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    • Article
    • Open Access

    Radio altimetry is important for sensing the near-ground altitude of airborne platforms operating at several-kilometre altitudes. In urban environments, multipath propagation and coherent superposition from buildings and ground surfaces can alter echo delay, energy, and waveform, thereby affecting downstream ranging and altitude-estimation decisions. Conventional echo models often cannot retain the geometric propagation delays, material properties, polarization transformations, and coherent phase relationships of individual scattering components in kilometer-scale three-dimensional scenes, limiting their ability to reconstruct physically consistent time-domain echoes. To address this, this study combines radio-altimetry echo simulation with electromagnetic simulation of urban environments and develops a finite-distance spherical-wave physical-optics method for modeling time-domain echoes in large-scale urban scenes. The method maps the scattering responses of urban surface facets to the received time-domain echo. Representative cases verify the accuracy of calculations of scattering amplitude, range attenuation, and two-way propagation delay. The results show that a uniform material assignment predominantly affects echo amplitude and energy while exerting only a limited influence on the delay structure. In contrast, variations in urban geometry alter the spatial locations and orientations of effective scattering facets and the coherence relationships among their complex fields, resulting in distinct main-peak positions, energy-delay distributions, and early- and late-arriving multipath structures.

    Electronics

    15 October 2026

    • Urology around the World
    • Open Access

    Nigeria bears a substantial burden of prostate cancer, which represents the leading cause of cancer mortality and the most frequently diagnosed malignancy among its male population [...].

    Soc. Int. Urol. J.

    15 October 2026

    • Article
    • Open Access

    Microgrid scheduling is a nonlinear, multimodal, and highly constrained optimization problem that requires effective coordination among renewable generation, controllable distributed generators, energy storage, and grid interaction. To improve the search capability of the original Crayfish Optimization Algorithm (COA), this study proposes an Enhanced Crayfish Optimization Algorithm (ECOA) inspired by the coordination characteristics of cross-media performing arts. Rather than simply combining independent operators, ECOA constructs a state-aware and behavior-specific adaptive search framework around the intrinsic behavioral structure of COA. Specifically, a rhythm-guided adaptive search strategy is embedded into the summer-resort behavior to dynamically regulate search intensity, a multi-role collaborative guidance strategy reconstructs the competition behavior through time-varying information interaction, and a stagnation-aware stage-transition perturbation strategy selectively reactivates exploration when the search becomes stagnant. Extensive experiments are conducted on the CEC2014, CEC2017, and CEC2022 benchmark suites under six-dimensional settings, and the results are compared with those of nine representative metaheuristic algorithms. The results show that ECOA achieves highly competitive convergence accuracy and run-to-run stability on most benchmark functions. Wilcoxon rank-sum tests and Cliff’s delta effect-size analysis indicate that many of the observed improvements are statistically significant and practically meaningful, while the Friedman test ranks ECOA first in all six benchmark settings. Ablation experiments further demonstrate that all three mechanisms contribute positively to performance and that their coordinated integration is more effective than any individual strategy. Parameter-sensitivity analysis shows that ECOA maintains effective convergence over a relatively broad range of the disturbance coefficient , with providing a balanced setting across different landscapes. Finally, ECOA is applied to a deterministic day-ahead microgrid scheduling problem with explicit feasibility repair and power-balance penalty handling. Under the considered operating scenario, ECOA achieves the lowest mean operating cost of 1361.8028 among all compared algorithms and produces coordinated power-allocation schedules satisfying the modeled operational constraints. These results demonstrate the effectiveness of ECOA for complex numerical optimization and constrained engineering scheduling problems.

