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21 Results Found

  • Article
  • Open Access
14 Citations
4,047 Views
15 Pages

The Untapped Australasian Diversity of Astaxanthin-Producing Yeasts with Biotechnological Potential—Phaffia australis sp. nov. and Phaffia tasmanica sp. nov.

  • Márcia David-Palma,
  • Diego Libkind,
  • Patrícia H. Brito,
  • Margarida Silva,
  • Nicolás Bellora,
  • Marco A. Coelho,
  • Joseph Heitman,
  • Paula Gonçalves and
  • José Paulo Sampaio

Phaffia is an orange-colored basidiomycetous yeast genus of the order Cystofilobasidiales that contains a single species, P. rhodozyma. This species is the only fungus known to produce the economically relevant carotenoid astaxanthin. Although Phaffi...

  • Article
  • Open Access
2 Citations
2,017 Views
16 Pages

Leftover Food as a Sustainable Source of Astaxanthin Through Fermentation Using Phaffia rhodozyma

  • Rossella Vadalà,
  • Eleonora Di Salvo,
  • Laura De Maria,
  • Giovanna Lo Vecchio,
  • Giovanni Bartolomeo,
  • Rita De Pasquale,
  • Claudia Genovese,
  • Nicola Cicero and
  • Rosaria Costa

31 March 2025

Natural astaxanthin is a bioactive with high antioxidant power, widely suitable for many applications. This study explores the potential of leftover food as a sustainable and low-cost substrate for producing astaxanthin via direct fermentation using...

  • Article
  • Open Access
9 Citations
3,946 Views
13 Pages

Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats

  • Alexander L. Semenov,
  • Margarita L. Tyndyk,
  • Julia D. Von,
  • Elena D. Ermakova,
  • Anastasia A. Dorofeeva,
  • Irina A. Tumanyan,
  • Ekaterina A. Radetskaya,
  • Maria N. Yurova,
  • Alexander Zherebker and
  • Vladimir N. Anisimov
  • + 3 authors

26 January 2023

Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent (NADES) extract of Pueraria lobata roots rich in isoflavones (ISF) and Phaffia rhodozyma ex...

  • Article
  • Open Access
4 Citations
2,440 Views
14 Pages

Research on the Cell Wall Breaking and Subcritical Extraction of Astaxanthin from Phaffia rhodozyma

  • Wenxuan Jiang,
  • Xiangrong Deng,
  • Lanxian Qin,
  • Dahai Jiang,
  • Mengqi Lu,
  • Kai Chen,
  • Manqi Yang,
  • Liangliang Zhang,
  • Jianchun Jiang and
  • Liming Lu

4 September 2024

This study focused on developing an effective cell wall-breaking method for Phaffia rhodozyma, followed by utilizing subcritical fluid extraction to isolate, extract, and concentrate astaxanthin from the complex fermentation products of P. rhodozyma....

  • Article
  • Open Access
345 Views
21 Pages

Comparative Transcriptomic Analyses Reveal Potential Stp1 Regulatory Roles Independent of Sre1 in Phaffia rhodozyma

  • Marcelo Baeza,
  • Melissa Gómez,
  • Salvador Barahona,
  • Maximiliano Coche-Miranda,
  • Gabriela Apariz and
  • Jennifer Alcaíno

13 December 2025

Sterol regulatory element-binding proteins (SREBPs) regulate lipid homeostasis in mammals via sequential activation by the site-1 (S1P) and site-2 (S2P) proteases. In the yeast Phaffia rhodozyma, homologs of SREBP (Sre1) and S2P (Stp1) were identifie...

  • Article
  • Open Access
6 Citations
3,474 Views
19 Pages

Unraveling the Molecular Basis of Mycosporine Biosynthesis in Fungi

  • Dionisia Sepúlveda,
  • Sebastián Campusano,
  • Martín Moliné,
  • Salvador Barahona,
  • Marcelo Baeza,
  • Jennifer Alcaíno,
  • Fernando Colabella,
  • Blanca Urzúa,
  • Diego Libkind and
  • Víctor Cifuentes

The Phaffia rhodozyma UCD 67-385 genome harbors a 7873 bp cluster containing DDGS, OMT, and ATPG, encoding 2-desmethy-4-deoxygadusol synthase, O-methyl transferase, and ATP-grasp ligase, respectively, of the mycosporine glutaminol (MG) biosynthesis p...

