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16 pages, 2393 KB

Open AccessArticle

A High-Precision Segmentation Method for Photovoltaic Modules Integrating Transformer and Improved U-Net

by Kesheng Jin, Sha Gao, Hui Yu and Ji Zhang

Processes 2025, 13(12), 4013; https://doi.org/10.3390/pr13124013 (registering DOI) - 11 Dec 2025

To address the challenges of insufficient robustness and limited feature extraction in photovoltaic module image segmentation under complex scenarios, we propose a high-precision PV module segmentation model (Pv-UNet) that integrates Transformer and improved U-Net architecture. The model introduces a MultiScale Transformer in the [...] Read more.

To address the challenges of insufficient robustness and limited feature extraction in photovoltaic module image segmentation under complex scenarios, we propose a high-precision PV module segmentation model (Pv-UNet) that integrates Transformer and improved U-Net architecture. The model introduces a MultiScale Transformer in the encoding path to achieve cross-scale feature correlation and semantic enhancement, combines residual structure with dynamic channel adaptation mechanism in the DoubleConv module to improve feature transfer stability, and incorporates an Attention Gate module in the decoding path to suppress complex background interference. Experimental data were obtained from UAV visible light images of a photovoltaic power station in Yuezhe Town, Qiubei County, Yunnan Province. Compared with U-Net, BatchNorm-UNet, and Seg-UNet, Pv-UNet achieved significant improvements in IoU, Dice, and Precision metrics to 97.69%, 93.88%, and 97.99% respectively, while reducing the Loss value to 0.0393. The results demonstrate that our method offers notable advantages in both accuracy and robustness for PV module segmentation, providing technical support for automated inspection and intelligent monitoring of photovoltaic power stations. Full article

(This article belongs to the Section Environmental and Green Processes)

17 pages, 2654 KB

Open AccessTechnical Note

Development and Validation of Nanoedw 1.0: An Integrated Computational Tool for Drug Delivery Research and Nanotechnology Applications

by Edwar D. Montenegro, Marcia S. Rizzo, Heurison de Sousa e Silva and Marcília Pinheiro da Costa

J 2025, 8(4), 47; https://doi.org/10.3390/j8040047 - 11 Dec 2025

Abstract

Quantitative analyses in drug-delivery research are frequently distributed across multiple tools, which increases manual handling and the risk of transcription errors. NanoEDW 1.0 is an open source Python application that integrates calibration-curve generation, encapsulation-efficiency (EE%) calculation, and release kinetics modeling in a single, [...] Read more.

Quantitative analyses in drug-delivery research are frequently distributed across multiple tools, which increases manual handling and the risk of transcription errors. NanoEDW 1.0 is an open source Python application that integrates calibration-curve generation, encapsulation-efficiency (EE%) calculation, and release kinetics modeling in a single, streamlined workflow. This study aims to validate the performance of NanoEDW 1.0 by benchmarking it against spreadsheet/OriginLab^® OriginPro 2025 analyses on experimental datasets from polymeric nanocarrier systems commonly used in drug encapsulation. The software performs linear regression to convert absorbance into concentration, computes EE% from raw experimental values, and fits drug-release profiles to classical models (including zero/first-order, Higuchi, Korsmeyer–Peppas, Weibull, and Modified Gompertz) using non-linear least squares with standard goodness-of-fit metrics (R², RMSE). Results show close agreement with reference workflows for calibration parameters and EE%, as well as statistically comparable release-model fits, while reducing manual steps and analysis time. In conclusion, the validation confirms that NanoEDW 1.0 can streamline routine analyses and enhance reproducibility and accessibility in nanopharmaceutical research; source code and example datasets are provided to foster adoption. Full article

(This article belongs to the Special Issue Feature Papers of J—Multidisciplinary Scientific Journal in 2025)

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27 pages, 540 KB

Open AccessArticle

From Intelligence to Creativity: Can AI Adoption Drive Sustained Corporate Innovation Investment?

by Kongwen Wang, Sihan Zhang and Changjiang Zhang

Sustainability 2025, 17(24), 11127; https://doi.org/10.3390/su172411127 - 11 Dec 2025

Abstract

Artificial intelligence (AI) technology has brought unprecedented impact and opportunities for the sustainable development of family firms. This paper examines the impact of AI on innovation investment in family firms using a sample of Chinese A-share listed family firms from 2007 to 2024. [...] Read more.

Artificial intelligence (AI) technology has brought unprecedented impact and opportunities for the sustainable development of family firms. This paper examines the impact of AI on innovation investment in family firms using a sample of Chinese A-share listed family firms from 2007 to 2024. The results show that AI significantly promotes innovation investment in family firms to achieve sustainable development. Mechanism analysis shows that AI enhances both the willingness and capability of family firms to invest in innovation by improving their risk-taking levels and resource allocation efficiency, thereby promoting innovation investment. Heterogeneity analysis shows that the promotion effect of AI on innovation investment of family firms is more significant in smaller family firms, those directly founded by families, those with more family involvement in management, and those prior to intergenerational succession. Furthermore, the study finds that AI significantly improves the innovation performance of family firms. Our findings provide important theoretical and practical guidance for enterprises seeking to leverage AI to catalyze innovation investment and thereby achieve long-term value growth and sustainable development. Full article

(This article belongs to the Special Issue Sustainable Entrepreneurship, Innovation, and Management)

14 pages, 295 KB

Open AccessArticle

Differential Effects of Vitamin C from Fruit and Vegetables Versus Supplements on the Risk of Frailty

by Seulgi Lee and Kirang Kim

Nutrients 2025, 17(24), 3876; https://doi.org/10.3390/nu17243876 - 11 Dec 2025

Abstract

Background/Objectives: Frailty represents a critical aging-related condition, but evidence on how different sources of vitamin C relate to frailty risk remains limited. Thus, this study aimed to examine the relationship between frailty risk and sources of vitamin C intake (dietary, including fruit and [...] Read more.

