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22 Results Found

  • Review
  • Open Access
19 Citations
22,242 Views
46 Pages

Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges

  • Laura Haidar,
  • Camelia Felicia Bănărescu,
  • Cristina Uța,
  • Sandra Iulia Moldovan,
  • Elena-Larisa Zimbru,
  • Răzvan-Ionuț Zimbru,
  • Elena Ciurariu,
  • Marius Georgescu and
  • Carmen Panaitescu

25 December 2024

Pollen–food allergy syndrome (PFAS), also known as oral allergy syndrome, is a common condition affecting individuals sensitized to pollens such as birch, ragweed, and grass. This syndrome arises from immunological cross-reactivity between poll...

(This article belongs to the Special Issue New Diagnostic and Therapeutic Approaches in Food Allergy)
  • Review
  • Open Access
984 Views
19 Pages

Pollen-Food Allergy Syndrome in Children: Global Prevalence and Pathogenesis

  • Aleksandra Marzec,
  • Dominika Mysiorska,
  • Julia Młyńska,
  • Anna Nowak-Wegrzyn,
  • Urszula Jedynak-Wąsowicz and
  • Elżbieta Jarocka-Cyrta

9 July 2026

Pollen–food allergy syndrome is an IgE-mediated allergic condition resulting from cross-reactivity between pollen allergens and homologous proteins present in plant-derived foods. PFAS typically presents with rapid-onset itching, burning, swell...

(This article belongs to the Special Issue Allergy in Pediatrics: Nutritional Prevention and Intervention)
  • Review
  • Open Access
75 Citations
11,259 Views
11 Pages

Pollen-Food Allergy Syndrome: A not so Rare Disease in Childhood

  • Carla Mastrorilli,
  • Fabio Cardinale,
  • Arianna Giannetti and
  • Carlo Caffarelli

26 September 2019

Seasonal allergic rhinoconjunctivitis (SAR) affects millions of people worldwide, particularly in childhood and adolescence. Pollen food allergy syndrome (PFAS) is a common adverse reaction occurring few minutes after the consumption of vegetable foo...

(This article belongs to the Special Issue Food Allergies)
  • Case Report
  • Open Access
3 Citations
5,849 Views
7 Pages

Carrot-Induced Systemic Reaction: A Unique Presentation of Pollen-Food Allergy Syndrome in a Young Boy

  • Weronika M. Balas,
  • Joanna Strzelecka,
  • Aleksandra Godyńska and
  • Adam J. Sybilski

15 November 2023

Pollen-food allergy syndrome (PFAS) is a common IgE-mediated allergic condition resulting from cross-reactions between pollen and plant food allergens, primarily those in the PR-10 subfamily. Mostly symptoms are limited to the mouth and throat causin...

(This article belongs to the Section Pediatric Allergy and Immunology)
  • Review
  • Open Access
3 Citations
6,138 Views
17 Pages

Pollen Food Allergy Syndrome in Southern European Adults: Patterns and Insights

  • Christina Rousou,
  • Egor Kostin,
  • Eleni Christodoulou,
  • Theodoros Theodorou,
  • Zenon Pavlou and
  • Constantinos Pitsios

3 April 2025

Oral Allergy Syndrome (OAS) is an allergic reaction that occurs upon contact of the mouth and throat with food, leading to symptoms primarily affecting the oral mucosa. In patients with allergic rhinitis, OAS may develop due to cross-reactivity betwe...

(This article belongs to the Special Issue New Diagnostic and Therapeutic Approaches in Food Allergy)
  • Article
  • Open Access
20 Citations
4,413 Views
10 Pages

Pollen Food Allergy Syndrome in Allergic March

  • Hiroki Yasudo,
  • Kiwako Yamamoto-Hanada,
  • Limin Yang,
  • Mayako Saito-Abe,
  • Miori Sato,
  • Yumiko Miyaji,
  • Mami Shimada,
  • Seiko Hirai,
  • Kenji Toyokuni and
  • Yukihiro Ohya
  • + 4 authors

27 June 2022

The association between pollen food allergy syndrome (PFAS) and allergic march remains unclear. In this prospective cohort study of the general population in Tokyo (T-Child Study), we found that sensitization to Cry j 1 and Fel d 1 at ages 5 and 9 ye...