  • Review
  • Open Access
122 Citations
13,461 Views
17 Pages

Biosynthesis of Astaxanthin as a Main Carotenoid in the Heterobasidiomycetous Yeast Xanthophyllomyces dendrorhous

  • Jose L. Barredo,
  • Carlos García-Estrada,
  • Katarina Kosalkova and
  • Carlos Barreiro

30 July 2017

Carotenoids are organic lipophilic yellow to orange and reddish pigments of terpenoid nature that are usually composed of eight isoprene units. This group of secondary metabolites includes carotenes and xanthophylls, which can be naturally obtained f...

  • Article
  • Open Access
12 Citations
5,926 Views
17 Pages

Developing integrated biorefineries requires the generation of high-value co-products produced alongside cellulosic ethanol. Most industrial yeast strains produce ethanol at high titers, but the small profit margins for generating ethanol require tha...

  • Article
  • Open Access
27 Citations
7,158 Views
24 Pages

Towards a Complete Exploitation of Brewers’ Spent Grain from a Circular Economy Perspective

  • Chiara Allegretti,
  • Emanuela Bellinetto,
  • Paola D’Arrigo,
  • Gianmarco Griffini,
  • Stefano Marzorati,
  • Letizia Anna Maria Rossato,
  • Eleonora Ruffini,
  • Luca Schiavi,
  • Stefano Serra and
  • Stefano Turri
  • + 2 authors

In the present work, brewers’ spent grain (BSG), which represents the major by-product of the brewing industry, was recovered from a regional brewery and fractionated in order to obtain a complete valorization. In particular, the whole process...

  • Feature Paper
  • Article
  • Open Access
318 Views
21 Pages

Effects of Different Sources and Dietary Inclusion Levels of Astaxanthin on Growth Performance, Skin Pigmentation, and Physiological Parameters of Red Sea Bream (Pagrus major) Juveniles

  • Arkadios Dimitroglou,
  • Stephanie Carvajal Acevedo,
  • Konstantina Evangelia Gleni,
  • Athanasios Samaras,
  • Dimitrios Barkas,
  • Leonidas Papaharisis and
  • Michael Pavlidis

5 February 2026

Red seabream (Pagrus major) reared under intensive rearing conditions faces hypermelanosis and dyspigmentation, resulting in darker and less pink/red skin color, losing the natural appearance of the species. This has a great negative impact on consum...

  • Article
  • Open Access
10 Citations
3,900 Views
24 Pages

Comprehensive Comparison of Effects of Antioxidant (Astaxanthin) Supplementation from Different Sources in Haliotis discus hannai Diet

  • Weiguang Zou,
  • Jiawei Hong,
  • Wenchao Yu,
  • Yaobin Ma,
  • Jiacheng Gan,
  • Yanbo Liu,
  • Xuan Luo,
  • Weiwei You and
  • Caihuan Ke

19 August 2023

Dietary antioxidant supplementation, especially astaxanthin, has shown great results on reproductive aspects, egg quality, growth, survival, immunity, stress tolerance, and disease resistance in aquatic animals. However, the effects of dietary astaxa...

  • Article
  • Open Access
24 Citations
5,546 Views
12 Pages

Immobilization of the β-fructofuranosidase from Xanthophyllomyces dendrorhous by Entrapment in Polyvinyl Alcohol and Its Application to Neo-Fructooligosaccharides Production

  • Noa Míguez,
  • María Gimeno-Pérez,
  • David Fernández-Polo,
  • Fadia V. Cervantes,
  • Antonio O. Ballesteros,
  • María Fernández-Lobato,
  • María H. Ribeiro and
  • Francisco J. Plou

11 May 2018

The β-fructofuranosidase (Xd-INV) from the basidiomycota yeast Xanthophyllomyces dendrorhous (formerly Phaffia rhodozyma) is unique in its ability to synthesize neo- fructooligosaccharides (neo-FOS). In order to facilitate its industrial application,...