Background/Objectives: Frailty represents a critical aging-related condition, but evidence on how different sources of vitamin C relate to frailty risk remains limited. Thus, this study aimed to examine the relationship between frailty risk and sources of vitamin C intake (dietary, including fruit and vegetable (FV) vs. supplemental) among Korean adults. Method: We analyzed data from 9478 adults in the Korea National Health and Nutrition Examination Survey (KNHANES 2018–2019). Frailty was assessed using a modified Fried phenotype. A multivariable logistic regression model was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for frailty according to vitamin C intake source. Results: More than 60% of participants had inadequate FV intake. Significant associations were observed primarily in women. Increased FV intake (OR = 0.44, 95% CI = 0.264–0.731, comparing the highest intake group (fourth quartile, Q4) vs. the lowest intake group (first quartile, Q1)) for dietary vitamin C intake (OR = 0.60, 95% CI = 0.393–0.914, Q4 vs. Q1) and vitamin C intake from FV (OR = 0.54, 95% CI = 0.348–0.851, Q4 vs. Q1), was significantly associated with a lower risk of frailty. Women with inadequate FV intake had a higher risk of frailty (OR = 2.06, 95% CI = 1.34–3.16) compared to those with adequate intake, regardless of vitamin C supplement use. In contrast, vitamin C supplementation was not significantly associated with frailty risk in either men or women. Conclusion: A higher intake of FV and dietary vitamin C, but not supplemental vitamin C, was associated with a lower risk of frailty, particularly among women. These findings suggest that improving overall diet quality through increased FV consumption may be more effective for frailty prevention than relying on single-nutrient supplementation. Full article

(This article belongs to the Special Issue Antioxidant-Rich Natural Fruit and Vegetable Foods and Human Health)

22 pages, 1792 KB

Open AccessReview

Awareness, Knowledge and Practice of Dental Professionals Regarding Biomedical Waste Management for a Green Dentistry: A Scoping Review

by Alice Murariu, Gabriela Luminița Gelețu, Livia Bobu, Simona Stoleriu, Gianina Iovan, Diana Zapodeanu, Bianca-Andreea Onofrei, Costin Iulian Lupu and Elena-Raluca Baciu

Dent. J. 2025, 13(12), 594; https://doi.org/10.3390/dj13120594 - 11 Dec 2025

Abstract

Background/Objectives: Climate change is a major global issue affecting all facets of society, including dentistry. In response, the idea of green dentistry has developed, prioritising the reduction in environmental damage and the protection of patient health. This scoping review seeks to assess [...] Read more.

Background/Objectives: Climate change is a major global issue affecting all facets of society, including dentistry. In response, the idea of green dentistry has developed, prioritising the reduction in environmental damage and the protection of patient health. This scoping review seeks to assess the level of awareness, understanding and practices of oral health professionals concerning the proper management of biomed. Methods: Searches were carried out in the Medline/PubMed, Scopus, Web of Science, Embase, and Google Scholar databases, analysing studies published between 2020 and 2025. Out of a total of 822 articles, 27 met the eligibility criteria. Results: In most of these studies, the respondents’ level of knowledge was found to be unsatisfactory or average, and only 17% of the studies reported respondents having a positive attitude towards adherence to sustainability principles. Although many professionals stated they were aware that dental waste could negatively impact the environment and human health if not properly managed, some still failed to provide correct answers to all the questions. Conclusions: The synthesis results indicated that oral health professionals have significant gaps in certain aspects of biomedical waste management, highlighting the need for proper training and to supplement the undergraduate and postgraduate curricula with courses on this topic. Full article

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31 pages, 5430 KB

Open AccessArticle

Sustainable Synthesis of Copper Oxide Nanoparticles: Data-Driven Photocatalysis, Pt-Free Hydrogen Production, and Antibacterial Assessment

by Umar Farooq, Mohammad Ehtisham Khan, Akbar Mohammad, Nazim Hasan, Abdullah Ali Alamri and Mukul Sharma

Catalysts 2025, 15(12), 1163; https://doi.org/10.3390/catal15121163 - 11 Dec 2025

Abstract

This study reports the green synthesis of copper oxide nanoparticles (CuO NPs) using Oxystelma esculentum extract as a reducing and stabilizing agent. The state-of-the-art analysis confirmed their spherical morphology, with an average particle size ranging from 20 to 25 nm, while XRD indicated [...] Read more.

This study reports the green synthesis of copper oxide nanoparticles (CuO NPs) using Oxystelma esculentum extract as a reducing and stabilizing agent. The state-of-the-art analysis confirmed their spherical morphology, with an average particle size ranging from 20 to 25 nm, while XRD indicated a crystalline structure consistent with the standard JCPDS card. The photocatalytic degradation of norfloxacin (NOR) was optimized using Response Surface Methodology (RSM), which identified the optimal conditions as a reaction time = 47.51 min, CuO-NPs dose = 48.46 mg, NOR dose = 35.90 ppm, and pH = 5.23. Under these optimized conditions, the CuO NPs achieved an initial degradation efficiency of 90%. In addition to photocatalytic degradation, the hydrogen (H₂) evolution performance of the CuO NPs was evaluated, yielding a H₂ production rate of 19.52 mmol g⁻¹ h⁻¹ under visible light. Moreover, the antimicrobial activity of the CuO NPs was assessed, showing significant antibacterial effects with inhibition zones of 8 mm and 9 mm against Klebsiella and Bacillus species. The CuO NPs also exhibited potent anticancer activity with an IC₅₀ value of 15.3 ± 1.40 μM against the HeLa cell line and notable antifungal activity with inhibition rates ranging from 70% to 90% against various fungal species. Full article

(This article belongs to the Special Issue Advanced Catalysis for Energy and a Sustainable Environment)

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16 pages, 1500 KB

Open AccessArticle

Migration of Nanoplastic in Soil: Effects of Polymer Properties and Rainfall Conditions

by Fang Wang, Hui Li, Yuchen Zhang, Jiannan Chen, Yuhe Zhang, Sibo Zhang and Bin Wang

Water 2025, 17(24), 3512; https://doi.org/10.3390/w17243512 - 11 Dec 2025

Abstract

The pervasive presence of nanoplastics (NPs) in the soil environment has been widely documented. However, the mechanisms governing their transport through soil remain poorly understood. This study investigated the migration and vertical distribution of NPs under simulated rainfall, examining the effects of NP [...] Read more.

The pervasive presence of nanoplastics (NPs) in the soil environment has been widely documented. However, the mechanisms governing their transport through soil remain poorly understood. This study investigated the migration and vertical distribution of NPs under simulated rainfall, examining the effects of NP properties (concentration, polymer type, aging) and rainfall conditions (duration, pH). The results demonstrated that rainfall facilitated the entry and retention of NPs in soil, with long-term rainfall promoting gradual migration to deeper layers or groundwater. NP mobility was inversely related to their contamination levels. Lower concentrations enhanced downward transport, while higher concentrations led to preferential retention in the topsoil. Due to its hydrophilicity, polyamide (PA) exhibits greater mobility in soil than hydrophobic polystyrene (PS). Both UV aging and acidic rainfall conditions inhibited the migration of NPs, which increased their long-term retention in soil, thereby elevating ecological risk. These results highlight the need for increased attention to the risk of groundwater contamination posed by hydrophilic NPs following long-term rainfall, as well as the threat posed by hydrophobic NPs, particularly after aging and under acidic rainfall conditions, to soil organisms and food safety. Our findings provide critical insights for assessing NP risks in soil environments. Full article

(This article belongs to the Section Soil and Water)

9 pages, 2447 KB

Open AccessArticle

Duration and Predictive Factors of Plastic Biliary Stent Patency: Results of a Large Prospective Database Analysis

by Egle Dieninyte, Eugenijus Jasiunas, Aistis Lemezis, Emilija Kezeviciute, Juozas Stanaitis and Tomas Poskus

J. Clin. Med. 2025, 14(24), 8788; https://doi.org/10.3390/jcm14248788 - 11 Dec 2025

Abstract

Background/Objectives: Endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent placement is a mainstay of current management for biliary obstruction, with stent occlusion being the most common and severe complication. The mechanism of stent occlusion is well known; however, factors affecting individual stent patency [...] Read more.