    Symmetry

    15 October 2026

    • Review
    • Open Access

    Hydrogel-based flexible sensors have emerged as a promising platform at the intersection of materials science, flexible electronics, and biomedical engineering, owing to their tissue-like mechanical compliance, tunable ionic conductivity, and versatile chemical functionalizability. To translate laboratory-scale hydrogel devices into durable, reliable wearable systems, this review critically summarizes recent progress in functional hydrogels and organogels, covering literature reported up to September 2026, and organizes the discussion along the complete chain from material synthesis and characterization to wearable deployment. We first outline the synthesis principles of gel network architectures, including double networks, semi-interpenetrating networks engineered with nanosheet crosslinkers, organohydrogels employing mixed solvent systems, and mechanically interlocked topologies, followed by MXene-based composite gel materials and advanced 3D printing fabrication strategies. Six representative sensing mechanisms, namely piezoresistive, capacitive, triboelectric, thermoelectric, electrochemical, and multimodal decoupling, are then qualitatively and, where possible, quantitatively compared regarding their performance characterizations. We also discuss signal processing and readout electronics for each sensing mechanism, which are critical for wearable deployment. Dedicated sections analyze performance enhancement strategies aimed at mechanical robustness and sensitivity, and summarize self-healing chemistries along with environmental adaptation approaches, such as solvent replacement and deep eutectic solvent engineering, which are essential for long-term operational stability. We further propose a minimum reporting checklist for standardization and benchmarking and provide a systematic evaluation of long-term stability, toxicity, degradation data, leachables, . Finally, we highlight application frontiers of these gel materials in health monitoring biosensing, electronic skin, and human–machine interaction, and conclude with a critical assessment of key challenges in scalable manufacturing, biocompatibility, multimodal crosstalk, energy autonomy, and environmental sustainability. A dedicated discussion of environmental impact and sustainability, covering bio-based polymers, biodegradability, recycling, and life-cycle assessment.

    Gels

    15 October 2026

    • Article
    • Open Access

    Post-COVID-19 balance and postural control alterations have been reported after SARS-CoV-2 infection, but individual-level phenotyping remains challenging because post-acute sequelae are heterogeneous and often lack clear clinical ground truths. We analyzed motion capture balance data from 140 participants, including 114 post-COVID-19 participants and 26 control-group participants, who completed sensory organization/postural balance tasks under single-task and cognitive dual-task conditions. Relative joint angle trajectories were transformed into 0–5 Hz frequency-domain spectra, from which 13 balance-derived task contrasts were constructed to capture cognitive dual-task versus single-task differences, closed-eyes versus open-eyes task condition differences, and related task condition changes. Joint-wise spectral contrast features were encoded using a vector-quantized variational autoencoder. Control-distant subgroup discovery was then formulated as a control-anchored, graph-based QUBO clustering problem and solved using a quantum annealing workflow. Simulated annealing and tabu search were applied to the identical BQM/QUBO formulation as classical solver-level references, whereas Gaussian mixture modeling was retained as an unconstrained classical clustering reference. Consistent with the control-anchored design of the QUBO objective, QUBO clustering identified a selective subset of post-COVID-19 participants with control-distant latent balance profiles while largely preserving the control-group reference structure. Across all task contrasts, quantum annealing assigned 1 of 307 control-group participant–contrast assignments (0.3%) and 118 of 1366 post-COVID-19 participant–contrast assignments (8.6%) to the control-distant group. Simulated annealing and tabu search produced slightly larger but similar control-distant post-COVID-19 subsets, assigning 143 of 1366 post-COVID participant–contrast assignments (10.5%) and 0 of 307 control-group participant–contrast assignments (0.0%) to the control-distant group. In contrast, GMM assigned 63 of 307 control-group participant–contrast assignments (20.5%) and 266 of 1366 post-COVID-19 participant–contrast assignments (19.5%) to the control-distant group. Parameter sensitivity analysis showed high overall assignment agreement for the same BQM/QUBO formulation, but the exact membership of the sparse control-distant subset was more variable. Simulated annealing sensitivity analysis showed overall agreement of 98.3–100.0% and control-distant Jaccard indices of 0.836–1.000 relative to the baseline, whereas a representative QPU sensitivity analysis showed overall agreement of 93.6–100.0% and control-distant Jaccard indices of 0.443–1.000. Frequency band profiles further suggested that QUBO-derived control-distant assignments corresponded to contrast-dependent and exploratory interpretable postural control patterns, particularly in low-frequency postural sway-dominant and mid–low-frequency postural control bands. These findings support the feasibility of objective-driven, control-anchored QUBO-based quantum-assisted clustering for exploratory subgroup discovery in heterogeneous, label-limited biomedical datasets. The proposed framework does not establish diagnostic criteria for long COVID or evidence of quantum speedup but provides a hypothesis-generating approach for interpretable post-COVID-19 neuromotor phenotyping and related medical data analysis applications.

