Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Human Skin Aging
edited by
submission deadline 15 Jan 2025 | 2 articles | Viewed by 2379 | Submission Open
Keywords: skin aging; UV; extracellular matrix; fibroblast; prevention
Cellular and Molecular Biology of Neurodevelopment
edited by
submission deadline 15 Jan 2025 | Viewed by 29 | Submission Open
Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders
Physiological and Pathological Functions of Crystallins
edited by and John Clark
submission deadline 20 Jan 2025 | 1 articles | Viewed by 1756 | Submission Open
Keywords: crystallin; small heat shock protein chaperone; transparency; phase separation; aging; age related disease; cataract; cancer; schizophrenia; fertility
(This special issue belongs to the Section Biomacromolecules: Proteins)
Immune Responses in Type 1 Diabetes
edited by and Sally C. Kent
submission deadline 20 Jan 2025 | Viewed by 301 | Submission Open
Keywords: type 1 diabetes; insulitis; immune response
(This special issue belongs to the Section Molecular Biology)
Structural Proteomics–Structural Biology Led by Advancements in Mass Spectrometry Techniques
edited by , Corie Ralston and
submission deadline 20 Jan 2025 | Viewed by 67 | Submission Open
Keywords: hydroxyl radical protein footprinting MS (XFP; FPOP); hydrogen/deuterium exchange MS (HDX-MS); cross-linking MS (XL-MS); covalent labeling MS; top-down MS; native MS
(This special issue belongs to the Section Biomacromolecules: Proteins)
More than Just Adhesion: Recognition Molecules, a Theme Issue Honoring Professor Melitta Schachner
edited by
submission deadline 25 Jan 2025 | 1 articles | Viewed by 2363 | Submission Open
Keywords: cell adhesion molecules; extracellular matrix; glycans; nervous system regeneration; nervous system development
(This special issue belongs to the Section Biological Factors)
Biogenic Amines, Their Receptors and Transporters in Health and Disease: Commemorative Issue in Honor of Professor Marc G. Caron (1946–2022)
edited by , , Jean Martin Beaulieu and Stephen S.G. Ferguson
submission deadline 31 Jan 2025 | 14 articles | Viewed by 30965 | Submission Open
Keywords: dopamine; serotonin; norepinephrine; epinephrine; histamine; trace amines; beta-phenylethylamine; GPCR; TAAR
(This special issue belongs to the Section Biological Factors)
Novel Materials for Biomedical Applications II submission deadline 31 Jan 2025 | 6 articles | Viewed by 12478 | Submission Open
Keywords: micro-/nanocarriers; synthesis or conjugation of biomaterials; drug delivery; targeted therapy/immunotherapy for combinatorial treatment; regenerative medicine/tissue engineering
(This special issue belongs to the Section Biological and Bio- Materials)
Recent Advances in Neurological Diseases
edited by Sara Carpi, and
submission deadline 31 Jan 2025 | 4 articles | Viewed by 6516 | Submission Open
Keywords: neurological disorders; neurodegeneration; neuroinflammation; myelin damage; developmental disorders; epilepsy; neurodegenerative rare diseases; neuromuscular diseases; lipid storage diseases; psychiatric diseases
(This special issue belongs to the Section Molecular Medicine)
Hyaluronic Acid and Proteoglycans: Basic and Biomedical Applications
edited by
submission deadline 31 Jan 2025 | 3 articles | Viewed by 4731 | Submission Open
Keywords: hyaluronic acid; proteoglycans; GAGs; extracellular matrix; hyaluronic acid and proteoglycans in disease; cancer; inflammation; angiogenesis; vascular homeostasis and damage; arthritis and arthrosis; glycobiology
(This special issue belongs to the Section Biomacromolecules: Carbohydrates)
The Structure and Function of Proteins, Lipids and Nucleic Acids
edited by
submission deadline 31 Jan 2025 | 3 articles | Viewed by 4145 | Submission Open
(This special issue belongs to the Section Molecular Structure and Dynamics)
Prostate Cancer Biomarkers and Therapeutics
edited by Kamlesh Kumar Yadav