Background/Objectives: Endoscopic retrograde cholangiopancreatography (ERCP) with biliary stent placement is a mainstay of current management for biliary obstruction, with stent occlusion being the most common and severe complication. The mechanism of stent occlusion is well known; however, factors affecting individual stent patency are still controversial. The objective of this study was to determine the duration and factors affecting plastic biliary stent patency. Methods: We conducted a retrospective analysis of the consecutive procedures of endoscopic retrograde cholangiopancreatography (ERCP) and biliary stent placement in a single tertiary center during the period of 2010–2019. The primary outcome of the study was the time of stent patency. Secondary outcomes were the development of cholangitis upon re-stenting and whether subsequent re-stenting was emergent. Re-stenting was considered emergent if it happened before the planned elective re-stenting date, irrespective of indication (development of cholangitis, rising jaundice, suspected dislodgement, etc.). Results: Between 2010 and 2019, a total of 5462 ERCP procedures were performed, with 2659 resulting in plastic biliary stent placement. On average, the plastic biliary stent was patent for 63 (25, 96) days with significant differences between the indications for ERCP groups. The strongest risk factors for the development of cholangitis upon re-stenting was cholangitis during index ERCP (HR = 1.83; 95% CI: 1.48–2.27; p < 0.001), intrabiliary malignancy being the indication for stenting (HR = 1.34; 95% CI: 1.12–1.60; p < 0.001) and increasing number of stents being placed (HR = 1.73; 95% CI: 1.27–2.36; p < 0.001). Conclusions: Patients with an underlying malignancy, history of cholangitis, and multiple biliary stents are at an increased risk for stent occlusion and cholangitis, warranting a tailored stent exchange interval to prevent complications. Full article

(This article belongs to the Special Issue Advanced Endoscopy and Imaging in Gastrointestinal Diseases)

34 pages, 27827 KB

Open AccessArticle

Confined Fluids in Gel Matrices for the Selective Cleaning of a Tibetan Altar Table

by Chiara Biribicchi, Jessica Chasen and Laura Maccarelli

Gels 2025, 11(12), 1001; https://doi.org/10.3390/gels11121001 - 11 Dec 2025

Abstract

LACMA’s 19th-century Tibetan Altar Table with Auspicious Symbols is characterized by a complex stratigraphy comprising animal glue-based ground and paint layers, a presumably original tung oil-based varnish, and a dark surface layer composed of a complex mixture of paraffinic wax, shellac, and rapeseed [...] Read more.

LACMA’s 19th-century Tibetan Altar Table with Auspicious Symbols is characterized by a complex stratigraphy comprising animal glue-based ground and paint layers, a presumably original tung oil-based varnish, and a dark surface layer composed of a complex mixture of paraffinic wax, shellac, and rapeseed oil, which obscures the object’s original decorative scheme. This study examines the use of nanostructured fluids and organic solvents confined within hydrogels and organogels for the selective removal of the dark surface layer while preserving the underlying paint and varnish. Following the analysis of the artwork’s constituent materials, cleaning tests were conducted and evaluated using visible and ultraviolet fluorescence (UVF) imaging, spectrophotometry, and digital microscopy. The homogeneous absorption of solvent mixtures by the organogels was assessed through gas chromatography–mass spectrometry (GC–MS). Results indicate that confining cleaning fluids within the gels’ porous networks significantly improved solvent retention and control of fluid release. While conventional cleaning methods proved insufficiently selective, the gradual release of a nanostructured fluid containing a small amount of benzyl alcohol, combined with the nanostructural properties of the poly(vinyl alcohol)–sebacic acid (PSA2) hydrogel, enabled targeted removal of the surface layer while preserving the integrity of the underlying layers. Full article

(This article belongs to the Special Issue Advances in the Design and Application of Gels in Heritage Conservation)

30 pages, 4674 KB

Open AccessArticle

Climate Change Indicators and Impacts on Mastic Tree Cultivation in Chios, Greece

by Konstantinos Theodosiou, Konstantinos Papageorgiou, Athanasios Argiriou and Spyridon Κ. Golfinopoulos

Land 2025, 14(12), 2407; https://doi.org/10.3390/land14122407 - 11 Dec 2025

Abstract

Climate change, a natural phenomenon driven by anthropogenic interventions, represents a global challenge that requires immediate and effective action. Significant alterations in atmospheric parameters and the occurrence of extreme climatic events have become increasingly evident. To evaluate extreme climate conditions and their variations [...] Read more.

Climate change, a natural phenomenon driven by anthropogenic interventions, represents a global challenge that requires immediate and effective action. Significant alterations in atmospheric parameters and the occurrence of extreme climatic events have become increasingly evident. To evaluate extreme climate conditions and their variations within a specific region, climate data spanning at least five decades is essential. This study focuses on assessing the impacts of climate change on the island of Chios, with particular emphasis on its influence on the cultivation and harvesting of mastic gum, a unique product derived from the Pistacia lentiscus var. chia tree. Using ClimDex and analyzing 29 climate indices from 1960 to 2024, this paper evaluates historical and current climatic conditions. Key climate phenomena, such as the number of days with very high or low temperatures, extreme rainfall events, daily temperature variations, frost days, and days exceeding 25 °C—widely recognized indicators of climate change—are documented and correlated. Full article

(This article belongs to the Section Land–Climate Interactions)

20 pages, 3014 KB

Open AccessArticle

Single-Cell and Bulk RNA Sequencing Reveal SPINK1 and TIMP1 as Epithelial Cell Marker Genes Linked to Colorectal Cancer Survival and Tumor Immune Microenvironment Profiles

by Noor N. Al-Bzour, Zaid Nassar Abu-Rjai’, Ayah N. N. Al-Bzour, Abdulrahman Qasaymeh, Anwaar Saeed and Azhar Saeed

Int. J. Mol. Sci. 2025, 26(24), 11964; https://doi.org/10.3390/ijms262411964 - 11 Dec 2025

Abstract

Colorectal cancer (CRC) is a major cause of cancer death, with the tumor microenvironment and gene expression influencing outcomes. Identifying survival-associated epithelial marker genes (EMGs) may improve prognosis and guide therapy. We obtained single-cell RNA-sequencing (scRNA-seq) data from CRC patients (n = [...] Read more.

