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402 Results Found

  • Perspective
  • Open Access
2 Citations
2,084 Views
8 Pages

26 January 2025

A spectrum of neuro-ocular changes has been observed in astronauts during and after prolonged exposure to microgravity on long-duration spaceflights. These changes, collectively referred to as “spaceflight associated neuro-ocular syndrome&rdquo...

  • Article
  • Open Access
7 Citations
6,567 Views
16 Pages

12 December 2022

As the development of science and technology has reached the point where the desire to travel to Mars has become a tangible reality, the physical limits of human movement are also part of the systematic research based on the space environment. The cr...

  • Article
  • Open Access
3 Citations
2,127 Views
18 Pages

Smart Task Assistance in Mixed Reality for Astronauts

  • Qingwei Sun,
  • Wei Chen,
  • Jiangang Chao,
  • Wanhong Lin,
  • Zhenying Xu and
  • Ruizhi Cao

27 April 2023

Mixed reality (MR) registers virtual information and real objects and is an effective way to supplement astronaut training. Spatial anchors are generally used to perform virtual–real fusion in static scenes but cannot handle movable objects. To...

  • Article
  • Open Access
13 Citations
21,210 Views
16 Pages

13 August 2020

This paper, based mainly on astronauts’ first-person writings, historical documents, and my own ethnographic interviews with nine astronauts conducted between 2004 and 2020, explores how encountering the earth and other celestial objects in way...

  • Review
  • Open Access
23 Citations
9,959 Views
31 Pages

Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review

  • Rosa Drago-Ferrante,
  • Riccardo Di Fiore,
  • Fathi Karouia,
  • Yashwanth Subbannayya,
  • Saswati Das,
  • Begum Aydogan Mathyk,
  • Shehbeel Arif,
  • Ana Paula Guevara-Cerdán,
  • Allen Seylani and
  • Jean Calleja-Agius
  • + 10 authors

Outer space is an extremely hostile environment for human life, with ionizing radiation from galactic cosmic rays and microgravity posing the most significant hazards to the health of astronauts. Spaceflight has also been shown to have an impact on e...

  • Article
  • Open Access
1 Citations
2,017 Views
19 Pages

6 December 2022

The application of intravehicular robotic assistants (IRA) can save valuable working hours for astronauts in space stations. There are various types of IRA, such as an accompanying drone working in microgravity and a dexterous humanoid robot for coll...

  • Article
  • Open Access
1 Citations
6,484 Views
18 Pages

Current scientific developments have reached the stage where human aspirations of space exploration are not science fiction but a reality involving travelling to the Earth’s orbit, the Moon and Mars. In the second half of the twentieth century,...

  • Article
  • Open Access
9 Citations
4,128 Views
18 Pages

Modular Robotic Limbs for Astronaut Activities Assistance

  • Sikai Zhao,
  • Jie Zhao,
  • Dongbao Sui,
  • Tianshuo Wang,
  • Tianjiao Zheng,
  • Chuanwu Zhao and
  • Yanhe Zhu

21 September 2021

In order to meet the assist requirements of extravehicular activity (EVA) for astronauts, such as moving outside the international space station (ISS) or performing on-orbit tasks by a single astronaut, this paper proposes an astronaut robotic limbs...

  • Review
  • Open Access
27 Citations
8,101 Views
18 Pages

Prospective Use of Probiotics to Maintain Astronaut Health during Spaceflight

  • Sahaj Bharindwal,
  • Nidhi Goswami,
  • Pamela Jha,
  • Siddharth Pandey and
  • Renitta Jobby

8 March 2023

Maintaining an astronaut’s health during space travel is crucial. Multiple studies have observed various changes in the gut microbiome and physiological health. Astronauts on board the International Space Station (ISS) had changes in the microb...

  • Article
  • Open Access
8 Citations
2,787 Views
17 Pages

Running Experimental Research of a Cable-Driven Astronaut on-Orbit Physical Exercise Equipment

  • Lailu Li,
  • Lixun Zhang,
  • Bing Wang,
  • Feng Xue,
  • Yupeng Zou and
  • Da Song

Manned spaceflight has already become an important approach to space science exploration, while long-term exposure to the microgravity environment will lead to severe health problems for astronauts, including bone loss, muscle atrophy, and cardiovasc...

