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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms
edited by and Chi-Su Yoon
submission deadline 31 Aug 2025 | Viewed by 80 | Submission Open
Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms
edited by
submission deadline 31 Aug 2025 | Viewed by 80 | Submission Open
Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Immunotherapy in Cancer
edited by Magdalena Król
submission deadline 31 Aug 2025 | Viewed by 78 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; monoclonal antibodies; cytokine signaling; tumor immune evasion; metabolic regulation in cancer; cell-based therapies
(This special issue belongs to the Section Molecular Immunology)
Focus on the Tryptophan Pathway
edited by
submission deadline 31 Aug 2025 | Viewed by 77 | Submission Open
Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan
(This special issue belongs to the Section Molecular Biology)
Cancer Progression and Therapeutic Resistance Mechanisms
edited by
submission deadline 31 Aug 2025 | Viewed by 76 | Submission Open
Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds
(This special issue belongs to the Section Molecular Oncology)
Ovarian Pathologies: Insights into Mechanisms and Therapeutic Strategy
edited by Anna Ptak
submission deadline 31 Aug 2025 | Viewed by 73 | Submission Open
Keywords: subfertility and infertility; hormonal dysfunction; diminished ovarian reserve (DOR); ovarian cysts; polycystic ovary syndrome (PCOS); primary ovarian insufficiency (POI); ovarian cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development
edited by Gabriela Verónica Salamone
submission deadline 31 Aug 2025 | Viewed by 72 | Submission Open
Keywords: gliomas tumor microenvironment immune
(This special issue belongs to the Section Molecular Oncology)
Regulation of Gene Expression in Cell Differentiation
edited by
submission deadline 31 Aug 2025 | Viewed by 71 | Submission Open
Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Imprinting Technologies for Biological and Biomedical Applications submission deadline 31 Aug 2025 | Viewed by 70 | Submission Open
Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications
(This special issue belongs to the Section Molecular Informatics)
Genetics and Genomics of Silkworm
edited by
submission deadline 31 Aug 2025 | Viewed by 70 | Submission Open
Keywords: silkworm genome; gene identification; comparative genomics; silkworm domestication; population genetics; functional genomics; insect immunity; genetic manipulation; silkworm breeding
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Advances in Food Allergenicity: From Molecular Mechanisms to Innovative Mitigation Strategies submission deadline 31 Aug 2025 | Viewed by 67 | Submission Open
Keywords: food allergenicity; food allergen detection; biosensors; mass spectrometry; immunoassays; allergen reduction; hypoallergenic food alternatives; personalized nutrition approaches
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Molecular Research in Neuroimmunology
edited by Mireya Fernández-Fournier
submission deadline 31 Aug 2025 | Viewed by 60 | Submission Open
Keywords: neuroimmunology; antibodies; virus; multiple sclerosis; progression
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Cellular Neurobiology of Headache and Migraine
edited by
submission deadline 31 Aug 2025 | Viewed by 59 | Submission Open
Keywords: headache; migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; PACAP; cluster headache
(This special issue belongs to the Section Molecular Neurobiology)
Plant–Rhizobium Interaction
edited by Rujin Chen
submission deadline 31 Aug 2025 | Viewed by 55 | Submission Open
Keywords: legume; rhizobia; symbiotic nitrogen fixation
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Amyloid Aggregation and Its Inhibition: Implementing Insights from Physiological Conditions submission deadline 31 Aug 2025 | Viewed by 55 | Submission Open
Keywords: protein aggregation; amyloid; physiological conditions; aggregation inhibition; neurodegenerative diseases; amyloidosis
(This special issue belongs to the Section Molecular Neurobiology)
Multifunctional Antioxidants and Enzyme Inhibitors: Design, Synthesis and Mechanisms of Actions
edited by Choon Young Lee
submission deadline 31 Aug 2025 | Viewed by 52 | Submission Open
Keywords: antioxidant synthesis; multifunctional antioxidants; oxidant-generating enzyme inhibitors; activators of antioxidant-generating enzymes; phenolic antioxidant; thiol-based antioxidant; nitrogen-based antioxidants; anti-inflammatory; oxidative stress; free radical scavenging; reactive oxygen species; reactive nitrogen species; mechanisms of action; metal chelator
(This special issue belongs to the Section Macromolecules)
Recent Research in Nanoelectrochemistry
edited by
submission deadline 31 Aug 2025 | Viewed by 44 | Submission Open
Keywords: nanoelectrochemistry; single-entity electrochemistry; nanoscale imaging; molecular electronics devices; nanostructured electrodes; electrochemical sensors; energy storage; catalysis; biomedical applications
(This special issue belongs to the Section Materials Science)
Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research
edited by Paola Muggeo
submission deadline 31 Aug 2025 | Viewed by 43 | Submission Open
Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies
(This special issue belongs to the Section Molecular Oncology)