Colorectal cancer (CRC) is a major cause of cancer death, with the tumor microenvironment and gene expression influencing outcomes. Identifying survival-associated epithelial marker genes (EMGs) may improve prognosis and guide therapy. We obtained single-cell RNA-sequencing (scRNA-seq) data from CRC patients (n = 23,176 cells) from the TISCH database to identify EMGs through differential expression analysis. These were intersected with malignant cell markers. We used bulk RNA-seq data from TCGA-COAD (n = 375) to assess EMG prognostic value via univariable Cox analysis, followed by LASSO regression. Significant genes were evaluated using multivariable Cox models. An EMGs-based risk score was developed and validated using GSE39582 (n = 585) and GSE17536 (n = 177). Immune infiltration was assessed using xCELL and TIMER algorithms. A total of 107 EMGs were identified and assessed in TCGA data. Cox analysis identified 18 survival-related EMGs, which were narrowed by LASSO to SPINK1 and TIMP1. Multivariable analysis confirmed SPINK1 (HR: 0.88, 95% CI: 0.79–0.97, p = 0.009) and TIMP1 (HR: 1.66, 95% CI: 1.29–2.13, p < 0.001) as independent survival predictors. Patients were classified into high- (n = 187) and low-risk (n = 188) groups. The low-risk group had significantly better overall and disease-free survival. Immune profiling revealed distinct patterns, where the high-risk group showed higher dendritic cells, memory T-cells, macrophages, and immune checkpoint expression, while the low-risk group showed enrichment of NK cells, plasma cells, and CD4+ T-helper cells. These findings were validated in the GSE39582 and GSE17536 cohorts. EMGs have prognostic value in CRC, with SPINK1 and TIMP1 as independent survival predictors. Distinct immune patterns support integrating EMGs with immune profiling for improved risk stratification and personalized treatment. Full article

(This article belongs to the Section Molecular Oncology)

17 pages, 10887 KB

Open AccessArticle

The Effect of Bulk Nucleation Parameters on the Solidification Structure of Large Slabs During Electroslag Remelting and Optimization of Production Process Parameters

by Qi Li, Yu Du, Zhenquan Jing and Yanhui Sun

Crystals 2025, 15(12), 1052; https://doi.org/10.3390/cryst15121052 - 11 Dec 2025

Abstract

In this paper, the moving heat transfer boundary method is adopted to establish a three-dimensional solidification microstructure model based on the coupling technology of the cellular automata method (CA) and finite element method (FE), simulate the ingot growth process, and optimize the nucleation [...] Read more.

In this paper, the moving heat transfer boundary method is adopted to establish a three-dimensional solidification microstructure model based on the coupling technology of the cellular automata method (CA) and finite element method (FE), simulate the ingot growth process, and optimize the nucleation parameters. In addition, this study also explored the influence of process parameters such as melting rate, molten pool temperature, and cooling intensity on the solidification structure of ingots, providing a theoretical basis for process optimization. The results show that the maximum nucleation undercooling degree and the maximum nucleation density have significant effects on different crystal regions of the ingot solidification structure, while the maximum nucleation variance has no obvious effect on the changes in the solidification structure. When the maximum bulk nucleus undercooling degree

{Δ T}_{v, \max}

= 4 K, the bulk nucleus standard deviation

{Δ T}_{v, σ}

= 5 K, and the maximum bulk nucleus density

n_{v, \max}

= 3 × 107, the simulation results of the solidification structure can be well consistent with the experimental results. With the increase in smelting speed, the number of grains in the ingot structure gradually increases, while the average area of grains gradually decreases. The melting temperature and the intensity of side wall cooling have no obvious influence on the solidification structure of the ingot. Full article

(This article belongs to the Special Issue Crystallization of High-Performance Metallic Materials (3rd Edition))

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14 pages, 2434 KB

Open AccessArticle

Determining Olefin Content of Gasoline by Adaptive Partial Least Squares Regression Combined with Near-Infrared Spectroscopy

by Biao Du, Hongfu Yuan, Lu Hao, Yutong Wu, Chen He, Qinghong Wang and Chunmao Chen

Molecules 2025, 30(24), 4742; https://doi.org/10.3390/molecules30244742 - 11 Dec 2025

Abstract

The accurate and rapid determination of olefin content in gasoline is crucial for fuel quality control. While near-infrared spectroscopy (NIR) offers a rapid analytical solution, multiple parameters in the conventional partial least squares regression (PLSR) modeling process rely on the modeler’s subjective judgment. [...] Read more.

The accurate and rapid determination of olefin content in gasoline is crucial for fuel quality control. While near-infrared spectroscopy (NIR) offers a rapid analytical solution, multiple parameters in the conventional partial least squares regression (PLSR) modeling process rely on the modeler’s subjective judgment. Consequently, the quantitative accuracy of the model is often influenced by the modeler’s experience. To address this limitation, this study developed an integrated adaptive PLSR framework. The methodology incorporates four core adaptive components: automated selection of latent variables based on the rate of decrease in PRESS values, dynamic formation of calibration subsets using Spectral Angle Distance and sample number thresholds, optimization of informative wavelength regions via correlation coefficients, and systematic database cleaning through iterative residual analysis. Applied to 248 gasoline samples, this strategy dramatically enhanced model performance, increasing the coefficient of determination (R²) from 0.7391 to 0.9102 and reducing the root mean square error (RMSE) from 1.51% to 0.866% compared to the global PLSR model. This work demonstrates that the adaptive PLSR framework effectively mitigates spectral nonlinearity and improves predictive robustness, thereby providing a reliable and practical solution for the on-site, rapid monitoring of gasoline quality using handheld NIR spectrometers. Full article

11 pages, 1708 KB

Open AccessArticle

Switchable Thermal Emission Control Enabled by In₃SbTe₂ Phase Transition

by Yuanfang Lin, Jimin Wan, Weiyi Zha, Jiabao Sun, Zhenfang Yu, Huzheng Zhu, Pintu Ghosh and Qiang Li

Photonics 2025, 12(12), 1224; https://doi.org/10.3390/photonics12121224 - 11 Dec 2025

Abstract

Two types of devices capable of switchable infrared spectral control are demonstrated by utilizing the phase-change characteristics of In₃SbTe₂ (Indium–Antimony–Tellurium, IST), which transitions from a low-loss dielectric amorphous phase to a high-loss metallic crystalline state. Through comprehensive structural design, theoretical [...] Read more.

