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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Medicinal Plants and Natural Compounds in Health and Disease: Progresses, Challenges, Opportunities, 2nd Edition

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Nov 2025 | 2 articles | Viewed by 8986 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; oxidative stress; gene expression; protein expression; cellular signaling; ethnopharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Research on Chemokines and Chemokine Receptors

edited by

Bouchra Edderkaoui

submission deadline 20 Nov 2025 | 4 articles | Viewed by 8926 | Submission Open

Keywords: chemokines; chemokine receptors; chronic diseases; angiogenesis; fracture; regeneration; chemokine function; expression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physiology and Molecular Medicine of Molecular Hydrogen

edited by

Tyler W. LeBaron

and John Nagi Kheir

submission deadline 20 Nov 2025 | 2 articles | Viewed by 8840 | Submission Open

Keywords: molecular hydrogen; reactive oxygen species; nitric oxide; inflammation; cardiovascular disease

(This special issue belongs to the Section Molecular Biology)

Splice-Switching Antisense Oligonucleotides: 30 Years After Advocating Exon-Skipping Therapy for Duchenne Muscular Dystrophy

edited by

Masafumi Matsuo

submission deadline 20 Nov 2025 | 3 articles | Viewed by 8798 | Submission Open

Keywords: antisense oligonucleotides; modified nucleic acid; splicing; splicing switch; exon skipping; pseudoexon; N-of-1; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Signaling and Stress Adaptation in Plants

edited by

Kangdi Hu

and

Yi Han

submission deadline 20 Nov 2025 | 8 articles | Viewed by 8379 | Submission Open

Keywords: plants; environmental stress; stress signaling; reactive oxygen/nitrogen species; calcium; protein kinases; stress resistance; adaptive mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Abnormal Organelles and Protein Expression in Acute and Chronic Neurodegeneration

edited by

Francesco Fornai

submission deadline 20 Nov 2025 | 3 articles | Viewed by 8347 | Submission Open

Keywords: brain ischemia; epileptic damage; basal ganglia pathology; catecholamine cell damage; excitotoxicity; autophagy; dopamine system norepinephrine system; protein unfolding; protein misfolding; cholinergic system

(This special issue belongs to the Section Molecular Neurobiology)

Cardiovascular Disease and Diabetes: A New Challenge in Treatment and Management

edited by Graziano Riccioni

submission deadline 20 Nov 2025 | 4 articles | Viewed by 8224 | Submission Open

Keywords: hypertension; atherosclerosis; congestive heart failure; diabetes mellitus; therapy; hypercholesterolemia; coronary artery disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 20 Nov 2025 | 7 articles | Viewed by 8183 | Submission Open

Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers

(This special issue belongs to the Section Molecular Oncology)

Cheminformatics in Drug Discovery and Green Synthesis

edited by

Ana Amić

submission deadline 20 Nov 2025 | 6 articles | Viewed by 8128 | Submission Open

Keywords: cheminformatics; drug discovery; databases; in silico methods; green chemistry

(This special issue belongs to the Section Molecular Informatics)

Recent Advances in Antimicrobial Nanoparticles

edited by

Tarek Ali Ahmed Ibrahim Alshaal

submission deadline 20 Nov 2025 | 1 articles | Viewed by 8078 | Submission Open

Keywords: nanotechnology; antimicrobial agents; nanoparticle synthesis; biomedical applications; targeted delivery; mechanisms of action

(This special issue belongs to the Section Molecular Nanoscience)

Cardiovascular Diseases: From Pathology to Therapeutics

edited by

Woongbi Jang

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7770 | Submission Open

Keywords: cardiovascular diseases; pathologies; cardiac progenitor cells; molecular pathways; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drosophila: A Versatile Model in Biology and Medicine—2nd Edition

edited by

Maria Grazia Giansanti

and

Roberto Piergentili

submission deadline 20 Nov 2025 | 9 articles | Viewed by 7688 | Submission Open

Keywords: model organism; human disease; inherited disease; cancer; neurodegeneration; rare disease; genetics

(This special issue belongs to the Section Molecular Biology)

Astrocyte-Endothelial Interactions at the Blood-Brain Barrier, 2nd Edition

edited by

Dariusz Szukiewicz

submission deadline 20 Nov 2025 | 2 articles | Viewed by 7661 | Submission Open

Keywords: blood– brain barrier (BBB); astrocyte– endothelial interactions; cytokine signaling; astrocytic modulation; brain microvascular endothelial cells; chemokine receptors; BBB permeability; BBB dysfunction; BBB pharmacokinetics; cerebrovascular disease; oxidative stress; BBB models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights in Reproductive Immunology and Placental Pathology, 2nd Edition

edited by

Dariusz Szukiewicz

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7629 | Submission Open

Keywords: gamete immunology; in vitro fertilization; infertility; immunocontraception; implantation; placentation; immunotolerance; reproductive immunology; inflammation; cytokine network; placenta-derived stem cells; placental development; placental insufficiency; endometriosis; immunopathology of pregnancy; sex hormones