  • Article
  • Open Access
5 Citations
2,870 Views
15 Pages

A Multi-View Vision System for Astronaut Postural Reconstruction with Self-Calibration

  • Shuwei Gan,
  • Xiaohu Zhang,
  • Sheng Zhuge,
  • Chenghao Ning,
  • Lijun Zhong and
  • You Li

Space exploration missions involve significant participation from astronauts. Therefore, it is of great practical importance to assess the astronauts’ performance via various parameters in the cramped and weightless space station. In this paper...

  • Article
  • Open Access
7 Citations
7,055 Views
18 Pages

13 October 2022

This paper proposes a full-size and free-flying humanoid robot named Taikobot that aims to assist astronauts in a space station and maintain spacecrafts between human visits. Taikobot adopts a compact and lightweight (∼25 kg) design to work in mi...

  • Article
  • Open Access
6 Citations
4,906 Views
19 Pages

22 January 2021

TORVEastro robot design is presented with a built prototype in LARM2 (Laboratory of Robot Mechatronics) for testing and characterizing its functionality for service in space stations. Several robot astronauts are designed with bulky human-like struct...

  • Article
  • Open Access
23 Citations
3,766 Views
15 Pages

A Mission to Mars: Prediction of GCR Doses and Comparison with Astronaut Dose Limits

  • Ricardo L. Ramos,
  • Mario P. Carante,
  • Alfredo Ferrari,
  • Paola Sala,
  • Valerio Vercesi and
  • Francesca Ballarini

24 January 2023

Long-term human space missions such as a future journey to Mars could be characterized by several hazards, among which radiation is one the highest-priority problems for astronaut health. In this work, exploiting a pre-existing interface between the...

  • Article
  • Open Access
6 Citations
3,627 Views
13 Pages

15 November 2023

Astronauts often face orientation challenges while on orbit, which can lead to operator errors in demanding spatial tasks. In this study, we investigated the impact of long-duration spaceflight on the neural processes supporting astronauts’ spa...

  • Article
  • Open Access
5 Citations
2,210 Views
20 Pages

12 October 2023

In recent years, virtual microgravity training technology for astronauts based on cable-driven designs has emerged, and it solves the following problems: high costs, short training times, and low safety of existing equipment. However, this technology...

  • Article
  • Open Access
11 Citations
2,998 Views
19 Pages

The Unresolved Methodological Challenge of Detecting Neuroplastic Changes in Astronauts

  • Ford Burles,
  • Rebecca Williams,
  • Lila Berger,
  • G. Bruce Pike,
  • Catherine Lebel and
  • Giuseppe Iaria

11 February 2023

After completing a spaceflight, astronauts display a salient upward shift in the position of the brain within the skull, accompanied by a redistribution of cerebrospinal fluid. Magnetic resonance imaging studies have also reported local changes in br...

  • Review
  • Open Access
55 Citations
19,508 Views
47 Pages

28 March 2022

During space missions, astronauts are faced with a variety of challenges that are unique to spaceflight and that have been known to cause physiological changes in humans over a period of time. Several of these changes occur at the microbiome level, a...

  • Review
  • Open Access
23 Citations
3,818 Views
21 Pages

A Dusty Road for Astronauts

  • Silvana Miranda,
  • Shannon Marchal,
  • Lina Cumps,
  • Jenne Dierckx,
  • Marcus Krüger,
  • Daniela Grimm,
  • Sarah Baatout,
  • Kevin Tabury and
  • Bjorn Baselet

The lunar dust problem was first formulated in 1969 with NASA’s first successful mission to land a human being on the surface of the Moon. Subsequent Apollo missions failed to keep the dust at bay, so exposure to the dust was unavoidable. In 19...

  • Article
  • Open Access
4 Citations
5,718 Views
15 Pages

18 February 2023

Space exploration and extraterrestrial civilization have fascinated humankind since the earliest days of human history. It was only in the last century that humankind finally began taking significant steps towards these goals by sending astronauts in...

  • Article
  • Open Access
1 Citations
1,325 Views
13 Pages

(1) Background: Evidence from non-human animal and spaceflight analog studies have suggested that traveling to outer space could have a significant impact on the structural properties of the hippocampus, a brain region within the medial temporal lobe...

  • Article
  • Open Access
2 Citations
2,569 Views
18 Pages

Predicting Bone Adaptation in Astronauts during and after Spaceflight

  • Tannis D. Kemp,
  • Bryce A. Besler,
  • Leigh Gabel and
  • Steven K. Boyd

9 November 2023

A method was previously developed to identify participant-specific parameters in a model of trabecular bone adaptation from longitudinal computed tomography (CT) imaging. In this study, we use these numerical methods to estimate changes in astronaut...