Two types of devices capable of switchable infrared spectral control are demonstrated by utilizing the phase-change characteristics of In₃SbTe₂ (Indium–Antimony–Tellurium, IST), which transitions from a low-loss dielectric amorphous phase to a high-loss metallic crystalline state. Through comprehensive structural design, theoretical calculation, simulation analysis, experimental measurement, and application demonstration, we realize distinct switching effects and functions of these two devices. In the first design, IST mono-layer thin films integrated with infrared-transparent substrates (KBr and ZnSe) enable switching between amorphous high transmittance and crystalline high reflectance states over the 2.5–15 μm range, suitable for infrared optical switches and stealth applications. In the second design, introducing a Si metasurface disk array atop the IST mono-layer thin film enables switching between broadband infrared transparency and narrowband high emissivity. This configuration allows independent spectral control of the infrared spectra within the non-atmospheric (5–8 μm) and atmospheric (8–14 μm) windows, providing a versatile platform for tunable thermal radiation management and adaptive infrared camouflage. Full article

(This article belongs to the Special Issue Optical Metasurfaces: Applications and Trends)

18 pages, 13130 KB

Open AccessArticle

Pseudoscorpions from Motu Motiro Hiva, a Remote Polynesian Island, with the Description of a New Genus of Chernetidae (Pseudoscorpiones)

by Mark S. Harvey, Matías Portflitt-Toro, J. Judson Wynne, Catalina Romero-Ortiz and Darko D. Cotoras

Diversity 2025, 17(12), 852; https://doi.org/10.3390/d17120852 - 11 Dec 2025

Abstract

Pseudoscorpions collected from the remote southeast Pacific Island of Motu Motiro Hiva (also known as Isla Salas y Gómez) yielded two different species. A juvenile specimen of the genus Garypus (Garypidae) was found near the seashore, which represents the most southerly record of [...] Read more.

Pseudoscorpions collected from the remote southeast Pacific Island of Motu Motiro Hiva (also known as Isla Salas y Gómez) yielded two different species. A juvenile specimen of the genus Garypus (Garypidae) was found near the seashore, which represents the most southerly record of Garypus in the Pacific Ocean. Numerous specimens of an unusual chernetid were taken from inside mummified carcasses of seabirds that breed on the island. Although they show morphological similarities to some other American genera such as Americhernes Muchmore, Cordylochernes Beier, and Lustrochernes Beier, the gaping fingers on the male chela and the positions of the trichobothria clearly differentiate them from all other genera. We therefore propose the new genus and species Motuchernes spatiodigitus sp. nov., which is endemic to this small remote and isolated island. Full article

(This article belongs to the Special Issue Arachnida Diversity and Conservation)

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14 pages, 4229 KB

Open AccessArticle

Formation of the Structure, Properties, and CorrosionResistance of Zirconium Alloy Under Three-Roll Skew Rolling Conditions

by Anna Kawałek, Alexandr Arbuz, Kirill Ozhmegov, Irina Volokitina, Andrey Volokitin, Nikita Lutchenko and Fedor Popov

Materials 2025, 18(24), 5578; https://doi.org/10.3390/ma18245578 - 11 Dec 2025

Abstract

Zirconium and its alloys are widely used in nuclear power engineering due to their favorable physical and mechanical properties and their low thermal-neutron absorption cross-section. Their high corrosion resistance in aqueous and steam environments at elevated temperatures is essential for the reliable operation [...] Read more.

Zirconium and its alloys are widely used in nuclear power engineering due to their favorable physical and mechanical properties and their low thermal-neutron absorption cross-section. Their high corrosion resistance in aqueous and steam environments at elevated temperatures is essential for the reliable operation of fuel assemblies and is associated with the formation of a stable, compact ZrO₂ oxide layer. However, under reactor conditions, the presence of hydrogen, iodine and other fission products can reduce corrosion resistance, making detailed corrosion assessment necessary. Manufacturing technology, alongside alloy composition, also plays a decisive role in determining corrosion behavior. This study presents corrosion test results for a Zr-1%Nb alloy processed under thermomechanical conditions corresponding to rolling in a special type of three-roll skew rolling–Radial-Shear Rolling (RSR). The applied rolling technology ensured the formation of a pronounced ultrafine-grained (UFG) structure in the near-surface layers, with an average grain size below 0.6 µm. EBSD and TEM observations revealed a largely equiaxed microstructure with refined grains and increased grain boundary density. The corrosion testing was performed in high-temperature steam vessels at 400 °C and 10.3 MPa for 72, 336, 720 and 1440 h. The results demonstrate that RSR processing is an efficient alternative to conventional multi-pass normal bar rolling with vacuum heat treatments, allowing a significant reduction in processing steps and eliminating the need for expensive tooling and intermediate thermal or chemical treatments. Bars manufactured using this method meet the ASTM B351 requirements. The specific weight gain did not exceed 22 mg/dm² after 72 h and 34.5 mg/dm² after 336 h. After 1440 h, the samples exhibited a continuous, uniform dark-grey oxide layer with an average thickness below 5.3 µm. Full article

(This article belongs to the Special Issue Corrosion Behavior and Mechanical Properties of Metallic Materials (Second Edition))

21 pages, 4553 KB

Open AccessArticle

Quality Differences in Ziziphus jujuba Mill. cv. Jinsi from Different Geographical Origins: A Comprehensive Multi-Indicator and Multivariate Statistical Evaluation

by Tianrui Pei, Jie Ji, Huaqian Gong, Ronghua Yue, Jialing Zhang, Xiaohui Ma, Li Lin and Ling Jin

Agriculture 2025, 15(24), 2570; https://doi.org/10.3390/agriculture15242570 - 11 Dec 2025

Abstract

Ziziphus jujuba Mill. cv. Jinsi (Z. jujuba), a commercially significant cultivar of Chinese jujube, is extensively cultivated across diverse regions of China. However, comprehensive evaluations addressing the quality disparities of Z. jujuba originating from different geographical regions have received limited attention. [...] Read more.

Ziziphus jujuba Mill. cv. Jinsi (Z. jujuba), a commercially significant cultivar of Chinese jujube, is extensively cultivated across diverse regions of China. However, comprehensive evaluations addressing the quality disparities of Z. jujuba originating from different geographical regions have received limited attention. To systematically evaluate quality variations in Z. jujuba across origins, 14 commercially cultivated commercial batches from 7 Chinese provinces were collected, with comprehensive parameters determined, including appearance, color, safety, aroma, flavor, and functional components. Multivariate statistical analyses, specifically Principal Component Analysis (PCA), Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA), and the entropy weight Technique for Order Preference by Similarity to Ideal Solution (TOPSIS), were employed for data interpretation. All samples met national standards for aflatoxin and SO₂ residues. Shanxi samples had the largest length and weight, while Jiangsu and Shaanxi showed optimal color. Key volatiles included nitrogen oxides and sulfides, with sweetness as the main sensory trait. Ningxia samples had the highest total triterpenes, Jiangxi the highest flavonoids, and Shandong the highest polysaccharides, and Shaanxi samples possessed the highest total oligosaccharides. Entropy weight TOPSIS ranked quality as Ningxia > Shaanxi > Jiangsu > Jiangxi > Shanxi > Shandong > Henan. These findings confirm origin-related environmental effects on Z. jujuba quality, providing a scientific basis for its quality evaluation and sustainable development. Full article

(This article belongs to the Section Agricultural Product Quality and Safety)

26 pages, 4335 KB

Open AccessArticle

Effects of Station-Area Built Environment on Metro Ridership: The Role of Spatial Synergy

by Shiyun Luo, Yuluo Chen, Lina Yu, Yibin Zhang, Xuefeng Li, Sen Lin and Li Jiang

Sustainability 2025, 17(24), 11126; https://doi.org/10.3390/su172411126 - 11 Dec 2025

Abstract

Evaluating transit-oriented development (TOD) efficiency in metro station areas remains challenging, as the traditional “Node–Place” model gives limited consideration to guiding factors and struggles to account for inter-regional flows under spatial heterogeneity. To address these limitations, this study develops an enhanced “Node–Place–Accessibility” model [...] Read more.

