The growing interest in plant-derived bioactive secondary metabolites has renewed attention to grape pomace as a promising source within the context of sustainable and circular bioeconomy strategies. Its chemically diverse composition, influenced by...
The electrochemical reduction of nitrate to ammonia offers a promising solution for both alleviating nitrate pollution in wastewater and providing a sustainable ammonia source for agriculture use. This review focuses on the role of carbon-based catal...
Expanding swept volume technology via continuous-phase polymer solution and dispersed-phase particle gel is an important technique to increase oil production and control water production in mature waterflooding reservoirs. However, problems such as t...
This review summarizes recent progress in the catalytic conversion of glycerol to glycerol carbonate (GC) via transesterification with alkyl carbonates, a sustainable route for valorizing surplus glycerol from biodiesel production. Emphasis is placed...
Bioactive polyphenols are increasingly recognized as modulators of multiple biological processes relevant to human health and disease. Among these compounds, genistein, a soy-derived isoflavone, and butein, a naturally occurring chalcone, have been i...
This paper investigates the transient synchronization stability mechanisms and technological advancements associated with grid-following (GFL) converters, providing a systematic review of the current research landscape and future directions in this f...
Drug resistance among microbial pathogens and oxidative stress caused by reactive oxygen species are two of the most challenging global issues. Firstly, drug-resistant pathogens cause several fatalities every year. Secondly aging and a variety of dis...
The latent left–right asymmetry (chirality) of vascular plants is best witnessed as a helical elongation of cylindrical organs in climbing plants. Interestingly, helical handedness is usually fixed in given species, suggesting genetic control o...
Irritable Bowel Syndrome (IBS) is one of the most prevalent gastrointestinal disorders, affecting about 11% of the global population and exerting a substantial burden on quality of life and healthcare systems. Despite the emerging interest in this di...
As nervous systems mature, neural circuit connections are reorganized to optimize the performance of specific functions in adults. This reorganization of connections is achieved through a remarkably conserved phase of developmental circuit remodeling...
Emerging Mechanistic Insights into AAA Complexes Regulating Proteasomal Degradation
The atherothrombotic substrates for acute coronary syndromes (ACS) consist of plaque ruptures, erosions and calcified nodules, while the non-atherothrombotic etiologies, such as spontaneous coronary artery dissection, coronary artery spasm and corona...
Mycorrhizal symbiosis, the mutually beneficial association between plants and fungi, has gained significant attention in recent years due to its widespread significance in agricultural productivity. Specifically, arbuscular mycorrhizal fungi (AMF) pr...
The removal of persistent pharmaceutical compounds such as carbamazepine (CBZ) by advanced oxidation processes (AOPs) remains a major challenge in water treatment, particularly in relation to understanding the operating conditions governing reaction...
Histone deacetylase 6 (HDAC6) is increasingly recognized for its potential in targeted disease therapy. This study delves into the mechanistic and structural nuances of HDAC6 inhibition by difluoromethyl-1,3,4-oxadiazole (DFMO) derivatives, a class o...
Bacterial biofilm is a major contributor to the persistence of infection and the limited efficacy of antibiotics. Antibiofilm molecules that interfere with the biofilm lifestyle offer a valuable tool in fighting bacterial pathogens. Ellagic acid (EA)...
Bladder cancer (BC), particularly muscle-invasive urothelial bladder carcinoma (UBC), remains a clinical challenge due to frequent recurrence, chemoresistance, and limited treatment options. This study investigates the functional and mechanistic insi...
Epithelial ovarian cancer is an aggressive disease of the female reproductive system and a leading cause of cancer death in women. Standard of care includes surgery and platinum-based chemotherapy, yet patients continue to experience a high rate of r...
The myocardium/heart is the most mitochondria-rich tissue in the human body with mitochondria comprising approximately 30% of total cardiomyocyte volume. As the resident “powerhouse” of cells, mitochondria help to fuel the high energy dem...
Research efforts are placing an ever increasing emphasis on identifying signal transduction pathways related to the chemopreventive activity of curcumin. Its anticarcinogenic effects are presumably mediated by the regulation of signaling cascades, in...
Incorporating comonomers in propylene polymerization plays a critical role in tuning the physical and chemical properties of the resulting polymers. In this study, the impact of three developed comonomers on propylene polymerization over the triethyl...
Cancer remains one of the most complex diseases to study and treat, with tumour microenvironment heterogeneity and therapeutic resistance continuing to limit clinical progress. Biomaterials-based nanoparticles have emerged as versatile platforms that...
This study investigates the electrochemical oxidation mechanisms of chlorpromazine (CPZ), revealing a novel three-electron oxidation pathway that challenges the traditionally accepted two-electron paradigm, offering new insights into CPZ oxidation pa...
The oxidation of glycerol offers a valuable route for producing high-value chemicals. This review provides an in-depth analysis of the current advancements and mechanistic insights into novel metal-based catalysts for glycerol oxidation. We discuss t...
Osteoporosis, a metabolic bone disorder characterized by decreased bone mass per unit volume, poses a significant global health burden due to its association with heightened fracture risk and adverse impacts on patients’ quality of life. This r...