  • Review
  • Open Access
7 Citations
4,372 Views
12 Pages

The Case for Bisphosphonate Use in Astronauts Flying Long-Duration Missions

  • Reece Rosenthal,
  • Victor S. Schneider,
  • Jeffrey A. Jones and
  • Jean D. Sibonga

13 August 2024

Changes in the structure of bone can occur in space as an adaptive response to microgravity and on Earth due to the adaptive effects to exercise, to the aging of bone cells, or to prolonged disuse. Knowledge of cell-mediated bone remodeling on Earth...

  • Review
  • Open Access
1 Citations
1,538 Views
23 Pages

Physical Activity Guidelines for Astronauts: An Immunological Perspective

  • Amirhossein Ahmadi Hekmatikar and
  • Katsuhiko Suzuki

30 September 2025

Spaceflight imposes unique physiological stressors that profoundly disrupt immune regulation, including impaired lymphocyte activation, latent viral reactivation, and chronic low-grade inflammation. While structured exercise is the cornerstone counte...

  • Article
  • Open Access
438 Views
33 Pages

10 November 2025

Low-gravity and microgravity simulation devices for training astronauts to manipulate objects under terrestrial conditions are critical for improving operational performance and efficiency in extraterrestrial environments while minimizing risk. To th...

  • Article
  • Open Access
3 Citations
1,477 Views
18 Pages

Pixel-Wise and Class-Wise Semantic Cues for Few-Shot Segmentation in Astronaut Working Scenes

  • Qingwei Sun,
  • Jiangang Chao,
  • Wanhong Lin,
  • Dongyang Wang,
  • Wei Chen,
  • Zhenying Xu and
  • Shaoli Xie

Few-shot segmentation (FSS) is a cutting-edge technology that can meet requirements using a small workload. With the development of China Aerospace Engineering, FSS plays a fundamental role in astronaut working scene (AWS) intelligent parsing. Althou...

  • Article
  • Open Access
30 Citations
8,474 Views
27 Pages

Non-Invasive UWB Sensing of Astronauts’ Breathing Activity

  • Marco Baldi,
  • Graziano Cerri,
  • Franco Chiaraluce,
  • Lorenzo Eusebi and
  • Paola Russo

30 December 2014

The use of a UWB system for sensing breathing activity of astronauts must account for many critical issues specific to the space environment. The aim of this paper is twofold. The first concerns the definition of design constraints about the pulse am...

  • Article
  • Open Access
58 Citations
11,463 Views
14 Pages

13 December 2013

Exposure to microgravity during spaceflight is known to elicit orientation illusions, errors in sensory localization, postural imbalance, changes in vestibulo-spinal and vestibulo-ocular reflexes, and space motion sickness. The objective of this expe...

  • Article
  • Open Access
7 Citations
10,768 Views
10 Pages

Sixty Years of Manned Spaceflight—Incidents and Accidents Involving Astronauts between Launch and Landing

  • Jan Schmitz,
  • Matthieu Komorowski,
  • Thais Russomano,
  • Oliver Ullrich and
  • Jochen Hinkelbein

2 November 2022

Introduction: Since Gagarin became the first human to travel into space and complete one orbit around the Earth, on 12 April 1961, the number of manned spaceflights has increased significantly. Spaceflight is still complex and has potential risk for...

  • Article
  • Open Access
2 Citations
2,516 Views
10 Pages

Radioprotection for Astronauts’ Missions: Numerical Results on the Nomex Shielding Effectiveness

  • Filomena Loffredo,
  • Emanuele Vardaci,
  • Davide Bianco,
  • Antonio Di Nitto and
  • Maria Quarto

15 March 2023

Space missions with humans expose the crews to ionizing radiation, mainly due to the galactic cosmic radiation (GCR). All radiation protection programs in space aim to minimize crews’ exposure to radiation. The radiation protection of astronaut...

  • Article
  • Open Access
7 Citations
4,267 Views
20 Pages

Designing Procedure Execution Tools with Emerging Technologies for Future Astronauts

  • John A. Karasinski,
  • Isabel C. Torron Valverde,
  • Holly L. Brosnahan,
  • Jack W. Gale,
  • Ron Kim,
  • Melodie Yashar and
  • Jessica J. Marquez

10 February 2021

NASA’s human spaceflight efforts are moving towards long-duration exploration missions requiring asynchronous communication between onboard crew and an increasingly remote ground support. In current missions aboard the International Space Station, th...