Evaluating transit-oriented development (TOD) efficiency in metro station areas remains challenging, as the traditional “Node–Place” model gives limited consideration to guiding factors and struggles to account for inter-regional flows under spatial heterogeneity. To address these limitations, this study develops an enhanced “Node–Place–Accessibility” model by introducing an accessibility dimension to better capture station-level connectivity and walkability. DepthmapX and a convex space approach were applied to quantify station-area accessibility, reflecting passengers’ perceived spatial distance during transfers. The model establishes a TOD measurement framework based on spatial coupling and functional connectivity, enabling the identification of factors influencing metro ridership across different spatial scales. Moran’s I was employed to describe spatial agglomeration and a local spatial clustering method integrating both passenger flow and built-environment (BE) characteristics was constructed to reveal differentiated spatial patterns. The Multiscale Geographically Weighted Regression (MGWR) model was further employed to quantify the spatially varying impacts of BE factors on ridership. Results indicate that the improved model provides stronger discriminative power in identifying “balanced stations,” and that BE conditions exert significant impact on metro ridership, particularly in areas with strong coordination among TOD components. Among the BE dimensions, design granularity exerts a more substantial impact on ridership than connectivity, density, and accessibility. This methodology provides large cities with a reliable tool for formulating targeted strategies that promote positive interactions between transportation and land use, thereby supporting sustainable urban development. Full article

(This article belongs to the Section Sustainable Transportation)

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17 pages, 1657 KB

Open AccessArticle

The Effect of Deep Tillage Combined with Organic Amendments on Soil Organic Carbon and Nitrogen Stocks in Northeast China

by Wenyu Liang, Mingjian Song, Naiwen Zhang, Ming Gao, Xiaozeng Han, Xu Chen, Xinchun Lu, Jun Yan, Yuanchen Zhu, Shuli Wang and Wenxiu Zou

Agronomy 2025, 15(12), 2853; https://doi.org/10.3390/agronomy15122853 - 11 Dec 2025

Abstract

Soil organic carbon (SOC) and total nitrogen (TN) are fundamental indicators of soil fertility and long-term agricultural sustainability. However, intensive cultivation, residue removal, and imbalanced fertilization have resulted in substantial declines in SOC and TN across many agroecosystems, particularly in Northeast China. This [...] Read more.

Soil organic carbon (SOC) and total nitrogen (TN) are fundamental indicators of soil fertility and long-term agricultural sustainability. However, intensive cultivation, residue removal, and imbalanced fertilization have resulted in substantial declines in SOC and TN across many agroecosystems, particularly in Northeast China. This study investigated SOC and TN dynamics within the 0–35 cm profile of four representative soils in Northeast China under a continuous maize cropping system. Five treatments were assessed: conventional tillage (CT), deep tillage (DT), deep tillage with straw (SDT), deep tillage with organic fertilizer (MDT), and deep tillage combined with straw and organic fertilizer (SMDT). Compared with DT, organic amendment treatments increased SOC and TN contents in the 0–20 cm layer by 9.41–57.57% and 5.29–60.76%, respectively. The SMDT treatment achieved the highest SOC and TN stocks (65.03 Mg ha⁻¹ and 7.91 Mg ha⁻¹) and enhanced nutrient accumulation in the 20–35 cm layer. In the subsoil, the ratio of soil C and N (C/N) under SMDT increased by 3.11%, 11.08%, 2.10%, and −7.01% across the four soils, indicating improved C–N balance and reduced nutrient stratification. SOC and TN stocks were linearly correlated with cumulative C input, confirming that organic amendments were among the main drivers of C and N sequestration. Mantel and path analyses further revealed that clay content and mean annual precipitation enhanced SOC and TN storage by improving soil structure and C–N balance through increased C input and reduced bulk density. Overall, deep tillage combined with amendments strengthened C–N coupling, improved soil fertility, and provided a mechanistic basis for reconstructing fertile tillage layers and sustaining productivity in Northeast China. Full article

(This article belongs to the Special Issue Effects of Arable Farming Measures on Soil Quality—2nd Edition)

21 pages, 20704 KB

Open AccessArticle

Structural Adaptations to Saline Stress: Histomorphological Changes in the Osmoregulatory and Metabolic Organs of Perca schrenkii Under Acute and Chronic Challenges

by Guanping Xing, Kaipeng Zhang, Shixin Gao, Yichao Hao, Zhulan Nie, Jie Wei, Tao Ai, Shijing Zhang, Jiasong Zhang and Zhaohua Huang

Biology 2025, 14(12), 1775; https://doi.org/10.3390/biology14121775 - 11 Dec 2025

Abstract

The escalating scarcity of freshwater resources necessitates the utilization of alternative saline waters for sustainable aquaculture. Perca schrenkii, an endemic fish from the Ili River basin, demonstrates considerable potential for cultivation in chloride-type saline–alkaline waters: its 96 h acute salinity tolerance is [...] Read more.

The escalating scarcity of freshwater resources necessitates the utilization of alternative saline waters for sustainable aquaculture. Perca schrenkii, an endemic fish from the Ili River basin, demonstrates considerable potential for cultivation in chloride-type saline–alkaline waters: its 96 h acute salinity tolerance is higher than that of freshwater populations of its congeneric Perca fluviatilis. This study systematically investigated the histomorphological responses of its key osmoregulatory and metabolic organs—gill, kidney, intestine, and liver—under acute (12–14 ppt for 96 h) and chronic (3–7 ppt for 60 days) salinity stress. Acute exposure induced dose- and time-dependent structural damage, including lamellar fusion in gills, glomerular reduction in kidneys, mucosal atrophy in intestines, and hepatocellular swelling. In contrast, chronic acclimation revealed active remodeling, such as lamellar shortening, renal tubular dilation, intestinal muscularis thickening, and biphasic hepatocyte adjustments. A hierarchical framework of structural adaptation was proposed, delineating Safe (≤3 ppt), Acclimation (5 ppt), Tolerance (7 ppt), and Lethal (≥13 ppt) zones. These findings elucidate the structural basis of salinity tolerance in Perca schrenkii and provide practical morphological indicators for assessing fish health in saline aquaculture. Full article

(This article belongs to the Special Issue Adaptation of Living Species to Environmental Stress)

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37 pages, 503 KB

Open AccessArticle

Hooked and Distracted? A Network Analysis on the Interplay of Social Media Addiction, Fear of Missing Out, Cyberloafing, Work Engagement and Organizational Commitment

by Phillip Ozimek, Anna Sander, Nele Borgert, Elke Rohmann and Hans-Werner Bierhoff

Behav. Sci. 2025, 15(12), 1719; https://doi.org/10.3390/bs15121719 - 11 Dec 2025

Abstract

This study investigates interrelations among social media addiction (SMA), Fear of Missing Out (FoMO), cyberloafing (CL), work engagement (WE), and organizational commitment (OC) using network analysis. An online survey in Germany/Switzerland (n = 452; OC assessed in the employed subsample, n = 173) [...] Read more.

