heart failure; arrhythmias; ischemic heart disease; myocardial regeneration; inflammation; gene- or cell-based therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Vegetable Genetics and Genomics, 3rd Edition

edited by

Yunsong Lai

and

Xixiang Li

submission deadline 20 Mar 2026 | 7 articles | Viewed by 11756 | Submission Open

Keywords: major vegetable crops; genome; variome; genotyping; GWAS; QTL mapping; functional genome; metabolome; breeding target characters; genetic mechanism; functional genes

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research Progress of Skin and Skin Diseases: 2nd Edition

edited by

Ji Hyun Lee

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11494 | Submission Open

Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Density Functional Theory and Related Methods for Molecular Computational Chemistry

edited by Paolo Umari

submission deadline 20 Mar 2026 | 4 articles | Viewed by 11349 | Submission Open

Keywords: density functional theory; quantum chemistry; algorithms; quantum computing; high-performance computing; machine learning; many-body perturbations theory; quantum Monte Carlo

(This special issue belongs to the Section Molecular Informatics)

Plant Resilience: Insights into Abiotic and Biotic Stress Adaptations

edited by

Xujun Zhu

submission deadline 20 Mar 2026 | 6 articles | Viewed by 11284 | Submission Open

Keywords: plants; basis of life; environmental stress; complex responses; molecular mechanisms; abiotic and biotic stress adaptations

(This special issue belongs to the Section Molecular Plant Sciences)

Gynecologic Diseases: From Molecular Basis to Therapy

edited by Domenico Baldini

submission deadline 20 Mar 2026 | 2 articles | Viewed by 11243 | Submission Open

Keywords: infertility; sterility; gynecologic desease; genetic; IVF; gynecologic therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology and New Therapies of Alopecia

edited by Jong-Hyuk Sung

submission deadline 20 Mar 2026 | 2 articles | Viewed by 11224 | Submission Open

Keywords: alopecia; pathophysiology; novel pharmacological treatments; regenerative medicines; gene therapy; cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Mar 2026 | 3 articles | Viewed by 11170 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Autoimmune Diseases

edited by

Tsvetelina Velikova

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11079 | Submission Open

Keywords: autoimmunity; autoimmune mechanisms; molecular pathogenesis; immune signalling pathways; cytokine regulation; epigenetics in autoimmunity; molecular biomarkers; gene expression profiling; regulatory T cells; immunogenetics; molecular therapeutics; signal transduction; immunometabolism; microRNA in autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Neurodegenerative Disease: From Molecular Basis to Therapy, 4th Edition

edited by

Claudia Ricci

submission deadline 20 Mar 2026 | 9 articles | Viewed by 11068 | Submission Open

Keywords: neurodegenerative diseases; molecular biology; neurogenetics; pathogenesis; therapy; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Chromatin Structure and Dynamics

edited by Stephanie Portillo-Ledesma

submission deadline 20 Mar 2026 | 5 articles | Viewed by 10724 | Submission Open

Keywords: chromatin structure and dynamics; genome architecture; epigenetic regulation

(This special issue belongs to the Section Biochemistry)

Applications of Bacteriophages

edited by

Grzegorz Wegrzyn

submission deadline 20 Mar 2026 | 2 articles | Viewed by 10124 | Submission Open

Keywords: bacteriophages; gene cloning; phage display technology; phage

(This special issue belongs to the Section Molecular Biology)

Protein Methyltransferases in Human Health and Diseases

edited by

Byron Baron

submission deadline 20 Mar 2026 | 3 articles | Viewed by 10109 | Submission Open

Keywords: lysine and arginine methylation; mass spectrometry; PTM cross talk; functional proteomics; cancer; neurological disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism in Cardiovascular Pathology

edited by Andrea Marzullo

submission deadline 20 Mar 2026 | 6 articles | Viewed by 10098 | Submission Open

Keywords: cardiovascular diseases; molecular biology; sudden death; cardiomyopathies; heart failure; coronary artery diseases; pericarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics

edited by

Deokho Lee

submission deadline 20 Mar 2026 | 4 articles | Viewed by 9935 | Submission Open

Keywords: diabetic retinopathy; retinopathy of prematurity; retinal vein occlusion; retinal artery occlusion; pathologic myopia; age-related macular degeneration; glaucoma; ocular ischemic syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondria: Central Players in Cancer

edited by

Annamaria Piscazzi

and

Domenica Mangieri

submission deadline 20 Mar 2026 | 4 articles | Viewed by 9885 | Submission Open

Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1051-1100 on page 22 of 63.

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