(This article belongs to the Section Nutritional Immunology)
  • Article
  • Open Access
3 Citations
4,291 Views
15 Pages

Pollen-Food Allergy Syndrome: From Food Avoidance to Deciphering the Potential Cross-Reactivity between Pru p 3 and Ole e 7

  • Paula Álvarez,
  • Rocío Aguado,
  • Juan Molina,
  • Antonio Trujillo-Aguilera,
  • Mayte Villalba,
  • Araceli Díaz-Perales,
  • Carmen Oeo-Santos,
  • Eduardo Chicano,
  • Nadine Blanco and
  • Aurora Jurado
  • + 2 authors

27 August 2024

Background: Cross-reactivity between nonspecific lipid transfer proteins could cause anaphylaxis, further influencing food avoidance and nutrient deficiencies. The one affecting olive pollen (Ole e 7) and peach (Pru p 3) may underlie a variety of pol...

(This article belongs to the Section Clinical Nutrition)
  • Article
  • Open Access
1 Citations
2,722 Views
21 Pages

Structural and Stability Analysis of GRP Family Allergens Pru p 7 and Cry j 7, Which Cause Pollen and Food Allergy Syndrome

  • Jingkang Zheng,
  • Hiroyuki Kumeta,
  • Yasuhiro Kumaki,
  • Tomona Iizuka,
  • Ichiho Yoshikawa,
  • Ami Hanaoka and
  • Tomoyasu Aizawa

6 February 2025

Cry j 7 is a 7 kDa cysteine-rich gibberellin regulatory protein (GRP) with six disulfide bonds. It was isolated from Japanese cedar as the pollen allergen in this study. It exhibits cross-reactivity with food allergens such as Pru p 7 from peach and...

(This article belongs to the Section Molecular Structure and Dynamics)
  • Article
  • Open Access
3,551 Views
7 Pages

The Role of Peamaclein (Pru p 7) in PFAS Patients: An Italian Real-Life Study

  • Marco Spalletti,
  • Valentina Lasala,
  • Paolo Cameli,
  • Laura Bergantini,
  • Marco Saletti,
  • Valerio Beltrami,
  • Elena Bargagli and
  • Miriana d’Alessandro

10 August 2023

Pollen food allergy syndrome (PFAS) is an allergic reaction to specific foods in persons previously sensitised to pollen. The diagnosis of PFAS is made after taking a patient’s medical history and, in some cases, conducting skin tests and oral...

  • Review
  • Open Access
24 Citations
7,427 Views
9 Pages

Hazelnut Allergy

  • Elisabetta Calamelli,
  • Alessia Trozzo,
  • Elisabetta Di Blasi,
  • Laura Serra and
  • Paolo Bottau

14 January 2021

Background and Objectives: Hazelnuts are frequently involved in IgE-mediated reactions and represent the main culprit of nut allergy in Europe. The clinical presentation varies from mild symptoms limited to the oropharynx [oral allergy syndrome (OAS)...

  • Review
  • Open Access
24 Citations
8,693 Views
14 Pages

Phenotypes and Endotypes of Peach Allergy: What Is New?

  • Simona Barni,
  • Davide Caimmi,
  • Fernanda Chiera,
  • Pasquale Comberiati,
  • Carla Mastrorilli,
  • Umberto Pelosi,
  • Francesco Paravati,
  • Gian Luigi Marseglia and
  • Stefania Arasi

26 February 2022

Peach allergy is emerging as a common type of fresh-fruit allergy in Europe, especially in the Mediterranean area. The clinical manifestations of peach allergy tend to have a peculiar geographical distribution and can range from mild oral symptoms to...