  • Article
  • Open Access
750 Views
18 Pages

Defying Lunar Dust: A Revolutionary Helmet Design to Safeguard Astronauts’ Health in Long-Term Lunar Habitats

  • Christopher Salvino,
  • Kenneth Altshuler,
  • Paul Beatty,
  • Drew DeJarnette,
  • Jesse Ybanez,
  • Hazel Obana,
  • Edwin Osabel,
  • Andrew Dummer,
  • Eric Lutz and
  • Moe Momayez

30 September 2025

Lunar dust remains one of the most critical unresolved challenges to long-duration lunar missions. Its sharp, abrasive, and electrostatically charged particles are easily inhaled and can penetrate deep into the lungs, reaching the bloodstream and the...

  • Review
  • Open Access
317 Views
26 Pages

3 February 2026

As humanity continues to strive for extraplanetary exploration, which is quickly gaining marked governmental and industrial support and recognition, there are still substantial detriments to astronaut health during long-duration spaceflight (i.e., mu...

  • Review
  • Open Access
7 Citations
3,864 Views
22 Pages

As humanity advances into deep space exploration, astronauts on long-duration missions face significant challenges posed by circadian rhythm disruptions and sleep disorders, which arise from extreme environmental stressors such as microgravity, ioniz...

  • Article
  • Open Access
2 Citations
6,053 Views
10 Pages

Evaluation of Physiotherapy Impact on Neuromuscular Tension in Analog Astronauts at the LunAres Habitat

  • Barbara Gronwald,
  • Karina Kijak,
  • Piotr Baszuk,
  • Danuta Lietz-Kijak,
  • Kamil Kosko,
  • Mikołaj Matuszczak,
  • Piotr Skomro,
  • Hanna Bielawska-Victorini,
  • Leszek Orzechowski and
  • Helena Gronwald
  • + 1 author

The evaluation of manual Trigger Point Therapy (TrPt) on mandible abduction range of Analog Astronauts (AA) surviving isolation conditions during consecutive missions at the LunAres Habitat was performed. This physiotherapy method was applied to decr...

  • Review
  • Open Access
43 Citations
11,405 Views
14 Pages

2 April 2014

Musculoskeletal pathologies associated with decreased bone mass, including osteoporosis and disuse-induced bone loss, affect millions of Americans annually. Microgravity-induced bone loss presents a similar concern for astronauts during space mission...

  • Article
  • Open Access
3 Citations
1,701 Views
15 Pages

Polymer Boron-Containing Composite for Protecting Astronauts of Manned Orbital Stations from Secondary Neutron Radiation

  • Roman Nikolaevich Yastrebinsky,
  • Anna Viktorovna Yastrebinskaya,
  • Andrey Ivanovich Gorodov and
  • Anastasia Vladislavovna Akimenko

21 September 2024

This article considers the prospects of using heat-resistant polyimide boron-containing composites to protect astronauts of manned orbital stations from secondary neutron radiation. Variant calculations are performed regarding neutron and gamma-quant...

  • Review
  • Open Access
3 Citations
3,849 Views
19 Pages

4 February 2022

Escalating government and commercial efforts to plan and deploy viable manned near-to-deep solar system exploration and habitation over the coming decades now drives next-generation space medicine innovations. The application of cutting-edge precisio...

  • Review
  • Open Access
12 Citations
5,651 Views
28 Pages

3 March 2023

Galactic cosmic rays (GCR) pose a serious threat to astronauts’ health during deep space missions. The possible functional alterations of the central nervous system (CNS) under GCR exposure can be critical for mission success. Despite the obvio...

  • Review
  • Open Access
1 Citations
1,917 Views
16 Pages

Effect of Microgravity and Space Radiation Exposure on Human Oral Health: A Systematic Review

  • Shahnawaz Khijmatgar,
  • Matteo Pellegrini,
  • Martina Ghizzoni and
  • Massimo Del Fabbro

29 September 2025

A systematic review was conducted to assess the effects of microgravity and space radiation on astronauts’ oral health. This review aimed to determine if these conditions increase the risk of dental and periodontal diseases, identify pre-missio...

  • Review
  • Open Access
1,763 Views
16 Pages

Beyond Earth, Beyond Time: Preserving Female Fertility in Space Missions

  • Loris Marin,
  • Luciana Bordin,
  • Chiara Sabbadin,
  • Guido Ambrosini and
  • Alessandra Andrisani

24 August 2025

The number of female astronauts participating in space missions is increasing, and concerns about the impact of spaceflight on reproductive health have emerged. Space radiation and microgravity pose potential threats to ovarian reserve and uterine fu...