    Sensors

    15 October 2026

    • Article
    • Open Access

    Collaborating with service users with lived experience of systems and processes, including the Criminal Justice System, can help tailor services, which in turn might increase accessibility, engagement, and satisfaction. Despite domestic abuse survivors often expressing a desire to be involved in developing and improving services, opportunities to do so have traditionally been limited, and their experiences of providing a ‘victim voice’ have not been extensively explored. The present paper outlines findings from interviews conducted with five survivors who took part in a range of collaborative engagement activities with criminal justice practitioners and other service providers (e.g., housing and social services) as ‘experts by experience’. During the interviews they reflected on their experiences and considered opportunities for increased involvement of survivors in developing services and support provisions moving forward. Key themes from thematic analysis of the interview data included the importance of survivors’ voices being heard, with their experience acknowledged and their contributions valued, as well as the need for effective facilitation and management of collaborative opportunities. More broadly, notable personal benefits were described by all participants, including feeling empowered by being given the opportunity to have a voice in driving change.

    Soc. Sci.

    15 October 2026

    • Article
    • Open Access

    The red-claw crayfish, Cherax quadricarinatus, is a commercially valuable freshwater aquaculture species, with muscle flavor representing a core trait driving consumer preference and market value. Under identical farming conditions, same-batch crayfish commonly develop marked size divergence within and between sexes, but the impacts of this variation on muscle volatile flavor profiles remain largely unexplored. Here, C. quadricarinatus reared under consistent environmental conditions were categorized into four groups by body weight and sex: large-size female (GUBF), large-size male (GUBM), small-size female (GUSF), and small-size male (GUSM). Headspace solid-phase microextraction–gas chromatography–mass spectrometry (HS-SPME/GC-MS) was employed to profile volatile organic compounds. Multivariate statistical analysis, relative odor activity value calculation, metabolic pathway and network analysis, and receiver operating characteristic (ROC) analysis were combined to dissect flavor variation patterns, identify key aroma compounds, reveal underlying metabolic mechanisms, and screen potential biomarkers. Proximate composition analysis showed significant size differences in crude protein, lipid, moisture, and meat yield, with no significant sex differences. One hundred thirty-six volatile metabolites across 15 chemical categories were identified in all samples. Multivariate statistical analyses revealed clear separation among the four groups, suggesting that both body size and sex shape muscle volatile metabolite profiles, with stronger effects observed in females. Thirty-eight shared aroma-active compounds were detected, mainly including alcohols, aldehydes, ketones, esters, and aromatic hydrocarbons. The overall sensory profile was dominated by sweet-like notes, followed by fruity and green notes. Sex-related flavor differences were relatively slight in large-size crayfish but pronounced in small-size individuals. Large-size female crayfish had simpler flavor composition, while small-size females showed higher diversity and abundance of flavor compounds; size variation had limited effects on male flavor. Butanoate metabolism was significantly enriched in both the small-size sex comparison and female size comparison. Core metabolic frameworks were generally conserved across groups, but key hub metabolites differed by comparison type. This study systematically characterized the volatile flavor profiles of C. quadricarinatus muscle across different body sizes and sexes under controlled farming conditions, providing preliminary references for quality evaluation and premium aquaculture optimization of C. quadricarinatus.