This study investigates interrelations among social media addiction (SMA), Fear of Missing Out (FoMO), cyberloafing (CL), work engagement (WE), and organizational commitment (OC) using network analysis. An online survey in Germany/Switzerland (n = 452; OC assessed in the employed subsample, n = 173) measured the five constructs. Unregularized and EBICglasso partial-correlation networks were estimated, and centrality and bridge indices were computed. Two robust edges emerged: a strong SMA–FoMO association and a strong positive WE–OC link; the regularized network additionally indicated a triangular SMA–FoMO–CL pattern. FoMO and OC acted as bridge nodes between problematic social media behaviors and work attitudes, whereas direct SMA links to WE/OC were weak or absent. Findings position FoMO as a pivotal mechanism connecting social media use to organizational attitudes and support, distinguishing functional micro-breaks from disruptive CL. Limitations include the cross-sectional design, student-skewed sample, self-report measures, smaller OC subsample, and a German/Swiss context. Full article

(This article belongs to the Section Social Psychology)

18 pages, 8129 KB

Open AccessArticle

Combined Application of Acidic Phosphate Fertilizers Improves Drip-Irrigated Soybean Yield and Phosphorus Utilization Efficiency in Liming Soil

by Dongfei Liu, Hailong Di, Songlin Liu, Yuchen Hao, Wenli Cui, Kaiyong Wang, Hong Huang and Hua Fan

Agronomy 2025, 15(12), 2852; https://doi.org/10.3390/agronomy15122852 - 11 Dec 2025

Abstract

Phosphorus (P) characteristics significantly affect crop yield and P use efficiency (PUE). It is unclear whether different types of acidic phosphate fertilizers can enhance the availability of phosphorus in liming soil and soybean yields. In this field experiment in 2022 and 2023 in [...] Read more.

Phosphorus (P) characteristics significantly affect crop yield and P use efficiency (PUE). It is unclear whether different types of acidic phosphate fertilizers can enhance the availability of phosphorus in liming soil and soybean yields. In this field experiment in 2022 and 2023 in Xinjiang, China, four phosphate fertilization treatments, including no phosphate fertilization (CK), application of monoammonium phosphate (MAP), application of urea phosphate (UP), and application of a mixture of monoammonium phosphate and urea phosphate (8:2, M8U2), were designed. Then, the impacts of the four phosphate treatments on the PUE, growth, and yield of the high-oil soybean variety Kennong 23 under drip irrigation were explored. The results showed that the application of phosphate fertilizers significantly increased the soil inorganic P, available P, and total P content compared with CK, promoting the growth and yield formation of soybeans. The soil Ca2-P content of the UP treatment was higher than that of the MAP treatment. The soil Ca8-P content of the M8U2 treatment was higher than that of the MAP treatment, but the soil phosphorus fixation was lower. The soil available P content, soybean plant P accumulation, leaf photosynthetic capacity, and dry matter accumulation all reached the maximum in the M8U2 treatment. The soybean yield, net revenue, and PUE of the M8U2 treatment were 6.04%, 9.37%, and 14.16% higher than those of the MAP treatment, and 7.64%, 16.59%, and 23.50% higher than those of the UP treatment, respectively. Therefore, the combined application of acidic phosphate fertilizers (MAP and UP) can increase soil available P content and plant P absorption in liming soil and stimulate photosynthesis, enhancing soybean yield and PUE. This study will provide a technical reference for the P reduction and soybean yield enhancement in arid areas. Full article

(This article belongs to the Topic Climate Change Impacts and Adaptation: Interdisciplinary Perspectives, 2nd Edition)

24 pages, 7331 KB

Open AccessArticle

Coarse-Grained Molecular Dynamics Simulations of Lipid Nanodroplets and Endosomal Membranes: Focusing on the Fusion Mechanisms

by Yeon Ju Go, Erkhembayar Jadamba and Hyunjin Shin

Int. J. Mol. Sci. 2025, 26(24), 11960; https://doi.org/10.3390/ijms262411960 - 11 Dec 2025

Abstract

Lipid nanoparticles (LNPs) have received significant attention as effective RNA carriers in RNA-based therapeutics and vaccines. Particularly, ionizable lipids (ILs) of LNPs play a crucial role in endosomal escape and lipid-mediated RNA delivery owing to their pH-dependent molecular characteristics. Therefore, it is essential [...] Read more.

Lipid nanoparticles (LNPs) have received significant attention as effective RNA carriers in RNA-based therapeutics and vaccines. Particularly, ionizable lipids (ILs) of LNPs play a crucial role in endosomal escape and lipid-mediated RNA delivery owing to their pH-dependent molecular characteristics. Therefore, it is essential to enhance the endosomal escape efficiency of ILs, which is primary bottleneck in the successful cytoplasmic delivery of RNA. However, the molecular-level understanding of the roles and dynamics of ILs during the endosomal escape stage remains unclear. To elucidate this, we utilized coarse-grained (CG) molecular dynamics (MD) simulations. In this simulation, we designed lipid nanodroplets (LNDs) containing D-Lin-MC3-DMA (MC3) and ALC-0315, which have proven effective as LNPs in RNA-based therapeutics and vaccines, respectively, while accounting for the pH environments of early and late endosomes. Also, we formulated lipid bilayers reflecting the composition of early and late endosomal membranes to investigate the fusion process between LNDs and endosomal membranes. Our findings reveal that, irrespective of endosomal membrane composition and LNP types, ILs are the first lipids to enter the endosomal membrane during the fusion, and the flip-flop process of ILs from the inner leaflet to the outer leaflet of the endosomal membrane is a critical step for LNP endosomal escape. More specifically, we observed that protonated ILs predominantly participate in the flip-flop process, while many deprotonated ILs remain clustered and disordered within the intermediate layer of the endosomal membrane. Furthermore, we found that the extent of IL flip-flop varies with the cholesterol content of the endosomal membrane. Additionally, under identical pH conditions, MC3-containing LNDs exhibited a more active IL flip-flop process toward the outer leaflet than ALC-0315-containing LNDs. This observation supports experimental findings that MC3-containing LNPs manifest higher endosomal escape efficiency than ALC-0315-containing LNPs in mRNA delivery studies. The mechanistic insights into the endosomal escape mechanism demonstrated by our simulations could aid in the development of effective ILs. Full article

