Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Pathogenesis and Genetic Adaptation of Bacterial Pathogens
edited by
submission deadline 31 Oct 2026 | Viewed by 141 | Submission Open
Keywords: host– pathogen interactions; virulence; proteins; enzymes; toxins; nucleic acids; metabolites; antibiotic resistance; biomolecules
(This special issue belongs to the Section Molecular Biology)
Properties and Functions of Endometrial Stromal Cells—2nd Edition submission deadline 31 Oct 2026 | Viewed by 132 | Submission Open
Keywords: endometrium; endometriosis; molecular reproduction; implantation; decidualization; placentation; inflammation; reproductive endocrinology; assisted reproductive technology; molecular reproductive biology
(This special issue belongs to the Section Molecular Reproduction)
High-Field MRI-Guided Boron Neutron Capture Therapy (BNCT): Targeted Delivery and Efficacy Monitoring in Glioma
edited by and Paola Porcari
submission deadline 31 Oct 2026 | Viewed by 127 | Submission Open
Keywords: boron neutron capture therapy (BNCT); accelerator-based neutron sources; glioma MRI; 19F MRI and MRS; boronophenylalanine (BPA); fluorinated boron agents; glioblastoma; quantitative treatment monitoring; precision radiotherapy; tanslational neuro-oncology
(This special issue belongs to the Section Chemical Biology)
Microtubule-Based Motor Proteins in Health and Disease: Mechanisms, Regulation and Cellular Functions
edited by Weihong Qiu
submission deadline 31 Oct 2026 | Viewed by 114 | Submission Open
Keywords: motor proteins; kinesins; dyneins; microtubule
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Advances in Porphyria and Liver Disease Research
edited by Andrew G. Smith
submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open
Keywords: porphyria; liver disease; heme; mechanisms; susceptibilities
(This special issue belongs to the Section Molecular Medicine)
Advances in the Molecular Mechanisms of Inflammatory Arthritis and Inflammation-Related Bone Changes: 2nd Edition
edited by
submission deadline 1 Nov 2026 | 1 articles | Viewed by 1084 | Submission Open
Keywords: inflammatory arthritis; molecular mechanisms; bone changes; osteoimmunology; autoimmunity
(This special issue belongs to the Section Molecular Medicine)
Synthetic Chemistry in Drug Discovery: Novel Compounds for Antimicrobial and Antioxidant Applications submission deadline 7 Nov 2026 | 3 articles | Viewed by 5334 | Submission Open
Keywords: synthetic chemistry; drug discovery; essential oils; antimicrobial activity; antiproliferative agents; antioxidant properties; bioactive molecules; structure– activity relationship; natural product derivatives; medicinal chemistry; chemical synthesis; pharmacological evaluation
(This special issue belongs to the Section Chemical Biology)
Research Progress on Anti-Aging with Natural Products
edited by
submission deadline 10 Nov 2026 | 2 articles | Viewed by 5871 | Submission Open
Keywords: natural products; anti-aging signaling; autophagy; antioxidants; skin aging; bioactive compounds; molecular mechanisms; translational applications
(This special issue belongs to the Section Biological Factors)
The Mechanisms of Nervous System Injury
edited by and Antal Nógrádi
submission deadline 10 Nov 2026 | Viewed by 78 | Submission Open
Keywords: nervous system injury; neuroprotection; stem cell secretome; inflammasome; extracellular vesicles; neuroinflammation; regenerative medicine; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
The Kynurenine Pathway in Mood Disorders: From Mechanisms to Therapeutics
edited by Gregory F. Oxenkrug
submission deadline 17 Nov 2026 | 1 articles | Viewed by 984 | Submission Open
Keywords: kynurenine; tryptophan; mood disorders; stress; inflammation
(This special issue belongs to the Section Biological Factors)
Advances in the Structure and Function of Microtubule-Associated Motor Proteins
edited by Arne Gennerich
submission deadline 20 Nov 2026 | 4 articles | Viewed by 6128 | Submission Open
Keywords: microtubules; kinesin; dynein; CryoEM; post-translational modifications
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Advances in S-Triazine-Based Therapeutics: From Antimicrobials to Neurodegenerative Disease Modulators
edited by
submission deadline 20 Nov 2026 | 1 articles | Viewed by 2233 | Submission Open
Keywords: 1; 3; 5-triazine; s-triazine; biological activity; drug discovery; antibacterial agent; antifungal agent; anticancer activity; antiviral agents; antimalarial activity; anti-Alzheimer’ s activity; anti-Alzheimer’ s agents; cholinesterase inhibitors; BACE1 inhibitors; anti-neurodegenerative effects; anti-inflammatory activity; molecular mechanisms of s-triazine activity
