Disease Risks and Toxic Pathway from Environmental Chemical Exposure

Abstract submission deadline

30 January 2025

Manuscript submission deadline

30 March 2025

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Topic Information

Dear Colleagues,

Human health can be influenced by many environmental factors, including physical, chemical, biological, and radiological contaminants. Among them, exposure to environmental chemicals is a serious ongoing public health issue. Understanding public health risks posed by environmental chemical exposure is complicated. There are many impact factors including population susceptibility, latencies between exposure and disease manifestations, and background environmental exposure. Relationships between environmental exposure and health outcomes can only be established through well-designed epidemiological, toxicological, and clinical studies. Therefore, along with traditional risk assessment, integrating all available types of data, such as traditional toxicology, environmental epidemiology, and the environmental exposome would approach environmental chemical risk assessment from a new lens. There is an immediate need to develop good research associated with the disease risk and toxicity posed by environmental chemical exposure. This Special Issue aims to explore the perspective of environmental chemical risk assessment. We invite researchers to contribute original research and articles as well as review articles in the scope of this Special Issue. The topics of interest include but are not limited to:

• Public health and health impact assessment and environmental epidemiology
• Environmental risk assessments and management
• Environmental toxicology
• Wastewater-based epidemiology
• Environmental technology for environmental health protection

Dr. Zhenglu Wang
Dr. Chuang Liu
Dr. Jiana Li
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Environments environments	3.7	5.9	2014	23.7 Days	CHF 1800	Submit
International Journal of Molecular Sciences ijms	5.6	7.8	2000	16.3 Days	CHF 2900	Submit
Journal of Xenobiotics jox	6.0	4.6	2011	21.7 Days	CHF 1600	Submit
Pollutants pollutants	-	-	2021	21.7 Days	CHF 1000	Submit
Toxics toxics	4.6	3.4	2013	14.7 Days	CHF 2600	Submit

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Published Papers (2 papers)

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All Environments IJMS JoX Pollutants Toxics

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9 pages, 1854 KiB  

Open AccessArticle

Aminomethylphosphonic Acid (AMPA), a Glyphosate Metabolite, Decreases Plasma Cholinesterase Activity in Rats

by Jesús Chávez-Reyes, Fernando Saráchaga-Terrazas, Oliver Alejandro Colis-Arenas, Carlos H. López-Lariz, Carlos M. Villalón and Bruno A. Marichal-Cancino

J. Xenobiot. 2024, 14(2), 604-612; https://doi.org/10.3390/jox14020035 - 7 May 2024

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Abstract

Glyphosate, a widely used herbicide, is linked to a plethora of deleterious effects in both clinical and preclinical studies. Nevertheless, the effects of its main metabolite, aminomethylphosphonic acid (AMPA), whose half-life in soil is even longer than that of glyphosate, have been little [...] Read more.

Glyphosate, a widely used herbicide, is linked to a plethora of deleterious effects in both clinical and preclinical studies. Nevertheless, the effects of its main metabolite, aminomethylphosphonic acid (AMPA), whose half-life in soil is even longer than that of glyphosate, have been little explored. On this basis, as a first approach, in this work, we report that intraperitoneal (i.p.) administration of AMPA or glyphosate (at 10, 56, and 100 mg/kg) decreased, to a similar extent, plasma cholinesterase (ChE) activity in acutely exposed rats. Moreover, we designed an experimental protocol to analyze and compare the effects of AMPA and glyphosate on human plasma ChE activity; this protocol consisted of adding these compounds to human plasma to subsequently test the effects of this plasma on the contraction to acetylcholine (ACh) in the frog rectus abdominis muscle (an indirect estimate of ChE activity). Accordingly, this muscular contraction to ACh was evaluated before and after pre-incubation of ACh with (i) plasma alone, (ii) plasma with AMPA, and (iii) plasma with glyphosate. Our results indicate that AMPA, like glyphosate, decreased ChE activity in the plasma of rats (when given i.p.) and humans (when added in vitro), suggesting that both xenobiotics may exert similar toxicological effects. Full article

(This article belongs to the Topic Disease Risks and Toxic Pathway from Environmental Chemical Exposure)

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12 pages, 297 KiB  

Open AccessArticle

Air Pollution and Primary DNA Damage among Zagreb (Croatia) Residents: A Cross-Sectional Study

by Marko Gerić, Gordana Pehnec, Katarina Matković, Jasmina Rinkovec, Ivana Jakovljević, Ranka Godec, Silva Žužul, Ivan Bešlić, Ante Cvitković, Luka Delić, Pascal Wild, Irina Guseva Canu, Nancy B. Hopf and Goran Gajski

J. Xenobiot. 2024, 14(1), 368-379; https://doi.org/10.3390/jox14010023 - 13 Mar 2024

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Abstract

More than eight million premature deaths annually can be attributed to air pollution, with 99% of the world’s population residing in areas below recommended air quality standards. Hence, the present study aimed to examine the association between primary DNA damage and air pollution [...] Read more.

More than eight million premature deaths annually can be attributed to air pollution, with 99% of the world’s population residing in areas below recommended air quality standards. Hence, the present study aimed to examine the association between primary DNA damage and air pollution data among 123 participants enrolled between 2011 and 2015 in Zagreb, Croatia. While most measured air pollutants adhered to regulatory limits, benzo[a]pyrene concentrations bound to PM₁₀ exceeded them. Factorial analysis narrowed down air pollution data to four exposure factors (particulate matter, two metal factors, and other pollutants). Despite the absence of significant positive associations between modeled air pollution exposure factors and comet assay descriptors (tail length, tail intensity, tail moment, and highly damaged nuclei), the critical health implications of air pollution warrant further investigations, particularly with biomarkers of exposure and different biomarkers of effect in populations facing air pollution exposure. Full article

(This article belongs to the Topic Disease Risks and Toxic Pathway from Environmental Chemical Exposure)

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