Ficus religiosa (Bo tree or sacred fig) and Ficus benghalensis (Indian banyan) are of immense spiritual and therapeutic importance. Various parts of these trees have been investigated for their antioxidant, antimicrobial, anticonvulsant, antidiabetic...
An optimized synthetic protocol toward the assembly of Kuhn verdazyls based on an azo coupling of arenediazonium salts with readily available hydrazones followed by the base-mediated cyclization of in situ formed formazans with formalin was developed...
Diabetic foot ulcers represent a major complication driven by chronic inflammation, oxidative stress, impaired angiogenesis, and defective extracellular matrix remodeling. This integrative review synthesizes mechanistic evidence from 51 preclinical s...
Periodontitis is a chronic non-communicable inflammatory disease in which oxidative stress plays an important role in tissue destruction and alveolar bone loss. Excessive production of reactive oxygen species disrupts redox homeostasis, activates inf...
Quinoa (Chenopodium quinoa Willd.) is an ancient Andean crop renowned for its exceptional nutritional profile and diverse bioactive compounds, including polysaccharides, polyphenols, saponins, and essential fatty acids. As global incidence of colonic...
While metabolomics captures the dynamic chemical landscape of biological systems, its inherent high dimensionality and complexity pose significant analytical hurdles. Interpretable Machine Learning (IML) is revolutionizing the field by moving beyond...
Asparagus racemosus, popularly known as Shatavari, is a well-acclaimed medicinal herb for the rejuvenation of reproductive and cognitive health. The therapeutic potential of the herb is primarily due to its famed bioactive compound, Shatavarin IV, wh...
Aberrations in fibroblast growth factor receptors (FGFRs) constitute a key oncogenic mechanism across multiple solid tumors, influencing tumor initiation, therapeutic response, and clinical outcomes. This review synthesizes current knowledge on the m...
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder driven by complex interactions between protein aggregation, oxidative stress, neuroinflammation, and cellular dysfunction. Among plant-derived compounds, curcumin has emerg...
Age-related macular degeneration (AMD) severely affects central vision due to progressive macular degeneration and its staggering prevalence is rising globally, especially in the elderly population above 55 years. Increased oxidative stress with agin...
In this contribution, we present an industrial example on how tailored operando spectroscopic methodologies provide the insights needed for the development of new catalytic technologies and support their global utilization. We describe the use of ope...
Background/Objectives: Tributyltin (TBT) remains a persistent aquatic contaminant with documented neurotoxic effects, yet the underlying mechanisms of its neurotoxicity remain poorly understood. Methods: We investigated the comprehensive molecular me...
Short stature is a common pediatric endocrine–metabolic disorder characterized by impaired linear growth and increased risks of adverse health outcomes. Although previous reviews have summarized associations between gut microbiota and childhood...
ELK1 is a Transcription factor (TF) belonging to the ETS-domain TF family, mainly activated via RAS-RAF-MEK-ERK signaling. As a nethermost pathway molecule, ELK1 binds to Serum-response elements (SREs) and directly regulates the transcription of Imme...
Although human mammary glands were traditionally considered sterile, accumulating evidence has established the presence of distinct microbial communities that may have colonized breast tissue primarily via retrograde nipple flow or via hematogenous o...
Magnetic fields (MFs) represent an emerging modality in cancer therapy, encompassing static, low-frequency, pulsed, and nanoparticle-mediated alternating fields. These interventions have demonstrated the capacity to modulate proliferation, apoptosis,...
The ethanol oxidation reaction (EOR) is a key process for direct ethanol fuel cells (DEFCs), offering a high-energy-density and carbon-neutral pathway for sustainable energy conversion. However, the practical implementation of DEFCs is significantly...
Hyperlipidemia is a major metabolic disorder that leads to cardiovascular diseases. Natural products have drawn more attention as supplemental treatment approaches for lipid management. However, there is still a lack of adequate characterizations of...
Background/Objectives: Antibody–drug conjugates (ADCs) have transformed the therapeutic landscape of breast cancer, expanding treatment opportunities across multiple disease settings. However, their increasing clinical use has revealed a heterogeneou...
Sulforaphane, a bioactive isothiocyanate abundant in cruciferous vegetables, has emerged as a potential multi-target therapeutic agent capable of mitigating these pathological processes. Here, using evidence from preclinical and clinical literature,...
Deep eutectic solvents (DESs) have emerged as promising green alternatives to conventional organic solvents for the extraction of bioactive compounds from natural matrices because of their tunable physicochemical properties, low toxicity, and environ...
Galectin-1 (Gal-1), a β-galactoside-binding lectin, plays a complex role in cardiovascular diseases (CVDs), exerting both protective and pathological effects depending on the context. This review synthesizes findings from the past decade to expl...
Background/Objectives: The mutational dynamics of microsatellites over deep evolutionary timescales are poorly understood. This study aims to elucidate the life history of trinucleotide microsatellites by tracing orthologous loci across divergent ver...
Elevated cholesterol levels play important mitogenic roles. Pseurotin A (PsA) is a fermentation product that has recently been reported as a dual inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) secretion and protein-protein interac...
Atrial fibrillation (AF) is the most common sustained arrhythmia, and its initiation and progression involve multiple mechanisms, including electrical remodeling, structural remodeling, inflammatory responses, and oxidative stress. In recent years, t...
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