  • Review
  • Open Access
93 Citations
13,889 Views
23 Pages

Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties

  • Anagha Nair,
  • Ankesh Ahirwar,
  • Shashikala Singh,
  • Reeta Lodhi,
  • Aishwarya Lodhi,
  • Anshuman Rai,
  • Dipak A Jadhav,
  • Harish,
  • Sunita Varjani and
  • Vandana Vinayak
  • + 3 authors

13 March 2023

Astaxanthin (3,3-dihydroxy-β, β-carotene-4,4-dione) is a ketocarotenoid synthesized by Haematococcus pluvialis/lacustris, Chromochloris zofingiensis, Chlorococcum, Bracteacoccus aggregatus, Coelastrella rubescence, Phaffia rhodozyma, some b...

  • Article
  • Open Access
8 Citations
3,530 Views
13 Pages

Oleaginous Yeast Extracts and Their Possible Effects on Human Health

  • Marie Vysoka,
  • Martin Szotkowski,
  • Eva Slaninova,
  • Lucia Dzuricka,
  • Paulina Strecanska,
  • Jana Blazkova and
  • Ivana Marova

Four non-conventional oleaginous and pigmented yeast strains of Metschnikowia pulcherrima, Cystofilobasidium infirmominiatum, Phaffia rhodozyma, and Rhodotorula kratochvilovae were used in this study. Complex yeast extracts were prepared and tested f...

  • Review
  • Open Access
3 Citations
3,010 Views
21 Pages

Marine-Derived Astaxanthin: Molecular Mechanisms, Biomedical Applications, and Roles in Stem Cell Biology

  • Aretha Rambaldi,
  • Francesca Paris,
  • Pasquale Marrazzo,
  • Roberta Costa,
  • Stefano Ratti and
  • Francesco Alviano

29 May 2025

Astaxanthin (ASX) is a xanthophyll carotenoid mainly derived from marine microalgae such as Haematococcus pluvialis and Chlorella zofingiensis, as well as the yeast Phaffia rhodozyma. Its chemical nature structure, rich in conjugated double bonds, ca...

  • Article
  • Open Access
11 Citations
4,693 Views
13 Pages

20 April 2021

Rhodotorula diobovata is an oleaginous and carotenogenic yeast, useful for diverse biotechnological applications. To understand the molecular basis of its potential applications, the genome was sequenced using the Illumina MiSeq and Ion Torrent platf...

  • Article
  • Open Access
15 Citations
5,140 Views
23 Pages

27 July 2022

Astaxanthin is gaining recognition as a natural bioactive component. This study aimed to test whether astaxanthin could protect adipose-derived stromal stem cells (ASCs) from apoptosis, mitochondrial dysfunction and oxidative stress. Phaffia rhodozym...

  • Review
  • Open Access
1,765 Citations
96,072 Views
25 Pages

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

  • Ranga Rao Ambati,
  • Siew-Moi Phang,
  • Sarada Ravi and
  • Ravishankar Gokare Aswathanarayana

7 January 2014

There is currently much interest in biological active compounds derived from natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases. Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4...

  • Article
  • Open Access
42 Citations
6,508 Views
18 Pages

15 December 2022

The coloring efficiency and physiological function of astaxanthin in fish vary with its regions. The aim of this study was to compare the retention rates of dietary astaxanthin from different sources and its effects on growth, pigmentation, and physi...

  • Article
  • Open Access
18 Citations
3,946 Views
25 Pages

Chlamydomonas reinhardtii is a unicellular green alga that can grow heterotrophically by using acetate as a carbon source. Carotenoids are natural pigments with biological activity and color, which have functions such as antioxidant, anti-inflammator...

  • Article
  • Open Access
10 Citations
4,054 Views
15 Pages

10 May 2024

Astaxanthin is an important pigment for the rainbow trout Oncorhynchus mykiss. This study was conducted to investigate the effects of different sources of dietary astaxanthin on the growth, coloration, and antioxidant capacity of the commercial-sized...