    Foods

    15 October 2026

    • Article
    • Open Access

    This article studies how narrativity, performativity and visuality are employed in Shakespeare comics: single-volume adaptations of individual Shakespeare plays in comic book, graphic novel or manga form. The cases studied include two Classics Illustrated titles (Julius Caesar, Hamlet), two No Fear Shakespeare Graphic Novels (Hamlet, Macbeth) and the Manga Classics Macbeth. These are all geared towards older children, but like most comics they can be enjoyed by readers of all ages. In discussions framed by adaptation theory and research on children’s editions of Shakespeare, I study how verbal content such as paraphrase, captions in text boxes and original Shakespearean verse interact with visual elements in these comics, and I argue that the legibility, aesthetic interest and reader engagement engendered by Shakespeare comics emerge primarily from their multimodal narrative design—which has literary, dramatic and visual arts qualities—whilst paraphrasing the verbal language is less effective. Scholarship on Shakespearean prose retellings for older children identifies cultural assumptions that underlie this genre of adaptation and demonstrates how narrative has been used to reinscribe problematic moral stances, worldviews and a form of bardolatry. Comics’ visual–verbal narrative design enables reinterrogations of the canon through comparing several Shakespeare comics. I show how the manner in which framing devices, drawing styles, character designs and settings interact and interblend with the verbal content, thus determining how Shakespeare comics create meaning, and how they help us reassess Shakespeare’s position in culture. At the same time, the conspicuous co-authorship seen in Shakespeare comics, between text, textual adaptation, mise-en-page and visual art, contributes towards subverting the notion of Shakespeare as singular genius.

    Literature

    15 October 2026

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Highly Accessed Articles

  • Article
  • Open Access

I argue that the emerging sciences of synthetic morphology and diverse intelligence suggest non-physicalist models of mind and show how they can be empirically investigated. Whence the anatomical, physiological, molecular-biological, and behavioral properties of engineered new beings that have never before existed, and do not have a history of selection? Understanding, predicting, and guiding new forms of life and mind requires characterizing a structured latent space of patterns. Developmental, synthetic, and behavioral biology should take seriously, and exploit, the kinds of non-physicalist ideas that are already a staple of Platonist mathematics. I propose the following hypotheses. (1) Patterns in this space span a highly variable degree of agency, comprising a spectrum ranging from static truths studied by mathematicians to active ones studied by behavioral scientists (i.e., some patterns on the same spectrum as mathematical truths are kinds of minds). (2) The relationship between mind and body is the same as the relationship between causally instructive mathematical facts and physics. (3) Living beings have no monopoly on the “free lunches” provided by the ingression of these patterns into the physical world. While traditional computationalist views of living and cognitive systems are insufficient, my framework erases artificial distinctions between organisms and machines, framing all physical constructs (natural or engineered) as being, to various degrees, in-formed by patterns from the latent space. I sketch a research program, already begun, inspired by these ideas. Such frameworks, while contradicting long-held assumptions of both mechanists and organicists, could have many implications for evolutionary biology, regenerative medicine, AI, and the ethics of synthbiosis with the forthcoming immense diversity of morally important beings.

Philosophies

9 September 2026

73,994 Views
Bodies and minds self-assemble from single cells as a process of alignment and autopoiesis. (A) Most complex biological forms begin as one cell—a fertilized oocyte, commonly thought to be well-described by the laws of physics and chemistry. (B) A gradual, slow process of developmental morphogenesis results in the final form of the organism, which may have complex structure and a mind which may not believe it is a “machine”. Our transformation from a chemical soup into an active embodied mind is continuous but heterogeneous: (C) while we commonly think of ourselves as a unified intelligence with a “centralized” brain, the fact is that even the pineal gland, of which there is only one in the brain, is made of cells (C′) and those cells in turn are made of myriad other active components (C″)—we are a collective intelligence at all scales. (D) The creation of an “individual” out of an excitable medium such as an embryonic blastoderm with hundreds of thousands of cells is a dynamic process that is not hardwired: scratches made in that blastoderm would result in independent self-organization in each island, resulting in multiple embryos forming. This reveals the potentiality for some non-pre-determined number of minds to arise out of the same substrate. Images in (A,B,D) courtesy of Jeremy Guay of Peregrine Creative, used previously in [29]. Image (B) used with permission from [30]. Image in (C′) courtesy of Jose Calvo, Science Photo Library. Image in (C″) courtesy of Evan Ingersoll and Gaël McGill. Image (D) used with permission from [31].
  • Review
  • Open Access