(This special issue belongs to the Section Chemical Biology)
Molecular Signaling Pathways in Tumorigenesis and Tumor Suppression, 2nd Edition
edited by
submission deadline 20 Nov 2026 | Viewed by 103 | Submission Open
Keywords: cancer cell biology; RB; E2F; ARF; p53
(This special issue belongs to the Section Molecular Biology)
Translational Insights from Insect Immunity: Antimicrobial Strategies and Infection Models submission deadline 20 Nov 2026 | Viewed by 102 | Submission Open
Keywords: insect immunity; antimicrobial peptides; host-pathogen interaction; innate immune response; infection models
(This special issue belongs to the Section Molecular Medicine)
Tumor Biomarkers and Precision Therapy: Epigenetic, Immune, and Proteomic Strategies submission deadline 25 Nov 2026 | 1 articles | Viewed by 1320 | Submission Open
Keywords: tumors; biomarkers; epigenetics; immune targets; proteomics; mass-spectrometry based proteomics; targeted therapy
(This special issue belongs to the Section Molecular Biomarkers)
Molecular and Cellular Mechanisms of Therapy Resistance in Acute Myeloid Leukemia
edited by
submission deadline 25 Nov 2026 | Viewed by 246 | Submission Open
Keywords: acute myeloid leukemia; molecular mechanism; cellular mechanism; therapy resistance; microenvironment; immunotherapy
(This special issue belongs to the Section Cellular Biochemistry)
Metabolic Pathways, COVID-19 and Other Viral Acute Respiratory Infections: Mechanisms and Clinical Implications: 2nd Edition
edited by and
submission deadline 30 Nov 2026 | 3 articles | Viewed by 10898 | Submission Open
Keywords: COVID-19; respiratory syncytial virus; influenza; SARS-CoV-2; viral acute respiratory infections; metabolic pathways; herpes virus
(This special issue belongs to the Section Molecular Medicine)
Advances and Novel Strategies for Studying Post-Translational Modifications (PTMs)
edited by
submission deadline 30 Nov 2026 | 3 articles | Viewed by 10033 | Submission Open
Keywords: post-translational modifications proteomics; chemical biology; cell signaling; epigenetics; metabolic regulation; cancer; diabetes; microbiome; aging
(This special issue belongs to the Section Molecular Biology)
New Insight into the Structures and Host Cell Interactions of Emerging Viruses
edited by and
submission deadline 30 Nov 2026 | 3 articles | Viewed by 3867 | Submission Open
Keywords: emerging viruses; virus structure; structural biology; Cryo-EM/Cryo-ET/CLEM; virus– host interactions; viral receptor binding and entry; viral assembly; maturation; and egress; immune evasion; molecular dynamics simulation; antiviral targets
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Impact of Systemic Inflammation on Neuroinflammation, Neurodegenerative Diseases and Mental Disorders submission deadline 30 Nov 2026 | 1 articles | Viewed by 3771 | Submission Open
Keywords: systemic inflammation; neuroinflammation diseases; neurodegenerative diseases; mental disorders
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Signaling Pathways in Autoimmune Diseases
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3538 | Submission Open
Keywords: autoimmune diseases; molecular mechanisms; signaling pathways; therapeutic targets; biomarkers
(This special issue belongs to the Section Molecular Biology)
Novel Insights and Applications of Pluripotent Stem Cells
edited by and Ben Rollo
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2812 | Submission Open
Keywords: pluripotent stem cells; pluripotency; differentiation; stem cell transplant; regenerative medicine; disease modeling; organoids; therapeutic screening; cell therapies; drug discovery
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Mechanisms and Therapeutic Potential of Extracellular Vesicles in Neurovascular Diseases
edited by
submission deadline 30 Nov 2026 | 3 articles | Viewed by 2731 | Submission Open
Keywords: extracellular vesicles; neurovascular diseases; cellular communications; biomarkers; therapeutic targets
(This special issue belongs to the Section Cellular Biochemistry)
Glycomics in Health, Aging and Disease
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1762 | Submission Open
Keywords: glycome; glycobiology; glycochemistry; glycans; glycoconjugates
(This special issue belongs to the Section Cellular Biochemistry)
Exploring Physical Mechanisms in Inflammation Regulation submission deadline 30 Nov 2026 | 1 articles | Viewed by 1222 | Submission Open
Keywords: physical stimuli; transduction; magnetic field; electric field; magnetotherapy; laser therapy
(This special issue belongs to the Section Biological Factors)
Advances in Molecular Mechanisms and Predictive Biomarkers in Cancer Immunotherapy