(This article belongs to the Special Issue Nutrition, Diet and Food Allergy)
  • Review
  • Open Access
10 Citations
6,575 Views
21 Pages

Current Insights on the Impact of Proteomics in Respiratory Allergies

  • Juan Carlos Vizuet-de-Rueda,
  • Josaphat Miguel Montero-Vargas,
  • Miguel Ángel Galván-Morales,
  • Raúl Porras-Gutiérrez-de-Velasco and
  • Luis M. Teran

Respiratory allergies affect humans worldwide, causing extensive morbidity and mortality. They include allergic rhinitis (AR), asthma, pollen food allergy syndrome (PFAS), aspirin-exacerbated respiratory disease (AERD), and nasal polyps (NPs). The st...

(This article belongs to the Section Molecular Endocrinology and Metabolism)
  • Brief Report
  • Open Access
3 Citations
2,115 Views
15 Pages

Immunoblotting Analysis of Fruit Proteins in Mexican Pediatric Patients Suggests the Existence of New Allergens

  • Angélica Torres-Arroyo,
  • Maidelen Suárez-Gutiérrez,
  • Andrea Iglesias-Amaya,
  • Aramiz López-Durán,
  • Luisa Díaz-García,
  • Horacio Reyes-Vivas and
  • David Alejandro Mendoza-Hernández

1 September 2025

Background: Food allergies are chronic diseases that compromise quality of life and can be potentially fatal due to anaphylaxis. The WHO estimates a 1–11% global prevalence, which has been increasing in recent years. They are considered, along with o...

  • Review
  • Open Access
4,846 Views
25 Pages

Shedding Light on FIRE Syndrome: An Overview of a Novel Condition in Eosinophilic Esophagitis

  • Selda Ali,
  • Maria Cătălina Cernat,
  • Mihaela Ruxandra Vintilă,
  • Elena Camelia Berghea and
  • Roxana Silvia Bumbăcea

5 June 2025

Food-Induced Immediate Response of the Esophagus (FIRE) is a newly described syndrome observed in eosinophilic esophagitis (EoE) patients. It is defined by an immediate hypersensitivity reaction of the esophagus that occurs when specific foods and be...

(This article belongs to the Special Issue New Diagnostic and Therapeutic Approaches in Food Allergy)
  • Case Report
  • Open Access
3 Citations
4,145 Views
11 Pages

Pollen Sensitization Can Increase the Allergic Reaction to Non-Cross-Reactive Allergens in a Soy-Allergic Patient

  • Daniela Briceno Noriega,
  • Huub F. J. Savelkoul,
  • Ad Jansen,
  • Malgorzata Teodorowicz and
  • Janneke Ruinemans-Koerts

During and after the pollen season, an increase in food-triggered allergic symptoms has been observed in pollen-food syndrome patients, possibly due to seasonal boosting of pollen-IgE levels. It has been suggested that consumption of birch-pollen-rel...

  • Feature Paper
  • Article
  • Open Access
6 Citations
4,182 Views
12 Pages

Birch Pollen Related Pear Allergy: A Single-Blind Oral Challenge TRIAL with 2 Pear Cultivars

  • Nicolette W. de Jong,
  • Severina Terlouw,
  • Frank E. van Boven,
  • M.S. van Maaren,
  • Marco W.J. Schreurs,
  • Dianne B.P.M. van den Berg-Somhorst,
  • Diederik Esser and
  • Shanna Bastiaan-Net

18 April 2021

Approximately 70% of birch pollen allergic patients in Europe experience hypersensitivity reactions to Immunoglobulin E (IgE) cross-reactive food sources. This so-called pollen-food syndrome (PFS) is defined by allergic symptoms elicited promptly by...