Background: Chlorine dioxide (ClO2), formulated as an aqueous solution (CDS), has been proposed as a therapeutic agent, yet its classification among oxidizing compounds is frequently confounded with chemically distinct species—sodium chlorite (NaClO2) and sodium hypochlorite (NaOCl). Objective: This study aimed to synthesize the physicochemical, mechanistic and cellular basis of ClO2 action and to delineate the distinctions between ClO2 and related oxidants, with explicit separation of established data from hypothesized data. Methods: The methodology includes a narrative synthesis of electrochemical data, primary toxicological and clinical literature (PubMed) and the redox-biology literature on low-dose oxidant signaling. Results: ClO2 is a neutral free radical that acts via one-electron transfer (E°′ = +0.95 V vs. SHE for the half-reaction ClO2 + e− → ClO2−, essentially pH-independent over pH 4–8, pH-independent) without chlorination. Its antimicrobial action is attributable to oxidation of thiol-dependent enzymes and membrane constituents and to the inhibition of bacterial respiratory metabolism; host-cell sparing is consistent with differential glutathione-dependent buffering. Controlled human ingestion studies at low concentrations report a favorable short-term safety profile; conversely, the principal metabolite (chlorite) is associated with documented developmental toxicity in animals and regulatory caution by EPA/WHO. Low-dose ClO2 exposure is hypothesized—but not yet directly demonstrated—to elicit dose-dependent adaptive redox responses and redox-regulatory modulation. Conclusions: The one-electron, non-chlorinating chemistry of ClO2 provides a coherent mechanistic framework. The translation of this framework into clinical application requires prospective trials and direct mechanistic measurement, ideally conducted by independent investigators. The following mechanisms are hypothesized and have not yet been directly demonstrated in vivo: modulation of oxidative phosphorylation, mitochondrial oxygenation, and associated redox-regulatory signaling. Reported antimicrobial efficacy typically occurs in the low-ppm range (0.1–5 ppm), whereas adverse effects on mammalian cells in the reviewed literature are reported at concentrations at least one order of magnitude higher; direct head-to-head cytotoxicity comparisons remain scarce and are identified as a priority for future work. This differential thiol buffering—in particular, the higher glutathione content of many mammalian cells relative to many pathogens—has been proposed as a contributing basis for host-cell sparing; direct quantitative confirmation in vivo is not yet available. Bacterial species possess their own thiol-based defense systems (e.g., mycothiol in actinomycetes, bacillithiol in Firmicutes), and the interplay between ClO2 and these systems requires further investigation.

Biophysica

21 September 2026

11,498 Views
Mechanistic overview. ClO2 acts via one-electron oxidation of microbial targets (thiol oxidation, envelope and nucleic acid damage, respiratory inhibition); host cells are spared through glutathione-dependent redox buffering. The proposed low-dose hormetic response is a hypothesis requiring direct experimental confirmation, as discussed in Section 4.2.
  • Article
  • Open Access

Nanoconfinement-Enhanced CO2 Retention in Fenamate-Loaded Silica Aerogels

  • Konstantin Belov,
  • Maria Ikim and
  • Ilya Khodov
  • + 6 authors

The interaction between carbon dioxide and molecularly confined pharmaceutical compounds can result in CO2 retention that exceeds that achieved through conventional physical adsorption. This study investigates CO2 retention following sorption in hydrophilic and hydrophobic silica aerogels containing the fenamates mefenamic acid and flufenamic acid. The Thermal stability of the retained CO2 was characterized using temperature-programmed oxidation and temperature-programmed desorption measurements. Concurrently, single-point nitrogen adsorption measurements monitored relative changes in the apparent accessible surface area of the porous matrix. Untreated silica aerogels did not exhibit a significant CO2 desorption peak at elevated temperatures. In contrast, all composites containing fenamates exhibited an additional high-temperature desorption step beginning at approximately 225 °C, indicating enhanced CO2 retention after sorption once the external CO2 layer was removed. This characteristic persisted following preliminary thermal treatment, suggesting it is not solely attributable to residual volatile substances. Surface-area measurements indicated minimal changes in the original aerogels after the CO2 cycle, whereas composites with flufenamic acid demonstrated more pronounced alterations. Considering previous nuclear magnetic resonance, spectroscopic, and computational studies, these findings suggest a combined effect of nanoconfinement, surface-dependent interfacial phenomena, and specific interactions involving the fenamate-containing phase. Reversible chemical interactions may contribute to the observed retention, although the current measurements do not allow for quantitative separation of their effects from those of physical confinement.