  • Brief Report
  • Open Access
1,544 Views
7 Pages

22 August 2024

The human organism is affected by multiple stressors every single day, especially during extremely demanding activities. It needs a method to regulate itself better. One of the stressors that is affecting humans is social isolation. The state of prol...

  • Article
  • Open Access
3 Citations
2,142 Views
25 Pages

1 January 2023

It is necessary to conduct virtual training for astronauts on the ground to improve the efficiency and safety of astronauts carrying objects in space. Cooperation between the two astronauts is required when handling massive objects. During this proce...

  • Article
  • Open Access
52 Citations
14,264 Views
12 Pages

Drug Stability Analysis by Raman Spectroscopy

  • Chetan Shende,
  • Wayne Smith,
  • Carl Brouillette and
  • Stuart Farquharson

22 December 2014

Pharmaceutical drugs are available to astronauts to help them overcome the deleterious effects of weightlessness, sickness and injuries. Unfortunately, recent studies have shown that some of the drugs currently used may degrade more rapidly in space,...

  • Article
  • Open Access
11 Citations
5,253 Views
11 Pages

Prototype Design and Performance Tests of Beijing Astronaut Robot

  • Zeyuan Sun,
  • Hui Li,
  • Zhihong Jiang,
  • Zhenzi Song,
  • Yang Mo and
  • Marco Ceccarelli

10 August 2018

This paper proposes a novel chameleon-like astronaut robot that is designed to assist, or even substitute, a human astronauts in a space station to complete dangerous and prolonged work, such as maintenance of solar panels, and so on. The robot can m...

  • Perspective
  • Open Access
6 Citations
4,185 Views
71 Pages

Circuits and Biomarkers of the Central Nervous System Relating to Astronaut Performance: Summary Report for a NASA-Sponsored Technical Interchange Meeting

  • Joshua S. Alwood,
  • Ajitkumar P. Mulavara,
  • Janani Iyer,
  • Siddhita D. Mhatre,
  • Susanna Rosi,
  • Mark Shelhamer,
  • Catherine Davis,
  • Christopher W. Jones,
  • Xiao Wen Mao and
  • Thomas J. Williams
  • + 2 authors

31 August 2023

Biomarkers, ranging from molecules to behavior, can be used to identify thresholds beyond which performance of mission tasks may be compromised and could potentially trigger the activation of countermeasures. Identification of homologous brain region...

  • Article
  • Open Access
3,650 Views
30 Pages

25 February 2022

The article is devoted to the preliminary concept of the Future Planetary Defense System (FPDS) emphasizing astroballistics. This paper is intended to support international efforts to improve the planetary security of Earth. The work covers three are...

  • Article
  • Open Access
7 Citations
4,389 Views
21 Pages

Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight

  • Dieter Blottner,
  • Manuela Moriggi,
  • Gabor Trautmann,
  • Sandra Furlan,
  • Katharina Block,
  • Martina Gutsmann,
  • Enrica Torretta,
  • Pietro Barbacini,
  • Daniele Capitanio and
  • Michele Salanova
  • + 4 authors

Long-duration mission (LDM) astronauts from the International Space Station (ISS) (>180 ISS days) revealed a close-to-normal sarcolemmal nitric oxide synthase type-1 (NOS1) immunoexpression in myofibers together with biochemical and quantitative q...

  • Perspective
  • Open Access
2,283 Views
13 Pages

Imaging the Anterior Segment in Spaceflight: Understanding and Preserving Astronaut Ocular Health for Long-Duration Missions

  • Joshua Ong,
  • Ritu Sampige,
  • Ryung Lee,
  • Hamza Memon,
  • Nicholas Panzo,
  • Cihan Mehmet Kadipasaoglu,
  • Yannie Guo,
  • Baltaj S. Sandhur,
  • Benjamin Soares and
  • Andrew G. Lee
  • + 10 authors

In light of the potential effects of spaceflight on the anterior segment of the eye, there is a pressing need for anterior segment imaging to be available and accessible to monitor astronauts’ ocular health, including alterations to the cornea...

  • Review
  • Open Access
8 Citations
5,295 Views
15 Pages

Joint Cartilage in Long-Duration Spaceflight

  • Bergita Ganse,
  • Magali Cucchiarini and
  • Henning Madry

This review summarizes the current literature available on joint cartilage alterations in long-duration spaceflight. Evidence from spaceflight participants is currently limited to serum biomarker data in only a few astronauts. Findings from analogue...

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