submission deadline 31 Jan 2025 | 2 articles | Viewed by 3576 | Submission Open
Keywords: prostate cancer; biomarkers; therapeutics; chemotherapy; immunotherapy; radiation therapy; machine learning
(This special issue belongs to the Section Molecular Biomarkers)
Selected Papers from the 3rd International Electronic Conference on Biomolecules submission deadline 31 Jan 2025 | Viewed by 1006 | Submission Open
The Role of CD36 in Human Health and Disease
edited by and Mihail E. Hinescu
submission deadline 31 Jan 2025 | 1 articles | Viewed by 786 | Submission Open
Keywords: CD36; lipid scavenger; cell-to-matrix adhesion; metastasis; neoangiogenesis; biomarker
(This special issue belongs to the Section Molecular Medicine)
The Role of Glia in Alzheimer's Disease
edited by
submission deadline 31 Jan 2025 | 1 articles | Viewed by 625 | Submission Open
Keywords: Alzheimer's disease; neurodegeneration; glial cells
(This special issue belongs to the Section Molecular Medicine)
Therapeutic Potential of Natural Products in Metabolic Diseases submission deadline 31 Jan 2025 | Viewed by 265 | Submission Open
Keywords: natural products; metabolic disorders; diabetes mellitus; dietary constituents; phytotherapy; integrative medicine; obesity; dyslipidemia; non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatohepatitis (MASH); nutraceuticals; supplements
New Insights into RNA-Binding Proteins
edited by
submission deadline 31 Jan 2025 | Viewed by 181 | Submission Open
Keywords: RNA-binding protein; RBP; RNA; riboregulation; RNA interactome; protein– RNA interaction; protein– RNA complex; ribonucleoprotein
(This special issue belongs to the Section Biomacromolecules: Proteins)
Heterocyclic Compounds as Novel Anti-cancer Agents and Their Mechanisms of Action
edited by Chandra Mishra and
submission deadline 31 Jan 2025 | Viewed by 166 | Submission Open
Keywords: heterocyclic compounds; anticancer; synthetic; natural
Mitochondria and Central Nervous System Disorders: 3rd Edition submission deadline 31 Jan 2025 | Viewed by 105 | Submission Open
Keywords: mitochondria; metabolism; neurodegeneration; neuroinflammation; ageing; central nervous system
Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition
edited by , and Haiting Chai
submission deadline 31 Jan 2025 | Viewed by 45 | Submission Open
Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics
The Role of Nanoparticles in Tumor Treatment
edited by
submission deadline 31 Jan 2025 | Viewed by 37 | Submission Open
Keywords: nanoparticles; cancer therapy; nanotechnology
New Advances of Cannabinoid Receptors in Health and Disease: 2nd Edition submission deadline 15 Feb 2025 | Viewed by 31 | Submission Open
Keywords: neurodegeneration; alcohol; addiction; signaling; structure– function
Exploring Novel Molecular Pathways and Emerging Treatments for Myotonic Dystrophy submission deadline 15 Feb 2025 | Viewed by 20 | Submission Open
Keywords: gene therapy; repurposing; therapeutic oligonucleotides; personalized medicine; biomarkers
The Role of Vascular Dysfunction in Neuronal Degeneration and Cognitive Impairment (2nd Edition)
edited by
submission deadline 28 Feb 2025 | 3 articles | Viewed by 3060 | Submission Open
Keywords: blood cells; plasma components; vascular wall components; neurovascular unit; neuroinflammation; cognitive decline
(This special issue belongs to the Section Molecular Biology)
New Insights into Mesothelioma Immunotherapy
edited by
submission deadline 28 Feb 2025 | 1 articles | Viewed by 2247 | Submission Open
Keywords: mesothelioma/malignant pleural mesothelioma (MPM)/peritoneal mesothelioma; immunotherapy; immunology; immune profiling; immune response; immunosuppression; immune checkpoint/inhibitor; immune score; tumor immune microenvironment; epithelial-mesenchymal transition (EMT) gene signature
(This special issue belongs to the Section Cellular Biochemistry)