Molecules

14 September 2026

12,261 Views
TPO (black) and TPD (red) curves for AG-H-Phil (a) and AG-H-Phob (b) recorded over the temperature range from 30 °C to 500 °C.
  • Article
  • Open Access

Digital Facial Approximation of Jebel Irhoud Composite Skull (~315,000 BP)

  • Cicero Moraes,
  • Elena Varotto and
  • Johari Yap Abdullah
  • + 3 authors

The archeological site of Jebel Irhoud, Morocco, houses the oldest fossils attributed to Homo sapiens, dated to approximately 315,000 years before present (BP). This study presents a forensic facial approximation based on data from a three-dimensional composite skull derived from Layer 7 of the site, with structural predominance of the Irhoud 1 fossil. The methodology employed open-source software tools, combining anatomical projections and the constrained anatomical deformation technique. Endocast segmentation yielded a volume of 1364 mL, a result fully compatible with measurements and segmentations obtained in previous studies directly from the fossil, while also aligning with the variation observed in modern populations. Two sets of images were produced: an objective approximation in grayscale, focused on osteological correspondence, and a colored artistic version featuring skin pigmentation and facial hair for scientific communication. The results reinforce the feasibility and reproducibility of open-access methodologies applied to paleoanthropology, offering an anatomically coherent representation of this Middle Pleistocene hominin.

Heritage

13 September 2026

10,777 Views
(A) Photogrammetry performed from video (credit: Philipp Gunz, MPI EVA Leipzig, License: CC-BY-SA 2.0). (B) One of the scale adjustments based on images of the findings. (C) Adjustment of the virtual donor to the endocranial structure (credit: Philipp Gunz, MPI EVA Leipzig, License: CC-BY-SA 2.0). (D) Segmentation of the endocranium from the anatomical deformation of the virtual donor. References available in [3].

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Editor's Choice Articles

  • Article
  • Open Access

This study investigates the compound surface modification of 7075 aluminum alloy through the High-Speed Cutting-Solid Projectile Embedded Water Jet (HSC-SPEWJ) method. The research employed SEM, XRD, TEM, and HRTEM techniques to assess how process parameters such as jet pressure, nozzle distance, and nozzle traverse speed influence surface properties, including surface quality, roughness, microhardness, residual stress, and microstructural evolution in the alloy. The results indicate that the surface of the alloy treated with the SPEWJ process primarily exhibits features such as “craters,” microcracks, and micropores, with the lowest surface roughness recorded at 0.6214 μm. The modification leads to the formation of a plastic deformation layer with depths varying between 28 and 78 μm, with the maximum depth of 78 μm achieved at a jet pressure of 15 MPa. This treatment results in an 8.8% increase in the maximum microhardness when compared to the untreated sample. The greatest work-hardened layer observed extended to a depth of 100 μm. Furthermore, the surface residual compressive stress reached −210.37 MPa, with the stress field extending to 356 μm below the surface. The HSC-SPEWJ treatment also facilitated the formation of high-density dislocations and grain refinement in the alloy, while the size of the Precipitate-Free Zone (PFZ) was reduced by 5 to 10 nm relative to the untreated sample.

Coatings

29 September 2026

(a) Machining Setup; (b) Schematic Diagram of Machining Process; (c) Cutting Tool.
  • Review
  • Open Access