(This special issue belongs to the Section Molecular Immunology)

Drug Design and Development for Neurological Diseases

edited by

Alicja Nowaczyk

and

Grzegorz Grześk

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7625 | Submission Open

Keywords: neurological disorders and their therapies; molecular modeling; synthesis and structural analysis; neurotransmitters ligands; mechanism of action; drug repurposing

(This special issue belongs to the Section Molecular Pharmacology)

New Insights into Mitochondria in Health and Diseases

edited by

Josephine S. Modica-Napolitano

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7503 | Submission Open

Keywords: mitochondrial bioenergetics; reactive oxygen species; apoptosis; aging; immune function; mtDNA mutations; mitochondrial dysfunction; mitochondria-targeted therapies

(This special issue belongs to the Section Biochemistry)

Microbial Infections and Novel Biological Molecules for Treatment

edited by Matthew Cheesman

submission deadline 20 Nov 2025 | 9 articles | Viewed by 7429 | Submission Open

Keywords: microbial infections; infectious diseases; new antibiotics; antimicrobial resistance (AMR); antimicrobial drugs; active substance; bacterial; virus

(This special issue belongs to the Section Molecular Microbiology)

Skeletal Muscle Function and Metabolism: Molecular Mechanisms and Treatment—2nd Edition

edited by

Andrea Telek

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7170 | Submission Open

Keywords: skeletal muscle; metabolism; mitochondria; epigenetics; exercise; signalization

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bacteriophage—Molecular Studies (6th Edition)

edited by

Alicja Wegrzyn

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7144 | Submission Open

Keywords: bacteriophage biodiversity; regulation of bacteriophage development; molecular processes in bacteriophages; bacteriophage-based biotechnology; phage therapy

(This special issue belongs to the Section Biochemistry)

From Biomolecules to Therapies: Bridging the Gap with Molecular Mechanisms, Computational Design, and Drug Delivery

edited by

Jesús Vicente de Julián-Ortiz

Francisco Torrens

and

Gloria Castellano

submission deadline 20 Nov 2025 | 3 articles | Viewed by 7074 | Submission Open

Keywords: biomolecules; molecular mechanisms; computational studies; drug delivery; xenobiotics

(This special issue belongs to the Section Molecular Informatics)

Exploring the Molecular Mechanisms of Chronic Kidney Disease

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 Nov 2025 | 4 articles | Viewed by 6940 | Submission Open

Keywords: chronic kidney disease; hereditary renal disease; renal hypertension; diabetic nephropathy; secondary hyperparathyroidism; cardiovascular disease; renal osteodystrophy; peritoneal dialysis; hemodialysis; anemia; metabolic acidosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition

edited by

Donatella Delle Cave

submission deadline 20 Nov 2025 | 6 articles | Viewed by 6839 | Submission Open

Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine

(This special issue belongs to the Section Molecular Oncology)

Recent Research of Natural Products from Microalgae and Cyanobacteria

edited by

Biswajita Pradhan

submission deadline 20 Nov 2025 | 3 articles | Viewed by 6594 | Submission Open

Keywords: marine and fresh water microalgal and cyanobacterial bioactive compounds; microalgal and cyanobacterial carotenoids; vitamins; phenolics; and phycobiliproteins; microalgal and cyanobacterial alkaloids; microalgal and cyanobacterial polysaccharides; microalgal and cyanobacterial peptides; microalgal and cyanobacterial polyphenols; microalgal and cyanobacterial antioxidants; microalgal and cyanobacterial pharmaceuticals; microalgal and cyanobacterial nutraceuticals; microalgal and cyanobacterial anti-inflammatory compounds; microalgal and cyanobacterial antimicrobial compounds; microalgal and cyanobacterial anticancer compounds; microalgal and cyanobacterial neuroprotective compounds; microalgal and cyanobacterial antiviral compounds; microalgal and cyanobacterial-derived anti-aging compounds; microalgal and cyanobacterial extracts

(This special issue belongs to the Section Biochemistry)