Computational, Structural and Spectroscopic Studies of Macromolecules
edited by Sanja Dolanski Babić
submission deadline 10 Sep 2025 | 2 articles | Viewed by 3477 | Submission Open
Keywords: macromolecules; structure DNA; effects on DNA; protein; carbohydrate; lipids; spectroscopic methods; FTIR; NMR; UV; CD; numerical methods
(This special issue belongs to the Section Macromolecules)
Preimplantation Genetic Testing in Assisted Reproductive Technologies
edited by
submission deadline 10 Sep 2025 | Viewed by 120 | Submission Open
Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Current Advances in the Pathophysiology and Treatment of Multiple Sclerosis and Related Disorders
edited by Natalia Szejko and
submission deadline 10 Sep 2025 | Viewed by 91 | Submission Open
Keywords: multiple sclerosis; MS; central nervous system; pathophysiology; immunological system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant-Microbe Interaction Studies
edited by
submission deadline 10 Sep 2025 | Viewed by 60 | Submission Open
Keywords: plant-pathogen; plant microorganisms; microbial stress; plant diseases and pests; plant protection
(This special issue belongs to the Section Molecular Microbiology)
Advances in Molecular Research of Facial Adipose Compartments
edited by Marius Valeriu Hînganu
submission deadline 15 Sep 2025 | Viewed by 377 | Submission Open
Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing
(This special issue belongs to the Section Molecular Biology)
Regulatory Mechanism and Network of Abiotic Stress-Response in Plants 2.0
edited by
submission deadline 20 Sep 2025 | 17 articles | Viewed by 30064 | Submission Open
Keywords: abiotic stress response; osmotic stress; temperature stress; transcriptional regulation; post-transcriptional regulation; regulatory mechanism; gene regulatory network
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights in Tumor Immunity
edited by
submission deadline 20 Sep 2025 | 9 articles | Viewed by 27898 | Submission Open
Keywords: tumor immunity; tumor evolution; tumor antigens; immune surveillance; cancer immunoediting; tumor microenvironment; immunotherapies; immune checkpoints; tumor-specific lymphocytes
(This special issue belongs to the Section Molecular Immunology)
From Molecular Insights to Novel Therapies: Neurological Diseases
edited by
submission deadline 20 Sep 2025 | 14 articles | Viewed by 27304 | Submission Open
Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation
(This special issue belongs to the Section Molecular Neurobiology)
Skin, Autoimmunity and Inflammation 2.0 submission deadline 20 Sep 2025 | 2 articles | Viewed by 24374 | Submission Open
Keywords: skin diseases; skin immunology; skin autoimmunity; skin inflammation; inflammatory cytokines; biological therapies; immunotherapy; target therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Biosystems in Toxicology and Pharmacology submission deadline 20 Sep 2025 | 4 articles | Viewed by 23324 | Submission Open
(This special issue belongs to the Section Molecular Biology)
Reproductive Endocrinology Research
edited by
submission deadline 20 Sep 2025 | 7 articles | Viewed by 22286 | Submission Open
Keywords: molecular endocrinology; reproductive genetics; hormonal signaling pathways; fertility and infertility; epigenetics in reproduction; environmental impact on reproduction
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Oxygen Variations, 2nd Edition submission deadline 20 Sep 2025 | 7 articles | Viewed by 21711 | Submission Open
Keywords: hypoxia; hyperoxia; normoxia; biochemichal response; integrative approach; normo-hypo-hyperbaric; molecular research; gene expression; adaptive reactions; extreme environments
(This special issue belongs to the Section Molecular Biology)
Recent Approaches for Wound Treatment—2nd Edition submission deadline 20 Sep 2025 | 7 articles | Viewed by 20926 | Submission Open
(This special issue belongs to the Section Molecular Pharmacology)
Novel Natural Compound for Wound and Tissue Repair and Regeneration: 3rd Edition submission deadline 20 Sep 2025 | 6 articles | Viewed by 17120 | Submission Open
Keywords: wound repair; tissue regeneration; natural compounds; phytochemicals; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Demyelinating Diseases: From Molecular Mechanisms to, Therapeutic Strategies—3rd Edition submission deadline 20 Sep 2025 | 5 articles | Viewed by 16752 | Submission Open
Keywords: biomarkers; cellular and molecular biology; cell differentiation; cellular metabolism; demyelinating diseases; drug developing strategies and drug repositioning; glia cell (oligodendrocytes; astrocytes and microglia); inflammation; lipid metabolism; mitochondria; myelination and remyelination nuclear receptors; nutraceuticals; signal transduction mechanisms; target identification
(This special issue belongs to the Section Molecular Neurobiology)
Recent Research in Gut Microbiota–Gut–Brain Axis
edited by Ying Han
submission deadline 20 Sep 2025 | 3 articles | Viewed by 16479 | Submission Open
Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; short-chain fatty acid; immune pathway; vagus nerve; neuropsychiatric disorders; depression
(This special issue belongs to the Section Molecular Biology)
Biomaterials for Dental and Orthopedic Applications
edited by and
submission deadline 20 Sep 2025 | 8 articles | Viewed by 16010 | Submission Open