Idiosyncratic drug-induced severe neutropenia and agranulocytosis are rare but potentially life-threatening adverse drug reactions. They cause profound neutrophil depletion after exposure to non-cytotoxic medications. Advances in supportive care have substantially reduced mortality. Long-term management nevertheless remains challenging. Clinicians must decide whether a structurally or pharmacologically related drug can be prescribed safely (cross-reactivity). They must also decide whether the culprit drug can ever be reintroduced (rechallenge). Current evidence supports an immune-mediated pathogenesis. It involves reactive drug metabolites, hapten formation, human leukocyte antigen (HLA)-restricted antigen presentation, and T-cell activation. The strength of evidence for cross-reactivity varies considerably across drug classes. Clinically meaningful cross-reactivity is well established for antithyroid thionamides. Evidence for beta-lactam antibiotics and thienopyridine antiplatelet agents remains limited, resting largely on case reports and pharmacovigilance data. For most other medications, evidence is insufficient to support generalized class-wide avoidance. Evidence supporting drug rechallenge is similarly heterogeneous. The most robust data concern clozapine. Carefully selected patients with previous neutropenia—but generally not agranulocytosis—may successfully undergo rechallenge under intensive hematologic monitoring, often with granulocyte colony-stimulating factor (G-CSF) support. Outside this setting, deliberate rechallenge is rarely justified. It should be reserved for exceptional clinical circumstances when no effective therapeutic alternative exists. This review summarizes current mechanistic insights. It evaluates the available evidence for cross-reactivity and rechallenge across major drug classes, discusses the emerging role of pharmacogenomics, and proposes a practical framework to guide individualized clinical decision-making. Permanent discontinuation of the culprit drug remains the standard approach. Advances in immunology, pharmacogenomics, and international pharmacovigilance registries are progressively enabling more personalized risk assessment.

Hemato

28 September 2026

Schematic summary of the principal mechanisms proposed in idiosyncratic drug-induced severe neutropenia and agranulocytosis, integrating reactive-metabolite/hapten formation, innate danger signals, HLA-restricted antigen presentation, genetic susceptibility, and a minor contribution from direct marrow-progenitor toxicity.
  • Systematic Review
  • Open Access

Artificial intelligence (AI) is increasingly applied to image-based and image-formatted geoscientific evidence across mineral exploration, from regional and surface surveys to drilling/core analysis and laboratory characterization. However, the literature remains distributed across different research communities, making it difficult to compare how visual evidence, AI tasks, methodological choices, and geological outputs relate across exploration contexts. This systematic mapping review searched the Web of Science Core Collection, Scopus, and IEEE Xplore for English-language journal articles published between 2016 and 2026. Of 397 identified records, 91 studies were retained after deduplication, screening, and full-text assessment. The studies were mapped across exploration contexts, visual-data domains, AI visual tasks, methodological paradigms, and geological outputs. Regional and surface survey data dominate the evidence base, while drilling/core and laboratory imaging remain less represented. Classification is the most frequent visual task, and CNN-based models remain the dominant methodological paradigm, with hybrid and emerging architectures forming the next major group. The evidence does not indicate a single architecture that is uniformly suitable across mineral-exploration settings; model choice depends on input structure, required geological output, labeled-data availability, and spatial scale. Multisource integration can combine complementary evidence, but differences in spatial support, annotation, sensing conditions, and validation design continue to limit direct comparison and cross-region generalization. Future progress requires more traceable public resources, geographically independent validation, and more systematic integration of complementary geological evidence.

Minerals

25 September 2026

Conceptual overview of exploration contexts, visual data sources, AI vision tasks, learning paradigms, and geological outputs covered in this review.
  • Article
  • Open Access

Effect of the Network Structure of Serpentine on Pyrite Flotation

  • Yanhong Wang,
  • Rongjiao Li and
  • Shiqi Liu
  • + 1 author

In the process of sulfide ore beneficiation, layered silicate minerals, such as serpentine, tend to degrade the flotation effect. In order to fully understand the influence and mechanism of serpentine on pyrite flotation, an artificial mixed ore of pyrite–serpentine–quartz was used in this paper. The results showed that as the serpentine content increased, the recovery of pyrite decreased, along with the decrease in the flotation rate constant. The decrease in the flotation rate constant and concentrate grade was associated with possible slime coating and increased gangue transport to the concentrate at lower serpentine contents (≤30 wt.%). Mg distribution further confirmed that a considerable proportion of serpentine was reported to the concentrate. With the addition of serpentine, the pulp transitioned into a non-Newtonian fluid, accompanied by an increase in yield stress. The increases in pulp viscosity and structural resistance were associated with the network structure of serpentine. The development of E-F and E-E network structures was associated with higher apparent viscosity and yield stress, thereby contributing to the deterioration in flotation kinetics. This study provides a guideline for controlling the flotation process containing serpentine minerals.

Minerals

25 September 2026

Rheological measurement setup: (a) MCR 102 rheometer; (b) paddle rotor used for rheological measurements.