Editorial Board Members’ Collection Series: “Molecular Dynamics”

edited by

Paulino Gómez-Puertas

and

James K. Bashkin

submission deadline 20 Nov 2025 | 3 articles | Viewed by 6513 | Submission Open

Keywords: quantum mechanics; classical mechanics; hybrid QM/MM; molecular dynamics at the atomic level; steered molecular dynamics; coarse-graining; docking(protein– protein; protein– ligand); the molecular dynamics of protein– ligand interactions; drug design; virtual screening

(This special issue belongs to the Section Molecular Biophysics)

Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements

edited by

Xiang Lin

submission deadline 20 Nov 2025 | 7 articles | Viewed by 6261 | Submission Open

Keywords: Sjö gren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Involvement of Neuroinflammatory Processes in Psychiatric Conditions

edited by

Cristina Núñez

submission deadline 20 Nov 2025 | 4 articles | Viewed by 6171 | Submission Open

Keywords: neuroinflammation; glia; chemokine; cytokine; psychiatry disorder; motivation; learning; behavior; mental illness; psychopharmacology

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Autophagy in Disease and Cancer

edited by

Antonio Ieni

and

Giovanni Tuccari

submission deadline 20 Nov 2025 | 3 articles | Viewed by 6069 | Submission Open

Keywords: autophagy; autophagy-related proteins; target therapy; cancer; neurodegenerative disease; infections; aging; metabolic disease; autoimmunity

(This special issue belongs to the Section Molecular Biology)

Molecular Insights in Antivirals and Vaccines

edited by

Gergana Zahmanova

Ivan Minkov

and

Yoana Dimitrova Kiselova-Kaneva

submission deadline 20 Nov 2025 | 2 articles | Viewed by 6041 | Submission Open

Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants

(This special issue belongs to the Section Molecular Microbiology)

Synthesis of Advanced Polymer Materials, 3rd Edition

edited by

Haiyang Gao

submission deadline 20 Nov 2025 | 4 articles | Viewed by 5783 | Submission Open

Keywords: polymer synthesis; polymer chemistry; coordination polymerization; organometallic catalysts; polyolefin; degradable polymer materials; green and sustainable polymeric materials; homogeneous polymerization; heterogeneous polymerization

(This special issue belongs to the Section Macromolecules)

Molecular Research on the Drug Toxicity

edited by

Annagiulia Di Trana

submission deadline 20 Nov 2025 | 2 articles | Viewed by 5760 | Submission Open

Keywords: drug toxicity; new psychoactive substances; toxicology; drug metabolism; drug intoxication

(This special issue belongs to the Section Molecular Toxicology)

The Role of miRNA in Human Diseases

edited by

Seungil Ro

and Seeun Ha

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5724 | Submission Open

Keywords: miRNA; diabetes; obesity; fatty liver disease; gastrointestinal disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Progress in Molecular Mechanisms of Sperm Metabolism and Development

edited by Karl Kerns

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5713 | Submission Open

Keywords: sperm development ; germ cell proliferation ; sperm cell metabolism ; seminal fluid biochemical composition ; spermatogenesis ; epididymal maturation ; sperm capacitation ; oocyte activation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Perspectives on Virus–Host Interactions

edited by

Qibin Geng

submission deadline 20 Nov 2025 | 6 articles | Viewed by 5653 | Submission Open

Keywords: viral manipulation of host metabolics; virus– host interactions; host– pathogen co-evolution; susceptibility and resistance to viral infection; novel antiviral strategies

(This special issue belongs to the Section Molecular Microbiology)

Microbiota and Cancer: 4th Edition

edited by

Silvia Turroni

and

Riccardo Masetti

submission deadline 20 Nov 2025 | 2 articles | Viewed by 5637 | Submission Open

Keywords: gut microbiota; cancer; hematopoietic stem cell transplantation; human microbiome; immune system; colon cancer; carcinogenesis; nutrition; short-chain fatty acids; metagenomic; dysbiosis

(This special issue belongs to the Section Molecular Oncology)

The Application of Machine Learning to Molecular Dynamics Simulations

edited by

Isabella Romeo

submission deadline 20 Nov 2025 | 4 articles | Viewed by 5566 | Submission Open

Keywords: molecular dynamics simulations; machine learning; AI in drug discovery; pharmacokinetics prediction; protein folding simulations; toxicity prediction using ML; free energy calculations; virtual screening; protein– ligand interactions; protein– protein interactions