(This article belongs to the Special Issue Editorial Board Members’ Collection Series: “Molecular Dynamics”)

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17 pages, 379 KB

Open AccessArticle

An Exploratory Analysis of Tumor Site- and Sex-Specific Associations of SNPs of LncRNA CCAT1, CCAT2, H19, HOTAIR, and PTCSC3 in Colorectal Lesions: A Hungarian Case–Control Study

by Krisztina Varajti, Andrea Vereczkei, Márk Kovács-Valasek, Afshin Zand, Tímea Varjas and István Kiss

Biomedicines 2025, 13(12), 3058; https://doi.org/10.3390/biomedicines13123058 - 11 Dec 2025

Abstract

Background: Colorectal cancer is a major public health burden in Hungary, with one of the highest incidence and mortality rates in Europe. Long non-coding RNAs (lncRNAs) have emerged as key regulators in tumorigenesis, but population-specific genetic associations remain understudied. This study aimed to [...] Read more.

Background: Colorectal cancer is a major public health burden in Hungary, with one of the highest incidence and mortality rates in Europe. Long non-coding RNAs (lncRNAs) have emerged as key regulators in tumorigenesis, but population-specific genetic associations remain understudied. This study aimed to investigate whether single-nucleotide polymorphisms (SNPs) in lncRNA genes are associated with colorectal cancer susceptibility, with attention to tumor site- and sex-specific effects. Methods: We conducted an exploratory case–control study involving 91 Hungarian participants (38 patients with colorectal lesions and 53 controls). Genotyping of six SNPs located in HOTAIR, PTCSC3, H19, CCAT1, and CCAT2 was performed using TaqMan-based qPCR. Associations were tested using allele frequency analysis, different genotype models (dominant, recessive, additive), and binary logistic regression, including stratified analyses by tumor subtype and sex. Results: While no significant associations were found in the unadjusted overall case–control comparisons, logistic regression including sex revealed that HOTAIR rs12826786 and rs7958904 were significantly associated with a reduced risk of colorectal lesions, particularly in females (p = 0.022 and p = 0.043). Analyses by tumor localization revealed that H19 rs2839698 and PTCSC3 rs944289 were more frequent in colon than in rectal tumors (p = 0.017 and p = 0.035) and were associated with a reduced risk of rectal tumors (OR = 0.18 and OR = 0.20), suggesting that these variants may influence tumor site rather than overall susceptibility. None of the results remained significant after Bonferroni correction. Conclusions: Our findings suggest that these selected lncRNA-related SNPs may contribute to colorectal cancer risk in a sex- and site-specific manner. These preliminary results warrant further validation in larger, independent cohorts and functional studies. Full article

(This article belongs to the Special Issue Exploring Human Diseases Through Genomic and Genetic Analyses)

22 pages, 35665 KB

Open AccessArticle

Cyber-Physical System for Terminal Infrastructure Monitoring: A Depth-Free Registration Framework via Geometric-Model Fusion

by Wanli Dang, Jian Cheng, Chao Wang, Qian Luo and Meng Li

Appl. Sci. 2025, 15(24), 13079; https://doi.org/10.3390/app152413079 - 11 Dec 2025

Abstract

The monitoring and security of large-scale terminal infrastructures represent a critical application domain for industrial cyber-physical systems. However, real-time 3D visualization in such environments faces significant challenges from dense crowds, specular reflections, and complex architectural layouts. This paper presents a cyber-physical system for [...] Read more.

The monitoring and security of large-scale terminal infrastructures represent a critical application domain for industrial cyber-physical systems. However, real-time 3D visualization in such environments faces significant challenges from dense crowds, specular reflections, and complex architectural layouts. This paper presents a cyber-physical system for terminal infrastructure monitoring, underpinned by a novel, depth-free camera registration framework. At its core, the system establishes explicit geometric mappings across four coordinate systems (world, 3D model, camera, image), leveraging known installation parameters to eliminate dependency on depth sensors. Dynamic inconsistencies are resolved through a multi-stage layout refinement process, enabling robust operation under terminal-specific challenges. The framework maintains real-time performance at over 25 FPS when processing 16 concurrent video streams on commercial hardware. Extensive evaluations demonstrate a 44.9% reduction in registration error compared to state-of-the-art methods, validating the system’s practicality for enhancing situational awareness and security in large-scale, dynamic terminals. Full article

(This article belongs to the Section Computing and Artificial Intelligence)

9 pages, 207 KB

Open AccessArticle

Impact of Different DOACs on Complications of TBI After Low-Energy Trauma

by Anna Antoni, Philipp Puhl, Lukas Wedrich, Rebecca Wagner, Matthias Millesi, Valerie Weihs, Elisabeth Schwendenwein, Silke Aldrian and Stefan Hajdu

J. Clin. Med. 2025, 14(24), 8787; https://doi.org/10.3390/jcm14248787 - 11 Dec 2025

Abstract

Background/Objectives: While direct oral anticoagulants (DOACs) are widely used, robust evidence for low-energy trauma is scarce. Studies have shown similar or better outcomes of traumatic brain injury (TBI) under DOAC therapy compared to vitamin K antagonists, but there is limited data on the [...] Read more.

Background/Objectives: While direct oral anticoagulants (DOACs) are widely used, robust evidence for low-energy trauma is scarce. Studies have shown similar or better outcomes of traumatic brain injury (TBI) under DOAC therapy compared to vitamin K antagonists, but there is limited data on the differences among DOAC types. Methods: We performed a retrospective study of TBI patients with pre-injury DOACs who presented to our level 1 trauma unit and received cranial computed tomography. Only low-energy trauma mechanisms were included. Results: We included 643 patients with an average age of 82 years. As per the Glasgow Coma Scale, 637 patients (99.1%) had a mild TBI and 34 patients (5.3%) had intracranial hematomas. No delayed intracranial bleeding occurred during in-hospital observation. Rivaroxaban was the most frequent DOAC (278, 43.2%), followed by apixaban (221, 34.4%), dabigatran (84, 13.1%), and edoxaban (60, 9.3%). Neurosurgical interventions were performed in three cases (0.5%). The head injury-related in-hospital mortality was 0.9% (six patients). Fisher’s Exact Test and regression analysis did not demonstrate statistically significant differences among the DOAC types regarding occurrence of intracranial bleeding, surgical interventions, or mortality. Conclusions: We found no statistically significant differences between DOACs regarding complications of TBI after low-energy trauma. This study shows an overall low risk of complications after low-energy trauma in a predominantly geriatric population with TBI and DOAC therapy. Full article

(This article belongs to the Special Issue Advances in Traumatic Brain Injury: Causes and Recovery)

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