Chemoinformatics and Molecular Modeling of Pharmacologically Active Biomolecules: A Themed Issue in Honor of Prof. José L. Medina-Franco
edited by Carlos A. Velázquez-Martínez and
submission deadline 28 Feb 2025 | 1 articles | Viewed by 2139 | Submission Open
Keywords: drug design; molecular modelling; chemoinformatics; materials science; big data; machine learning; predictive modeling; toxicology
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Amyloid-Beta and Alzheimer’s Disease submission deadline 28 Feb 2025 | 2 articles | Viewed by 2131 | Submission Open
Keywords: Alzheimer's disease (AD); amyloid-beta (Aβ ); neurotoxicity of Aβ ; Tau protein; Aβ phagocytosis; Aβ clearance; autophagy– lysosome system; anti-Aβ monoclonal antibodies; neuroinflammation in AD; glial cells in AD
(This special issue belongs to the Section Cellular Biochemistry)
Diet and Immune Response
edited by
submission deadline 28 Feb 2025 | 1 articles | Viewed by 1651 | Submission Open
(This special issue belongs to the Section Molecular Medicine)
The Role of Amyloid in Neurological Disorders
edited by and Tamara Berno
submission deadline 28 Feb 2025 | 1 articles | Viewed by 1581 | Submission Open
Keywords: amyloid-beta; neurodegenerative disorders; aducanumab; oligomers; cross-amyloid intraction
(This special issue belongs to the Section Biomacromolecules: Proteins)
Role of TRAF1 in Regulating Inflammation and Cell Survival
edited by Ali Abdul-Sater
submission deadline 28 Feb 2025 | 2 articles | Viewed by 1410 | Submission Open
Keywords: TRAF1; inflammation; inflammasome; TNFRs; apoptosis; cellular survival
(This special issue belongs to the Section Biological Factors)
State of the Art and Perspectives in Retinal Pigment Epithelium submission deadline 28 Feb 2025 | Viewed by 158 | Submission Open
Keywords: retinal pigment epithelium; innovative treatments/therapeutic approaches; retinal diseases; bioactive molecules; eye delivery strategy
(This special issue belongs to the Section Cellular Biochemistry)
Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials
edited by and Rachael Dickman
submission deadline 28 Feb 2025 | Viewed by 113 | Submission Open
Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular and Genetic Basis of Neurodegenerative Diseases
edited by Teresa M. Gunn and Andrea Grindeland
submission deadline 28 Feb 2025 | Viewed by 72 | Submission Open
Keywords: neurodegeneration; neurodegenerative diseases; protein misfolding; protein trafficking; mitochondrial dysfunction; oxidative stress; neuronal homeostasis; neuroinflammation
Advances in Purinergic Signaling Research: From Molecular Biology to Human Diseases
edited by Ricardo Rodrigues
submission deadline 28 Feb 2025 | Viewed by 65 | Submission Open
Keywords: ATP; adenosine; P1 receptors; P2 receptors; P2X receptors; P2Y receptors; ecto-nucleotidases
(This special issue belongs to the Section Molecular Biology)
Application of Bioinformatics in Medicine
edited by
submission deadline 28 Feb 2025 | Viewed by 39 | Submission Open
Keywords: computer-aided drug design (CADD); bioinformatics; systems medicine; drug discovery; computational biology
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Biochemistry of Wine and Beer, 3rd Edition submission deadline 28 Feb 2025 | Viewed by 37 | Submission Open
Keywords: grape biochemistry; barley and malt biochemistry; role of prefermentative enzymatic reactions; wine and beer’ s fermentation process; aging reactions; phenolic compounds; aroma compounds; protein and nitrogen compounds
(This special issue belongs to the Section Biological Factors)
The Role of Astrocytes in Neurodegenerative Diseases
edited by
submission deadline 28 Feb 2025 | Viewed by 33 | Submission Open
Keywords: astrocytes; neurodegeneration; neuroinflammation; neuroprotection; neuroregeneration
(This special issue belongs to the Section Cellular Biochemistry)