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms and New Markers of Cancer

edited by

Antonio D’Amati

submission deadline 20 Nov 2025 | 4 articles | Viewed by 5563 | Submission Open

Keywords: molecular pathology; molecular mechanisms; immunotherapy; cancer; oncology; pathology; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Bioactive Compounds from Agro-Industrial Waste Biomass

edited by

Ana Lima

and

Elisabete Maria de Castro Lima

submission deadline 20 Nov 2025 | 2 articles | Viewed by 5549 | Submission Open

Keywords: by-product; biocompound; bioactivity; component analysis; in vitro/in vivo experiments; circular economy; sustainability; biomass residues valorization

(This special issue belongs to the Section Biochemistry)

The Molecular Basis of Plant–Microbe Interactions

edited by

Stephan Pollmann

Luis Morales-Quintana

and

Patricio Ramos

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5480 | Submission Open

Keywords: plant immune and defense responses; microbe and microbiome function; microbial biodiversity; abiotic and biotic stress mitigation; gene regulatory mechanisms; plant hormones in plant– microbe interactions; molecular mechanisms of plant growth and microbe interactions; chemical communication in plant– microbe interactions; microbe effects on fruit quality; OMICs approaches (metagenomics; metatranscriptomics; epigenomics; transcriptomics; metabolomics); bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Basic Mechanisms of Physiological and Pathological Autoimmunity and Their Role in the Development of Autoimmune Diseases

edited by

Péter Németh

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5327 | Submission Open

Keywords: physiologic autoimmunity; autoimmune diseases; natural immune system; pathologic autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Emerging Therapies in Neurovascular Disease

edited by Leonidas D. Panos

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5097 | Submission Open

Keywords: neurovascular diseases; blood– brain barrier; endothelial dysfunction; cellular signaling; gene therapy

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Catalytic Materials (Second Edition)

edited by

Julio Macedo

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5071 | Submission Open

Keywords: synthetic routes; nanomaterials; catalysis; sustainability; biomass; biofuel; photocatalysis; fine chemistry

(This special issue belongs to the Section Materials Science)

Antioxidant and Antibacterial Properties of Phytochemicals

edited by

Dalia Urbonaviciene

and Vytaute Starkute

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5041 | Submission Open

Keywords: phytochemicals; natural preservatives; antioxidants; antibacterial properties; food; cosmetics; pharmaceuticals; animal feed

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Molecular Pathophysiology of Diabetes, Hypertension and Cardiovascular Diseases

edited by Alessandro Durante

submission deadline 20 Nov 2025 | 1 articles | Viewed by 5026 | Submission Open

Keywords: diabetes; hypertension; cardiology; cardiovascular diseases; coronary artery diseases; athero-sclerosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Cancer: Update on Molecular Pathology, Mechanisms and Treatments

edited by

Norio Sogawa

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5007 | Submission Open

Keywords: oral cancer; mechanisms of incidence and development of oral cancer; metastasis; diagnosis; biomarkers; treatments (active ingredients; medicines; biomedicines; and gene therapy)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endometriosis and Infertility

edited by Ludwig Kiesel

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4980 | Submission Open

Keywords: endometriosis; infertility; subfertility; physiological mechanisms; treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Alzheimer’s Disease Treatment: Exploring Novel Approaches and Strategies

edited by

Sunmin Park

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4966 | Submission Open

Keywords: Alzheimer’ s disease; bioinformatics; novel compounds; in vitro; in vivo; clinical study; Alzheimer’ s disease models

(This special issue belongs to the Section Molecular Neurobiology)

Natural Products and Synthetic Derivatives in Cancer and Inflammatory Diseases

edited by

Nelson G.M. Gomes

submission deadline 20 Nov 2025 | 2 articles | Viewed by 4957 | Submission Open

Keywords: angiogenesis inhibition; caspase activation; cytokine modulation; drug discovery; ethnopharmacology; plant metabolites; marine natural products; molecular docking; oxidative stress; tumor microenvironment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Aspects of Hematological Malignancies and Benign Hematological Disorders—3rd Edition

edited by

Amelia Maria Găman

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4930 | Submission Open

Keywords: myeloproliferative neoplasms; leukemia; lymphoma; multiple myeloma; oxidative stress; inflammation; microbiome; genetics; molecular biology

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Technologies in Molecular Detection: From Nanosensors to AI-Driven Analysis

edited by

Long Wu

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4892 | Submission Open

Keywords: molecular detection; analytical techniques; nanosensors; food science; DNA analysis

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Cognitive Dysfunction from COVID-19 Infection and Other Respiratory Viruses

edited by

Abdullah Mosabbir

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4869 | Submission Open

Keywords: long COVID; post-COVID; cognitive dysfunction; virus; cognition; brain; viral infection; virol-ogy; RNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1051-1100 on page 22 of 70.

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