(This special issue belongs to the Section Materials Science)
Effects of Bioactive Compounds in Oxidative Stress and Inflammation submission deadline 20 Sep 2025 | 7 articles | Viewed by 15124 | Submission Open
Keywords: natural products; antioxidant effects; anti-inflammatory effects; molecular targets; health beneficial effect; bioactive compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Relationship, Mechanisms, and Treatment Strategies of Diabetes Mellitus and Related Diseases
edited by Maria Kokozidou
submission deadline 20 Sep 2025 | 5 articles | Viewed by 14846 | Submission Open
Keywords: diabetes mellitus; molecular mechanisms; related diseases; genetic basis; microRNAs; incretins; targeted therapies; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immunotherapy in Cancer: Molecular Basis and Novel Therapeutic Approaches
edited by Yonggu Lee
submission deadline 20 Sep 2025 | 7 articles | Viewed by 14654 | Submission Open
Keywords: cellular immunotherapy; adoptive immunotherapy; chimeric antigen receptor T-cell; epigenetic modulation; immunometabolism; microbiome; immune checkpoint inhibitor; cancer vaccine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Update on Immunotherapies for Cancer submission deadline 20 Sep 2025 | 5 articles | Viewed by 14287 | Submission Open
Keywords: cell therapies; monoclonal antibodies; molecular adjuvants; oncolytic therapies; immunogenic; chemotherapy and radiotherapy; cancer vaccines; immunodominance; neoantigens; clinical trials; tumor immune microenvironment
(This special issue belongs to the Section Molecular Oncology)
Advances in Spermatogenesis and Male Infertility
edited by Wanxi Yang
submission deadline 20 Sep 2025 | 8 articles | Viewed by 13603 | Submission Open
Keywords: male reproduction; hormone regulation; blood– testis barrier; male reproductive diseases; male infertility
(This special issue belongs to the Section Molecular Biology)
Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 12984 | Submission Open
Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer
(This special issue belongs to the Section Molecular Pharmacology)
Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management submission deadline 20 Sep 2025 | 10 articles | Viewed by 12662 | Submission Open
Keywords: insulin resistance; hypertension; diabetes mellitus; obesity; inflammation; stress; metabolic disorders; reproductive endocrine disorders; polycystic ovarian syndrome; waist circumference; estrogen deficiency; disturbances in adipose tissue; physical inactivity; overnutrition; cardiovascular diseases; abdominal obesity; genetics and epigenetics of metabolic syndrome; computational analysis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in the Molecular Diagnosis and Treatment of Pancreatic Cancer
edited by Steven T. Brower and Robert Pergolizzi
submission deadline 20 Sep 2025 | 5 articles | Viewed by 12534 | Submission Open
Keywords: pancreatic cancer; molecular diagnostics; biomarkers; oncogenes; epigenetics; genomic profiling; next-generation sequencing; liquid biopsy; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Molecular Research in Breast Cancer: Pathophysiology and Treatment
edited by Costa Frangou
submission deadline 20 Sep 2025 | 6 articles | Viewed by 12451 | Submission Open
Keywords: breast; biomarker; early detection; immunotherapy; metastasis; microenvironment; outcomes; prognosis; relapse; treatment; tumor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Genome Stability submission deadline 20 Sep 2025 | 5 articles | Viewed by 11733 | Submission Open
Keywords: genome stability; DNA damage response; DNA repair; DNA replication; DNA recombination; ATR/ATM pathway; GENOTOXINS
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neurodegenerative Diseases: Molecular Mechanisms and Therapies, 3rd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 11733 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; protein aggregation; pathogenesis; therapy; mitochondria; neuroinflammation; oxidative stress; cell therapy; clinical trial 
(This special issue belongs to the Section Molecular Neurobiology)
The Emerging Role of Neutrophils in Cancer: Molecular Aspects of Plasticity and Potential Therapeutic Targets
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 11332 | Submission Open
Keywords: neutrophils; cancer; tumor microenvironment; tumor-associated neutrophils; innate immunity
(This special issue belongs to the Section Molecular Oncology)
The Zebrafish Model in Animal and Human Health Research, 2nd Edition submission deadline 20 Sep 2025 | 7 articles | Viewed by 10873 | Submission Open
Keywords: zebrafish; environmental toxicology; predictive toxicology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Biology and Hormonal Regulation in Reproductive Processes
edited by and Helena Ban Frangež
submission deadline 20 Sep 2025 | 4 articles | Viewed by 10632 | Submission Open
Keywords: infertility; reproduction; embryos; genetics; epigenetics; signaling pathway; sperm; oocyte
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research on Bacteria
edited by
submission deadline 20 Sep 2025 | 10 articles | Viewed by 10523 | Submission Open
Keywords: infections; bacteria; molecular biology; antimicrobials; bacterial enzymes; bioremediation
(This special issue belongs to the Section Molecular Microbiology)
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