Molecular and Cellular Mechanisms in Anti-thrombosis submission deadline 28 Feb 2025 | Viewed by 32 | Submission Open
Keywords: platelet activation and thrombosis; neuroprotection; antithrombotic mechanisms
(This special issue belongs to the Section Molecular Medicine)
Recent Developments in the Biology of Extracellular or Cell-Free DNA, 2nd Edition
edited by
submission deadline 28 Feb 2025 | Viewed by 30 | Submission Open
Keywords: neutrophil extracellular traps; DNase; toll-like receptor 9; exosomes; autoimmunity
Nerve Conduction Inhibition to Alleviate Disease Symptoms: Clinical Drugs and Medicinal Plant Compounds
edited by
submission deadline 28 Feb 2025 | Viewed by 25 | Submission Open
Keywords: nerve conduction; action potential; clinical drug; medicinal plant compound; voltage-gated ion channel
Inflammation—The Surprising Bridge between Diseases submission deadline 28 Feb 2025 | Viewed by 23 | Submission Open
Keywords: low-grade inflammation; lung inflammation; atherosclerosis; ischemic heart disease; peripheral artery disease; inflammatory bowel disease; fatty liver disease; inflammatory rheumatic diseases; cancer
Glutamate and Glutamate Receptors in Health and Diseases, Second Edition submission deadline 28 Feb 2025 | Viewed by 12 | Submission Open
Keywords: glutamate receptors; addiction; pain; learning and memory; anxiety; depression; autism; neurodegeneration
Molecular Mechanisms of Drug Resistance in Breast Cancer
edited by
submission deadline 1 Mar 2025 | Viewed by 205 | Submission Open
Keywords: breast cancer; mechanism of resistance; targeted therapy resistance; ER+; HER2; TNBC; tumor microenvironment; recurrence; metastasis; tumor evasion
(This special issue belongs to the Section Molecular Medicine)
Protein Aggregation—Accident, Threat or Organized Assembly?
edited by
submission deadline 15 Mar 2025 | Viewed by 238 | Submission Open
Keywords: protein aggregation; protein misfolding; amyloids; inclusion bodies; phase separation
(This special issue belongs to the Section Biomacromolecules: Proteins)
Oxidative Stress and Inflammation in Aging and Cancer: Biological Bases, Therapeutic Strategies and Opportunities
edited by
submission deadline 15 Mar 2025 | Viewed by 88 | Submission Open
Keywords: ROS; inflammatory compounds; oxidative stress; chronic inflammation; aging; cancer; immunomodulation; antioxidant strategies; exercise; nutrition
Molecular Mechanisms and Therapeutic Targets in Leukaemia
edited by and
submission deadline 28 Mar 2025 | Viewed by 21 | Submission Open
Keywords: leukaemia; blood; genetics; genomics; chromosome
(This special issue belongs to the Section Molecular Medicine)
Lipids Metabolism in Cardiovascular Disease
edited by Anand K. Rohatgi
submission deadline 31 Mar 2025 | 1 articles | Viewed by 834 | Submission Open
Keywords: lipid; lipoprotein; vascular disease; therapy; atherosclerosis
(This special issue belongs to the Section Molecular Medicine)
Impact of Exercise Physiology and Diet on Adipokines in Health and Diseases
edited by Aurora Daniele and
submission deadline 31 Mar 2025 | Viewed by 70 | Submission Open
Keywords: adipose tissue; adiponectin; adiponectin receptors; physical exercise; exercise; health; disease
Crosstalk between the Immune and Nervous Systems
edited by Fuminori Tsuruta
submission deadline 31 Mar 2025 | Viewed by 58 | Submission Open
Keywords: microglia; astrocytes; macrophages; cerebral blood vessels; cerebrospinal fluid (CSF); meninges; immune cells; neuroinflammation; neurodegenerative disorders; psychiatric disorders
(This special issue belongs to the Section Molecular Biology)
Molecular Aspects of Female Infertility
edited by
submission deadline 31 Mar 2025 | Viewed by 56 | Submission Open
Keywords: female infertility; reproduction; ovary; reproductive aging; genetic disorders
(This special issue belongs to the Section Molecular Biology)
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