(This article belongs to the Special Issue Update on Nutrition and Food Allergy)
  • Review
  • Open Access
34 Citations
18,432 Views
21 Pages

Revisiting Fruit Allergy: Prevalence across the Globe, Diagnosis, and Current Management

  • Thanachit Krikeerati,
  • Pongsawat Rodsaward,
  • Jutamard Nawiboonwong,
  • Kanokkarn Pinyopornpanish,
  • Songwut Phusawang and
  • Mongkhon Sompornrattanaphan

10 November 2023

Fruit allergies manifest with a diverse array of clinical presentations, ranging from localized contact allergies and oral allergy syndrome to the potential for severe systemic reactions including anaphylaxis. The scope of population-level prevalence...

(This article belongs to the Special Issue Food Allergy: Mechanisms, Allergen Characterization and Management)
  • Article
  • Open Access
7 Citations
7,867 Views
10 Pages

Higher Risk for Sensitization to Commonly Consumed Herbs among Adults and Youngsters Suffering from Birch, Mugwort or Grass Pollinosis

  • Waldemar Wagner,
  • Krzysztof Buczyłko,
  • Aneta Wagner,
  • Angelika Szwed-Kowalska and
  • Anna Stasiak

Background: According to recent findings, mugwort and birch pollen-allergic patients represent a high-risk group for developing adverse allergic reactions to herbal spices due to cross-reacting allergens found in both pollen and raw herbs. Such assoc...

  • Article
  • Open Access
5 Citations
2,694 Views
16 Pages

Utilizing the Banana S-Adenosyl-L-Homocysteine Hydrolase Allergen to Identify Cross-Reactive IgE in Ryegrass-, Latex-, and Kiwifruit-Allergic Individuals

  • Tatjana Đurašinović,
  • Zorana Lopandić,
  • Isidora Protić-Rosić,
  • Tina Ravnsborg,
  • Gordan Blagojević,
  • Lidija Burazer,
  • Ole N. Jensen and
  • Marija Gavrović-Jankulović

Food allergies mediated by specific IgE (sIgE) have a significant socioeconomic impact on society. Evaluating the IgE cross-reactivity between allergens from different allergen sources can enable the better management of these potentially life-threat...

(This article belongs to the Special Issue Deciphering Allergies—Structural and Immunological Characterization of Allergenic Proteins and Immunomodulatory Agents)
  • Article
  • Open Access
2 Citations
2,876 Views
11 Pages

Sensitization to Food and Aero-Allergens in Children with Coeliac Disease Assessed with the Use of a Multiplex Molecular Diagnostic Technique

  • Izabela Knyziak-Mędrzycka,
  • Bożena Cukrowska,
  • Wojciech Nazar,
  • Joanna Beata Bierła,
  • Kamil Janeczek,
  • Paulina Krawiec,
  • Weronika Gromek,
  • Mariusz Wysokiński,
  • Ewa Konopka and
  • Emilia Majsiak
  • + 2 authors

19 May 2024

(1) Background. Coeliac disease (CD) often co-occurs with autoimmune conditions or genetic syndromes, but there are few studies on the co-existence of CD and immunoglobulin E (IgE)-mediated allergies. The purpose of this study was to assess sens...

(This article belongs to the Section Immunology & Rheumatology)
  • Article
  • Open Access
18 Citations
5,901 Views
14 Pages

Purification and Characterization of Pathogenesis Related Class 10 Panallergens

  • Jane K. McBride,
  • Hsiaopo Cheng,
  • Soheila J. Maleki and
  • Barry K. Hurlburt

22 November 2019

Oral allergy syndrome (OAS) describes an allergic reaction where an individual sensitized by pollen allergens develops symptoms after eating certain foods. OAS is caused by cross-reactivity among a class of proteins ubiquitous in plants called pathog...

  • Case Report
  • Open Access
1 Citations
6,257 Views
10 Pages

Idiopathic nephrotic syndrome (INS) is one of the chronic kidney diseases that occurs in childhood. Starting from a few case reports in the 1950s–1970s and up to the present, the relationship between idiopathic nephrotic syndrome (INS) and the...