edited by Fabrizio Nelli, and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 575 | Submission Open
Keywords: immune checkpoint inhibitors; solid tumors; predictive biomarkers; resistance mechanisms; PD-1/PD-L1 pathway; efficacy; response; immune-related adverse events; real-world evidence
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Determinants of Helicobacter pylori Pathogenicity and Antibiotic Resistance
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 545 | Submission Open
Keywords: Helicobacter pylori; pathogenicity; antibiotic resistance; virulence factors; host– pathogen interaction; gastric cancer; genomics; transcriptomics; proteomics; metabolomics
(This special issue belongs to the Section Molecular Medicine)
Key Mechanisms in the Pathogenesis of ALS submission deadline 30 Nov 2026 | Viewed by 464 | Submission Open
Keywords: amyotrophic lateral sclerosis; motor neuron disease; neurodegeneration; pathogenesis; protein aggregation; non-coding RNA; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Molecular Chaperones in Neurodegenerative Diseases: Mechanistic Role and Therapeutic Potential
edited by Umesh Kumar Jinwal
submission deadline 30 Nov 2026 | Viewed by 343 | Submission Open
Keywords: molecular chaperones; neurodegenerative diseases; Hsp90; Hsp70; Alzheimer's Disease; Parkinson’ s Disease; Huntington's disease; amyotrophic lateral sclerosis
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Immune Microenvironment in Cancer: Myeloid Cells and Therapeutic Insights submission deadline 30 Nov 2026 | Viewed by 275 | Submission Open
Keywords: cancer; immunotherapy; myeloid cells; macrophages; neutrophils; tumor microenvironment; therapy resistance
(This special issue belongs to the Section Molecular Medicine)
Citrin Deficiency: Molecular Pathogenesis and Novel Targets for Therapy
edited by
submission deadline 30 Nov 2026 | Viewed by 245 | Submission Open
Keywords: citrin deficiency; pathogenesis; therapeutic procedures
(This special issue belongs to the Section Molecular Medicine)
Structural and Functional Insights into Metalloantibiotics
edited by
submission deadline 30 Nov 2026 | Viewed by 228 | Submission Open
Keywords: metal ion; biomolecules; enzyme; antimicrobial resistance
(This special issue belongs to the Section Enzymology)
Molecular Pathogenesis and Emerging Therapeutic Targets and Strategies in Huntington’s Disease
edited by and
submission deadline 30 Nov 2026 | Viewed by 208 | Submission Open
Keywords: Huntington’ s disease; huntingtin; polyglutamine; neurodegeneration; pathogenesis; therapeutic targets; proteopathy; autophagy dysfunction; transcriptional dysregulation; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Medicine)
Gut Microbiome and Related Diseases in Animals submission deadline 30 Nov 2026 | Viewed by 198 | Submission Open
Keywords: intestinal microbiota; dysbiosis; prebiotic; probiotic; postbiotic; nutraceutical; companion animals
(This special issue belongs to the Section Biological Factors)
Extracellular Vesicles as Biomarkers of Diseases: 2nd Edition submission deadline 30 Nov 2026 | Viewed by 196 | Submission Open
Keywords: extracellular vesicles; metabolic syndrome; cancer; cardiovascular diseases; neurodegenerative diseases; biomarkers
(This special issue belongs to the Section Molecular Biomarkers)
Natural and Synthetic Bioactive Compounds: Efficacy and Safety in Chemoprevention
edited by
submission deadline 30 Nov 2026 | Viewed by 189 | Submission Open
Keywords: chemoprevention; bioactive compound; natural products
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular and Genetic Basis of Hormonal Signaling and Inter-Organ Crosstalk in Steatotic Liver Disease
edited by Karuna Rasineni and Sundararajan Mahalingam
submission deadline 30 Nov 2026 | Viewed by 185 | Submission Open
Keywords: metabolic liver disease; organ crosstalk; hormones; gut– liver axis; adipose– liver axis; neuroendocrine control of liver function
(This special issue belongs to the Section Molecular Medicine)
Molecular Insight into Embryogenesis and Organogenesis
edited by
submission deadline 30 Nov 2026 | Viewed by 183 | Submission Open
Keywords: morphogenesis; progenitor; differentiation; gastrulation
(This special issue belongs to the Section Molecular Biology)
Regulation of Bacterial Stress Responses by Sigma Factors: From Transcriptional Control to Metabolic and Physiological Adaptation
edited by Agnese Serafini
submission deadline 30 Nov 2026 | Viewed by 171 | Submission Open
Keywords: sigma factors; environmental stress; bacterial physiology; metabolism
Cannabinoids in Neurobehavioral Modulation: 2nd Edition submission deadline 30 Nov 2026 | Viewed by 156 | Submission Open
Keywords: cannabinoids; neurobehavior; brain diseases; therapeutic; translational
(This special issue belongs to the Section Molecular Biology)
Infection in CNS Disease: Neuroinflammation and Brain–Retina Pathology submission deadline 30 Nov 2026 | Viewed by 151 | Submission Open
Keywords: pathogens; retinal infection; neurodegeneration; pathogen– host interactions
(This special issue belongs to the Section Molecular Medicine)
Natural Product-Inspired Synthesis for Neurological and Oncological Therapeutics submission deadline 30 Nov 2026 | Viewed by 151 | Submission Open
Keywords: natural product derivatives; total synthesis; neurotherapeutics; targeted cancer therapy; medicinal chemistry; bioactive scaffolds; drug design
(This special issue belongs to the Section Molecular Medicine)
Molecular Pathogenesis and Immune Evasion in Chronic Lymphocytic Leukemia (CLL)
edited by
submission deadline 30 Nov 2026 | Viewed by 144 | Submission Open
Keywords: chronic lymphocytic leukemia; molecular pathogenesis; immune evasion; tumor microenvironment; b-cell receptor signaling; genomic and epigenomic alterations; therapy resistance; immunotherapy; precision medicine
(This special issue belongs to the Section Molecular Medicine)
Molecular Insights into Myelin Dynamics: From Demyelination to Remyelination in Central Nervous System Diseases
edited by
submission deadline 30 Nov 2026 | Viewed by 140 | Submission Open
Keywords: demyelination; remyelination; axoglial interactions; myelin plasticity; myelin and aging; myelin and autophagy; activity-dependent myelination; remodeling myelin (mechanisms); myelin and neurodegenerative diseases; multiple sclerosis
(This special issue belongs to the Section Cellular Biochemistry)
Novel Molecules for Cancer Treatment (4th Edition) submission deadline 30 Nov 2026 | Viewed by 138 | Submission Open
Keywords: small-molecule inhibitors; antibody-drug-conjugated (ADC); tyrosine kinase inhibitors; target therapy; monoclonal antibodies; immune checkpoint inhibitors; natural compounds; CAR-T therapy; peptide-based therapeutics; drug delivery systems; drug repurposing; phytochemicals; marine-derived compounds; secondary metabolites; synthetic compounds; bioactive molecules
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Metabolic Plasticity and Epigenetic Rewiring in Solid Tumors
edited by Fabiana Crispo and
submission deadline 30 Nov 2026 | Viewed by 115 | Submission Open
Keywords: metabolomic reprogramming; epigenetic rewiring; tumor microenvironment; phenotypic plasticity; solid tumors; tumor adaptative strategies; therapeutic co-targeting
(This special issue belongs to the Section Molecular Medicine)
Immunoregulatory Mechanisms of γδ T Cells and Their Associations with Cancer/Autoimmune Diseases
edited by
submission deadline 30 Nov 2026 | Viewed by 113 | Submission Open
Keywords: γ δ ; T cells; cancer; autoimmunity
(This special issue belongs to the Section Chemical Biology)
Molecular Electronics: Insights and Challenges
edited by
submission deadline 30 Nov 2026 | Viewed by 107 | Submission Open
Keywords: single-molecule electronics; molecular electronics; single-molecule conductance; charge transport in molecules; nanoscale transport mechanisms; quantum transport in molecular junctions; coherence and dephasing; hopping transport; electron– phonon interactions; ion and proton-coupled transport; electrode– molecule interfaces; charge injection barriers; molecular junctions; scanning probe measurements (STM; cAFM); molecular sensing; label-free detection; molecular-scale devices; molecular assemblies; organic and polymer electronics; biomolecular electronics; protein electronics; DNA electronics; electron transport in DNA; hybrid bioelectronic systems; molecular device integration
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Structure-Based Mechanisms of Protein Functions
edited by Vasiliki Fadouloglou
submission deadline 30 Nov 2026 | Viewed by 100 | Submission Open
Keywords: pseudoenzymes; moonlighting proteins; metamorphic proteins; intrinsically disordered proteins
(This special issue belongs to the Section Molecular Biology)
Molecular Therapies and Metabolic Mechanisms in Genetic Disorders
edited by Estera Rintz
submission deadline 30 Nov 2026 | Viewed by 96 | Submission Open
Keywords: genetic disorders; molecular therapies; gene therapy; genome editing; RNA therapeutics; metabolic mechanisms; metabolic dysregulation; inherited diseases; mitochondrial dysfunction; precision medicine; multi-omics; biomarker discovery; translational research
(This special issue belongs to the Section Molecular Genetics)
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